المؤلفون: Benton, BM, Zang, JH, Thorner, J

المصدر: Journal of Cell Biology. 127(3)

مصطلحات موضوعية: Biochemistry and Cell Biology, Biomedical and Clinical Sciences, Biological Sciences, Genetics, Amino Acid Isomerases, Amino Acid Sequence, Base Sequence, Carrier Proteins, Cell Nucleolus, Cloning, Molecular, DNA, Fungal, Escherichia coli, Genes, Fungal, Genotype, Heat-Shock Proteins, Molecular Sequence Data, Mutagenesis, Site-Directed, Oligodeoxyribonucleotides, Peptidylprolyl Isomerase, Polyenes, Polymerase Chain Reaction, Recombinant Proteins, Restriction Mapping, Saccharomyces cerevisiae, Sequence Deletion, Sequence Homology, Amino Acid, Sirolimus, Tacrolimus, Tacrolimus Binding Proteins, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/6wg2r46p

المؤلفون: Gruenbaum, Y, Landesman, Y, Drees, B, Bare, JW, Saumweber, H, Paddy, MR, Sedat, JW, Smith, DE, Benton, BM, Fisher, PA

المصدر: Journal of Cell Biology. 106(3)

مصطلحات موضوعية: Biological Sciences, Genetics, Biotechnology, Amino Acid Sequence, Animals, Base Sequence, Cloning, Molecular, DNA, Drosophila Proteins, Drosophila melanogaster, Female, Genes, Immunoassay, Lamins, Molecular Sequence Data, Nuclear Proteins, Nucleic Acid Hybridization, Protein Biosynthesis, Protein Precursors, RNA, Messenger, Sequence Homology, Nucleic Acid, Transcription, Genetic, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/8689549p

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المؤلفون: Skepper CK; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Armstrong D; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Balibar CJ; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Bauer D; Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland., Bellamacina C; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Benton BM; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Bussiere D; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., De Pascale G; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., De Vicente J; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Dean CR; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Dhumale B; Piramal Discovery Solutions, Pharmaceutical Special Economic Zone, Sarkhej Bavla Highway, Ahmedabad, Gujarat 382213, India., Fisher LM; Molecular and Clinical Sciences Research Institute, St George's University of London, London SW17 0RE, U.K., Fuller J; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Fulsunder M; Piramal Discovery Solutions, Pharmaceutical Special Economic Zone, Sarkhej Bavla Highway, Ahmedabad, Gujarat 382213, India., Holder LM; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Hu C; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Kantariya B; Piramal Discovery Solutions, Pharmaceutical Special Economic Zone, Sarkhej Bavla Highway, Ahmedabad, Gujarat 382213, India., Lapointe G; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Leeds JA; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Li X; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Lu P; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Lvov A; Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, United States., Ma S; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Madhavan S; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Malekar S; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., McKenney D; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Mergo W; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Metzger L; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Moser HE; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Mutnick D; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Noeske J; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Osborne C; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Patel A; Piramal Discovery Solutions, Pharmaceutical Special Economic Zone, Sarkhej Bavla Highway, Ahmedabad, Gujarat 382213, India., Patel D; Piramal Discovery Solutions, Pharmaceutical Special Economic Zone, Sarkhej Bavla Highway, Ahmedabad, Gujarat 382213, India., Patel T; Piramal Discovery Solutions, Pharmaceutical Special Economic Zone, Sarkhej Bavla Highway, Ahmedabad, Gujarat 382213, India., Prajapati K; Piramal Discovery Solutions, Pharmaceutical Special Economic Zone, Sarkhej Bavla Highway, Ahmedabad, Gujarat 382213, India., Prosen KR; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Reck F; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Richie DL; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Rico A; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Sanderson MR; Randall Centre for Cell and Molecular Biophysics, King's College, Guy's Campus, London Bridge, London SE1 1UL, U.K., Satasia S; Piramal Discovery Solutions, Pharmaceutical Special Economic Zone, Sarkhej Bavla Highway, Ahmedabad, Gujarat 382213, India., Sawyer WS; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Selvarajah J; Molecular and Clinical Sciences Research Institute, St George's University of London, London SW17 0RE, U.K., Shah N; Piramal Discovery Solutions, Pharmaceutical Special Economic Zone, Sarkhej Bavla Highway, Ahmedabad, Gujarat 382213, India., Shanghavi K; Piramal Discovery Solutions, Pharmaceutical Special Economic Zone, Sarkhej Bavla Highway, Ahmedabad, Gujarat 382213, India., Shu W; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Thompson KV; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Traebert M; Novartis Institutes for BioMedical Research, 4002 Basel, Switzerland., Vala A; Piramal Discovery Solutions, Pharmaceutical Special Economic Zone, Sarkhej Bavla Highway, Ahmedabad, Gujarat 382213, India., Vala L; Piramal Discovery Solutions, Pharmaceutical Special Economic Zone, Sarkhej Bavla Highway, Ahmedabad, Gujarat 382213, India., Veselkov DA; Randall Centre for Cell and Molecular Biophysics, King's College, Guy's Campus, London Bridge, London SE1 1UL, U.K., Vo J; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Wang M; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Widya M; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Williams SL; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Xu Y; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Yue Q; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Zang R; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Zhou B; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States., Rivkin A; Novartis Institutes for BioMedical Research, Emeryville, California 94608, United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2020 Jul 23; Vol. 63 (14), pp. 7773-7816. Date of Electronic Publication: 2020 Jul 07.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Bacterial Agents/*pharmacology , Drug Resistance, Bacterial/*drug effects , Fluoroquinolones/*pharmacology , Gram-Negative Bacteria/*drug effects , Topoisomerase II Inhibitors/*pharmacology, Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/metabolism ; Anti-Bacterial Agents/toxicity ; Binding Sites ; Cell Line, Tumor ; DNA Gyrase/metabolism ; DNA Topoisomerase IV/antagonists & inhibitors ; DNA Topoisomerase IV/chemistry ; Fluoroquinolones/chemical synthesis ; Fluoroquinolones/metabolism ; Fluoroquinolones/toxicity ; Gram-Negative Bacteria/enzymology ; Humans ; Microbial Sensitivity Tests ; Molecular Structure ; Structure-Activity Relationship ; Topoisomerase II Inhibitors/chemical synthesis ; Topoisomerase II Inhibitors/metabolism ; Topoisomerase II Inhibitors/toxicity

المؤلفون: Lee PS; Novartis Institutes for Biomedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Lapointe G; Novartis Institutes for Biomedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Madera AM; Novartis Institutes for Biomedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Simmons RL; Novartis Institutes for Biomedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Xu W; Novartis Institutes for Biomedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Yifru A; Novartis Institutes for Biomedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Tjandra M; Novartis Institutes for Biomedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Karur S; Novartis Institutes for Biomedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Rico A; Novartis Institutes for Biomedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Thompson K; Novartis Institutes for Biomedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Bojkovic J; Novartis Institutes for Biomedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Xie L; Novartis Institutes for Biomedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Uehara K; Novartis Institutes for Biomedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Liu A; Novartis Institutes for Biomedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Shu W; Novartis Institutes for Biomedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Bellamacina C; Novartis Institutes for Biomedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., McKenney D; Novartis Institutes for Biomedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Morris L; Novartis Institutes for Biomedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Tonn GR; Novartis Institutes for Biomedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Osborne C; Novartis Institutes for Biomedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Benton BM; Novartis Institutes for Biomedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., McDowell L; Novartis Institutes for Biomedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Fu J; Novartis Institutes for Biomedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Sweeney ZK; Novartis Institutes for Biomedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2018 Oct 25; Vol. 61 (20), pp. 9360-9370. Date of Electronic Publication: 2018 Oct 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Amidohydrolases/*antagonists & inhibitors , Isoxazoles/*chemistry , Isoxazoles/*pharmacology , Oxazolidinones/*chemistry , Oxazolidinones/*pharmacology, Animals ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Drug Evaluation, Preclinical ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/pharmacology ; Mice ; Microbial Sensitivity Tests ; Models, Molecular ; Molecular Conformation

المؤلفون: Moreau RJ; Novartis Institutes for BioMedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Skepper CK; Novartis Institutes for BioMedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Appleton BA; Novartis Institutes for BioMedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Blechschmidt A; Novartis Institutes for BioMedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Balibar CJ; Novartis Institutes for BioMedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Benton BM; Novartis Institutes for BioMedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Drumm JE 3rd; Novartis Institutes for BioMedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Feng BY; Novartis Institutes for BioMedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Geng M; Novartis Institutes for BioMedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Li C; Novartis Institutes for BioMedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Lindvall MK; Novartis Institutes for BioMedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Lingel A; Novartis Institutes for BioMedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Lu Y; Novartis Institutes for BioMedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Mamo M; Novartis Institutes for BioMedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Mergo W; Novartis Institutes for BioMedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Polyakov V; Novartis Institutes for BioMedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Smith TM; Novartis Institutes for BioMedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Takeoka K; Novartis Institutes for BioMedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Uehara K; Novartis Institutes for BioMedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Wang L; Novartis Institutes for BioMedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Wei JR; Novartis Institutes for BioMedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Weiss AH; Novartis Institutes for BioMedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Xie L; Novartis Institutes for BioMedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Xu W; Novartis Institutes for BioMedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., Zhang Q; Novartis Institutes for BioMedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States., de Vicente J; Novartis Institutes for BioMedical Research , 5300 Chiron Way , Emeryville , California 94608 , United States.

المصدر: Journal of medicinal chemistry [J Med Chem] 2018 Apr 26; Vol. 61 (8), pp. 3309-3324. Date of Electronic Publication: 2018 Apr 09.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Anti-Bacterial Agents/*pharmacology , Enzyme Inhibitors/*pharmacology , Escherichia coli Proteins/*antagonists & inhibitors , Heterocyclic Compounds, 2-Ring/*pharmacology , Nucleotidyltransferases/*antagonists & inhibitors, Anti-Bacterial Agents/chemical synthesis ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/metabolism ; Benzimidazoles/chemical synthesis ; Benzimidazoles/chemistry ; Benzimidazoles/metabolism ; Benzimidazoles/pharmacology ; Binding Sites ; Drug Discovery ; Enzyme Inhibitors/chemical synthesis ; Enzyme Inhibitors/chemistry ; Enzyme Inhibitors/metabolism ; Escherichia coli/drug effects ; Escherichia coli/enzymology ; Escherichia coli Proteins/chemistry ; Escherichia coli Proteins/metabolism ; Heterocyclic Compounds, 2-Ring/chemical synthesis ; Heterocyclic Compounds, 2-Ring/chemistry ; Heterocyclic Compounds, 2-Ring/metabolism ; Microbial Sensitivity Tests ; Molecular Structure ; Nucleotidyltransferases/chemistry ; Nucleotidyltransferases/metabolism ; Protein Binding ; Pseudomonas aeruginosa/drug effects ; Pseudomonas aeruginosa/enzymology ; Pyrimidinones/chemical synthesis ; Pyrimidinones/chemistry ; Pyrimidinones/metabolism ; Pyrimidinones/pharmacology ; Triazoles/chemical synthesis ; Triazoles/chemistry ; Triazoles/metabolism ; Triazoles/pharmacology