المؤلفون: Blise KE; Department of Biomedical Engineering, Oregon Health and Science University, Portland, Oregon.; The Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon., Sivagnanam S; The Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon.; Department of Cell, Developmental and Cancer Biology, Oregon Health and Science University, Portland, Oregon., Betts CB; The Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon.; Department of Cell, Developmental and Cancer Biology, Oregon Health and Science University, Portland, Oregon.; Current affiliation: Akoya Biosciences, Marlborough, Massachusetts., Betre K; Department of Cell, Developmental and Cancer Biology, Oregon Health and Science University, Portland, Oregon., Kirchberger N; Department of Cell, Developmental and Cancer Biology, Oregon Health and Science University, Portland, Oregon., Tate BJ; The Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon.; Immune Monitoring and Cancer Omics Services, Oregon Health and Science University, Portland, Oregon., Furth EE; Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania.; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Dias Costa A; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts., Nowak JA; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Wolpin BM; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts., Vonderheide RH; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Parker Institute for Cancer Immunotherapy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Goecks J; Department of Biomedical Engineering, Oregon Health and Science University, Portland, Oregon.; The Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon.; Current affiliation: Department of Machine Learning, H. Lee Moffitt Cancer Center, Tampa, Florida.; Current affiliation: Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center, Tampa, Florida., Coussens LM; The Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon.; Department of Cell, Developmental and Cancer Biology, Oregon Health and Science University, Portland, Oregon., Byrne KT; The Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon.; Department of Cell, Developmental and Cancer Biology, Oregon Health and Science University, Portland, Oregon.

المصدر: Cancer immunology research [Cancer Immunol Res] 2024 May 02; Vol. 12 (5), pp. 544-558.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101614637 Publication Model: Print Cited Medium: Internet ISSN: 2326-6074 (Electronic) Linking ISSN: 23266066 NLM ISO Abbreviation: Cancer Immunol Res Subsets: MEDLINE

مواضيع طبية MeSH: Machine Learning* , Pancreatic Neoplasms*/immunology , Pancreatic Neoplasms*/therapy , Pancreatic Neoplasms*/pathology , Tumor Microenvironment*/immunology , Neoadjuvant Therapy* , Immunotherapy*/methods , Carcinoma, Pancreatic Ductal*/immunology , Carcinoma, Pancreatic Ductal*/therapy , Carcinoma, Pancreatic Ductal*/pathology, Humans ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; CD40 Antigens/metabolism ; Treatment Outcome ; Female ; Lymphocytes, Tumor-Infiltrating/immunology ; Lymphocytes, Tumor-Infiltrating/metabolism ; Male

المؤلفون: Blise KE; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR USA.; The Knight Cancer Institute, Oregon Health & Science University, Portland, OR USA., Sivagnanam S; The Knight Cancer Institute, Oregon Health & Science University, Portland, OR USA.; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR USA., Betts CB; The Knight Cancer Institute, Oregon Health & Science University, Portland, OR USA.; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR USA.; Current affiliation: Akoya Biosciences, 100 Campus Drive, 6th Floor, Marlborough, MA USA., Betre K; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR USA., Kirchberger N; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR USA., Tate B; The Knight Cancer Institute, Oregon Health & Science University, Portland, OR USA.; Immune Monitoring and Cancer Omics Services, Oregon Health & Science University, Portland, OR USA., Furth EE; Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA USA.; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA., Dias Costa A; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA USA., Nowak JA; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA USA., Wolpin BM; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA USA., Vonderheide RH; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA.; Parker Institute for Cancer Immunotherapy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA., Goecks J; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR USA.; The Knight Cancer Institute, Oregon Health & Science University, Portland, OR USA.; Current affiliation: Department of Machine Learning, H. Lee Moffitt Cancer Center, Tampa, FL USA.; Current affiliation: Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center, Tampa, FL USA., Coussens LM; The Knight Cancer Institute, Oregon Health & Science University, Portland, OR USA.; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR USA., Byrne KT; The Knight Cancer Institute, Oregon Health & Science University, Portland, OR USA.; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR USA.; Lead contact.

المصدر: BioRxiv : the preprint server for biology [bioRxiv] 2023 Oct 23. Date of Electronic Publication: 2023 Oct 23.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

المؤلفون: Brockman AA; Department of Cell & Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Khurana R; Department of Cell & Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA., Bartkowiak T; Department of Cell & Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.; Department of Pathology, Microbiology, & Immunology, Nashville, Tennessee, USA., Thomas PL; Department of Microbiology, Immunology & Physiology, School of Medicine, Meharry Medical College, Nashville, Tennessee, USA.; School of Graduate Studies & Research, Meharry Medical College, Nashville, Tennessee, USA., Sivagnanam S; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, Oregon, USA.; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA., Betts CB; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, Oregon, USA.; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA., Coussens LM; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, Oregon, USA.; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA., Lovly CM; School of Graduate Studies & Research, Meharry Medical College, Nashville, Tennessee, USA.; Division of Hematology-Oncology, Department of Medicine, Nashville, Tennessee, USA., Irish JM; Department of Cell & Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.; Department of Pathology, Microbiology, & Immunology, Nashville, Tennessee, USA.; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Ihrie RA; Department of Cell & Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.; School of Graduate Studies & Research, Meharry Medical College, Nashville, Tennessee, USA.; Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA.; Department of Neurological Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

المصدر: Cytometry. Part B, Clinical cytometry [Cytometry B Clin Cytom] 2023 Sep; Vol. 104 (5), pp. 344-355. Date of Electronic Publication: 2023 Feb 07.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 101235690 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4957 (Electronic) Linking ISSN: 15524949 NLM ISO Abbreviation: Cytometry B Clin Cytom Subsets: MEDLINE

مواضيع طبية MeSH: Software* , Microscopy*, Humans ; Immunohistochemistry ; Flow Cytometry ; Cell Nucleus ; Image Processing, Computer-Assisted/methods

المؤلفون: Kitko CL; Vanderbilt University Medical Center, Nashville, TN., Arora M; University of Minnesota Masonic Cancer Center, Minneapolis, MN., DeFilipp Z; Massachusetts General Hospital, Boston, MA., Zaid MA; Indiana University Simon Cancer Center, Indianapolis, IN., Di Stasi A; University of Alabama, Birmingham, AL., Radojcic V; University of Utah Huntsman Cancer Institute, Salt Lake City, UT.; Syndax Pharmaceuticals, Inc, Waltham, MA., Betts CB; Department of Cell, Developmental, and Cancer Biology, Knight Cancer Institute, Oregon Health and Science University, Portland, OR., Coussens LM; Department of Cell, Developmental, and Cancer Biology, Knight Cancer Institute, Oregon Health and Science University, Portland, OR., Meyers ML; Syndax Pharmaceuticals, Inc, Waltham, MA., Qamoos H; Syndax Pharmaceuticals, Inc, Waltham, MA.; Kartos Therapeutics, Inc, Redwood City, CA., Ordentlich P; Syndax Pharmaceuticals, Inc, Waltham, MA., Kumar V; Syndax Pharmaceuticals, Inc, Waltham, MA.; Daiichi Sankyo, Inc, Basking Ridge, NJ., Quaranto C; Syndax Pharmaceuticals, Inc, Waltham, MA.; Aerovate Therapeutics, Inc, Waltham, MA., Schmitt A; Syndax Pharmaceuticals, Inc, Waltham, MA., Gu Y; Syndax Pharmaceuticals, Inc, Waltham, MA., Blazar BR; Division of Blood & Marrow Transplant & Cellular Therapy, Department of Pediatrics, University of Minnesota, Minneapolis, MN., Wang TP; Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL., Salhotra A; City of Hope Medical Center, Duarte, CA., Pusic I; Washington University School of Medicine, Saint Louis, MO., Jagasia M; Iovance Biotherapeutics, San Carlos, CA., Lee SJ; Fred Hutchinson Cancer Center, Seattle, WA.

المصدر: Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2023 Apr 01; Vol. 41 (10), pp. 1864-1875. Date of Electronic Publication: 2022 Dec 02.

نوع المنشور: Clinical Trial, Phase II; Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Society of Clinical Oncology Country of Publication: United States NLM ID: 8309333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-7755 (Electronic) Linking ISSN: 0732183X NLM ISO Abbreviation: J Clin Oncol Subsets: MEDLINE

مواضيع طبية MeSH: Bronchiolitis Obliterans Syndrome* , Graft vs Host Disease*/drug therapy , Biological Products*/therapeutic use, Humans ; Child ; Antibodies, Monoclonal, Humanized/therapeutic use ; Chronic Disease

المؤلفون: Mi H; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland., Sivagnanam S; Computatioanl Biology, Oregon Health and Science University, Portland, Oregon., Betts CB; Department of Cell, Development, and Cancer Biology, Oregon Health and Science University, Portland, Oregon., Liudahl SM; Department of Cell, Development, and Cancer Biology, Oregon Health and Science University, Portland, Oregon., Jaffee EM; Skip Viragh Center for Pancreatic Cancer, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Johns Hopkins Medicine, Baltimore, Maryland.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland., Coussens LM; Department of Cell, Development, and Cancer Biology, Oregon Health and Science University, Portland, Oregon.; Brenden-Colson Center for Pancreatic Care, Oregon Health and Science University, Portland, Oregon.; Knight Cancer Institute, Portland, Oregon., Popel AS; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland.; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland.

المصدر: Cancer research [Cancer Res] 2022 Dec 02; Vol. 82 (23), pp. 4359-4372.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Pancreatic Ductal*/pathology , Pancreatic Neoplasms*/pathology, Humans ; Tumor Microenvironment ; Prognosis ; Ecosystem ; Biomarkers, Tumor/genetics ; Pancreatic Neoplasms

المؤلفون: Abrego J; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, Oregon., Sanford-Crane H; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, Oregon., Oon C; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, Oregon., Xiao X; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California., Betts CB; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, Oregon., Sun D; Computational Biology Program, Oregon Health & Science University, Portland, Oregon., Nagarajan S; Medicinal Chemistry Core, Oregon Health & Science University, Portland, Oregon., Diaz L; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, Oregon., Sandborg H; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, Oregon., Bhattacharyya S; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, Oregon., Xia Z; Computational Biology Program, Oregon Health & Science University, Portland, Oregon.; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon., Coussens LM; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, Oregon.; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon., Tontonoz P; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.; Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, California., Sherman MH; Department of Cell, Developmental and Cancer Biology, Oregon Health & Science University, Portland, Oregon.; Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.

المصدر: Cancer discovery [Cancer Discov] 2022 Oct 05; Vol. 12 (10), pp. 2414-2433.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Pancreatic Ductal*/pathology , PPAR delta* , Pancreatic Neoplasms*/pathology, Aspartate Aminotransferases ; Aspartic Acid/metabolism ; Fatty Acids ; Humans ; Ligands ; Malates/metabolism ; Tumor Microenvironment ; Pancreatic Neoplasms

المؤلفون: Sepe JJ; Department of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon, USA.; Department of Medicine, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon, USA., Gardner RT; Department of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon, USA.; Department of Medicine, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon, USA., Blake MR; Department of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon, USA., Brooks DM; Department of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon, USA., Staffenson MA; Department of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon, USA., Betts CB; Department of Cell, Developmental and Cancer Biology, Oregon Health and Science University, Portland, Oregon, USA.; Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, USA., Sivagnanam S; Department of Cell, Developmental and Cancer Biology, Oregon Health and Science University, Portland, Oregon, USA.; Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, USA., Larson W; Department of Cell, Developmental and Cancer Biology, Oregon Health and Science University, Portland, Oregon, USA.; Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, USA., Kumar S; Department of Cell, Developmental and Cancer Biology, Oregon Health and Science University, Portland, Oregon, USA.; Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, USA., Bayles RG; Department of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon, USA., Jin H; Department of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon, USA., Cohen MS; Department of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon, USA., Coussens LM; Department of Cell, Developmental and Cancer Biology, Oregon Health and Science University, Portland, Oregon, USA.; Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon, USA., Habecker BA; Department of Chemical Physiology and Biochemistry, Oregon Health and Science University, Portland, Oregon, USA.; Department of Medicine, Knight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon, USA.

المصدر: JACC. Basic to translational science [JACC Basic Transl Sci] 2022 Aug 24; Vol. 7 (9), pp. 915-930. Date of Electronic Publication: 2022 Aug 24 (Print Publication: 2022).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier on behalf of the American College of Cardiology Foundation Country of Publication: United States NLM ID: 101677259 Publication Model: eCollection Cited Medium: Internet ISSN: 2452-302X (Electronic) Linking ISSN: 2452302X NLM ISO Abbreviation: JACC Basic Transl Sci Subsets: PubMed not MEDLINE

المؤلفون: Taylor MH; Division of Hematology and Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon., Betts CB; Department of Cell, Developmental, and Cancer Biology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon., Maloney L; Division of Hematology and Oncology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon.; Department of Cell, Developmental, and Cancer Biology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon., Nadler E; Baylor University Medical Center, Dallas, Texas., Algazi A; University of California San Francisco, San Francisco, California., Guarino MJ; Helen F. Graham Cancer Center and Research Institute, Newark, Delaware., Nemunaitis J; University of Toledo College of Medicine and Life Sciences, and ProMedica Health System, Toledo, Ohio., Jimeno A; University of Colorado Cancer Center, Denver, Colorado., Patel P; AstraZeneca, South San Francisco, California., Munugalavadla V; AstraZeneca, South San Francisco, California., Tao L; AstraZeneca, South San Francisco, California., Adkins D; Washington University School of Medicine, St. Louis, Missouri., Goldschmidt JH; Blue Ridge Cancer Care, Blacksburg, Virginia., Cohen EEW; University of California San Diego, Moores Cancer Center, La Jolla, California., Coussens LM; Department of Cell, Developmental, and Cancer Biology, Knight Cancer Institute, Oregon Health and Science University, Portland, Oregon.

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2022 Mar 01; Vol. 28 (5), pp. 903-914.

نوع المنشور: Clinical Trial, Phase II; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: The Association Country of Publication: United States NLM ID: 9502500 Publication Model: Print Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Combined Chemotherapy Protocols*/adverse effects , Head and Neck Neoplasms*/drug therapy , Head and Neck Neoplasms*/pathology , Squamous Cell Carcinoma of Head and Neck*/drug therapy , Squamous Cell Carcinoma of Head and Neck*/pathology, Antibodies, Monoclonal, Humanized/therapeutic use ; Benzamides/therapeutic use ; Humans ; Programmed Cell Death 1 Receptor ; Proteomics ; Pyrazines/therapeutic use

المؤلفون: Johnson BE; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, USA., Creason AL; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, USA., Stommel JM; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, USA., Keck JM; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA., Parmar S; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA., Betts CB; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Blucher A; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Boniface C; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, USA.; Cancer Early Detection Advanced Research Center, Oregon Health & Science University, Portland, OR 97239, USA., Bucher E; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, USA., Burlingame E; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, USA.; Computational Biology Program, Oregon Health & Science University, Portland, OR 97239, USA., Camp T; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA., Chin K; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, USA., Eng J; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, USA., Estabrook J; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97239, USA., Feiler HS; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, USA., Heskett MB; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97239, USA., Hu Z; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, USA., Kolodzie A; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA., Kong BL; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.; Department of Pharmacy Services, Oregon Health & Science University, Portland, OR 97239, USA., Labrie M; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Lee J; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA., Leyshock P; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA., Mitri S; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA., Patterson J; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.; Knight Diagnostic Laboratories, Oregon Health & Science University, Portland, OR 97239, USA., Riesterer JL; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, USA.; Multiscale Microscopy Core, Oregon Health & Science University, Portland, OR 97239, USA., Sivagnanam S; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA.; Computational Biology Program, Oregon Health & Science University, Portland, OR 97239, USA., Somers J; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97239, USA., Sudar D; Quantitative Imaging Systems LLC, Portland, OR 97239, USA., Thibault G; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, USA., Weeder BR; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, USA., Zheng C; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA., Nan X; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, USA.; Cancer Early Detection Advanced Research Center, Oregon Health & Science University, Portland, OR 97239, USA., Thompson RF; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, USA.; Division of Hospital and Specialty Medicine, VA Portland Healthcare System, Portland, OR 97239, USA., Heiser LM; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, USA., Spellman PT; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, USA.; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97239, USA., Thomas G; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.; Department of Pathology & Laboratory Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Demir E; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97239, USA., Chang YH; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, USA.; Computational Biology Program, Oregon Health & Science University, Portland, OR 97239, USA., Coussens LM; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Guimaraes AR; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.; Department of Diagnostic Radiology, Oregon Health & Science University, Portland, OR 97239, USA., Corless C; Department of Pharmacy Services, Oregon Health & Science University, Portland, OR 97239, USA.; Department of Pathology & Laboratory Medicine, Oregon Health & Science University, Portland, OR 97239, USA., Goecks J; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, USA., Bergan R; Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA., Mitri Z; Division of Hematology & Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.; Department of Medicine, Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA., Mills GB; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.; Department of Cell, Developmental & Cancer Biology, Oregon Health & Science University, Portland, OR 97239, USA., Gray JW; Knight Cancer Institute, Oregon Health & Science University, Portland, OR 97239, USA.; Department of Biomedical Engineering, Oregon Health & Science University, Portland, OR 97239, USA.

المصدر: Cell reports. Medicine [Cell Rep Med] 2022 Feb 15; Vol. 3 (2), pp. 100525. Date of Electronic Publication: 2022 Feb 15 (Print Publication: 2022).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: eCollection Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE

مواضيع طبية MeSH: Breast Neoplasms*/genetics, Biopsy ; Female ; Humans ; Tumor Microenvironment/genetics

المؤلفون: Byrne KT; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Parker Institute for Cancer Immunotherapy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Betts CB; Department of Cell, Developmental and Cancer Biology, Oregon Health and Science University, Portland, Oregon.; Knight Cancer Institute, Oregon Health and Science University-Portland State University School of Public Health, Portland, Oregon., Mick R; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Sivagnanam S; Department of Cell, Developmental and Cancer Biology, Oregon Health and Science University, Portland, Oregon., Bajor DL; Case Comprehensive Cancer Center, Cleveland, Ohio., Laheru DA; Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland., Chiorean EG; University of Washington School of Medicine, Fred Hutchinson Cancer Research Center, Seattle, Washington., O'Hara MH; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Liudahl SM; Department of Cell, Developmental and Cancer Biology, Oregon Health and Science University, Portland, Oregon., Newcomb C; Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Alanio C; Parker Institute for Cancer Immunotherapy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Department of Systems Pharmacology and Translational Therapeutics, Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Ferreira AP; Department of Cell, Developmental and Cancer Biology, Oregon Health and Science University, Portland, Oregon., Park BS; Knight Cancer Institute, Oregon Health and Science University-Portland State University School of Public Health, Portland, Oregon., Ohtani T; Department of Systems Pharmacology and Translational Therapeutics, Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Huffman AP; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Väyrynen SA; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts., Dias Costa A; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts., Kaiser JC; Fred Hutchinson Cancer Research Center, Seattle, Washington., Lacroix AM; Fred Hutchinson Cancer Research Center, Seattle, Washington., Redlinger C; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Stern M; Roche Pharma Research and Early Development, Roche Innovation Center, Zurich, Switzerland., Nowak JA; Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts., Wherry EJ; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Parker Institute for Cancer Immunotherapy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.; Department of Systems Pharmacology and Translational Therapeutics, Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Cheever MA; Fred Hutchinson Cancer Research Center, Seattle, Washington., Wolpin BM; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts., Furth EE; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania., Jaffee EM; Case Comprehensive Cancer Center, Cleveland, Ohio., Coussens LM; Department of Cell, Developmental and Cancer Biology, Oregon Health and Science University, Portland, Oregon.; Knight Cancer Institute, Oregon Health and Science University-Portland State University School of Public Health, Portland, Oregon., Vonderheide RH; Abramson Cancer Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania. rhv@upenn.edu.; Parker Institute for Cancer Immunotherapy, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2021 Aug 15; Vol. 27 (16), pp. 4574-4586. Date of Electronic Publication: 2021 Jun 10.

نوع المنشور: Clinical Trial, Phase I; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: The Association Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies, Monoclonal/*therapeutic use , Antibodies, Monoclonal, Humanized/*pharmacology , Antibodies, Monoclonal, Humanized/*therapeutic use , Pancreatic Neoplasms/*drug therapy , Tumor Microenvironment/*drug effects, Adult ; Aged ; Antibodies, Monoclonal/pharmacology ; CD40 Antigens/immunology ; Female ; Humans ; Male ; Middle Aged ; Neoadjuvant Therapy ; Pancreatic Neoplasms/surgery