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المؤلفون: Richters A; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; MIT Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Doyle SK; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; MIT Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Freeman DB; Kronos Bio, Inc., Cambridge, MA 02139, USA., Lee C; Kronos Bio, Inc., Cambridge, MA 02139, USA., Leifer BS; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; MIT Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Jagannathan S; Therapeutic Innovation Center, Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA., Kabinger F; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; MIT Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Koren JV; Therapeutic Innovation Center, Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA., Struntz NB; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; MIT Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Urgiles J; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Harvard-MIT Health Sciences and Technology, Boston, MA 02115, USA., Stagg RA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Department of Biology, Boston University, Boston, MA 02215, USA., Curtin BH; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; MIT Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Chatterjee D; Goethe-Universität Frankfurt, 60438 Frankfurt am Main, Germany., Mathea S; Goethe-Universität Frankfurt, 60438 Frankfurt am Main, Germany., Mikochik PJ; Kronos Bio, Inc., Cambridge, MA 02139, USA., Hopkins TD; Kronos Bio, Inc., Cambridge, MA 02139, USA., Gao H; Kronos Bio, Inc., Cambridge, MA 02139, USA., Branch JR; Janssen Research & Development, LLC, Spring House, PA, USA., Xin H; Janssen Research & Development, LLC, Spring House, PA, USA., Westover L; Janssen Research & Development, LLC, Spring House, PA, USA., Bignan GC; Janssen Research & Development, LLC, Spring House, PA, USA., Rupnow BA; Janssen Research & Development, LLC, Spring House, PA, USA., Karlin KL; Therapeutic Innovation Center, Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA., Olson CM; Therapeutic Innovation Center, Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA., Westbrook TF; Therapeutic Innovation Center, Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA., Vacca J; Kronos Bio, Inc., Cambridge, MA 02139, USA., Wilfong CM; Kronos Bio, Inc., Cambridge, MA 02139, USA., Trotter BW; Kronos Bio, Inc., Cambridge, MA 02139, USA., Saffran DC; Kronos Bio, Inc., Cambridge, MA 02139, USA., Bischofberger N; Kronos Bio, Inc., Cambridge, MA 02139, USA., Knapp S; Goethe-Universität Frankfurt, 60438 Frankfurt am Main, Germany., Russo JW; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Hickson I; Janssen Research & Development, LLC, Spring House, PA, USA; Cancer Research UK Newcastle Drug Discovery Unit, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Bischoff JR; Janssen Research & Development, LLC, Spring House, PA, USA., Gottardis MM; Janssen Research & Development, LLC, Spring House, PA, USA., Balk SP; Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA., Lin CY; Kronos Bio, Inc., Cambridge, MA 02139, USA; Therapeutic Innovation Center, Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX 77030, USA; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA., Pop MS; Kronos Bio, Inc., Cambridge, MA 02139, USA., Koehler AN; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; MIT Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, MA 02142, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: koehler@mit.edu.

المصدر: Cell chemical biology [Cell Chem Biol] 2021 Feb 18; Vol. 28 (2), pp. 134-147.e14. Date of Electronic Publication: 2020 Oct 20.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Androgen Receptor Antagonists/*pharmacology , Cyclin-Dependent Kinase 9/*antagonists & inhibitors , Prostatic Neoplasms, Castration-Resistant/*drug therapy , Protein Kinase Inhibitors/*pharmacology , Receptors, Androgen/*genetics , Transcription, Genetic/*drug effects, Androgen Receptor Antagonists/therapeutic use ; Animals ; Cell Line, Tumor ; Cyclin-Dependent Kinase 9/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Male ; Mice ; Mice, Inbred BALB C ; Models, Molecular ; Prostatic Neoplasms, Castration-Resistant/genetics ; Protein Kinase Inhibitors/therapeutic use

المؤلفون: Ross TM; West Chester University, Chemistry Department, West Chester, PA, USA. Electronic address: tross@wcupa.edu., Battista K; Ace Glass, Vineland, NJ, USA., Bignan GC; Johnson & Johnson Pharmaceutical Research and Development, LLC, Spring House, PA, USA., Brenneman DE; Fox Chase Chemical Diversity Center, Doylestown, PA, USA., Connolly PJ; Johnson & Johnson Pharmaceutical Research and Development, LLC, Spring House, PA, USA., Liu J; Sanofi-Aventis, Boston, MA, USA., Middleton SA; Hoffmann La-Roche, Nutley, NJ, USA., Orsini M; Bristol-Myers Squibb, New Brunswick, NJ, USA., Reitz AB; Fox Chase Chemical Diversity Center, Doylestown, PA, USA., Rosenthal DI; Burlington Community College, Pemberton, NJ, USA., Scott MK; Johnson & Johnson Pharmaceutical Research and Development, LLC, Spring House, PA, USA., Vaidya AH; Pfizer-Makro Technologies, Bridgewater, NJ, USA.

المصدر: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Feb 01; Vol. 25 (3), pp. 602-6. Date of Electronic Publication: 2014 Dec 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

مواضيع طبية MeSH: Receptors, Opioid/*agonists , Small Molecule Libraries/*chemistry , Spiro Compounds/*chemistry, Animals ; Anxiety/drug therapy ; Disease Models, Animal ; Motor Activity/drug effects ; Opioid Peptides/chemistry ; Opioid Peptides/metabolism ; Protein Binding ; Rats ; Receptors, Opioid/metabolism ; Small Molecule Libraries/pharmacology ; Small Molecule Libraries/therapeutic use ; Spiro Compounds/pharmacology ; Spiro Compounds/therapeutic use ; Structure-Activity Relationship ; Nociceptin Receptor ; Nociceptin