المؤلفون: Westcott PMK; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. westcott@cshl.edu.; Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA. westcott@cshl.edu., Muyas F; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge, UK., Hauck H; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Smith OC; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Sacks NJ; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Ely ZA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Jaeger AM; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Rideout WM 3rd; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Zhang D; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Bhutkar A; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Beytagh MC; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Canner DA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Jaramillo GC; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Bronson RT; Rodent Histopathology Core, Harvard Medical School, Boston, MA, USA., Naranjo S; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Jin A; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Patten JJ; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Cruz AM; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Shanahan SL; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Cortes-Ciriano I; European Molecular Biology Laboratory, European Bioinformatics Institute, Hinxton, Cambridge, UK. icortes@ebi.ac.uk., Jacks T; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. tjacks@mit.edu.; Rodent Histopathology Core, Harvard Medical School, Boston, MA, USA. tjacks@mit.edu.

المصدر: Nature genetics [Nat Genet] 2023 Oct; Vol. 55 (10), pp. 1686-1695. Date of Electronic Publication: 2023 Sep 14.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE

مواضيع طبية MeSH: Colorectal Neoplasms*/genetics , Brain Neoplasms* , Neoplastic Syndromes, Hereditary*, Animals ; Mice ; Antigens, Neoplasm/genetics ; Mutation ; DNA Mismatch Repair/genetics ; Biomarkers, Tumor/genetics

SCR Disease Name: Turcot syndrome

المؤلفون: Soto-Feliciano YM; Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, New York., Sánchez-Rivera FJ; Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York., Perner F; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Division of Hematology/Oncology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts.; Internal Medicine C, Greifswald University Medical Center, Greifswald, Germany., Barrows DW; Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, New York.; Bioinformatics Resource Center, The Rockefeller University, New York, New York., Kastenhuber ER; Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York., Ho YJ; Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York., Carroll T; Bioinformatics Resource Center, The Rockefeller University, New York, New York., Xiong Y; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Division of Hematology/Oncology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts., Anand D; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Internal Medicine C, Greifswald University Medical Center, Greifswald, Germany., Soshnev AA; Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, New York., Gates L; Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, New York., Beytagh MC; Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, New York., Cheon D; Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, New York., Gu S; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard School of Public Health, Boston, Massachusetts.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts., Liu XS; Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Harvard School of Public Health, Boston, Massachusetts.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts., Krivtsov AV; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Division of Hematology/Oncology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts., Meneses M; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York., de Stanchina E; Antitumor Assessment Core Facility, Memorial Sloan Kettering Cancer Center, New York, New York., Stone RM; Leukemia Division, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts., Armstrong SA; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.; Division of Hematology/Oncology, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts., Lowe SW; Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York., Allis CD; Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University, New York, New York.

المصدر: Cancer discovery [Cancer Discov] 2023 Jan 09; Vol. 13 (1), pp. 146-169.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE

مواضيع طبية MeSH: Myeloid-Lymphoid Leukemia Protein*/genetics , Leukemia*/drug therapy, Humans ; Mice ; Animals ; Histone-Lysine N-Methyltransferase/genetics ; Histone-Lysine N-Methyltransferase/metabolism ; Cell Line, Tumor ; Transcription Factors/genetics ; Chromatin ; Mammals/genetics ; Mammals/metabolism

المؤلفون: Beytagh MC; Medical Scientist Training Program, Biomedical Sciences Training Program, University of California, San Francisco, San Francisco, California., Weiss WA; Depart-ments of Neuro-logy, Pediatrics, and Neurosurgery, University of California, San Francisco, San Francisco, California.

المصدر: Cancer discovery [Cancer Discov] 2022 Dec 02; Vol. 12 (12), pp. 2730-2732.

نوع المنشور: Editorial; Comment

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE

مواضيع طبية MeSH: Glioma*/genetics, Animals ; Humans ; Child ; Epigenomics ; Adenosine Triphosphatases ; Neoplastic Stem Cells ; Epigenesis, Genetic ; Mammals ; DNA Helicases/genetics ; Nuclear Proteins/genetics ; Transcription Factors/genetics

المؤلفون: Beytagh MC; Medical Scientist Training Program and Graduate Program in Biomedical Sciences, University of California, San Francisco, CA, USA., Weiss WA; Medical Scientist Training Program and Graduate Program in Biomedical Sciences, University of California, San Francisco, CA, USA. waweiss@gmail.com.; Department of Neurology, University of California, San Francisco, CA, USA. waweiss@gmail.com.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA. waweiss@gmail.com.; Departments of Pediatrics and Neurological Surgery, University of California, San Francisco, CA, USA. waweiss@gmail.com.

المصدر: Nature cell biology [Nat Cell Biol] 2022 Aug; Vol. 24 (8), pp. 1189-1191.

نوع المنشور: Journal Article; Comment

بيانات الدورية: Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE

مواضيع طبية MeSH: ErbB Receptors*/genetics , Neoplasms*/genetics, Epidermal Growth Factor ; Humans ; Ligands

المؤلفون: Westcott PMK; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Sacks NJ; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Schenkel JM; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Ely ZA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Smith O; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Hauck H; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Jaeger AM; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Zhang D; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Backlund CM; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Beytagh MC; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Patten JJ; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Elbashir R; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA., Eng G; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA., Irvine DJ; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.; Department of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, USA., Yilmaz OH; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.; Department of Pathology, Massachusetts General Hospital, Boston, MA, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA., Jacks T; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA. tjacks@mit.edu.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA. tjacks@mit.edu.

المصدر: Nature cancer [Nat Cancer] 2021 Oct; Vol. 2 (10), pp. 1071-1085. Date of Electronic Publication: 2021 Sep 30.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer

مواضيع طبية MeSH: Colorectal Neoplasms*/genetics , T-Lymphocytes*, Animals ; Antigens, Neoplasm/genetics ; Humans ; Immunotherapy ; Mice ; Microsatellite Instability

المؤلفون: Gupta M; Stem Cell Program, Division of Hematology/Oncology and Division of Pulmonary Medicine, Boston Children's Hospital, Boston, Massachusetts.; Department of Genetics, Harvard Medical School, Boston, Massachusetts.; Biological and Biomedical Sciences PhD Program, Harvard University, Boston, Massachusetts., Concepcion CP; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts., Fahey CG; Stem Cell Program, Division of Hematology/Oncology and Division of Pulmonary Medicine, Boston Children's Hospital, Boston, Massachusetts.; Department of Genetics, Harvard Medical School, Boston, Massachusetts., Keshishian H; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Bhutkar A; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts., Brainson CF; Markey Cancer Center, University of Kentucky, Lexington, Kentucky.; Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky., Sanchez-Rivera FJ; Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, New York., Pessina P; Stem Cell Program, Division of Hematology/Oncology and Division of Pulmonary Medicine, Boston Children's Hospital, Boston, Massachusetts.; Department of Genetics, Harvard Medical School, Boston, Massachusetts., Kim JY; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts., Simoneau A; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts., Paschini M; Stem Cell Program, Division of Hematology/Oncology and Division of Pulmonary Medicine, Boston Children's Hospital, Boston, Massachusetts.; Department of Genetics, Harvard Medical School, Boston, Massachusetts., Beytagh MC; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts., Stanclift CR; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Schenone M; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Mani DR; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Li C; Massachusetts General Hospital Cancer Center and Department of Medicine, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts., Oh A; Massachusetts General Hospital Cancer Center and Department of Medicine, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts., Li F; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, New York., Hu H; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, New York., Karatza A; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, New York., Bronson RT; Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts., Shaw AT; Massachusetts General Hospital Cancer Center and Department of Medicine, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts., Hata AN; Massachusetts General Hospital Cancer Center and Department of Medicine, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts., Wong KK; Laura and Isaac Perlmutter Cancer Center, New York University Grossman School of Medicine, NYU Langone Health, New York, New York., Zou L; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts.; Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts., Carr SA; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Jacks T; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.; Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts.; Howard Hughes Medical Institute, Cambridge, Massachusetts., Kim CF; Stem Cell Program, Division of Hematology/Oncology and Division of Pulmonary Medicine, Boston Children's Hospital, Boston, Massachusetts. carla.kim@childrens.harvard.edu.; Department of Genetics, Harvard Medical School, Boston, Massachusetts.; Harvard Stem Cell Institute, Cambridge, Massachusetts.

المصدر: Cancer research [Cancer Res] 2020 Sep 15; Vol. 80 (18), pp. 3841-3854. Date of Electronic Publication: 2020 Jul 20.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Gene Deletion*, Ataxia Telangiectasia Mutated Proteins/*antagonists & inhibitors , Carcinoma, Non-Small-Cell Lung/*genetics , DNA Helicases/*genetics , Lung Neoplasms/*genetics , Nuclear Proteins/*genetics , Transcription Factors/*genetics, Animals ; Cell Cycle Proteins/metabolism ; Chromosomal Proteins, Non-Histone ; DNA Helicases/deficiency ; Disease Progression ; Female ; Forkhead Transcription Factors ; Gene Editing ; Humans ; Immunoprecipitation ; Mass Spectrometry ; Mice ; Mice, Inbred C57BL ; Mice, Nude ; Nuclear Proteins/deficiency ; Nuclear Proteins/metabolism ; Sequence Analysis, RNA ; Transcription Factors/deficiency

المؤلفون: Romero R; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA.; Massachusetts Institute of Technology Department of Biology, Cambridge, MA, USA., Sánchez-Rivera FJ; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA.; Massachusetts Institute of Technology Department of Biology, Cambridge, MA, USA.; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Westcott PMK; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA., Mercer KL; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Bhutkar A; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA., Muir A; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA.; Ben May Department for Cancer Research, University of Chicago, Chicago, IL, USA., González Robles TJ; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA., Rodríguez SL; Massachusetts Institute of Technology Department of Biology, Cambridge, MA, USA., Liao LZ; Massachusetts Institute of Technology Department of Biology, Cambridge, MA, USA., Ng SR; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA.; Massachusetts Institute of Technology Department of Biology, Cambridge, MA, USA., Li L; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA., Colón CI; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA., Naranjo S; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA.; Massachusetts Institute of Technology Department of Biology, Cambridge, MA, USA., Beytagh MC; Massachusetts Institute of Technology Department of Biology, Cambridge, MA, USA., Lewis CA; Whitehead Institute, Massachusetts Institute of Technology, Cambridge, MA, USA., Hsu PP; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA.; Massachusetts General Hospital Cancer Center, Boston, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA., Bronson RT; Tufts University, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Vander Heiden MG; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA.; Massachusetts Institute of Technology Department of Biology, Cambridge, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA., Jacks T; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA. tjacks@mit.edu.; Massachusetts Institute of Technology Department of Biology, Cambridge, MA, USA. tjacks@mit.edu.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. tjacks@mit.edu.

المصدر: Nature cancer [Nat Cancer] 2020 Sep; Vol. 1 (9), pp. 935.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Romero R; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA.; Massachusetts Institute of Technology Department of Biology, Cambridge, MA, USA., Sánchez-Rivera FJ; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA.; Massachusetts Institute of Technology Department of Biology, Cambridge, MA, USA.; Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Westcott PMK; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA., Mercer KL; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Bhutkar A; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA., Muir A; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA.; Ben May Department for Cancer Research, University of Chicago, Chicago, IL, USA., González Robles TJ; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA., Lamboy Rodríguez S; Massachusetts Institute of Technology Department of Biology, Cambridge, MA, USA., Liao LZ; Massachusetts Institute of Technology Department of Biology, Cambridge, MA, USA., Ng SR; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA.; Massachusetts Institute of Technology Department of Biology, Cambridge, MA, USA., Li L; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA., Colón CI; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA., Naranjo S; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA.; Massachusetts Institute of Technology Department of Biology, Cambridge, MA, USA., Beytagh MC; Massachusetts Institute of Technology Department of Biology, Cambridge, MA, USA., Lewis CA; Whitehead Institute, Massachusetts Institute of Technology, Cambridge, MA, USA., Hsu PP; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA.; Massachusetts General Hospital Cancer Center, Boston, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA., Bronson RT; Tufts University, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Vander Heiden MG; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA.; Massachusetts Institute of Technology Department of Biology, Cambridge, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA., Jacks T; Koch Institute for Integrative Cancer Research, Cambridge, MA, USA. tjacks@mit.edu.; Massachusetts Institute of Technology Department of Biology, Cambridge, MA, USA. tjacks@mit.edu.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. tjacks@mit.edu.

المصدر: Nature cancer [Nat Cancer] 2020 Jun; Vol. 1 (6), pp. 589-602. Date of Electronic Publication: 2020 Jun 08.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer

مواضيع طبية MeSH: Adenocarcinoma of Lung*/genetics , Kelch-Like ECH-Associated Protein 1*/genetics , Lung Neoplasms*/genetics , Membrane Transport Proteins*/genetics, Animals ; Humans ; Mice ; Mutation ; NF-E2-Related Factor 2/genetics

المؤلفون: Li L; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Ng SR; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Colón CI; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Drapkin BJ; Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA., Hsu PP; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.; Dana-Farber Cancer Institute, Boston, MA 02115, USA., Li Z; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Nabel CS; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.; Dana-Farber Cancer Institute, Boston, MA 02115, USA., Lewis CA; Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA., Romero R; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Mercer KL; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Bhutkar A; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Phat S; Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA., Myers DT; Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA., Muzumdar MD; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Westcott PMK; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Beytagh MC; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Farago AF; Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.; Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.; Harvard Medical School, Boston, MA 02115, USA., Vander Heiden MG; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Dana-Farber Cancer Institute, Boston, MA 02115, USA., Dyson NJ; Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA.; Harvard Medical School, Boston, MA 02115, USA., Jacks T; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. tjacks@mit.edu.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

المصدر: Science translational medicine [Sci Transl Med] 2019 Nov 06; Vol. 11 (517).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

مواضيع طبية MeSH: Molecular Targeted Therapy*, Lung Neoplasms/*drug therapy , Lung Neoplasms/*enzymology , Oxidoreductases Acting on CH-CH Group Donors/*antagonists & inhibitors , Small Cell Lung Carcinoma/*drug therapy , Small Cell Lung Carcinoma/*enzymology, Adenocarcinoma/drug therapy ; Adenocarcinoma/enzymology ; Adenocarcinoma/pathology ; Animals ; Biphenyl Compounds/pharmacology ; Biphenyl Compounds/therapeutic use ; Carcinoma, Pancreatic Ductal/drug therapy ; Carcinoma, Pancreatic Ductal/enzymology ; Carcinoma, Pancreatic Ductal/pathology ; Cell Line, Tumor ; DCMP Deaminase/metabolism ; Dihydroorotate Dehydrogenase ; Disease Progression ; Enzyme Inhibitors/pharmacology ; Enzyme Inhibitors/therapeutic use ; Humans ; Lung Neoplasms/pathology ; Mice ; Oxidoreductases Acting on CH-CH Group Donors/metabolism ; Pancreatic Neoplasms/metabolism ; Pyrimidines/biosynthesis ; Small Cell Lung Carcinoma/pathology ; Survival Analysis ; Xenograft Model Antitumor Assays ; Pancreatic Neoplasms