نتائج البحث - "Bloom syndrome protein"

1

Searching for the Roots of Bloom Syndrome Protein and Its Homologs Using Phylogenetic Analysis

المصدر: Volume: 4, Issue: 2 146-159
Kocaeli Journal of Science and Engineering

مصطلحات موضوعية: Cultural Studies, Genetics, Linguistics and Language, History, Phylogenetic tree, Bloom syndrome protein, Anthropology, Homologous chromosome, Biology, Biyoloji, Language and Linguistics, BLM RecQ Like Helicase (BLM),Maximum Parsimony,Phylogeny,Phylogenetic Tree

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b141caa39dfdd8c8b2ac43c7d4bda12
https://doi.org/10.34088/kojose.904914

2

Bloom Syndrome Helicase Compresses Single‐Stranded DNA into Phase‐Separated Condensates

المؤلفون: Teng Wang, Jiaojiao Hu, Yanan Li, Lulu Bi, Lijuan Guo, Xinshuo Jia, Xia Zhang, Dan Li, Xi‐Miao Hou, Mauro Modesti, Xu‐Guang Xi, Cong Liu, Bo Sun

المساهمون: ShanghaiTech University [Shanghai], Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences [Beijing] (CAS), Shanghai Jiao Tong University [Shanghai], Northwest A and F University, Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de biologie et pharmacologie appliquée (LBPA), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Ecole Normale Supérieure Paris-Saclay (ENS Paris Saclay), Modesti, Mauro, Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)

المصدر: Angewandte Chemie International Edition
Angewandte Chemie International Edition, 2022, 61 (39), pp.e202209463. ⟨10.1002/anie.202209463⟩
Angewandte Chemie International Edition, 2022, 61 (39), ⟨10.1002/anie.202209463⟩

مصطلحات موضوعية: DNA Repair, RecQ Helicases, Single-Molecule Studies, [SDV]Life Sciences [q-bio], Biomolecular Condensate, DNA, Single-Stranded, DNA, General Chemistry, General Medicine, Genomic Instability, Catalysis, Bloom Syndrome Protein, Helicase, [SDV] Life Sciences [q-bio], Phase Separation, Adenosine Triphosphate, Replication Protein A, Humans, Bloom Syndrome

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::903196986ce1edd99bd407a47a506e30
https://doi.org/10.1002/ange.202209463

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3

دورية أكاديمية

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4

Design, Synthesis, and Evaluation of New Quinazolinone Derivatives that Inhibit Bloom Syndrome Protein (BLM) Helicase, Trigger DNA Damage at the Telomere Region, and Synergize with PARP Inhibitors

المؤلفون: Shi-Liang Huang, Qi-Kun Yin, Jia-En Wang, Honggen Wang, Ding Li, Chen-Xi Wang, Jia-Heng Tan, Zhi-Shu Huang, Yao-Hao Xu, Yong Rao, Zi-Lin Zhang, Shuo-Bin Chen, Tian-Miao Ou, Jia-Li Tu, Qingjiang Li

المصدر: Journal of Medicinal Chemistry. 63:9752-9772

مصطلحات موضوعية: Models, Molecular, congenital, hereditary, and neonatal diseases and abnormalities, Protein Conformation, DNA damage, Poly ADP ribose polymerase, Apoptosis, Chemistry Techniques, Synthetic, Poly(ADP-ribose) Polymerase Inhibitors, 01 natural sciences, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, Humans, Polymerase, Cell Proliferation, Quinazolinones, 030304 developmental biology, 0303 health sciences, RecQ Helicases, biology, urogenital system, Chemistry, nutritional and metabolic diseases, Helicase, Drug Synergism, Telomere, HCT116 Cells, 0104 chemical sciences, Cell biology, 010404 medicinal & biomolecular chemistry, Bloom syndrome protein, Drug Design, Cancer cell, biology.protein, Molecular Medicine, DNA, DNA Damage

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f21267762456ab0e27c8001c4c005bf
https://doi.org/10.1021/acs.jmedchem.0c00917

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5

Vpu modulates DNA repair to suppress innate sensing and hyper-integration of HIV-1

المؤلفون: Lennart Koepke, Daniel Sauter, Konstantin M. J. Sparrer, Meta Volcic, Lisa Wiesmüller, Frank Kirchhoff, Christina M. Stürzel, Nathalie J. Arhel, Thomas G. Hofmann, Thomas Stamminger, Myriam Scherer, Dominik Hotter

المساهمون: University of Ulm (UUlm), German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), University of Mainz, Johannes Gutenberg - Universität Mainz (JGU), Institut de Recherche en Infectiologie de Montpellier (IRIM), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Université de Montpellier (UM), Centre National de la Recherche Scientifique (CNRS)

المصدر: Nature Microbiology
Nature Microbiology, Nature Publishing Group, 2020, 5 (10), pp.1247-1261. ⟨10.1038/s41564-020-0753-6⟩

مصطلحات موضوعية: Gene Expression Regulation, Viral, Microbiology (medical), DNA Repair, DNA repair, Virus Integration, viruses, Human Immunodeficiency Virus Proteins, Immunology, SUMO protein, HIV Infections, Biology, Models, Biological, [SDV.IMM.II]Life Sciences [q-bio]/Immunology/Innate immunity, Applied Microbiology and Biotechnology, Microbiology, 03 medical and health sciences, Immune system, Complementary DNA, Genetics, Humans, Viral Regulatory and Accessory Proteins, Nuclear pore, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, 0303 health sciences, 030306 microbiology, Recombinational DNA Repair, Sumoylation, Cell Biology, biochemical phenomena, metabolism, and nutrition, Immunity, Innate, Long terminal repeat, Rad52 DNA Repair and Recombination Protein, 3. Good health, Cell biology, Bloom syndrome protein, Host-Pathogen Interactions, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, HIV-1

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51c0d3a38f62853c25d3704c8119231b
https://doi.org/10.1038/s41564-020-0753-6

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6

Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein

المؤلفون: Gareth Williams, Sarah R. Walker, Simon E. Ward, Charlotte E L Fisher, Yusuf I Ali, Laurence H. Pearl, Xiangrong Chen, Jessica Hudson, S. Mark Roe, Jessica R Booth, Antony W. Oliver, Mohan B. Rajasekaran, Frances M. G. Pearl, Raquel Arribas-Bosacoma

المصدر: eLife, Vol 10 (2021)
Chen, X, Ali, Y I, Fisher, C E L, Arribas-Bosacoma, R, Rajasekaran, M B, Williams, G, Walker, S, Booth, J R, Hudson, J J R, Mark Roe, S, Pearl, L H, Ward, S E, Pearl, F M G & Oliver, A W 2021, ' Uncovering an allosteric mode of action for a selective inhibitor of human bloom syndrome protein ', eLIFE, vol. 10, e65339 . https://doi.org/10.7554/eLife.65339
eLife

مصطلحات موضوعية: 0301 basic medicine, Structural Biology and Molecular Biophysics, Synthetic lethality, allosteric, 0302 clinical medicine, Drug Discovery, Holliday junction, Bloom syndrome, Enzyme Inhibitors, Biology (General), 0303 health sciences, RecQ Helicases, biology, Chemistry, General Neuroscience, General Medicine, Branch migration, 3. Good health, Cell biology, inhibitor, Bloom syndrome protein, 030220 oncology & carcinogenesis, Medicine, Research Article, Human, congenital, hereditary, and neonatal diseases and abnormalities, DNA repair, DNA damage, QH301-705.5, Science, Allosteric regulation, DNA, Single-Stranded, General Biochemistry, Genetics and Molecular Biology, Helicase, Small Molecule Libraries, 03 medical and health sciences, RECQ, Biochemistry and Chemical Biology, medicine, Escherichia coli, Humans, 030304 developmental biology, DNA, Cruciform, General Immunology and Microbiology, urogenital system, E. coli, nutritional and metabolic diseases, DNA, medicine.disease, High-Throughput Screening Assays, DNA helicase activity, 030104 developmental biology, biology.protein