المؤلفون: Schmid T; Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590, Frankfurt, Germany., Blees JS; Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590, Frankfurt, Germany., Bajer MM; Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590, Frankfurt, Germany., Wild J; Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590, Frankfurt, Germany., Pescatori L; Dipartimento di Chimica e Tecnologie del Farmaco, Istituto Pasteur - Fondazione Cenci Bolognetti, 'Sapienza' University of Rome, 00185, Rome, Italy., Cuzzucoli Crucitti G; Dipartimento di Chimica e Tecnologie del Farmaco, Istituto Pasteur - Fondazione Cenci Bolognetti, 'Sapienza' University of Rome, 00185, Rome, Italy., Scipione L; Dipartimento di Chimica e Tecnologie del Farmaco, Istituto Pasteur - Fondazione Cenci Bolognetti, 'Sapienza' University of Rome, 00185, Rome, Italy., Costi R; Dipartimento di Chimica e Tecnologie del Farmaco, Istituto Pasteur - Fondazione Cenci Bolognetti, 'Sapienza' University of Rome, 00185, Rome, Italy., Henrich CJ; Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD, 21702, United States of America.; Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, United States of America., Brüne B; Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590, Frankfurt, Germany., Colburn NH; Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD, 21702, United States of America., Di Santo R; Dipartimento di Chimica e Tecnologie del Farmaco, Istituto Pasteur - Fondazione Cenci Bolognetti, 'Sapienza' University of Rome, 00185, Rome, Italy.

المصدر: PloS one [PLoS One] 2016 Mar 16; Vol. 11 (3), pp. e0151643. Date of Electronic Publication: 2016 Mar 16 (Print Publication: 2016).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Apoptosis Regulatory Proteins/*drug effects , RNA-Binding Proteins/*drug effects , Sulfides/*pharmacology , Tumor Suppressor Proteins/*drug effects, Apoptosis Regulatory Proteins/metabolism ; Cell Cycle ; Cell Proliferation ; HEK293 Cells ; Humans ; RNA-Binding Proteins/metabolism ; Structure-Activity Relationship ; Sulfides/chemistry ; Tumor Suppressor Proteins/metabolism

المؤلفون: Grkovic T; Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA. t.grkovic@griffith.edu.au., Blees JS; Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA. M_Bajer@gmx.de., Bayer MM; Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany. M_Bajer@gmx.de., Colburn NH; Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA. colburna@mail.nih.gov., Thomas CL; Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA. cltterry@mail.nih.gov., Henrich CJ; Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA. henrichcj@mail.nih.gov., Peach ML; Basic Science Program, Leidos Biomedical Research, Inc., Chemical Biology Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA. mpeach@helix.nih.gov., McMahon JB; Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA. mcmahoja@mail.nih.gov., Schmid T; Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany. M_Bajer@gmx.de., Gustafson KR; Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, MD 21702, USA. gustafki@mail.nih.gov.

المصدر: Marine drugs [Mar Drugs] 2014 Aug 21; Vol. 12 (8), pp. 4593-601. Date of Electronic Publication: 2014 Aug 21.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101213729 Publication Model: Electronic Cited Medium: Internet ISSN: 1660-3397 (Electronic) Linking ISSN: 16603397 NLM ISO Abbreviation: Mar Drugs Subsets: MEDLINE

مواضيع طبية MeSH: Alkaloids/*chemistry , Alkaloids/*pharmacology , Apoptosis Regulatory Proteins/*metabolism , Guanidine/*chemistry , Guanidine/*pharmacology , Porifera/*chemistry , RNA-Binding Proteins/*metabolism , Tumor Suppressor Proteins/*metabolism, Animals ; HEK293 Cells ; Humans ; Oleanolic Acid/analogs & derivatives ; Oleanolic Acid/chemistry ; Saponins/chemistry

المؤلفون: Bajer MM; Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany., Kunze MM; Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany., Blees JS; Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany., Bokesch HR; Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD 21702, USA; Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA., Chen H; The Hormel Institute, University of Minnesota, Austin, MN 55912, USA., Brauss TF; Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany., Dong Z; The Hormel Institute, University of Minnesota, Austin, MN 55912, USA., Gustafson KR; Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD 21702, USA., Biondi RM; Research Group PhosphoSites, Department of Internal Medicine I, University Clinic, 60590 Frankfurt, Germany., Henrich CJ; Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD 21702, USA; Basic Science Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA., McMahon JB; Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD 21702, USA., Colburn NH; Laboratory of Cancer Prevention, Center for Cancer Research, National Cancer Institute-Frederick, Frederick, MD 21702, USA., Schmid T; Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany. Electronic address: t.schmid@biochem.uni-frankfurt.de., Brüne B; Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, 60590 Frankfurt, Germany.

المصدر: Biochemical pharmacology [Biochem Pharmacol] 2014 Apr 01; Vol. 88 (3), pp. 313-21. Date of Electronic Publication: 2014 Feb 07.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Isoflavones/*pharmacology , Protein Biosynthesis/*drug effects , TOR Serine-Threonine Kinases/*antagonists & inhibitors, Apoptosis Regulatory Proteins/metabolism ; HEK293 Cells ; Humans ; MCF-7 Cells ; Mechanistic Target of Rapamycin Complex 1 ; Mechanistic Target of Rapamycin Complex 2 ; Molecular Docking Simulation ; Multiprotein Complexes/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; RNA-Binding Proteins/metabolism ; Ribosomal Protein S6 Kinases, 70-kDa/metabolism ; TOR Serine-Threonine Kinases/metabolism

المؤلفون: Rübsamen D; Institute of Biochemistry I, Goethe-University Frankfurt, 60590 Frankfurt, Germany., Blees JS, Schulz K, Döring C, Hansmann ML, Heide H, Weigert A, Schmid T, Brüne B

المصدر: RNA (New York, N.Y.) [RNA] 2012 Oct; Vol. 18 (10), pp. 1910-20. Date of Electronic Publication: 2012 Aug 22.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9509184 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-9001 (Electronic) Linking ISSN: 13558382 NLM ISO Abbreviation: RNA Subsets: MEDLINE

مواضيع طبية MeSH: Protein Biosynthesis*/drug effects , Protein Biosynthesis*/physiology, Early Growth Response Protein 2/*metabolism , Inflammation/*metabolism , Regulatory Sequences, Ribonucleic Acid/*physiology , Ribosomes/*metabolism, Base Sequence ; Binding Sites/drug effects ; Binding Sites/genetics ; Cells, Cultured ; Early Growth Response Protein 2/genetics ; Humans ; Inflammation/genetics ; Interleukin-1beta/pharmacology ; Models, Biological ; Molecular Sequence Data ; Nucleic Acid Conformation ; U937 Cells ; Up-Regulation/drug effects

المؤلفون: Blees JS; Institute of Biochemistry I, Faculty of Medicine, Goethe-University Frankfurt, Frankfurt, Germany., Bokesch HR, Rübsamen D, Schulz K, Milke L, Bajer MM, Gustafson KR, Henrich CJ, McMahon JB, Colburn NH, Schmid T, Brüne B

المصدر: PloS one [PLoS One] 2012; Vol. 7 (10), pp. e46567. Date of Electronic Publication: 2012 Oct 02.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Apoptosis Regulatory Proteins/*metabolism , RNA-Binding Proteins/*metabolism , Sesquiterpenes/*pharmacology , Ubiquitin-Protein Ligases/*metabolism , beta-Transducin Repeat-Containing Proteins/*metabolism, Blotting, Western ; Cell Line ; Humans ; Immunoprecipitation ; Magnetic Resonance Spectroscopy ; Protein Binding

المؤلفون: Schmid T; Institute of Biochemistry I, Goethe-University Frankfurt, Frankfurt, Germany. t.schmid@biochem.uni-frankfurt.de, Bajer MM, Blees JS, Eifler LK, Milke L, Rübsamen D, Schulz K, Weigert A, Baker AR, Colburn NH, Brüne B

المصدر: Carcinogenesis [Carcinogenesis] 2011 Oct; Vol. 32 (10), pp. 1427-33. Date of Electronic Publication: 2011 Jul 18.

نوع المنشور: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Irl Press At Oxford University Press Country of Publication: England NLM ID: 8008055 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2180 (Electronic) Linking ISSN: 01433334 NLM ISO Abbreviation: Carcinogenesis Subsets: MEDLINE

مواضيع طبية MeSH: Genes, Tumor Suppressor*, Apoptosis Regulatory Proteins/*metabolism , Breast Neoplasms/*metabolism , Breast Neoplasms/*pathology , Inflammation/*etiology , Proteasome Endopeptidase Complex/*metabolism , RNA-Binding Proteins/*metabolism, Animals ; Apoptosis Regulatory Proteins/genetics ; Blotting, Western ; Breast Neoplasms/genetics ; Carcinogens/pharmacology ; Cell Differentiation/drug effects ; Culture Media, Conditioned/pharmacology ; Female ; Humans ; Inflammation/metabolism ; Inflammation/pathology ; Interleukin-6/metabolism ; Interleukin-8/metabolism ; Macrophages/cytology ; Macrophages/drug effects ; Macrophages/metabolism ; Mice ; Mice, Inbred C57BL ; Monocytes/cytology ; Monocytes/drug effects ; Monocytes/metabolism ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphorylation ; RNA, Messenger/genetics ; RNA, Small Interfering/genetics ; RNA-Binding Proteins/genetics ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction ; TOR Serine-Threonine Kinases/genetics ; TOR Serine-Threonine Kinases/metabolism ; Tetradecanoylphorbol Acetate/pharmacology ; Tumor Microenvironment ; Tumor Necrosis Factor-alpha/metabolism ; U937 Cells

المؤلفون: Zhao LX; Yunnan Institute of Microbiology, Yunnan University, Kunming, Yunnan 650091, People's Republic of China., Huang SX, Tang SK, Jiang CL, Duan Y, Beutler JA, Henrich CJ, McMahon JB, Schmid T, Blees JS, Colburn NH, Rajski SR, Shen B

المصدر: Journal of natural products [J Nat Prod] 2011 Sep 23; Vol. 74 (9), pp. 1990-5. Date of Electronic Publication: 2011 Aug 26.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6025 (Electronic) Linking ISSN: 01633864 NLM ISO Abbreviation: J Nat Prod Subsets: MEDLINE

مواضيع طبية MeSH: Actinobacteria/*isolation & purification , Antineoplastic Agents/*pharmacology , Biological Products/*pharmacology , Ketones/*pharmacology, Antineoplastic Agents/chemistry ; Antineoplastic Agents/isolation & purification ; Apoptosis Regulatory Proteins/drug effects ; Biological Products/chemistry ; Biological Products/isolation & purification ; Drug Screening Assays, Antitumor ; Humans ; Ketones/chemistry ; Ketones/isolation & purification ; Molecular Structure ; Polyketides ; RNA-Binding Proteins/drug effects ; Tubercidin/chemistry ; Tubercidin/isolation & purification ; Tubercidin/pharmacology

المؤلفون: Grkovic T; Molecular Targets Laboratory, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, United States., Blees JS, Colburn NH, Schmid T, Thomas CL, Henrich CJ, McMahon JB, Gustafson KR

المصدر: Journal of natural products [J Nat Prod] 2011 May 27; Vol. 74 (5), pp. 1015-20. Date of Electronic Publication: 2011 May 03.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural

بيانات الدورية: Publisher: American Society of Pharmacognosy Country of Publication: United States NLM ID: 7906882 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6025 (Electronic) Linking ISSN: 01633864 NLM ISO Abbreviation: J Nat Prod Subsets: MEDLINE

مواضيع طبية MeSH: Apoptosis Regulatory Proteins/*drug effects , Cryptocarya/*chemistry , Polymers/*chemistry , Pyrones/*isolation & purification , Pyrones/*pharmacology , RNA-Binding Proteins/*drug effects, Apoptosis Regulatory Proteins/metabolism ; Genes, Tumor Suppressor ; Molecular Structure ; National Cancer Institute (U.S.) ; Nuclear Magnetic Resonance, Biomolecular ; Papua New Guinea ; Pyrones/chemistry ; RNA-Binding Proteins/metabolism ; United States

المؤلفون: Blees JS; Institute of Biochemistry I, Goethe-University Frankfurt am Main, Frankfurt, Germany., Schmid T, Thomas CL, Baker AR, Benson L, Evans JR, Goncharova EI, Colburn NH, McMahon JB, Henrich CJ

المصدر: Journal of biomolecular screening [J Biomol Screen] 2010 Jan; Vol. 15 (1), pp. 21-9. Date of Electronic Publication: 2009 Nov 09.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural

بيانات الدورية: Publisher: Sage Publications Country of Publication: United States NLM ID: 9612112 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-454X (Electronic) Linking ISSN: 10870571 NLM ISO Abbreviation: J Biomol Screen Subsets: MEDLINE

مواضيع طبية MeSH: Genes, Reporter*, Apoptosis Regulatory Proteins/*metabolism , High-Throughput Screening Assays/*methods , RNA-Binding Proteins/*metabolism , Tumor Suppressor Proteins/*metabolism, Apoptosis Regulatory Proteins/antagonists & inhibitors ; Apoptosis Regulatory Proteins/chemistry ; Biological Products/pharmacology ; Cell Line ; Humans ; Protein Stability/drug effects ; RNA-Binding Proteins/antagonists & inhibitors ; RNA-Binding Proteins/chemistry ; Reproducibility of Results ; Small Molecule Libraries/pharmacology ; Tumor Suppressor Proteins/antagonists & inhibitors ; Tumor Suppressor Proteins/chemistry