نتائج البحث - "Benjamin Noll"

المساهمون: Abdelaziz, Ahmed M, Diab, Sarah, Islam, Saiful, KC Basnet, Sunita, Noll, Benjamin, Li, Peng, Mekonnen, Laychiluh B, Lu, Jingfeng, Albrecht, Hugo, Milne, Robert W, Gerber, Cobus, Yu, Mingfeng, Wang, Shudong

المصدر: Medicinal Chemistry. 15:602-623

مصطلحات موضوعية: Mnk, Poly ADP ribose polymerase, Cell, Poly (ADP-Ribose) Polymerase-1, Down-Regulation, Antineoplastic Agents, Apoptosis, Context (language use), Protein Serine-Threonine Kinases, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, Drug Discovery, medicine, Humans, Structure–activity relationship, Pyrroles, Protein Kinase Inhibitors, 030304 developmental biology, 0303 health sciences, Molecular Structure, Chemistry, Kinase, EIF4E, Intracellular Signaling Peptides and Proteins, In vitro, Molecular Docking Simulation, inhibitor, Pyrimidines, medicine.anatomical_structure, Drug Design, 030220 oncology & carcinogenesis, Cancer research, Myeloid Cell Leukemia Sequence 1 Protein, Phosphorylation, anti-leukaemia, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78300ef209a34b429c837abbbb93df57
https://doi.org/10.2174/1573406415666181219111511

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Sulfonamide-Based Inhibitors of Biotin Protein Ligase as New Antibiotic Leads

المؤلفون: Kwangjun Lee, Andrew D. Abell, Steven W. Polyak, Beatriz Blanco-Rodriguez, John B. Bruning, Danielle Cini, Grant W. Booker, Robert W. Milne, Benjamin Noll, Andrew J. Hayes, Andrew C Marshall, Ashleigh S. Paparella, Jiage Feng, Matthew C.J. Wilce, Jingxian Yu, William Tieu

المساهمون: Lee, Kwang Jun, Tieu, William, Blanco-Rodriguez, Beatriz, Paparella, Ashleigh S, Yu, Jingxian, Hayes, Andrew, Feng, Jiage, Marshall, Andrew C, Noll, Benjamin, Milne, Robert, Cini, Danielle, Wilce, Matthew CJ, Booker, Grant W, Bruning, John B, Polyak, Steven W, Abell, Andrew D

المصدر: ACS Chemical Biology. 14:1990-1997

مصطلحات موضوعية: pharmacokinetic profile, 0301 basic medicine, Staphylococcus aureus, medicine.drug_class, Antibiotics, Microbial Sensitivity Tests, Molecular Dynamics Simulation, Crystallography, X-Ray, medicine.disease_cause, 01 natural sciences, Biochemistry, metabolic stability, Microbiology, Mice, 03 medical and health sciences, chemistry.chemical_compound, Bacterial Proteins, Drug Stability, Biotin, medicine, Animals, Carbon-Nitrogen Ligases, Enzyme Inhibitors, chemistry.chemical_classification, Sulfonamides, DNA ligase, 010405 organic chemistry, molecular dynamics simulations, General Medicine, Phosphate, Anti-Bacterial Agents, Rats, 0104 chemical sciences, Sulfonamide, 030104 developmental biology, chemistry, Drug Design, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17972eb42541dd574d7fb900e1b5a4a3
https://doi.org/10.1021/acschembio.9b00463

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5

Discovery of a potent, highly selective, and orally bioavailable inhibitor of CDK8 through a structure-based optimisation

المؤلفون: Theodosia Teo, Mingfeng Yu, Shudong Wang, Yuchao Yang, Benjamin Noll, Man-jun Li, Yi Long, Stephen Philip

المساهمون: Yu, Mingfeng, Long, Yi, Yang, Yuchao, Li, Manjun, Teo, Theodosia, Noll, Benjamin, Philip, Stephen, Wang, Shudong

المصدر: European journal of medicinal chemistry. 218

مصطلحات موضوعية: Male, Administration, Oral, Biological Availability, Antineoplastic Agents, Apoptosis, Pharmacology, 01 natural sciences, Rats, Sprague-Dawley, 03 medical and health sciences, Mice, Structure-Activity Relationship, Cell Line, Tumor, Drug Discovery, medicine, Animals, Humans, structure-based optimisation, MV4-11, Protein Kinase Inhibitors, 030304 developmental biology, Cell Proliferation, 0303 health sciences, Mice, Inbred BALB C, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Chemistry, Kinase, Organic Chemistry, Cancer, General Medicine, CDK8 inhibitor, Highly selective, medicine.disease, Cyclin-Dependent Kinase 8, kinase selectivity, 0104 chemical sciences, Bioavailability, Rats, oral bioavailability, Structure based, Cyclin-dependent kinase 8, anti-proliferation mechanism, Drug Screening Assays, Antitumor, G1 phase

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ef0bc6afe6fdcf34685615d9e589026
https://pubmed.ncbi.nlm.nih.gov/33823391

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Tacrolimus dose, blood concentrations and acute nephrotoxicity, but not CYP3A5/ABCB1 genetics, are associated with allograft tacrolimus concentrations in renal transplant recipients

المؤلفون: Rong Hu, Graeme R. Russ, Andrew A. Somogyi, Jonathan Tuke, Daniel T. Barratt, Benedetta C. Sallustio, Janet K. Coller, Benjamin Noll

المساهمون: Sallustio, Benedetta C, Noll, Benjamin D, Hu, Rong, Barratt, Daniel T, Tuke, Jonathan, Coller, Janet K, Russ, Graeme R, Somogyi, Andrew A

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f92d23f667a0cef3776f89a32945254f
https://hdl.handle.net/11541.2/147207

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Preclinical development of CDDD3-14, a potent and selective inhibitor of CDK4/6 for the treatment of breast cancer

المؤلفون: Benjamin Noll, Hugo Albrecht, Mingfeng Yu, Shudong Wang, Solomon Tadesse, Robert W. Milne, Gary K. Heinemann, Laychiluh Bantie, Jimma Likisa

المصدر: Oncology Abstracts.

مصطلحات موضوعية: Breast cancer, business.industry, medicine, Cancer research, General Medicine, medicine.disease, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4d4fe2e80f22bab18c5d9e0d68b1ea54
https://doi.org/10.1530/oncolabs.1.p050

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Discovery and pharmacological characterization of a novel series of highly selective inhibitors of cyclin-dependent kinases 4 and 6 as anticancer agents

المؤلفون: Laychiluh Bantie, Saiful Islam, Malika Kumarasiri, Solomon Tadesse, Benjamin Noll, Robert W. Milne, Khamis Tomusange, Ge Zhu, Nataliya Bykovska, Mingfeng Yu, Shudong Wang, Frankie Lam, Peng Li

المصدر: British Journal of Pharmacology. 175:2399-2413

مصطلحات موضوعية: 0301 basic medicine, Pharmacology, biology, Chemistry, Drug discovery, Cyclin-dependent kinase 4, Kinase, Cell cycle, 03 medical and health sciences, 030104 developmental biology, Cyclin-dependent kinase, Cancer cell, biology.protein, Cancer research, Cyclin-dependent kinase 6, E2F

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::245a3a7d6d4fa68a532dfb0d542e63b4
https://doi.org/10.1111/bph.13974

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9

Erratum to 'A first-in-class CDK4 inhibitor demonstrates in vitro, ex-vivo and in vivo efficacy against ovarian cancer' [Gynecologic Oncology 159 (2020) 827–838]

المؤلفون: Jimma Likisa, Shudong Wang, Solomon Tadesse, Martin K. Oehler, Andrew Beck, Robert W. Milne, Noor A. Lokman, Rupal Pradhan, Carmela Ricciardelli, Mingfeng Yu, Gary K. Heinemann, Benjamin Noll, Hugo Albrecht, Laychiluh Bantie

المصدر: Gynecologic Oncology. 163:215

مصطلحات موضوعية: Oncology, CDK4 Inhibitor, business.industry, In vivo, medicine, Cancer research, Obstetrics and Gynecology, Gynecologic oncology, Ovarian cancer, medicine.disease, business, Ex vivo, In vitro

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::e8035b333cf6e21eb3c9b79a8bc96007
https://doi.org/10.1016/j.ygyno.2021.07.018

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Full Text via ClinicalKey

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Potent and orally bioavailable CDK8 inhibitors: Design, synthesis, structure-activity relationship analysis and biological evaluation

المؤلفون: Muhammed H. Rahaman, John D. Hayball, Theodosia Teo, Stephen Philip, Laychiluh B. Mekonnen, Shudong Wang, Yi Long, Man-jun Li, Preethi Eldi, Mingfeng Yu, Benjamin Noll, Gary K. Heinemann, Yuchao Yang, Abel Tesfaye Anshabo, Robert W. Milne, Sarah Diab

المساهمون: Yu, Mingfeng, Teo, Theodosia, Yang, Yuchao, Li, Manjun, Long, Yi, Philip, Stephen, Noll, Benjamin, Heinemann, Gary K, Diab, Sarah, Eldi, Preethi, Mekonnen, Laychiluh, Anshabo, Abel T, Rahaman, Muhammed H, Milne, Robert, Hayball, John D, Wang, Shudong

المصدر: European Journal of Medicinal Chemistry. 214:113248

مصطلحات موضوعية: Male, Cell Survival, Pyridines, Administration, Oral, Biological Availability, Mice, Nude, Antineoplastic Agents, Pharmacology, Rats, Sprague-Dawley, Mice, Structure-Activity Relationship, Mediator, Transcription (biology), Cell Line, Tumor, Drug Discovery, Animals, Humans, Structure–activity relationship, drug-like properties, Kinase activity, Protein Kinase Inhibitors, Transcription factor, Cell Proliferation, Mice, Inbred BALB C, Dose-Response Relationship, Drug, Molecular Structure, Kinase, Chemistry, structure-activity relationship, Organic Chemistry, toxicity, General Medicine, CDK8 inhibitor, Cyclin-Dependent Kinase 8, Rats, Drug Design, Phosphorylation, Cyclin-dependent kinase 8, Female, Drug Screening Assays, Antitumor, pharmacokinetics

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9410b245d422cfbe104b9416c59eb800
https://doi.org/10.1016/j.ejmech.2021.113248

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