المؤلفون: Liu Q; Department of Pharmacy, Nantong Third People's Hospital, Affiliated Nantong Hospital 3 of Nantong University, Nantong., Cheng L; Department of Pharmacy, Changzhou Geriatric Hospital Affiliated to Soochow University, Changzhou No. 7 People's Hospital, Changzhou., Li F; Department of Pharmacy, Changzhou Geriatric Hospital Affiliated to Soochow University, Changzhou No. 7 People's Hospital, Changzhou., Zhu H; Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, Jiangsu., Lu X; Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, Jiangsu., Huang C; Department of Pharmacology, School of Pharmacy, Nantong University, Nantong, Jiangsu., Yuan X; Department of Cardiology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.

المصدر: Behavioural pharmacology [Behav Pharmacol] 2024 Jun 01; Vol. 35 (4), pp. 227-238. Date of Electronic Publication: 2024 Apr 24.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Lippincott Williams and Wilkins Country of Publication: England NLM ID: 9013016 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1473-5849 (Electronic) Linking ISSN: 09558810 NLM ISO Abbreviation: Behav Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Antidepressive Agents*/pharmacology , Benzothiepins* , Dose-Response Relationship, Drug* , S-Phase Kinase-Associated Proteins*/antagonists & inhibitors, Animals ; Female ; Male ; Mice ; Behavior, Animal/drug effects ; Depression/drug therapy ; Disease Models, Animal ; Fluoxetine/pharmacology ; Stress, Psychological/drug therapy

المؤلفون: Himes R; Department of Pediatric Gastroenterology, Hepatology, and Nutrition, Ochsner Health Center for Children, New Orleans, Louisiana, USA., Rosenthal P; Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, University of California, San Francisco, California, USA., Dilwali N; Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Johns Hopkins Children's Center, Baltimore, Maryland, USA., Smith K; Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Johns Hopkins Children's Center, Baltimore, Maryland, USA., Venick R; Department of Pediatric Gastroenterology, University of California Los Angeles, Los Angeles, California, USA., Gonzalez-Peralta RP; Pediatric Gastroenterology, Hepatology, and Liver Transplant, AdventHealth for Children and AdventHealth Transplant Institute, Orlando, Florida, USA.

المصدر: Journal of pediatric gastroenterology and nutrition [J Pediatr Gastroenterol Nutr] 2024 Mar; Vol. 78 (3), pp. 506-513. Date of Electronic Publication: 2024 Feb 09.

نوع المنشور: Review; Journal Article

بيانات الدورية: Publisher: Wiley Country of Publication: United States NLM ID: 8211545 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-4801 (Electronic) Linking ISSN: 02772116 NLM ISO Abbreviation: J Pediatr Gastroenterol Nutr Subsets: MEDLINE

مواضيع طبية MeSH: Alagille Syndrome*/complications , Alagille Syndrome*/drug therapy , Alagille Syndrome*/surgery , Benzothiepins* , Cholestasis*/drug therapy , Cholestasis*/complications, Humans ; Longitudinal Studies ; Pruritus/drug therapy ; Pruritus/etiology ; Clinical Trials as Topic ; Infant

المؤلفون: Shirley M; Springer Nature, Mairangi Bay, Private Bag 65901, Auckland, 0754, New Zealand. dru@adis.com.

المصدر: Drugs [Drugs] 2022 Jan; Vol. 82 (1), pp. 71-76.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Adis, Springer International Country of Publication: New Zealand NLM ID: 7600076 Publication Model: Print Cited Medium: Internet ISSN: 1179-1950 (Electronic) Linking ISSN: 00126667 NLM ISO Abbreviation: Drugs Subsets: MEDLINE

مواضيع طبية MeSH: Carrier Proteins*/antagonists & inhibitors , Cholestasis, Intrahepatic*/drug therapy , Membrane Glycoproteins*/antagonists & inhibitors , Benzothiepins*/administration & dosage , Benzothiepins*/pharmacology , Benzothiepins*/therapeutic use, Humans ; Alagille Syndrome/drug therapy ; Biliary Atresia/drug therapy ; Clinical Trials as Topic ; Drug Approval ; United States ; United States Food and Drug Administration

SCR Disease Name: Cholestasis, progressive familial intrahepatic 1

المؤلفون: Pustenko A; Latvian Institute of Organic Synthesis, Riga, Latvia.; Institute of Technology of Organic Chemistry, Faculty of Materials Science and Applied Chemistry, Riga Technical University, Riga, Latvia., Nocentini A; Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Universita degli Studi di Firenze, Florence, Italy., Balašova A; Latvian Institute of Organic Synthesis, Riga, Latvia., Alafeefy A; Faculty of Pharmacy, University Technology MARA, UiTM, Bandar, Malaysia., Krasavin M; Chemistry Department, Saint Petersburg State University, Saint Petersburg, Russian Federation., Žalubovskis R; Latvian Institute of Organic Synthesis, Riga, Latvia.; Institute of Technology of Organic Chemistry, Faculty of Materials Science and Applied Chemistry, Riga Technical University, Riga, Latvia., Supuran CT; Dipartimento Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Universita degli Studi di Firenze, Florence, Italy.

المصدر: Journal of enzyme inhibition and medicinal chemistry [J Enzyme Inhib Med Chem] 2020 Dec; Vol. 35 (1), pp. 245-254.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101150203 Publication Model: Print Cited Medium: Internet ISSN: 1475-6374 (Electronic) Linking ISSN: 14756366 NLM ISO Abbreviation: J Enzyme Inhib Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Benzothiepins/*pharmacology , Carbonic Anhydrase Inhibitors/*pharmacology , Carbonic Anhydrases/*metabolism, Benzothiepins/chemical synthesis ; Benzothiepins/chemistry ; Carbonic Anhydrase Inhibitors/chemical synthesis ; Carbonic Anhydrase Inhibitors/chemistry ; Dose-Response Relationship, Drug ; Humans ; Isoenzymes/antagonists & inhibitors ; Isoenzymes/metabolism ; Molecular Structure ; Structure-Activity Relationship

المؤلفون: Newsome PN; National Institute for Health Research, Birmingham Biomedical Research Centre at the University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK; Centre for Liver and Gastrointestinal Research, Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham, UK. Electronic address: p.n.newsome@bham.ac.uk., Palmer M; Shire Plc, a Takeda company, Lexington, MA, USA., Freilich B; Kansas City Research Institute, Kansas City, MO, USA., Sheikh MY; Fresno Clinical Research Center, Fresno, CA, USA., Sheikh A; GI Specialists of Georgia, Marietta, GA, USA., Sarles H; DHAT Research Institute, Garland, TX, USA., Herring R; Quality Medical Research, PLLC, Nashville, TN, USA., Mantry P; Methodist Health System Clinical Research Institute, Dallas, TX, USA., Kayali Z; Inland Empire Liver Foundation, Rialto, CA, USA., Hassanein T; Southern California Research Center, Coronado, CA, USA., Lee HM; Shire Plc, a Takeda company, Lexington, MA, USA., Aithal GP; National Institute for Health Research, Nottingham Biomedical Research Centre at the Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, UK; Nottingham Digestive Diseases Centre, School of Medicine, University of Nottingham, Nottingham, UK.

مؤلفون مشاركون: Volixibat in Adults study group

المصدر: Journal of hepatology [J Hepatol] 2020 Aug; Vol. 73 (2), pp. 231-240. Date of Electronic Publication: 2020 Mar 29.

نوع المنشور: Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8503886 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0641 (Electronic) Linking ISSN: 01688278 NLM ISO Abbreviation: J Hepatol Subsets: MEDLINE

مواضيع طبية MeSH: Benzothiepins*/administration & dosage , Benzothiepins*/adverse effects , Glycosides*/administration & dosage , Glycosides*/adverse effects , Liver*/diagnostic imaging , Liver*/drug effects , Liver*/metabolism , Liver*/pathology , Non-alcoholic Fatty Liver Disease*/diagnosis , Non-alcoholic Fatty Liver Disease*/drug therapy , Non-alcoholic Fatty Liver Disease*/metabolism, Alanine Transaminase/*blood , Cholestenones/*blood , Cholesterol/*blood, Biomarkers/blood ; Double-Blind Method ; Female ; Humans ; Lipid Regulating Agents/administration & dosage ; Lipid Regulating Agents/adverse effects ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Organic Anion Transporters, Sodium-Dependent/antagonists & inhibitors ; Patient Acuity ; Symporters/antagonists & inhibitors ; Treatment Outcome

المؤلفون: Walters JM; Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA., Kim EC; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA., Zhang J; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA., Jeong HG; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA., Bajaj A; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA., Baculis BC; Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA., Tracy GC; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA., Ibrahim B; Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.; Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA., Christian-Hinman CA; Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.; Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA., Llano DA; Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.; Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA., Huesmann GR; Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.; Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.; Department of Neurology, Carle Foundation Hospital, Urbana, Illinois, USA.; Carle Illinois College of Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA., Chung HJ; Neuroscience Program, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.; Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.; Beckman Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.

المصدر: Epilepsia [Epilepsia] 2022 May; Vol. 63 (5), pp. 1211-1224. Date of Electronic Publication: 2022 Feb 21.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Blackwell Science Country of Publication: United States NLM ID: 2983306R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-1167 (Electronic) Linking ISSN: 00139580 NLM ISO Abbreviation: Epilepsia Subsets: MEDLINE

مواضيع طبية MeSH: Dimethyl Sulfoxide*/adverse effects , Dimethyl Sulfoxide*/metabolism , Hippocampus*, Animals ; Benzothiepins ; Female ; Kainic Acid/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Rats ; Seizures/chemically induced ; Seizures/metabolism

المؤلفون: Palmer M; Global Development Lead Hepatology, Shire, 300 Shire Way, Lexington, MA, 02421, USA. mpalmer@shire.com., Jennings L; Global Development Lead Hepatology, Shire, 300 Shire Way, Lexington, MA, 02421, USA., Silberg DG; Shire International GmbH, Zahlerweg 10, 6301, Zug, Switzerland., Bliss C; Global Development Lead Hepatology, Shire, 300 Shire Way, Lexington, MA, 02421, USA., Martin P; Global Development Lead Hepatology, Shire, 300 Shire Way, Lexington, MA, 02421, USA.

المصدر: BMC pharmacology & toxicology [BMC Pharmacol Toxicol] 2018 Mar 16; Vol. 19 (1), pp. 10. Date of Electronic Publication: 2018 Mar 16.

نوع المنشور: Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101590449 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-6511 (Electronic) Linking ISSN: 20506511 NLM ISO Abbreviation: BMC Pharmacol Toxicol Subsets: MEDLINE

مواضيع طبية MeSH: Benzothiepins/*administration & dosage , Glycosides/*administration & dosage , Lipid Regulating Agents/*administration & dosage , Overweight/*metabolism, Adult ; Benzothiepins/adverse effects ; Benzothiepins/pharmacokinetics ; Bile Acids and Salts/analysis ; Cholestenones/blood ; Double-Blind Method ; Feces/chemistry ; Female ; Glycosides/adverse effects ; Glycosides/pharmacokinetics ; Healthy Volunteers ; Humans ; Lipid Regulating Agents/adverse effects ; Lipid Regulating Agents/pharmacokinetics ; Lipids/blood ; Male ; Middle Aged

المؤلفون: Siebers N; Covance Clinical Research Unit, 3402 Kinsman Boulevard, Madison, WI, 53704, USA. Nicholas.Siebers@covance.com., Palmer M; Shire, Lexington, MA, USA., Silberg DG; Shire, Zug, Switzerland., Jennings L; Shire, Lexington, MA, USA., Bliss C; Shire, Lexington, MA, USA., Martin PT; Shire, Lexington, MA, USA.

المصدر: European journal of drug metabolism and pharmacokinetics [Eur J Drug Metab Pharmacokinet] 2018 Feb; Vol. 43 (1), pp. 91-101.

نوع المنشور: Clinical Trial, Phase I; Journal Article

بيانات الدورية: Publisher: Springer France Country of Publication: France NLM ID: 7608491 Publication Model: Print Cited Medium: Internet ISSN: 2107-0180 (Electronic) Linking ISSN: 03787966 NLM ISO Abbreviation: Eur J Drug Metab Pharmacokinet Subsets: MEDLINE

مواضيع طبية MeSH: Benzothiepins/*pharmacokinetics , Glycosides/*pharmacokinetics, Adolescent ; Adult ; Benzothiepins/analysis ; Benzothiepins/blood ; Benzothiepins/urine ; Carbon Radioisotopes/pharmacokinetics ; Feces/chemistry ; Glycosides/analysis ; Glycosides/blood ; Glycosides/urine ; Healthy Volunteers ; Humans ; Male ; Middle Aged ; Young Adult

المؤلفون: Tiessen RG; Early Development Services, Pharmaceutical Research Associates (PRA) Health Sciences, Van Swietenlaan 6, 9728 NZ Groningen, PO Box 8144, 9702, Groningen, KC, Netherlands. tiessenrenger@prahs.com., Kennedy CA; Lumena Pharmaceuticals Inc. (part of the Shire group of companies), 12531 High Bluff Drive, Suite 110, San Diego, CA, 92130, USA., Keller BT; Lumena Pharmaceuticals Inc. (part of the Shire group of companies), 12531 High Bluff Drive, Suite 110, San Diego, CA, 92130, USA., Levin N; Lumena Pharmaceuticals Inc. (part of the Shire group of companies), 12531 High Bluff Drive, Suite 110, San Diego, CA, 92130, USA., Acevedo L; Lumena Pharmaceuticals Inc. (part of the Shire group of companies), 12531 High Bluff Drive, Suite 110, San Diego, CA, 92130, USA., Gedulin B; Lumena Pharmaceuticals Inc. (part of the Shire group of companies), 12531 High Bluff Drive, Suite 110, San Diego, CA, 92130, USA., van Vliet AA; Early Development Services, Pharmaceutical Research Associates (PRA) Health Sciences, Van Swietenlaan 6, 9728 NZ Groningen, PO Box 8144, 9702, Groningen, KC, Netherlands., Dorenbaum A; Lumena Pharmaceuticals Inc. (part of the Shire group of companies), 12531 High Bluff Drive, Suite 110, San Diego, CA, 92130, USA., Palmer M; Lexington, USA.

المصدر: BMC gastroenterology [BMC Gastroenterol] 2018 Jan 05; Vol. 18 (1), pp. 3. Date of Electronic Publication: 2018 Jan 05.

نوع المنشور: Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100968547 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-230X (Electronic) Linking ISSN: 1471230X NLM ISO Abbreviation: BMC Gastroenterol Subsets: MEDLINE

مواضيع طبية MeSH: Benzothiepins/*administration & dosage , Benzothiepins/*adverse effects , Diabetes Mellitus, Type 2/*drug therapy , Glycosides/*administration & dosage , Glycosides/*adverse effects , Membrane Glycoproteins/*antagonists & inhibitors , Non-alcoholic Fatty Liver Disease/*drug therapy , Organic Anion Transporters, Sodium-Dependent/*antagonists & inhibitors , Symporters/*antagonists & inhibitors, Adolescent ; Adult ; Aged ; Benzothiepins/pharmacokinetics ; Bile Acids and Salts/analysis ; Bile Acids and Salts/metabolism ; Blood Glucose/metabolism ; Cholestenones/blood ; Diabetes Mellitus, Type 2/metabolism ; Double-Blind Method ; Feces/chemistry ; Female ; Glycosides/pharmacokinetics ; Homeostasis ; Humans ; Lipid Metabolism ; Male ; Middle Aged ; Young Adult

المؤلفون: Moskaliuk VS; Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (SB RAS), Pr. Lavrentyeva 10, 630090 Novosibirsk, Russia. Electronic address: moskaliukvs@bionet.nsc.ru., Kozhemyakina RV; Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (SB RAS), Pr. Lavrentyeva 10, 630090 Novosibirsk, Russia. Electronic address: korimma@bionet.nsc.ru., Bazovkina DV; Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (SB RAS), Pr. Lavrentyeva 10, 630090 Novosibirsk, Russia. Electronic address: daryabazovkina@gmail.com., Terenina E; GenPhySE, Université de Toulouse, INRA, INPT, ENVT, F-31326 Castanet-Tolosan, France. Electronic address: elena.mormede@inra.fr., Khomenko TM; N.N. Vorozhtsov Institute of Organic Chemistry, SB RAS, 9 Lavrentieva Avenue, 630090 Novosibirsk, Russia. Electronic address: chomenko@nioch.nsc.ru., Volcho KP; N.N. Vorozhtsov Institute of Organic Chemistry, SB RAS, 9 Lavrentieva Avenue, 630090 Novosibirsk, Russia. Electronic address: volcho@nioch.nsc.ru., Salakhutdinov NF; N.N. Vorozhtsov Institute of Organic Chemistry, SB RAS, 9 Lavrentieva Avenue, 630090 Novosibirsk, Russia. Electronic address: anvar@nioch.nsc.ru., Kulikov AV; Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (SB RAS), Pr. Lavrentyeva 10, 630090 Novosibirsk, Russia. Electronic address: akulikov@ngs.ru., Naumenko VS; Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (SB RAS), Pr. Lavrentyeva 10, 630090 Novosibirsk, Russia. Electronic address: naumenko2002@mail.ru., Kulikova E; Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (SB RAS), Pr. Lavrentyeva 10, 630090 Novosibirsk, Russia. Electronic address: lisa_kulikova@ngs.ru.

المصدر: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie [Biomed Pharmacother] 2022 Mar; Vol. 147, pp. 112667. Date of Electronic Publication: 2022 Jan 29.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 8213295 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1950-6007 (Electronic) Linking ISSN: 07533322 NLM ISO Abbreviation: Biomed Pharmacother Subsets: MEDLINE

مواضيع طبية MeSH: Aggression/*drug effects , Anti-Anxiety Agents/*pharmacology , Benzothiepins/*pharmacology , Brain/*drug effects , Fear/*drug effects , Protein Tyrosine Phosphatases, Non-Receptor/*antagonists & inhibitors, Animals ; Behavior, Animal/drug effects ; Fluoxetine/pharmacology ; Hippocampus/drug effects ; Male ; Rats