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المؤلفون: Berke JM; Infectious Diseases Discovery, Infectious Diseases and Vaccines, Janssen Research and Development, Turnhoutseweg, Beerse, Belgium., Tan Y; Infectious Diseases Discovery, Janssen Research and Development, Jinchuang Mansion, Pudong, Shanghai, China., Sauviller S; Infectious Diseases Discovery, Infectious Diseases and Vaccines, Janssen Research and Development, Turnhoutseweg, Beerse, Belgium., Wu D-t; Infectious Diseases Discovery, Janssen Research and Development, Jinchuang Mansion, Pudong, Shanghai, China., Zhang K; Infectious Diseases Discovery, Janssen Research and Development, Jinchuang Mansion, Pudong, Shanghai, China., Conceição-Neto N; Infectious Diseases Discovery, Infectious Diseases and Vaccines, Janssen Research and Development, Turnhoutseweg, Beerse, Belgium., Blázquez Moreno A; Infectious Diseases Biomarkers, Infectious Diseases and Vaccines, Janssen Research and Development, Turnhoutseweg, Beerse, Belgium., Kong D; Infectious Diseases Discovery, Janssen Research and Development, Jinchuang Mansion, Pudong, Shanghai, China., Kukolj G; Infectious Diseases Discovery, Janssen Research and Development, Brisbane, California, USA., Li C; Infectious Diseases Discovery, Janssen Research and Development, Brisbane, California, USA., Zhu R; Infectious Diseases Discovery, Janssen Research and Development, Jinchuang Mansion, Pudong, Shanghai, China., Nájera I; Infectious Diseases Discovery, Janssen Research and Development, Brisbane, California, USA., Pauwels F; Infectious Diseases Discovery, Infectious Diseases and Vaccines, Janssen Research and Development, Turnhoutseweg, Beerse, Belgium.

المصدر: Journal of virology [J Virol] 2024 Mar 19; Vol. 98 (3), pp. e0150223. Date of Electronic Publication: 2024 Feb 05.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE

مواضيع طبية MeSH: Antiviral Agents*/pharmacology , Antiviral Agents*/therapeutic use , Apoptosis*/drug effects , Gene Expression Regulation, Viral* , Hepatitis B Core Antigens*/biosynthesis , Hepatitis B Core Antigens*/metabolism , Hepatitis B virus*/growth & development , Hepatitis B virus*/immunology , Hepatitis B virus*/metabolism , Hepatitis B virus*/pathogenicity , Hepatocytes*/drug effects , Hepatocytes*/metabolism , Hepatocytes*/pathology , Hepatocytes*/virology , Protein Biosynthesis*, Animals ; Mice ; Capsid/chemistry ; Capsid/classification ; Capsid/drug effects ; Capsid/metabolism ; Capsid Proteins/metabolism ; Hepatitis B/drug therapy ; Hepatitis B/immunology ; Hepatitis B/metabolism ; Hepatitis B/virology ; Hepatitis B e Antigens/metabolism ; Hepatitis B Surface Antigens/metabolism ; Mice, Inbred C57BL ; Mice, SCID ; Virus Replication ; Cell Line ; CD8-Positive T-Lymphocytes/immunology ; Antigen Presentation

المؤلفون: Lecoq L; Molecular Microbiology and Structural Biochemistry (MMSB), Labex Ecofect, UMR 5086 CNRS/Université de Lyon, 69367, Lyon, France., Brigandat L; Molecular Microbiology and Structural Biochemistry (MMSB), Labex Ecofect, UMR 5086 CNRS/Université de Lyon, 69367, Lyon, France., Huber R; Molecular Microbiology and Structural Biochemistry (MMSB), Labex Ecofect, UMR 5086 CNRS/Université de Lyon, 69367, Lyon, France., Fogeron ML; Molecular Microbiology and Structural Biochemistry (MMSB), Labex Ecofect, UMR 5086 CNRS/Université de Lyon, 69367, Lyon, France., Wang S; Molecular Microbiology and Structural Biochemistry (MMSB), Labex Ecofect, UMR 5086 CNRS/Université de Lyon, 69367, Lyon, France., Dujardin M; Molecular Microbiology and Structural Biochemistry (MMSB), Labex Ecofect, UMR 5086 CNRS/Université de Lyon, 69367, Lyon, France., Briday M; Molecular Microbiology and Structural Biochemistry (MMSB), Labex Ecofect, UMR 5086 CNRS/Université de Lyon, 69367, Lyon, France., Wiegand T; Physical Chemistry, ETH Zurich, 8093, Zurich, Switzerland.; Max-Planck-Institute for Chemical Energy Conversion, Stiftstr. 34-36, 45470, Mülheim an der Ruhr, Germany.; Institute of Technical and Macromolecular Chemistry, RWTH Aachen University, Worringerweg 2, 52074, Aachen, Germany., Callon M; Physical Chemistry, ETH Zurich, 8093, Zurich, Switzerland., Malär A; Physical Chemistry, ETH Zurich, 8093, Zurich, Switzerland., Durantel D; Centre de recherche en cancérologie de Lyon (CRCL), UMR 5286, Centre Léon Bérard, 69373, Lyon, France., Burdette D; Gilead Sciences, Foster, CA, USA., Berke JM; Janssen Pharmaceutica N.V, Beerse, Belgium., Meier BH; Physical Chemistry, ETH Zurich, 8093, Zurich, Switzerland. beme@ethz.ch., Nassal M; Dept. of Medicine II/Molecular Biology, University of Freiburg, Freiburg, Germany. michael.nassal@uniklinik-freiburg.de., Böckmann A; Molecular Microbiology and Structural Biochemistry (MMSB), Labex Ecofect, UMR 5086 CNRS/Université de Lyon, 69367, Lyon, France. a.bockmann@ibcp.fr.

المصدر: Nature communications [Nat Commun] 2023 Jan 28; Vol. 14 (1), pp. 471. Date of Electronic Publication: 2023 Jan 28.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Hepatitis B virus*/genetics , Hepatitis B virus*/metabolism , Capsid Proteins*/genetics , Capsid Proteins*/metabolism, Virus Assembly ; Capsid/metabolism ; Nucleocapsid/metabolism ; Antiviral Agents/pharmacology ; Antiviral Agents/metabolism

المؤلفون: Sauviller S; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Vergauwen K; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Jaensch S; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Gustin E; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Peeters D; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Vermeulen P; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Wuyts D; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Vandyck K; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Pauwels F; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Berke JM; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium. Electronic address: jberke@its.jnj.com.

المصدر: Journal of virological methods [J Virol Methods] 2021 Jul; Vol. 293, pp. 114150. Date of Electronic Publication: 2021 Apr 08.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 8005839 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0984 (Electronic) Linking ISSN: 01660934 NLM ISO Abbreviation: J Virol Methods Subsets: MEDLINE

مواضيع طبية MeSH: Capsid* , Hepatitis B virus*, Pyrimidines ; Virus Assembly ; Virus Replication

المؤلفون: Verbinnen T; Janssen Research & Development, Beerse, Belgium., Hodari M; Janssen Research & Development, Beerse, Belgium., Talloen W; Janssen Research & Development, Beerse, Belgium., Berke JM; Janssen Research & Development, Beerse, Belgium., Blue D; Janssen Biopharma Inc, South San Francisco, CA, USA., Yogaratnam J; Janssen Biopharma Inc, South San Francisco, CA, USA., Vandenbossche J; Janssen Research & Development, Beerse, Belgium., Shukla U; Janssen Pharmaceuticals Research & Development, Titusville, FL, USA., De Meyer S; Janssen Research & Development, Beerse, Belgium., Lenz O; Janssen Research & Development, Beerse, Belgium.

المصدر: Journal of viral hepatitis [J Viral Hepat] 2020 Nov; Vol. 27 (11), pp. 1127-1137. Date of Electronic Publication: 2020 Jul 20.

نوع المنشور: Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 9435672 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2893 (Electronic) Linking ISSN: 13520504 NLM ISO Abbreviation: J Viral Hepat Subsets: MEDLINE

مواضيع طبية MeSH: Hepatitis B virus*/genetics , Hepatitis B, Chronic*/drug therapy , Hepatitis B, Chronic*/virology, Antiviral Agents/therapeutic use ; Capsid ; DNA, Viral ; Hepatitis B e Antigens ; Humans ; Treatment Outcome

المؤلفون: Verbinnen T; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Tan Y; Janssen China Research & Development Center, 5F North Building #1 Jinchuang Mansion, 4560 Jinke Road, Shanghai 201210, China., Wang G; Janssen China Research & Development Center, 5F North Building #1 Jinchuang Mansion, 4560 Jinke Road, Shanghai 201210, China., Dehertogh P; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Vergauwen K; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Neefs JM; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Jacoby E; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Lenz O; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium., Berke JM; Janssen Research and Development, Turnhoutseweg 30, 2340 Beerse, Belgium.

المصدر: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2020 Sep 01; Vol. 75 (9), pp. 2526-2534.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 7513617 Publication Model: Print Cited Medium: Internet ISSN: 1460-2091 (Electronic) Linking ISSN: 03057453 NLM ISO Abbreviation: J Antimicrob Chemother Subsets: MEDLINE

مواضيع طبية MeSH: Hepatitis B virus*/genetics , Hepatitis B, Chronic*/drug therapy, Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Capsid ; Capsid Proteins ; DNA, Viral ; Genotype ; Hepatitis B e Antigens/therapeutic use ; Humans ; Mutation

المؤلفون: Berke JM; Janssen Research and Development, Beerse, Belgium jberke@its.jnj.com., Dehertogh P; Janssen Research and Development, Beerse, Belgium., Vergauwen K; Janssen Research and Development, Beerse, Belgium., Mostmans W; Janssen Research and Development, Beerse, Belgium., Vandyck K; Janssen Research and Development, Beerse, Belgium., Raboisson P; Janssen Research and Development, Beerse, Belgium., Pauwels F; Janssen Research and Development, Beerse, Belgium.

المصدر: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2020 Apr 21; Vol. 64 (5). Date of Electronic Publication: 2020 Apr 21 (Print Publication: 2020).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Electronic-Print Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

مواضيع طبية MeSH: Antiviral Agents/*pharmacology , Capsid/*drug effects , Hepatitis B virus/*drug effects , Organic Chemicals/*pharmacology, Capsid/ultrastructure ; Capsid Proteins/metabolism ; Cell Line ; DNA Replication/drug effects ; DNA, Viral/biosynthesis ; DNA, Viral/drug effects ; Dose-Response Relationship, Drug ; Drug Synergism ; Hepatitis B/drug therapy ; Hepatitis B/virology ; Hepatitis B virus/ultrastructure ; Hepatocytes/virology ; Humans ; Microbial Sensitivity Tests ; Primary Cell Culture ; Virus Replication/drug effects