المؤلفون: Givi, ME, Blokhuis, BR, Da Silva, CA, Adcock, I, Garssen, J, Folkerts, G, Redegeld, FA, Mortaz, E

مصطلحات موضوعية: TOLL-LIKE RECEPTORS, Male, Science & Technology, AIRWAY INFLAMMATION, Receptors, IgE, Smoking, Immunology, DEGRANULATION, ALLERGIC SENSITIZATION, CELL BIOLOGY, Flow Cytometry, OBSTRUCTIVE PULMONARY-DISEASE, DENDRITIC CELLS, Proto-Oncogene Proteins c-kit, Mice, 1107 Immunology, BASOPHILS, Smoke, Animals, Mast Cells, LIGAND, Life Sciences & Biomedicine, Cells, Cultured, RESPONSES

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od______1032::1029ae8692010d4327a389dbcdff22b9
http://hdl.handle.net/10044/1/31721

المؤلفون: Braber S, Thio M, Blokhuis BR, Henricks PA, Koelink PJ, Groot Kormelink T, Bezemer GF, Kerstjens HA, Postma DS, Garssen J, Kraneveld AD, Redegeld FA, Folkerts G

المصدر: American Journal of Respiratory & Critical Care Medicine; 4/15/2012, Vol. 185 Issue 8, p817-824, 8p

المؤلفون: Castenmiller C; Department of Experimental Immunology, Amsterdam University Medical Centers, Amsterdam Institute for Infection & Immunity, University of Amsterdam, Amsterdam, The Netherlands., Stigler M; Department of Biosciences and Medical Biology, Paris Lodron University of Salzburg, Salzburg, Austria., Kirpas ME; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, Mass; Harvard Medical School and Massachusetts General Hospital, Boston, Mass; Food Allergy Center, Massachusetts General Hospital, Boston, Mass, USA., Versteeg S; Department of Experimental Immunology, Amsterdam University Medical Centers, Amsterdam Institute for Infection & Immunity, University of Amsterdam, Amsterdam, The Netherlands., Akkerdaas JH; Department of Experimental Immunology, Amsterdam University Medical Centers, Amsterdam Institute for Infection & Immunity, University of Amsterdam, Amsterdam, The Netherlands., Pena-Castellanos G; Department of Biosciences and Medical Biology, Paris Lodron University of Salzburg, Salzburg, Austria., Blokhuis BR; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands., Dreskin SC; Division of Allergy and Clinical Immunology, Department of Medicine, University of Colorado, Aurora, Colorado, USA., Auger L; Angany Inc., Québec, Québec, Canada., Desgagnés R; Angany Inc., Québec, Québec, Canada., Martel C; Angany Inc., Québec, Québec, Canada., Mirande L; Angany Innovation, Val-de-Reuil, France., Morel B; Angany Innovation, Val-de-Reuil, France., Roberge J; Angany Inc., Québec, Québec, Canada., Stordeur V; Angany Innovation, Val-de-Reuil, France., Tropper G; Angany Inc., Québec, Québec, Canada., Vézina LP; Angany Inc., Québec, Québec, Canada., Gomord V; Angany Innovation, Val-de-Reuil, France., de Jong EC; Department of Experimental Immunology, Amsterdam University Medical Centers, Amsterdam Institute for Infection & Immunity, University of Amsterdam, Amsterdam, The Netherlands., Redegeld F; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands., Shreffler WG; Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Boston, Mass; Harvard Medical School and Massachusetts General Hospital, Boston, Mass; Food Allergy Center, Massachusetts General Hospital, Boston, Mass, USA., Aglas L; Department of Biosciences and Medical Biology, Paris Lodron University of Salzburg, Salzburg, Austria., van Ree R; Department of Experimental Immunology, Amsterdam University Medical Centers, Amsterdam Institute for Infection & Immunity, University of Amsterdam, Amsterdam, The Netherlands.; Department of Otorhinolaryngology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands.

المصدر: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology [Clin Exp Allergy] 2023 May; Vol. 53 (5), pp. 577-581. Date of Electronic Publication: 2023 Feb 13.

نوع المنشور: Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 8906443 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2222 (Electronic) Linking ISSN: 09547894 NLM ISO Abbreviation: Clin Exp Allergy Subsets: MEDLINE

مواضيع طبية MeSH: Allergens* , Peanut Hypersensitivity*, Humans ; Plant Proteins ; Antigens, Plant ; Arachis ; 2S Albumins, Plant

المؤلفون: Regner A; Comparative Medicine, The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University of Vienna, 1210 Vienna, Austria., Szepannek N; Comparative Medicine, The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University of Vienna, 1210 Vienna, Austria., Wiederstein M; Department of Biosciences, University of Salzburg, 5020 Salzburg, Austria., Fakhimahmadi A; Comparative Medicine, The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University of Vienna, 1210 Vienna, Austria.; Center of Pathophysiology, Infectiology and Immunology, Institute of Pathophysiology and Allergy Research, Medical University of Vienna, 1090 Vienna, Austria., Paciosis LF; Center for Plant Biotechnology and Genomics, Biotechnology Department, ETSIAAB, CBGP (UPM-INIA), Universidad Politécnica de Madrid, 28040 Madrid, Spain., Blokhuis BR; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CG Utrecht, The Netherlands., Redegeld FA; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584 CG Utrecht, The Netherlands., Hofstetter G; Comparative Medicine, The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University of Vienna, 1210 Vienna, Austria., Dvorak Z; Department of Cell Biology and Genetics, Faculty of Science, Palacky University, 78371 Olomouc, Czech Republic., Jensen-Jarolim E; Comparative Medicine, The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University of Vienna, 1210 Vienna, Austria.; Center of Pathophysiology, Infectiology and Immunology, Institute of Pathophysiology and Allergy Research, Medical University of Vienna, 1090 Vienna, Austria., Hufnagl K; Comparative Medicine, The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University of Vienna, 1210 Vienna, Austria.; Center of Pathophysiology, Infectiology and Immunology, Institute of Pathophysiology and Allergy Research, Medical University of Vienna, 1090 Vienna, Austria., Roth-Walter F; Comparative Medicine, The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University of Vienna, 1210 Vienna, Austria.; Center of Pathophysiology, Infectiology and Immunology, Institute of Pathophysiology and Allergy Research, Medical University of Vienna, 1090 Vienna, Austria.

المصدر: Antioxidants (Basel, Switzerland) [Antioxidants (Basel)] 2022 Dec 26; Vol. 12 (1). Date of Electronic Publication: 2022 Dec 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101668981 Publication Model: Electronic Cited Medium: Print ISSN: 2076-3921 (Print) Linking ISSN: 20763921 NLM ISO Abbreviation: Antioxidants (Basel) Subsets: PubMed not MEDLINE

المؤلفون: Afify SM; Comparative Medicine, The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University of Vienna, Vienna, Austria.; Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.; Laboratory Medicine and Immunology Department, Faculty of Medicine, Menoufia University, Shibin El Kom, Egypt., Regner A; Comparative Medicine, The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University of Vienna, Vienna, Austria., Pacios LF; Biotechnology Department, ETSIAAB, Center for Plant Biotechnology and Genomics, CBGP (UPM-INIA), Technical University of Madrid, Madrid, Spain., Blokhuis BR; Division of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands., Jensen SA; Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria., Redegeld FA; Division of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands., Pali-Schöll I; Comparative Medicine, The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University of Vienna, Vienna, Austria.; Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria., Hufnagl K; Comparative Medicine, The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University of Vienna, Vienna, Austria., Bianchini R; Comparative Medicine, The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University of Vienna, Vienna, Austria., Guethoff S; Bencard Allergie GmbH, Munich, Germany.; Allergy Therapeutics, Worthing, UK., Kramer MF; Bencard Allergie GmbH, Munich, Germany.; Allergy Therapeutics, Worthing, UK., Fiocchi A; Childrens Hospital Bambino Gesù, Rome, Italy., Dvorak Z; Department of Cell Biology and Genetics, Faculty of Science, Palacky University, Olomouc, Czech Republic., Jensen-Jarolim E; Comparative Medicine, The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University of Vienna, Vienna, Austria.; Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.; Biomedical International R+D GmbH, Vienna, Austria., Roth-Walter F; Comparative Medicine, The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University of Vienna, Vienna, Austria.; Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.

المصدر: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology [Clin Exp Allergy] 2022 Mar; Vol. 52 (3), pp. 426-441. Date of Electronic Publication: 2021 Dec 03.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Blackwell Scientific Publications Country of Publication: England NLM ID: 8906443 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2222 (Electronic) Linking ISSN: 09547894 NLM ISO Abbreviation: Clin Exp Allergy Subsets: MEDLINE

مواضيع طبية MeSH: Milk Hypersensitivity*, Allergens ; Animals ; Dietary Supplements ; Farms ; Humans ; Lactoglobulins/chemistry ; Mice ; Mice, Inbred BALB C

المؤلفون: Roth-Walter F; The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University Vienna, Vienna, Austria; Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria. Electronic address: franziska.roth-walter@meduniwien.ac.at., Afify SM; The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University Vienna, Vienna, Austria; Laboratory Medicine and Immunology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt., Pacios LF; Biotechnology Department, ETSIAAB, Center for Plant Biotechnology and Genomics, CBGP (UPM-INIA), Technical University of Madrid, Madrid, Spain., Blokhuis BR; Faculty of Science, Division of Pharmacology, Department of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands., Redegeld F; Faculty of Science, Division of Pharmacology, Department of Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands., Regner A; The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University Vienna, Vienna, Austria., Petje LM; The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University Vienna, Vienna, Austria., Fiocchi A; Childrens Hospital Bambino Gesù, Rome, Italy., Untersmayr E; Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria., Dvorak Z; Department of Cell Biology and Genetics, Faculty of Science, Palacky University, Olomouc, Czech Republic., Hufnagl K; The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University Vienna, Vienna, Austria; Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria., Pali-Schöll I; The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University Vienna, Vienna, Austria; Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria., Jensen-Jarolim E; The Interuniversity Messerli Research Institute of the University of Veterinary Medicine Vienna, Medical University Vienna and University Vienna, Vienna, Austria; Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria. Electronic address: erika.jensen-jarolim@medunwien.ac.at.

المصدر: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2021 Jan; Vol. 147 (1), pp. 321-334.e4. Date of Electronic Publication: 2020 May 30.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Mosby Country of Publication: United States NLM ID: 1275002 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6825 (Electronic) Linking ISSN: 00916749 NLM ISO Abbreviation: J Allergy Clin Immunol Subsets: MEDLINE

مواضيع طبية MeSH: Iron*/chemistry , Iron*/pharmacokinetics , Iron*/pharmacology , Lactoglobulins*/chemistry , Lactoglobulins*/pharmacokinetics , Lactoglobulins*/pharmacology, Leukocytes, Mononuclear/*immunology , Mast Cells/*immunology , Milk/*chemistry , Milk Hypersensitivity/*immunology, Animals ; Cattle ; Humans ; Mice ; Mice, Inbred BALB C ; Milk Hypersensitivity/drug therapy

المؤلفون: Hufnagl K; The interuniversity Messerli Research Institute of the University of Veterinary Medicine, Medical University of Vienna and University of Vienna, Vienna, Austria., Afify SM; The interuniversity Messerli Research Institute of the University of Veterinary Medicine, Medical University of Vienna and University of Vienna, Vienna, Austria.; Laboratory Medicine and Immunology Department, Faculty of Medicine, Menoufia University, Shebin El-Kom, Egypt., Braun N; The interuniversity Messerli Research Institute of the University of Veterinary Medicine, Medical University of Vienna and University of Vienna, Vienna, Austria., Wagner S; The interuniversity Messerli Research Institute of the University of Veterinary Medicine, Medical University of Vienna and University of Vienna, Vienna, Austria., Wallner M; Department of Biosciences, University of Salzburg, Salzburg, Austria., Hauser M; Department of Biosciences, University of Salzburg, Salzburg, Austria., Wiederstein M; Protein Bioinformatics Research Group, Department of Biosciences, University of Salzburg, Salzburg, Austria., Gadermaier G; Department of Biosciences, University of Salzburg, Salzburg, Austria., Wildner S; Department of Biosciences, University of Salzburg, Salzburg, Austria., Redegeld FA; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands., Blokhuis BR; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands., Hofstetter G; The interuniversity Messerli Research Institute of the University of Veterinary Medicine, Medical University of Vienna and University of Vienna, Vienna, Austria., Pali-Schöll I; The interuniversity Messerli Research Institute of the University of Veterinary Medicine, Medical University of Vienna and University of Vienna, Vienna, Austria., Roth-Walter F; The interuniversity Messerli Research Institute of the University of Veterinary Medicine, Medical University of Vienna and University of Vienna, Vienna, Austria., Pacios LF; Centre for Plant Biotechnology and Genomics, CBGP (UPM-INIA) and Department of Biotechnology-Plant Biology, Universidad Politécnica de Madrid, Madrid, Spain., Jensen-Jarolim E; The interuniversity Messerli Research Institute of the University of Veterinary Medicine, Medical University of Vienna and University of Vienna, Vienna, Austria.; Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University Vienna, Vienna, Austria.; Biomedical International R+D GmbH, Vienna, Austria.

المصدر: Allergy [Allergy] 2020 Aug; Vol. 75 (8), pp. 2073-2077. Date of Electronic Publication: 2020 Apr 16.

نوع المنشور: Letter; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: Denmark NLM ID: 7804028 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1398-9995 (Electronic) Linking ISSN: 01054538 NLM ISO Abbreviation: Allergy Subsets: MEDLINE

مواضيع طبية MeSH: Allergens* , Betula*, Animals ; Antigens, Plant ; Computer Simulation ; Desensitization, Immunologic ; Mice ; Mice, Inbred BALB C ; Plant Proteins ; Pollen ; Tretinoin

المؤلفون: Yu Y; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584CG Utrecht, The Netherlands. y.yu@uu.nl., Blokhuis BR; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584CG Utrecht, The Netherlands. b.r.j.blokhuis@uu.nl., Garssen J; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584CG Utrecht, The Netherlands. j.garssen@uu.nl.; Nutricia Research, 3584CT Utrecht, The Netherlands. j.garssen@uu.nl., Redegeld FA; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, 3584CG Utrecht, The Netherlands. F.A.M.Redegeld@uu.nl.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2019 Apr 04; Vol. 20 (7). Date of Electronic Publication: 2019 Apr 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci

مواضيع طبية MeSH: Colonic Neoplasms/*metabolism , Mast Cells/*metabolism , Transcriptome/*genetics, Cells, Cultured ; Colonic Neoplasms/genetics ; Cytokines/metabolism ; HT29 Cells ; Humans ; Matrix Metalloproteinase 2/metabolism ; Platelet-Derived Growth Factor/metabolism ; Receptor, Notch1/metabolism ; Ubiquitins/metabolism ; Vascular Endothelial Growth Factor A/metabolism

المؤلفون: Yu Y; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, the Netherlands., Blokhuis BR; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, the Netherlands., Garssen J; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, the Netherlands., Redegeld FA; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, the Netherlands. Electronic address: f.a.m.redegeld@uu.nl.

المصدر: European journal of pharmacology [Eur J Pharmacol] 2016 May 05; Vol. 778, pp. 33-43. Date of Electronic Publication: 2015 Jul 08.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Mast Cells/*cytology, Animals ; Humans ; Mast Cells/drug effects ; Mast Cells/immunology ; Mast Cells/metabolism

المؤلفون: Groot Kormelink T; Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands., Powe DG, Kuijpers SA, Abudukelimu A, Fens MH, Pieters EH, Kassing van der Ven WW, Habashy HO, Ellis IO, Blokhuis BR, Thio M, Hennink WE, Storm G, Redegeld FA, Schiffelers RM; Laboratory of Clinical Chemistry and Hematology, University Medical Center Utrecht, Utrecht, The Netherlands.

المصدر: Oncotarget [Oncotarget] 2014 May 30; Vol. 5 (10), pp. 3159-67.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Impact Journals Country of Publication: United States NLM ID: 101532965 Publication Model: Print Cited Medium: Internet ISSN: 1949-2553 (Electronic) Linking ISSN: 19492553 NLM ISO Abbreviation: Oncotarget Subsets: MEDLINE

مواضيع طبية MeSH: Biomarkers, Tumor/*immunology , Breast Neoplasms/*immunology , Immunoglobulin Light Chains/*immunology , Inflammation/*pathology , Mast Cells/*immunology, Adult ; Aged ; Animals ; Breast Neoplasms/pathology ; Cell Degranulation/immunology ; Disease Models, Animal ; Female ; Humans ; Immunoglobulin Light Chains/analysis ; Immunohistochemistry ; Kaplan-Meier Estimate ; Melanoma/immunology ; Melanoma/pathology ; Mice ; Mice, Inbred C57BL ; Middle Aged ; Neoplasms, Experimental ; Prognosis ; Proportional Hazards Models ; Tissue Array Analysis