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المؤلفون: Wanisa Salaemae, Andrew P. Thompson, Birgit I. Gaiser, Kwang Jun Lee, Michael T. Huxley, Christopher J. Sumby, Steven W. Polyak, Andrew D. Abell, John B. Bruning, Kate L. Wegener
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::5bd3bb7628f80537dee2c1e04bf286f8
https://doi.org/10.1101/2023.03.26.531482 -
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المؤلفون: Jordan L. Pederick, Birgit I Gaiser, Nicholas C Schumann, Kate L. Wegener, Kwangjun Lee, James Hodgkinson-Bean, Steven W. Polyak, Thomas D. Avery, Grant W. Booker, John B. Bruning, Andrew D. Abell, Wanisa Salaemae, Andrew P. Thompson
المصدر: ACS Chemical Biology. 16:2339-2347
مصطلحات موضوعية: Tuberculosis, In silico, 01 natural sciences, Biochemistry, Dethiobiotin synthase, Mycobacterium tuberculosis, 03 medical and health sciences, chemistry.chemical_compound, Biotin, Biosynthesis, medicine, Tetrazole, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, biology, 010405 organic chemistry, General Medicine, medicine.disease, biology.organism_classification, 0104 chemical sciences, 3. Good health, Enzyme, chemistry, biology.protein, Molecular Medicine
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المؤلفون: Nicholas C, Schumann, Kwang Jun, Lee, Andrew P, Thompson, Wanisa, Salaemae, Jordan L, Pederick, Thomas, Avery, Birgit I, Gaiser, James, Hodgkinson-Bean, Grant W, Booker, Steven W, Polyak, John B, Bruning, Kate L, Wegener, Andrew D, Abell
المصدر: ACS chemical biology. 16(11)
مصطلحات موضوعية: Drug Development, Molecular Structure, Antitubercular Agents, Carbon-Nitrogen Ligases, Mycobacterium tuberculosis, Enzyme Inhibitors, Crystallography, X-Ray, Protein Binding
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المؤلفون: Kira Røpke Jørgensen, David E. Gloriam, Jesper Mosolff Mathiesen, Mikael Frykman, Daniel Sejer Pedersen, Emil Märcher-Rørsted, Henrik Johansson, Tomasz M. Wróbel, Mia Danielsen, Hans Bräuner-Osborne, Birgit I. Gaiser
المصدر: Journal of Medicinal Chemistry. 62:7806-7839
مصطلحات موضوعية: Hydrophobic effect, chemistry.chemical_compound, Chemistry, Docking (molecular), Stereochemistry, Drug Discovery, Allosteric regulation, Molecular Medicine, Structure–activity relationship, Alprenolol, Binding site, Pharmacophore, Receptor
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المؤلفون: Birgit I, Gaiser, Mia, Danielsen, Emil, Marcher-Rørsted, Kira, Røpke Jørgensen, Tomasz M, Wróbel, Mikael, Frykman, Henrik, Johansson, Hans, Bräuner-Osborne, David E, Gloriam, Jesper Mosolff, Mathiesen, Daniel, Sejer Pedersen
المصدر: Journal of medicinal chemistry. 62(17)
مصطلحات موضوعية: Structure-Activity Relationship, Binding Sites, Allosteric Regulation, Dose-Response Relationship, Drug, Molecular Structure, Humans, Receptors, Adrenergic, beta-2, Molecular Dynamics Simulation, Alprenolol, Crystallography, X-Ray, Ligands, Hydrophobic and Hydrophilic Interactions
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المؤلفون: Daniel Sejer Pedersen, Birgit I. Gaiser, Philipp Fronik
المصدر: Journal of medicinal chemistry. 60(10)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Allosteric modulator, Binding Sites, Drug discovery, Stereochemistry, Chemistry, Allosteric regulation, Ligand (biochemistry), Ligands, Receptors, G-Protein-Coupled, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Allosteric Regulation, Cell surface receptor, 030220 oncology & carcinogenesis, Drug Discovery, Molecular Medicine, Animals, Humans, Binding site, Receptor, Allosteric Site, G protein-coupled receptor