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المؤلفون: Zheng Xue, Tonći Šuštić, René Bernards, Oscar M. Rueda, Daniel J. Vis, Alejandra Bruna, Sake van Wageningen, Ankita Sati Batra, Carlos Caldas, Evert Bosdriesz, Lodewyk F. A. Wessels
المساهمون: Bosdriesz, Evert [0000-0002-8788-9548], Bernards, René [0000-0001-8677-3423], Apollo - University of Cambridge Repository, Bioinformatics
المصدر: Xue, Z, Vis, D J, Bruna, A, Sustic, T, van Wageningen, S, Batra, A S, Rueda, O M, Bosdriesz, E, Caldas, C, Wessels, L F A & Bernards, R 2018, ' MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models ', Cell Research, vol. 28, no. 7, pp. 719-729 . https://doi.org/10.1038/s41422-018-0044-4
Cell Research
Cell Research, 28(7), 719-729. Nature Publishing Groupمصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Male, MAP Kinase Kinase 4, Nude, Drug Resistance, MAP2K4, Mitogen-activated protein kinase kinase, medicine.disease_cause, Receptor tyrosine kinase, Mice, Colonic Neoplasms/drug therapy, Loss of Function Mutation, MAP Kinase Kinase 4/antagonists & inhibitors, Inbred BALB C, Mutation, Mice, Inbred BALB C, Benzimidazoles/pharmacology, Tumor, Kinase, Mitogen-Activated Protein Kinase Kinases/antagonists & inhibitors, Colonic Neoplasms, Heterografts, Female, Prostatic Neoplasms/drug therapy, MAP Kinase Signaling System, MAP Kinase Kinase Kinase 1, Mice, Nude, Breast Neoplasms, Drug Resistance, Neoplasm/genetics, Biology, Article, Cell Line, 03 medical and health sciences, Breast Neoplasms/drug therapy, SDG 3 - Good Health and Well-being, Cell Line, Tumor, medicine, Animals, Humans, MAP Kinase Kinase Kinase 1/antagonists & inhibitors, Protein kinase A, Molecular Biology, Protein Kinase Inhibitors, Mitogen-Activated Protein Kinase Kinases, MAP Kinase Signaling System/drug effects, Neoplasm/genetics, Cancer, Prostatic Neoplasms, Cell Biology, medicine.disease, 030104 developmental biology, Drug Resistance, Neoplasm, Protein Kinase Inhibitors/pharmacology, Cancer research, biology.protein, Benzimidazoles
وصف الملف: application/pdf
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المؤلفون: Stefania Crippa, Javier Martin-Broto, Axel Le Cesne, Claudia Weiss, Sebastian Bauer, Elena Fumagalli, Olivier Bouché, Alessandro Comandone, Jean-Yves Blay, Antoine Adenis, M. Camozzi, Carlo Barone, Xavier Garcia del Muro, Antoine Italiano, Giovanni Grignani, Ramon Castellana, Claudia Valverde, Heikki Joensuu, Antonio López Pousa
المساهمون: University of Helsinki, Département cancer environnement (Centre Léon Bérard - Lyon), Centre Léon Bérard [Lyon], Gradenigo Hospital, Hospital Universitario Virgen del Rocío [Sevilla], Medical Genetics Service, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Candiolo Cancer Institute (IRCCS), Institut Català d'Oncologia-IDIBELL, 08907 L’Hospitalet (Barcelona) and Universitat de, Centre d'Investigation Clinique Antilles-Guyane (CIC - Antilles Guyane), CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université des Antilles et de la Guyane (UAG), Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] (UNICANCER/Lille), Université Lille Nord de France (COMUE)-UNICANCER, Vall d'Hebron University Hospital [Barcelona], Hospital de la Santa Creu i Sant Pau, Hôpital Robert Debré, Hôpital Robert Debré-Centre Hospitalier Universitaire de Reims (CHU Reims), Institut Bergonié [Bordeaux], UNICANCER, Universität Duisburg-Essen [Essen], Observatoire sociologique du changement (OSC), Sciences Po (Sciences Po)-Centre National de la Recherche Scientifique (CNRS), Novartis Pharma AG, Novartis Vaccines and Diagnostics [Siena], Novartis Farmacéutica SA, Sarcome, Département de médecine oncologique [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), Institut Gustave Roussy (IGR), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Université des Antilles et de la Guyane (UAG)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pointe-à-Pitre/Abymes [Guadeloupe] -CHU de Fort de France-Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française], Université de Lille-UNICANCER, Universität Duisburg-Essen = University of Duisburg-Essen [Essen], Università cattolica del Sacro Cuore [Milano] (Unicatt), Clinicum, Heikki Joensuu / Principal Investigator, Department of Oncology
المصدر: British Journal of Cancer
British Journal of Cancer, Cancer Research UK, 2017, 117 (9), pp.1278-1285. ⟨10.1038/bjc.2017.290⟩
British Journal of Cancer, 2017, 117 (9), pp.1278-1285. ⟨10.1038/bjc.2017.290⟩
BRITISH JOURNAL OF CANCER
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
instnameمصطلحات موضوعية: 0301 basic medicine, Oncology, Male, Cancer Research, MULTICENTER, Medizin, Salvage therapy, RESISTANT, Quinolones, gastrointestinal stromal tumour, 0302 clinical medicine, Clinical endpoint, FAILURE, Gastrointestinal Neoplasms, KIT MUTATIONS, GiST, Sunitinib, Middle Aged, Prognosis, 3. Good health, Tolerability, SAFETY, 030220 oncology & carcinogenesis, PHASE-II, Imatinib Mesylate, Female, TYROSINE KINASE INHIBITOR, medicine.drug, GIST, Adult, medicine.medical_specialty, Gastrointestinal Stromal Tumors, 3122 Cancers, [SDV.CAN]Life Sciences [q-bio]/Cancer, SUNITINIB, 03 medical and health sciences, Internal medicine, medicine, Biomarkers, Tumor, Humans, MESH: Benzimidazoles/pharmacology, Biomarkers, Tumor/metabolism, Drug resistance, Neoplasm/drug therapy, Adverse effect, neoplasms, Protein Kinase Inhibitors, Aged, Neoplasm Staging, Salvage Therapy, business.industry, Imatinib, EFFICACY, refractory, 030104 developmental biology, Imatinib mesylate, imatinib, Drug Resistance, Neoplasm, Clinical Study, Benzimidazoles, dovitinib, business, Follow-Up Studies
وصف الملف: application/pdf
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المؤلفون: Lodewyk F. A. Wessels, René Bernards, Robert J.D. Reid, John C. Dittmar, Evert Bosdriesz, Cor Lieftink, Roderick L. Beijersbergen, Sake van Wageningen, Rodney Rothstein, Tonći Šuštić
المساهمون: Bioinformatics
المصدر: Genome Medicine
Šuštić, T, van Wageningen, S, Bosdriesz, E, Reid, R J D, Dittmar, J, Lieftink, C, Beijersbergen, R L, Wessels, L F A, Rothstein, R & Bernards, R 2018, ' A role for the unfolded protein response stress sensor ERN1 in regulating the response to MEK inhibitors in KRAS mutant colon cancers ', Genome Medicine, vol. 10, no. 1, 90, pp. 90 . https://doi.org/10.1186/s13073-018-0600-z
Genome Medicine, 10(1):90. BioMed Central
Genome Medicine, Vol 10, Iss 1, Pp 1-13 (2018)مصطلحات موضوعية: 0301 basic medicine, Yeasts/genetics, Proto-Oncogene Proteins c-jun, Mutant, lcsh:Medicine, medicine.disease_cause, Colonic Neoplasms/drug therapy, Yeasts, Genetics (clinical), Tumor, Benzimidazoles/pharmacology, Pyrimidinones/pharmacology, Kinase, MEK inhibitor, MAP Kinase Kinase Kinases, Endoplasmic Reticulum Stress, 3. Good health, Colon cancer, Colonic Neoplasms, Molecular Medicine, KRAS, Signal transduction, Antineoplastic Agents/pharmacology, lcsh:QH426-470, Pyridones, Protein-Serine-Threonine Kinases/genetics, Antineoplastic Agents, Pyrimidinones, Ire1, Biology, Protein Serine-Threonine Kinases, Cell Line, Proto-Oncogene Proteins p21(ras), Proto-Oncogene Proteins p21(ras)/genetics, 03 medical and health sciences, SDG 3 - Good Health and Well-being, Cell Line, Tumor, Endoribonucleases, Endoribonucleases/genetics, Genetics, medicine, Humans, Molecular Biology, Protein Kinase Inhibitors, JUN, Pyridones/pharmacology, Research, lcsh:R, Correction, ERN1, Proto-Oncogene Proteins c-jun/genetics, lcsh:Genetics, MAP Kinase Kinase Kinases/antagonists & inhibitors, 030104 developmental biology, HEK293 Cells, Protein Kinase Inhibitors/pharmacology, Cancer cell, Cancer research, Unfolded protein response, Unfolded Protein Response, Benzimidazoles, JNK, Genetic screen
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المؤلفون: Hillege, H. L., Nitsch, D., Pfeffer, M. A., Swedberg, Karl, 1944, McMurray, J. J., Yusuf, S., Granger, C. B., Michelson, E. L., Ostergren, J., Cornel, J. H., de Zeeuw, D., Pocock, S., van Veldhuisen, D. J.
المصدر: Circulation. 113(5):671-8
مصطلحات موضوعية: Cardiac and Cardiovascular Systems, Kardiologi, Aged, Angiotensin II Type 1 Receptor Blockers, Benzimidazoles/pharmacology, Female, Heart Failure/*diagnosis/epidemiology/mortality, Hospitalization, Humans, *Kidney Diseases, Kidney Function Tests, Male, Middle Aged, Prognosis, Risk Factors, Stroke Volume, Survival Analysis, Tetrazoles/pharmacology
URL الوصول: https://gup.ub.gu.se/publication/115246
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المؤلفون: O'Meara, E., Clayton, T., McEntegart, M. B., McMurray, J. J., Lang, C. C., Roger, S. D., Young, J. B., Solomon, S. D., Granger, C. B., Ostergren, J., Olofsson, B., Michelson, E. L., Pocock, S., Yusuf, S., Swedberg, Karl, 1944, Pfeffer, M. A.
المصدر: Circulation. 113(7):986-94
مصطلحات موضوعية: Cardiac and Cardiovascular Systems, Kardiologi, Aged, Anemia/epidemiology/*etiology/*mortality, Benzimidazoles/pharmacology, Continental Population Groups, Female, Glomerular Filtration Rate, Heart Failure, Congestive/*complications/epidemiology/*mortality, Hemoglobins/analysis, Hospitalization, Humans, Male, Middle Aged, Multivariate Analysis, Prevalence, Risk Factors, Stroke Volume, Tetrazoles/pharmacology, Treatment Outcome
URL الوصول: https://gup.ub.gu.se/publication/52034
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المؤلفون: Ducharme, A., Swedberg, Karl, 1944, Pfeffer, M. A., Cohen-Solal, A., Granger, C. B., Maggioni, A. P., Michelson, E. L., McMurray, J. J., Olsson, L., Rouleau, J. L., Young, J. B., Olofsson, B., Puu, M., Yusuf, S.
المصدر: American heart journal. 152(1):86-92
مصطلحات موضوعية: Cardiac and Cardiovascular Systems, Kardiologi, Aged, Angiotensin II Type 1 Receptor Blockers/pharmacology/*therapeutic use, Atrial Fibrillation/epidemiology/physiopathology/*prevention & control, Benzimidazoles/pharmacology/*therapeutic use, Comorbidity, Female, Heart Failure, Congestive/*drug therapy/epidemiology, Humans, Logistic Models, Male, Middle Aged, Prospective Studies, Randomized Controlled Trials, Renin-Angiotensin System/drug effects/physiology, Tetrazoles/pharmacology/*therapeutic use
URL الوصول: https://gup.ub.gu.se/publication/50092
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المؤلفون: Yusuf, S., Ostergren, J. B., Gerstein, H. C., Pfeffer, M. A., Swedberg, Karl, 1944, Granger, C. B., Olofsson, B., Probstfield, J., McMurray, J. V.
المصدر: Circulation. 112(1):48-53
مصطلحات موضوعية: Cardiac and Cardiovascular Systems, Kardiologi, Adult, Angiotensin II Type 1 Receptor Blockers/pharmacology, Antihypertensive Agents/pharmacology, Benzimidazoles/*pharmacology, Body Mass Index, Diabetes Mellitus, Type 2/diagnosis/etiology/*prevention & control, Double-Blind Method, Female, Heart Failure, Congestive/*complications/*drug therapy, Humans, Incidence, Male, Middle Aged, Myocardial Infarction, Renin-Angiotensin System, Tetrazoles/*pharmacology
URL الوصول: https://gup.ub.gu.se/publication/52200
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المؤلفون: Skoog, Ingmar, Lithell, Hans, Hansson, Lennart, Elmfeldt, Dag, Hofman, Albert, Olofsson, Bertil, Trenkwalder, Peter, Zanchetti, Alberto
المصدر: Am J Hypertens. 18(8):1052-9
مصطلحات موضوعية: Aged, 80 and over, Analysis of Variance, Antihypertensive Agents/pharmacology/*therapeutic use, Benzimidazoles/pharmacology/*therapeutic use, Blood Pressure/*drug effects/physiology, Cognition/*drug effects/physiology, Comparative Study, Double-Blind Method, Female, Humans, Hypertension/*drug therapy/physiopathology, Male, Prognosis, Prospective Studies, Research Support, Non-U.S. Gov't, Tetrazoles/pharmacology/*therapeutic use, Treatment Outcome
وصف الملف: print
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المؤلفون: Randall K. Packer, Shana Ageloff, Mark A. Knepper, Heddwen L. Brooks, S. Turban, Robert A. Fenton, Shyama Masilamani, Jakob Nielsen, Kathleen Beutler
المصدر: Beutler, K T, Masilamani, S, Turban, S, Nielsen, J, Brooks, H L, Ageloff, S, Fenton, R A, Packer, R K & Knepper, M A 2003, ' Long-term regulation of ENaC expression in kidney by angiotensin II ', Hypertension, vol. 41, no. 5, pp. 1143-50 . https://doi.org/10.1161/01.HYP.0000066129.12106.E2
مصطلحات موضوعية: Male, Epithelial sodium channel, Angiotensin receptor, Time Factors, Bicarbonates/blood, Sodium Chloride Symporter Inhibitors, Sodium Channels/genetics, Gene Expression Regulation/drug effects, Tetrazoles, RNA, Messenger/drug effects, Kidney/drug effects, Spironolactone, Kidney, Spironolactone/pharmacology, Sodium Channels, Rats, Sprague-Dawley, Mineralocorticoid Receptor Antagonists/pharmacology, Diuretics, Kidney Tubules, Distal, Infusion Pumps, Mineralocorticoid Receptor Antagonists, Kidney Medulla/drug effects, Kidney Medulla, Benzimidazoles/pharmacology, Angiotensin Receptor Antagonists, Symporters, Chemistry, Angiotensin II, Sodium Chloride Symporter Inhibitors/pharmacology, Sodium Chloride Symporters, medicine.drug, medicine.medical_specialty, Kidney Cortex, medicine.drug_class, Injections, Subcutaneous, Immunoblotting, Benzothiadiazines, Internal medicine, Sodium Chloride, Dietary/administration & dosage, Internal Medicine, medicine, Animals, Kidney Tubules, Distal/drug effects, RNA, Messenger, Sodium Chloride, Dietary, Epithelial Sodium Channels, Angiotensin II receptor type 1, Quaternary Ammonium Compounds/urine, Biphenyl Compounds, Symporters/metabolism, Kidney metabolism, Tetrazoles/pharmacology, Rats, Potassium/urine, Quaternary Ammonium Compounds, Bicarbonates, Protein Subunits, Candesartan, Endocrinology, Gene Expression Regulation, Mineralocorticoid, Potassium, Angiotensin II/pharmacology, Protein Subunits/genetics, Benzimidazoles, Kidney Cortex/drug effects
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0002de7cb643a6e733f5d7ca3111bf2
https://doi.org/10.1161/01.hyp.0000066129.12106.e2 -
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المؤلفون: Laia Morató, Wei Li, Jef Verbeek, Carlo Viscomi, Keir J. Menzies, Kristina Schoonjans, Massimo Zeviani, Aurora Pujol, Silvie Timmers, Evan G. Williams, Laurent Mouchiroud, Ralph Imhof, Hongbo Zhang, Anthony A. Sauve, Young Suk Jo, Barbara van Loon, Carolina E. Hagberg, Norman Moullan, Carles Cantó, Patrick Schrauwen, Eija Pirinen, Johan Auwerx
المساهمون: Humane Biologie, RS: NUTRIM - R1 - Metabolic Syndrome, RS: NUTRIM - HB/BW section B, University of Zurich, Cantó, Carles
المصدر: Cell Metabolism, 19(6), 1034-1041
Cell Metabolism
Cell Metabolism, 19, 1034-41
Cell Metabolism, 19(6), 1034-1041. Cell Press
Cell metabolism
Cell Metabolism 19 (2014) 6
Cell Metabolism, 19, 6, pp. 1034-41مصطلحات موضوعية: Male, Muscle Fibers, Skeletal/metabolism, Animals, Benzamides, Benzimidazoles, Caenorhabditis elegans, Cells, Cultured, Energy Metabolism, Enzyme Inhibitors, Humans, Mice, Mice, Inbred C57BL, Mice, Knockout, Mitochondria, Muscle Fibers, Skeletal, Obesity, Phthalazines, Piperazines, Poly(ADP-ribose) Polymerases, Sirtuin 1, Poly(ADP-ribose) Polymerase Inhibitors, Physiology, Mitochondrion, Inbred C57BL, Poly (ADP-Ribose) Polymerase Inhibitor, 1307 Cell Biology, 0302 clinical medicine, Obesity/metabolism, Piperazines/pharmacology, Enzyme Inhibitors/pharmacology, 0303 health sciences, Benzimidazoles/pharmacology, Cultured, biology, Myogenesis, Skeletal, 10226 Department of Molecular Mechanisms of Disease, Cell biology, Sirtuin 1/genetics/metabolism, medicine.anatomical_structure, Biochemistry, Genetics & genetic processes [F10] [Life sciences], Génétique & processus génétiques [F10] [Sciences du vivant], Poly ADP ribose polymerase, Cells, Knockout, Poly(ADP-ribose) Polymerases/biosynthesis/metabolism, Muscle Fibers, Energy Metabolism/physiology, 03 medical and health sciences, Mitochondria/metabolism, 1312 Molecular Biology, medicine, Life Science, Gene, Molecular Biology, 030304 developmental biology, Other Research Radboud Institute for Health Sciences [Radboudumc 0], Benzamides/pharmacology, Skeletal muscle, 1314 Physiology, Cell Biology, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], biology.protein, 570 Life sciences, NAD+ kinase, Phthalazines/pharmacology, 030217 neurology & neurosurgery
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