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1دورية أكاديمية
المؤلفون: Christopher W. Pohlmeyer, Ching Shang, Pei Han, Zhi-Hua Cui, Randall M. Jones, Astrid S. Clarke, Bernard P. Murray, David A. Lopez, David W. Newstrom, M. David Inzunza, Franziska G. Matzkies, Kevin S. Currie, Julie A. Di Paolo
المصدر: BMC Rheumatology, Vol 5, Iss 1, Pp 1-13 (2021)
مصطلحات موضوعية: Spleen tyrosine kinase, SYK inhibition, B-cell receptor, B-cell signaling, Immunohistochemistry, Systemic lupus erythematosus, Diseases of the musculoskeletal system, RC925-935
وصف الملف: electronic resource
Relation: https://doaj.org/toc/2520-1026
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المؤلفون: Rheem A. Totah, S. Cyrus Khojasteh, Abdul Basit, Peter W. Fan, Christopher Wolford, Edward J. Kelly, Scott Heyward, Bhagwat Prasad, Bill J. Smith, Ryan H. Takahashi, Bernard P. Murray, Naveen K. Neradugomma
المصدر: Molecular Pharmaceutics. 17:4114-4124
مصطلحات موضوعية: Adult, Male, Adolescent, Absolute quantification, Pharmaceutical Science, 02 engineering and technology, Kidney, 030226 pharmacology & pharmacy, Young Adult, 03 medical and health sciences, Carboxylesterase, 0302 clinical medicine, Cytochrome P-450 Enzyme System, Abundance (ecology), Intestine, Small, Drug Discovery, Humans, Glucuronosyltransferase, Child, Lung, Aldehyde oxidase, Aged, Oxidative metabolism, biology, Chemistry, Myocardium, Cytochrome P450, Metabolism, Middle Aged, 021001 nanoscience & nanotechnology, Tissue Donors, Aldehyde Oxidase, Liver, Biochemistry, Child, Preschool, biology.protein, Molecular Medicine, Female, Cyp enzymes, Sulfotransferases, 0210 nano-technology, Carboxylic Ester Hydrolases
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المؤلفون: Abdul Basit, Peter W. Fan, Ryan H. Takahashi, S. Cyrus Khojasteh, Chris Wolford, Bill J. Smith, Bhagwat Prasad, Albert P. Li, Bernard P. Murray, Haeyoung Zhang, Kenneth E. Thummel
المصدر: Drug Metabolism and Disposition. 48:528-536
مصطلحات موضوعية: Adult, Male, Proteomics, Enterocyte, Quantitative proteomics, Pharmaceutical Science, Ileum, Irinotecan, 030226 pharmacology & pharmacy, Carboxylesterase, Jejunum, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Intestinal mucosa, Intestine, Small, medicine, Humans, Testosterone, Glucuronosyltransferase, Intestinal Mucosa, Enzyme Assays, Pharmacology, Chemistry, Middle Aged, Small intestine, Clopidogrel, medicine.anatomical_structure, Biochemistry, 030220 oncology & carcinogenesis, Imatinib Mesylate, Female, Sulfotransferases, Sucrase-isomaltase
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b8edcde89ea8248b5c327435baf0eed
https://doi.org/10.1124/dmd.120.090738 -
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المؤلفون: Yili Xu, Brian E. Schultz, Daniel Soohoo, Raju Subramanian, John P. Bilello, Ruidong Li, Darius Babusis, Jingyu Zhang, Cynthia Kim, Eisuke Murakami, Bill J. Smith, Jing Zou, Qin Yue, Roman Sakowicz, Congrong Niu, Joy Y. Feng, Jared Pitts, Li Li, Bin Ma, Xiaofeng Zhao, Xuping Xie, Bernard P. Murray, Albert Liclican, Pei Yong Shi
المصدر: Antimicrobial Agents and Chemotherapy
مصطلحات موضوعية: Adenosine monophosphate, Nerve Tissue Proteins, remdesivir, Antiviral Agents, nucleotide analogs, 03 medical and health sciences, chemistry.chemical_compound, prodrug activation, medicine, Humans, CES1, Pharmacology (medical), Lung, 030304 developmental biology, Pharmacology, chemistry.chemical_classification, 0303 health sciences, Alanine, SARS-CoV-2, 030306 microbiology, CatA, HINT1, COVID-19, Prodrug, Adenosine, Adenosine Monophosphate, COVID-19 Drug Treatment, Metabolic pathway, Infectious Diseases, Enzyme, Biochemistry, chemistry, Nucleoside triphosphate, Phosphorylation, Nucleoside, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e65d9cff18affdae94d721eea0e4267
https://doi.org/10.1128/aac.00602-21 -
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المؤلفون: Emma Rousseau, Roy Bannister, Kevin S. Currie, Jiyun Kim, Astrid S. Clarke, Kelly Wang, Julie Di Paolo, Franziska Matzkies, Bernard P. Murray
المصدر: Thrombosis Research. 170:109-118
مصطلحات موضوعية: Adult, Blood Platelets, 0301 basic medicine, Hemostasis, Adolescent, Chemistry, Syk, Linker for Activation of T cells, Hematology, Middle Aged, Pharmacology, Young Adult, 03 medical and health sciences, 030104 developmental biology, In vivo, Humans, Syk Kinase, Platelet, Platelet activation, GPVI, Protein Kinase Inhibitors, Ex vivo, Signal Transduction
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المؤلفون: Eric B. Lansdon, Helen Yu, Kropf Jeffrey E, Peter A. Blomgren, Jennifer R. Lo, Guoju Geng, Kevin S. Currie, Aaron C. Schmitt, Jayaraman Chandrasekhar, Chris Pohlmeyer, Scott A. Mitchell, Seung H. Lee, Wanchi Fung, Sarah Wise, Jin-Ming Xiong, Zhongdong Zhao, Randall Mark Jones, Kimberly Suekawa-Pirrone, Julie Di Paolo, Bernard P. Murray, Carmen Ip, Jianjun Xu
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Cell type, Systemic lupus erythematosus, 010405 organic chemistry, business.industry, Organic Chemistry, Regulator, Syk, Drug interaction, medicine.disease, 01 natural sciences, Biochemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Immune system, Pharmacokinetics, Drug Discovery, medicine, Cancer research, Once daily, business
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المؤلفون: Jean-Yves Christophe Chiva, Peter Pyun, Andrew John Keats, Linos Lazarides, Karine G. Poullennec, Neil Andrew Dunbar, Brian E. Schultz, Mingzhe Ji, Gregory M. Watt, Karki Kapil Kumar, Ruby Cai, Carina E. Cannizzaro, Uli Schmitz, David Kenneth Dean, Yu-Jen Lee, Sangi Michael, Victoria Alexandra Steadman, Adam J. Schrier, Simon B. Pettit, Hans G. Fliri, Adrian John Highton, Todd C. Appleby, Carol Austin, Richard L. Mackman, Caroline A. Blakemore, Hui Hon Chung, Dustin Siegel, Gregory Chin, Bernard P. Murray, Hai Yang, Yang Tian, George Stepan, Jonathan Sanvoisin, Albert Liclican, Mish Michael R, David Sperandio, Rex Santos, Petr Jansa, Haolun Jin
المصدر: Journal of Medicinal Chemistry. 61:9473-9499
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Protein Conformation, Administration, Oral, Biological Availability, Hepacivirus, Isomerase, Pharmacology, Antiviral Agents, 01 natural sciences, Virus, Cell Line, Cyclophilins, Lactones, 03 medical and health sciences, Protein structure, Drug Discovery, Spiro Compounds, Enzyme Inhibitors, Cyclophilin, 010405 organic chemistry, Chemistry, Total synthesis, 0104 chemical sciences, Bioavailability, Ring size, 030104 developmental biology, Cell culture, Drug Design, Molecular Medicine
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المؤلفون: Thomas Marbury, Bernard P. Murray, Kenneth C. Lasseter, Lisa Moorehead, Eric Lawitz, Diana M. Brainard, Robert Perry, Craig Curtis, Anita Mathias, Anu Osinusi, Kah Hiing John Ling, Erik Mogalian
المصدر: Clinical Pharmacokinetics. 57:1449-1457
مصطلحات موضوعية: Adult, Liver Cirrhosis, Male, medicine.medical_specialty, Cirrhosis, Adolescent, Sofosbuvir, Population, Antiviral Agents, Heterocyclic Compounds, 4 or More Rings, 030226 pharmacology & pharmacy, Gastroenterology, Sofosbuvir/velpatasvir, law.invention, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Pharmacokinetics, law, Internal medicine, Ribavirin, medicine, Hepatic Insufficiency, Humans, Pharmacology (medical), education, Uridine, Aged, Pharmacology, education.field_of_study, business.industry, Hepatitis C, Middle Aged, medicine.disease, Confidence interval, Drug Combinations, Drug Therapy, Combination, Female, 030211 gastroenterology & hepatology, Carbamates, business, medicine.drug
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المؤلفون: Jim Zheng, Matthew Robert Warr, Bill J. Smith, Lisa Moorehead, Bernard P. Murray, Jeffrey A. Silverman, John Ling, Raju Subramanian, Jingyu Zhang, Yan Xin, Ellen Kwan, J. Andrew Whitney, Hemenway Jeffrey N
المصدر: Drug Metabolism and Disposition. 46:237-247
مصطلحات موضوعية: Adult, Male, Adolescent, Metabolite, Pharmaceutical Science, Pharmacology, 030226 pharmacology & pharmacy, Cell Line, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, Dogs, 0302 clinical medicine, Cytochrome P-450 Enzyme System, Pharmacokinetics, In vivo, Cell Line, Tumor, Animals, Humans, Drug Interactions, Aldehyde oxidase, biology, Chemistry, Cytochrome P450, Biological activity, Hep G2 Cells, Metabolism, Middle Aged, In vitro, Rats, Pyrimidines, 030220 oncology & carcinogenesis, Benzamides, Leukocytes, Mononuclear, biology.protein, Female
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6ca91bf722b61fe9a2e7b79eeb79385
https://doi.org/10.1124/dmd.117.078899 -
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المؤلفون: L. Simpson, G. Min-Oo, E. Grant, J. A. Di Paolo, P. Gonzalez-Traves, Bernard P. Murray, Amy Meng
المصدر: Annals of the Rheumatic Diseases. 80:331.1-331
مصطلحات موضوعية: Cell signaling, education.field_of_study, medicine.diagnostic_test, business.industry, Immunology, Cell, Population, Pharmacology, Peripheral blood mononuclear cell, General Biochemistry, Genetics and Molecular Biology, Flow cytometry, medicine.anatomical_structure, Rheumatology, Tyrosine kinase 2, Immunology and Allergy, Medicine, business, education, Janus kinase, IC50