نتائج البحث - "Bittker, JA"

المؤلفون: Clemons PA; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA, USA., Bittker JA; Center for the Development of Therapeutics, Broad Institute, Cambridge, MA, USA.; Vertex Pharmaceuticals, Boston, MA, USA., Wagner FF; Center for the Development of Therapeutics, Broad Institute, Cambridge, MA, USA., Hands A; Center for the Development of Therapeutics, Broad Institute, Cambridge, MA, USA., Dančík V; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA, USA., Schreiber SL; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA, USA., Choudhary A; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA, USA., Wagner BK; Chemical Biology and Therapeutics Science Program, Broad Institute, Cambridge, MA, USA.

المصدر: SLAS discovery : advancing life sciences R & D [SLAS Discov] 2021 Aug; Vol. 26 (7), pp. 855-861. Date of Electronic Publication: 2021 Jun 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101697563 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2472-5560 (Electronic) Linking ISSN: 24725552 NLM ISO Abbreviation: SLAS Discov Subsets: MEDLINE

مواضيع طبية MeSH: Small Molecule Libraries*, Drug Discovery/*methods , Drug Evaluation, Preclinical/*methods, Humans ; Structure-Activity Relationship

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Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling.

المؤلفون: Corsello SM; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Nagari RT; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Spangler RD; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Rossen J; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Kocak M; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bryan JG; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Duke University, Durham, NC, USA., Humeidi R; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Peck D; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Wu X; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Tang AA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Wang VM; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bender SA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lemire E; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Narayan R; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Montgomery P; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ben-David U; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Human Molecular Genetics and Biochemistry, Tel Aviv University, Tel Aviv, Israel., Garvie CW; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Chen Y; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Rees MG; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Lyons NJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA., McFarland JM; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Wong BT; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Wang L; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; 10x Genomics, Pleasanton, CA, USA., Dumont N; Broad Institute of MIT and Harvard, Cambridge, MA, USA., O'Hearn PJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Relay Therapeutics, Cambridge, MA, USA., Stefan E; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Biogen, Cambridge, MA, USA., Doench JG; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Harrington CN; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Greulich H; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Meyerson M; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Vazquez F; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Subramanian A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Roth JA; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bittker JA; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Vertex Pharmaceuticals, Boston, MA, USA., Boehm JS; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Mader CC; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Flatiron Health, New York, NY, USA., Tsherniak A; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Golub TR; Broad Institute of MIT and Harvard, Cambridge, MA, USA. golub@broadinstitute.org.; Harvard Medical School, Boston, MA, USA. golub@broadinstitute.org.; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. golub@broadinstitute.org.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. golub@broadinstitute.org.

المصدر: Nature cancer [Nat Cancer] 2020 Feb; Vol. 1 (2), pp. 235-248. Date of Electronic Publication: 2020 Jan 20.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer

مواضيع طبية MeSH: Neoplasms*/drug therapy, Cell Line ; Disulfiram ; Drug Repositioning ; Humans

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8

دورية أكاديمية

High Throughput Screen Identifies Interferon γ-Dependent Inhibitors of Toxoplasma gondii Growth.

المؤلفون: Radke JB; Department of Molecular Microbiology , Washington University in Saint Louis School of Medicine , 660 S. Euclid Avenue , St. Louis , Missouri 63110 , United States., Carey KL; Infectious Disease and Microbiome Program , Broad Institute , Cambridge , Massachusetts 02142 , United States., Shaw S; Center for the Development of Therapeutics , Broad Institute of MIT and Harvard , 415 Main Street , Cambridge , Massachusetts 02142 , United States., Metkar SR; Center for the Development of Therapeutics , Broad Institute of MIT and Harvard , 415 Main Street , Cambridge , Massachusetts 02142 , United States., Mulrooney C; Center for the Development of Therapeutics , Broad Institute of MIT and Harvard , 415 Main Street , Cambridge , Massachusetts 02142 , United States., Gale JP; Center for the Development of Therapeutics , Broad Institute of MIT and Harvard , 415 Main Street , Cambridge , Massachusetts 02142 , United States., Bittker JA; Center for the Development of Therapeutics , Broad Institute of MIT and Harvard , 415 Main Street , Cambridge , Massachusetts 02142 , United States., Hilgraf R; Center for the Development of Therapeutics , Broad Institute of MIT and Harvard , 415 Main Street , Cambridge , Massachusetts 02142 , United States., Comer E; Chemical Biology and Therapeutics Science Program , Broad Institute , Cambridge , Massachusetts 02142 , United States., Schreiber SL; Chemical Biology and Therapeutics Science Program , Broad Institute , Cambridge , Massachusetts 02142 , United States.; Department of Chemistry and Chemical Biology , Harvard University , Cambridge , Massachusetts 02138 , United States., Virgin HW; Department of Pathology and Immunology , Washington University in Saint Louis School of Medicine , 660 S. Euclid Avenue , St. Louis , Missouri 63110 , United States., Perez JR; Center for the Development of Therapeutics , Broad Institute of MIT and Harvard , 415 Main Street , Cambridge , Massachusetts 02142 , United States., Sibley LD; Department of Molecular Microbiology , Washington University in Saint Louis School of Medicine , 660 S. Euclid Avenue , St. Louis , Missouri 63110 , United States.

المصدر: ACS infectious diseases [ACS Infect Dis] 2018 Oct 12; Vol. 4 (10), pp. 1499-1507. Date of Electronic Publication: 2018 Aug 28.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE

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دورية أكاديمية

High-Throughput Screens To Identify Autophagy Inducers That Function by Disrupting Beclin 1/Bcl-2 Binding.

المؤلفون: Chiang WC; Center for Autophagy Research, Department of Internal Medicine , University of Texas Southwestern Medical Center , Dallas , Texas 75390 , United States., Wei Y; Center for Autophagy Research, Department of Internal Medicine , University of Texas Southwestern Medical Center , Dallas , Texas 75390 , United States.; Howard Hughes Medical Research Institute , University of Texas Southwestern Medical Center , Dallas , Texas 75390 , United States., Kuo YC; Department of Pharmacology , University of Texas Southwestern Medical Center , Dallas , Texas 75390 , United States., Wei S; Department of Biochemistry , University of Texas Southwestern Medical Center , Dallas , Texas 75390 , United States., Zhou A; Department of Biochemistry , University of Texas Southwestern Medical Center , Dallas , Texas 75390 , United States., Zou Z; Center for Autophagy Research, Department of Internal Medicine , University of Texas Southwestern Medical Center , Dallas , Texas 75390 , United States.; Howard Hughes Medical Research Institute , University of Texas Southwestern Medical Center , Dallas , Texas 75390 , United States., Yehl J; Center for the Development of Therapeutics , Broad Institute of MIT and Harvard , Cambridge , Massachusetts 02142 , United States., Ranaghan MJ; Center for the Development of Therapeutics , Broad Institute of MIT and Harvard , Cambridge , Massachusetts 02142 , United States., Skepner A; Center for the Development of Therapeutics , Broad Institute of MIT and Harvard , Cambridge , Massachusetts 02142 , United States., Bittker JA; Center for the Development of Therapeutics , Broad Institute of MIT and Harvard , Cambridge , Massachusetts 02142 , United States., Perez JR; Center for the Development of Therapeutics , Broad Institute of MIT and Harvard , Cambridge , Massachusetts 02142 , United States., Posner BA; Department of Biochemistry , University of Texas Southwestern Medical Center , Dallas , Texas 75390 , United States., Levine B; Center for Autophagy Research, Department of Internal Medicine , University of Texas Southwestern Medical Center , Dallas , Texas 75390 , United States.; Howard Hughes Medical Research Institute , University of Texas Southwestern Medical Center , Dallas , Texas 75390 , United States.; Department of Microbiology , University of Texas Southwestern Medical Center , Dallas , Texas 75390 , United States.

المصدر: ACS chemical biology [ACS Chem Biol] 2018 Aug 17; Vol. 13 (8), pp. 2247-2260. Date of Electronic Publication: 2018 Jun 21.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Autophagy/*drug effects , Beclin-1/*metabolism , Drug Evaluation, Preclinical/*methods , High-Throughput Screening Assays/*methods , Protein Binding/*drug effects , Proto-Oncogene Proteins c-bcl-2/*metabolism, Cell Survival/drug effects ; HeLa Cells ; Humans ; Protein Interaction Maps/drug effects

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دورية أكاديمية

Genetic and transcriptional evolution alters cancer cell line drug response.

المؤلفون: Ben-David U; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Siranosian B; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Ha G; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA., Tang H; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Oren Y; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Harvard Medical School, Boston, MA, USA., Hinohara K; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA., Strathdee CA; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Dempster J; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Lyons NJ; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Burns R; Dana-Farber Cancer Institute, Boston, MA, USA., Nag A; Dana-Farber Cancer Institute, Boston, MA, USA., Kugener G; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Cimini B; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Tsvetkov P; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Maruvka YE; Broad Institute of Harvard and MIT, Cambridge, MA, USA., O'Rourke R; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA., Garrity A; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Tubelli AA; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Bandopadhayay P; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Tsherniak A; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Vazquez F; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Wong B; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Birger C; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Ghandi M; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Thorner AR; Dana-Farber Cancer Institute, Boston, MA, USA., Bittker JA; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Meyerson M; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Getz G; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Massachusetts General Hospital, Boston, MA, USA., Beroukhim R; Broad Institute of Harvard and MIT, Cambridge, MA, USA. rameen_beroukhim@dfci.harvard.edu.; Dana-Farber Cancer Institute, Boston, MA, USA. rameen_beroukhim@dfci.harvard.edu.; Harvard Medical School, Boston, MA, USA. rameen_beroukhim@dfci.harvard.edu.; Brigham and Women's Hospital, Boston, MA, USA. rameen_beroukhim@dfci.harvard.edu., Golub TR; Broad Institute of Harvard and MIT, Cambridge, MA, USA. golub@broadinstitute.org.; Dana-Farber Cancer Institute, Boston, MA, USA. golub@broadinstitute.org.; Harvard Medical School, Boston, MA, USA. golub@broadinstitute.org.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. golub@broadinstitute.org.

المصدر: Nature [Nature] 2018 Aug; Vol. 560 (7718), pp. 325-330. Date of Electronic Publication: 2018 Aug 08.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

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