المؤلفون: Berkowitz RL; Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA., Bluhm AP; Spatial Epidemiology and Ecology Research Laboratory, Department of Geography, College of Liberal Arts and Sciences, University of Florida, Gainesville, FL 32611, USA.; Emerging Pathogens Institute, University of Florida, Gainesville, FL 32601, USA., Knox GW; Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA., McCurdy CR; Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.; Translational Drug Development Core, Clinical and Translational Sciences Institute, University of Florida, Gainesville, FL 32610, USA., Ostrov DA; Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA., Norris MH; Emerging Pathogens Institute, University of Florida, Gainesville, FL 32601, USA.; School of Life Sciences, University of Hawai'i at Mānoa, Honolulu, HI 96822, USA.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2023 Oct 29; Vol. 24 (21). Date of Electronic Publication: 2023 Oct 29.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: COVID-19* , Receptors, sigma*, Animals ; Mice ; SARS-CoV-2 ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Lactoferrin ; Ligands ; Diphenhydramine

SCR Organism: SARS-CoV-2 variants

المؤلفون: Norris MH; Spatial Epidemiology and Ecology Research Laboratory, Department of Geography, University of Florida, Gainesville, FL, USA. mhnorris@ufl.edu.; Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA. mhnorris@ufl.edu., Bluhm AP; Spatial Epidemiology and Ecology Research Laboratory, Department of Geography, University of Florida, Gainesville, FL, USA.; Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA., Metrailer MC; Spatial Epidemiology and Ecology Research Laboratory, Department of Geography, University of Florida, Gainesville, FL, USA.; Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA., Jiranantasak T; Spatial Epidemiology and Ecology Research Laboratory, Department of Geography, University of Florida, Gainesville, FL, USA.; Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA., Kirpich A; Department of Population Health Sciences, School of Public Health, Georgia State University, Atlanta, GA, USA., Hadfield T; Spatial Epidemiology and Ecology Research Laboratory, Department of Geography, University of Florida, Gainesville, FL, USA.; Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA., Ponciano JM; Department of Biology, University of Florida, Gainesville, FL, USA., Blackburn JK; Spatial Epidemiology and Ecology Research Laboratory, Department of Geography, University of Florida, Gainesville, FL, USA.; Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA.

المصدر: Scientific reports [Sci Rep] 2023 Mar 28; Vol. 13 (1), pp. 5060. Date of Electronic Publication: 2023 Mar 28.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

مواضيع طبية MeSH: Bacillus anthracis*/metabolism, Sugars/metabolism ; Spores, Bacterial/metabolism ; Spores/metabolism ; Bacterial Proteins/metabolism

المؤلفون: Ekakoro JE; Department of Public and Ecosystem Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA., Lubega A; School of Veterinary Medicine and Animal Resources, College of Veterinary Medicine, Animal Resources and Biosecurity, Makerere University, Kampala P.O. Box 7062, Uganda., Kayaga EB; School of Veterinary Medicine and Animal Resources, College of Veterinary Medicine, Animal Resources and Biosecurity, Makerere University, Kampala P.O. Box 7062, Uganda., Ndoboli D; School of Veterinary Medicine and Animal Resources, College of Veterinary Medicine, Animal Resources and Biosecurity, Makerere University, Kampala P.O. Box 7062, Uganda., Bluhm AP; Spatial Epidemiology and Ecology Research Laboratory, Department of Geography, College of Liberal Arts and Sciences, University of Florida, Gainesville, FL 32611, USA.; Emerging Pathogens Institute, University of Florida, Gainesville, FL 32601, USA., Wampande EM; School of Veterinary Medicine and Animal Resources, College of Veterinary Medicine, Animal Resources and Biosecurity, Makerere University, Kampala P.O. Box 7062, Uganda., Blackburn JK; Spatial Epidemiology and Ecology Research Laboratory, Department of Geography, College of Liberal Arts and Sciences, University of Florida, Gainesville, FL 32611, USA.; Emerging Pathogens Institute, University of Florida, Gainesville, FL 32601, USA., Havas KA; Department of Public and Ecosystem Health, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA., Norris MH; Spatial Epidemiology and Ecology Research Laboratory, Department of Geography, College of Liberal Arts and Sciences, University of Florida, Gainesville, FL 32611, USA.; Emerging Pathogens Institute, University of Florida, Gainesville, FL 32601, USA.

المصدر: Pathogens (Basel, Switzerland) [Pathogens] 2022 Nov 16; Vol. 11 (11). Date of Electronic Publication: 2022 Nov 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101596317 Publication Model: Electronic Cited Medium: Print ISSN: 2076-0817 (Print) Linking ISSN: 20760817 NLM ISO Abbreviation: Pathogens Subsets: PubMed not MEDLINE

المؤلفون: Jiranantasak T; Department of Geography, Spatial Epidemiology & Ecology Research Laboratory, University of Florida, Gainesville, Florida, United States of America.; Emerging Pathogens Institute, University of Florida, Gainesville, Florida, United States of America., Benn JS; Department of Geography, Spatial Epidemiology & Ecology Research Laboratory, University of Florida, Gainesville, Florida, United States of America.; Emerging Pathogens Institute, University of Florida, Gainesville, Florida, United States of America., Metrailer MC; Department of Geography, Spatial Epidemiology & Ecology Research Laboratory, University of Florida, Gainesville, Florida, United States of America.; Emerging Pathogens Institute, University of Florida, Gainesville, Florida, United States of America., Sawyer SJ; Department of Geography, Spatial Epidemiology & Ecology Research Laboratory, University of Florida, Gainesville, Florida, United States of America.; Emerging Pathogens Institute, University of Florida, Gainesville, Florida, United States of America., Burns MQ; Department of Geography, Spatial Epidemiology & Ecology Research Laboratory, University of Florida, Gainesville, Florida, United States of America.; Emerging Pathogens Institute, University of Florida, Gainesville, Florida, United States of America., Bluhm AP; Department of Geography, Spatial Epidemiology & Ecology Research Laboratory, University of Florida, Gainesville, Florida, United States of America.; Emerging Pathogens Institute, University of Florida, Gainesville, Florida, United States of America., Blackburn JK; Department of Geography, Spatial Epidemiology & Ecology Research Laboratory, University of Florida, Gainesville, Florida, United States of America.; Emerging Pathogens Institute, University of Florida, Gainesville, Florida, United States of America., Norris MH; Department of Geography, Spatial Epidemiology & Ecology Research Laboratory, University of Florida, Gainesville, Florida, United States of America.; Emerging Pathogens Institute, University of Florida, Gainesville, Florida, United States of America.

المصدر: PloS one [PLoS One] 2022 Sep 21; Vol. 17 (9), pp. e0274645. Date of Electronic Publication: 2022 Sep 21 (Print Publication: 2022).

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Anthrax*/epidemiology , Anthrax*/microbiology , Anthrax*/veterinary , Bacillus anthracis* , Diptera*/microbiology, Animals ; Animals, Wild ; Disease Outbreaks ; Heroin ; Humans ; Soil ; Spores, Bacterial

المؤلفون: Grodzki M; Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, FL, USA., Bluhm AP; Department of Geography, College of Liberal Arts and Sciences, University of Florida, Gainesville, FL, USA.; Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA., Schaefer M; Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA., Tagmount A; Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA., Russo M; Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.; Present address: Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA., Sobh A; Univeristy of Florida Heath Cancer Center, University of Florida, Gainesville, FL, USA., Rafiee R; Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, Gainesville, FL, USA., Vulpe CD; Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA., Karst SM; Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, FL, USA. skarst@ufl.edu., Norris MH; Department of Geography, College of Liberal Arts and Sciences, University of Florida, Gainesville, FL, USA. mhnorris@ufl.edu.; Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA. mhnorris@ufl.edu.

المصدر: Genome medicine [Genome Med] 2022 Jan 27; Vol. 14 (1), pp. 10. Date of Electronic Publication: 2022 Jan 27.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101475844 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-994X (Electronic) Linking ISSN: 1756994X NLM ISO Abbreviation: Genome Med Subsets: MEDLINE

مواضيع طبية MeSH: Genome, Viral*, Clustered Regularly Interspaced Short Palindromic Repeats/*genetics , Host-Pathogen Interactions/*genetics , SARS-CoV-2/*genetics, Animals ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; COVID-19/pathology ; COVID-19/virology ; Chlorocebus aethiops ; Exoribonucleases/antagonists & inhibitors ; Exoribonucleases/genetics ; Exoribonucleases/metabolism ; Gene Editing/methods ; HEK293 Cells ; Host-Pathogen Interactions/drug effects ; Humans ; Microtubule-Associated Proteins/antagonists & inhibitors ; Microtubule-Associated Proteins/genetics ; Microtubule-Associated Proteins/metabolism ; Proteins/antagonists & inhibitors ; Proteins/genetics ; Proteins/metabolism ; RNA Interference ; RNA, Guide, CRISPR-Cas Systems/metabolism ; RNA, Small Interfering/metabolism ; SARS-CoV-2/drug effects ; SARS-CoV-2/physiology ; Vero Cells ; Virus Replication/genetics ; COVID-19 Drug Treatment

المؤلفون: Ostrov DA; Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA., Bluhm AP; Department of Geography, University of Florida College of Liberal Arts and Sciences, Gainesville, FL 32611, USA.; Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610, USA., Li D; Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL 32610, USA., Khan JQ; Department of Biochemistry, Microbiology, and Immunology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Rohamare M; Department of Biochemistry, Microbiology, and Immunology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Rajamanickam K; Division of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., K Bhanumathy K; Division of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Lew J; Vaccine and Infectious Disease Organization-International Vaccine Centre, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada., Falzarano D; Vaccine and Infectious Disease Organization-International Vaccine Centre, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada., Vizeacoumar FJ; Division of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.; Cancer Research Department, Saskatchewan Cancer Agency, Saskatoon, SK S7N 5E5, Canada., Wilson JA; Department of Biochemistry, Microbiology, and Immunology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada., Mottinelli M; Department of Medicinal Chemistry, University of Florida College of Pharmacy, Gainesville, FL 32610, USA., Kanumuri SRR; Department of Pharmaceutics, University of Florida College of Pharmacy, Gainesville, FL 32610, USA.; Translational Drug Development Core, University of Florida Clinical and Translational Sciences Institute, Gainesville, FL 32610, USA., Sharma A; Department of Pharmaceutics, University of Florida College of Pharmacy, Gainesville, FL 32610, USA.; Translational Drug Development Core, University of Florida Clinical and Translational Sciences Institute, Gainesville, FL 32610, USA., McCurdy CR; Department of Medicinal Chemistry, University of Florida College of Pharmacy, Gainesville, FL 32610, USA.; Translational Drug Development Core, University of Florida Clinical and Translational Sciences Institute, Gainesville, FL 32610, USA., Norris MH; Department of Geography, University of Florida College of Liberal Arts and Sciences, Gainesville, FL 32611, USA.; Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610, USA.

المصدر: Pathogens (Basel, Switzerland) [Pathogens] 2021 Nov 20; Vol. 10 (11). Date of Electronic Publication: 2021 Nov 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101596317 Publication Model: Electronic Cited Medium: Print ISSN: 2076-0817 (Print) Linking ISSN: 20760817 NLM ISO Abbreviation: Pathogens Subsets: PubMed not MEDLINE

المؤلفون: Heacock-Kang Y; School of Life Sciences, University of Hawai'i at Mānoa, Honolulu, HI, USA., McMillan IA; School of Life Sciences, University of Hawai'i at Mānoa, Honolulu, HI, USA., Norris MH; School of Life Sciences, University of Hawai'i at Mānoa, Honolulu, HI, USA.; Department of Geography and Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA., Sun Z; School of Life Sciences, University of Hawai'i at Mānoa, Honolulu, HI, USA., Zarzycki-Siek J; School of Life Sciences, University of Hawai'i at Mānoa, Honolulu, HI, USA., Bluhm AP; School of Life Sciences, University of Hawai'i at Mānoa, Honolulu, HI, USA.; Department of Geography and Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA., Cabanas D; School of Life Sciences, University of Hawai'i at Mānoa, Honolulu, HI, USA., Norton RE; Townsville Hospital, Townsville, QLD, Australia.; Faculty of Medicine, University of Queensland, Brisbane, Australia., Ketheesan N; Science and Technology, University of New England, New South Wales, Australia., Miller JF; Department of Microbiology, Immunology, and Molecular Genetics, and the California NanoSystems Institute, University of California, Los Angeles, CA, USA., Schweizer HP; Pathogen and Microbiome Institute, Northern Arizona University, Flagstaff, AZ, USA., Hoang TT; School of Life Sciences, University of Hawai'i at Mānoa, Honolulu, HI, USA. tongh@hawaii.edu.

المصدر: Nature communications [Nat Commun] 2021 Mar 26; Vol. 12 (1), pp. 1907. Date of Electronic Publication: 2021 Mar 26.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Bacterial Proteins/*genetics , Burkholderia pseudomallei/*genetics , Computational Biology/*methods , Gene Expression Profiling/*methods , Genes, Bacterial/*genetics , Virulence Factors/*genetics, Animals ; Burkholderia pseudomallei/cytology ; Burkholderia pseudomallei/pathogenicity ; Cell Line, Tumor ; Cell Membrane/microbiology ; Cytoplasm/microbiology ; HEK293 Cells ; Host-Pathogen Interactions ; Humans ; Melioidosis/microbiology ; Mice ; Mice, Inbred BALB C ; RAW 264.7 Cells ; Single-Cell Analysis/methods ; Vacuoles/microbiology ; Virulence/genetics

المؤلفون: Norris MH, Kirpich A, Bluhm AP, Zincke D, Hadfield T, Ponciano JM, Blackburn JK

المصدر: PLoS biology [PLoS Biol] 2021 Feb 08; Vol. 19 (2), pp. e3001112. Date of Electronic Publication: 2021 Feb 08 (Print Publication: 2021).

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Reznikov LR; Department of Physiological Sciences, University of Florida College of Veterinary Medicine, Gainesville, FL, USA., Norris MH; Department of Geography and the Emerging Pathogens Institute, Spatial Epidemiology and Ecology Research Laboratory, University of Florida, Gainesville, FL, USA., Vashisht R; Bakar Computational Health Sciences Institute, University of California San Francisco, San Francisco, CA, USA., Bluhm AP; Department of Geography and the Emerging Pathogens Institute, Spatial Epidemiology and Ecology Research Laboratory, University of Florida, Gainesville, FL, USA., Li D; Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, USA., Liao YJ; Department of Physiological Sciences, University of Florida College of Veterinary Medicine, Gainesville, FL, USA., Brown A; Department of Medicine, University of Florida College of Medicine, Gainesville, FL, USA., Butte AJ; Bakar Computational Health Sciences Institute, University of California San Francisco, San Francisco, CA, USA., Ostrov DA; Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, FL, USA. Electronic address: ostroda@pathology.ufl.edu.

المصدر: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 Jan 29; Vol. 538, pp. 173-179. Date of Electronic Publication: 2020 Dec 03.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

مواضيع طبية MeSH: Drug Repositioning* , COVID-19 Drug Treatment*, Angiotensin-Converting Enzyme 2/*chemistry , Antiviral Agents/*chemistry , Histamine Antagonists/*chemistry , SARS-CoV-2/*drug effects, Angiotensin-Converting Enzyme 2/genetics ; Angiotensin-Converting Enzyme 2/metabolism ; Animals ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Catalytic Domain ; Chlorocebus aethiops ; HEK293 Cells ; Histamine Antagonists/pharmacology ; Histamine Antagonists/therapeutic use ; Humans ; Ligands ; Protein Binding ; Receptors, Histamine/chemistry ; Receptors, sigma/chemistry ; Vero Cells ; Sigma-1 Receptor

المؤلفون: Norris MH; Spatial Epidemiology & Ecology Research Laboratory, Department of Geography, University of Florida, Gainesville, Florida, United States of America.; Emerging Pathogens Institute, University of Florida, Gainesville, Florida, United States of America., Kirpich A; Department of Population Health Services, Georgia State University, Atlanta, Georgia, United States of America., Bluhm AP; Spatial Epidemiology & Ecology Research Laboratory, Department of Geography, University of Florida, Gainesville, Florida, United States of America.; Emerging Pathogens Institute, University of Florida, Gainesville, Florida, United States of America., Zincke D; Spatial Epidemiology & Ecology Research Laboratory, Department of Geography, University of Florida, Gainesville, Florida, United States of America.; Emerging Pathogens Institute, University of Florida, Gainesville, Florida, United States of America., Hadfield T; Spatial Epidemiology & Ecology Research Laboratory, Department of Geography, University of Florida, Gainesville, Florida, United States of America.; Emerging Pathogens Institute, University of Florida, Gainesville, Florida, United States of America., Ponciano JM; Department of Biology, University of Florida, Gainesville, Florida, United States of America., Blackburn JK; Spatial Epidemiology & Ecology Research Laboratory, Department of Geography, University of Florida, Gainesville, Florida, United States of America.; Emerging Pathogens Institute, University of Florida, Gainesville, Florida, United States of America.

المصدر: PLoS biology [PLoS Biol] 2020 Dec 28; Vol. 18 (12), pp. e3001052. Date of Electronic Publication: 2020 Dec 28 (Print Publication: 2020).

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE

مواضيع طبية MeSH: Amino Sugars/*genetics , Bacillus anthracis/*genetics , Bacillus anthracis/*metabolism , Deoxyglucose/*analogs & derivatives, Amino Sugars/immunology ; Amino Sugars/metabolism ; Animals ; Anthrax/genetics ; Anthrax/immunology ; Anthrax/metabolism ; Bacillus anthracis/pathogenicity ; Biological Evolution ; Deoxyglucose/genetics ; Deoxyglucose/immunology ; Deoxyglucose/metabolism ; Disease Models, Animal ; Disease Outbreaks ; Evolution, Molecular ; Female ; Membrane Glycoproteins/metabolism ; Mice ; Mice, Inbred A ; Moths/microbiology ; Oligosaccharides/genetics ; Oligosaccharides/immunology ; Oligosaccharides/metabolism ; Spores, Bacterial/genetics ; Spores, Bacterial/immunology ; Spores, Bacterial/metabolism