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1
المؤلفون: Marc Abrams, Laura Sepp-Lorenzino, Steve Stirdivant, Joan Zugay-Murphy, Keith W. Rickert, Xianzhi Mao, Stephen C. Beck, Mark E. Fraley, Robert M. Garbaccio, Rob Lobell, Youwei Yan, Bob Drakas, Paul Zuck, Sylvie Jezequel-Sur, Kelly Hamilton, Timothy J. Hartingh, Constantine Kreatsoulas, Edward S. Tasber, Sanjeev Munshi, Antonella Converso, Eileen S. Walsh, George D. Hartman, Carolyn A. Buser, Weikang Tao, V V Sardana
المصدر: Bioorganic & Medicinal Chemistry Letters. 19:1240-1244
مصطلحات موضوعية: Clinical Biochemistry, Allosteric regulation, Molecular Conformation, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Molecular conformation, Drug Discovery, Combinatorial Chemistry Techniques, Humans, Transferase, Potency, CHEK1, Binding site, Protein Kinase Inhibitors, Molecular Biology, High concentration, Binding Sites, Molecular Structure, Chemistry, Chk1 Kinase, Organic Chemistry, Checkpoint Kinase 1, Quinazolines, Molecular Medicine, Protein Kinases
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2
المؤلفون: James Hardwick, Xianzhi Mao, Constanine Kreatsoulas, Eileen S. Walsh, Sanjeev Munshi, Marc Abrams, George D. Hartman, Laura Sepp-Lorenzino, Mark E. Fraley, Rob Lobell, Kelly Hamilton, Lawrence Kuo, Carolyn A. Buser, Weikang Tao, Robert M. Garbaccio, Mari Ikuta, Keith W. Rickert, Edward S. Tasber, Bob Drakas, Steve Stirdivant, Stephen C. Beck, Shaei Huang, Youwei Yan
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:6280-6285
مصطلحات موضوعية: Models, Molecular, Photochemistry, Stereochemistry, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Apoptosis, Quinolones, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Residue (chemistry), Cell Line, Tumor, Drug Discovery, Humans, Transferase, Structure–activity relationship, Enzyme Inhibitors, Molecular Biology, chemistry.chemical_classification, Binding Sites, Molecular Structure, biology, Organic Chemistry, Enzyme, chemistry, Enzyme inhibitor, Checkpoint Kinase 1, Lactam, biology.protein, Molecular Medicine, Amine gas treating, Protein Kinases
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3
المؤلفون: Keith Lee Spencer, Barbara Hanney, Eileen S. Walsh, George D. Hartman, Stephen C. Beck, Carolyn A. Buser, Weikang Tao, Robert B. Lobell, Youwei Yan, Lawrence C. Kuo, Kenneth L. Arrington, Edward J. Brnardic, Mari Ikuta, Sanjeev Munshi, Mark E. Fraley, Constantine Kreatsoulas, Justin T. Steen, Bob Drakas, Laura Sepp-Lorenzino, Kelly Hamilton, Yuntae Kim, Xianzhi Mao, James Hardwick, Steven M. Stirdivant, Keith W. Rickert
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:6049-6053
مصطلحات موضوعية: Models, Molecular, Indazoles, Stereochemistry, Clinical Biochemistry, Triazole, Pharmaceutical Science, Crystallography, X-Ray, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Cell Line, Tumor, Drug Discovery, Humans, Structure–activity relationship, Moiety, Potency, Hydroxymethyl, Protein Kinase Inhibitors, Molecular Biology, Indazole, Molecular Structure, biology, Cell Cycle, Organic Chemistry, chemistry, Enzyme inhibitor, Checkpoint Kinase 1, biology.protein, Molecular Medicine, Selectivity, Protein Kinases
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4
المؤلفون: Eileen S. Walsh, Steve Stirdivant, George D. Hartman, Kelly Hamilton, Marc Abrams, Robert M. Garbaccio, Laura Sepp-Lorenzino, Lawrence Kuo, Steve Beck, Joan Zugay Murphy, Constantine Kreatsoulas, Justin T. Steen, Sanjeev Munshi, Carolyn A. Buser, Weikang Tao, Shaei Huang, Youwei Yan, V V Sardana, Bob Drakas, Mari Ikuta, James Hardwick, Keith W. Rickert, Mark E. Fraley, Elizabeth Mahan, Xianzhi Mao, Rob Lobell, Michael Reilly
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:5907-5912
مصطلحات موضوعية: Indoles, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Quinolones, Crystallography, X-Ray, Biochemistry, Polar surface area, Structure-Activity Relationship, Drug Discovery, Animals, Humans, Structure–activity relationship, Potency, Enzyme Inhibitors, Binding site, Molecular Biology, Cell potency, chemistry.chemical_classification, Binding Sites, biology, Organic Chemistry, Active site, Enzyme, chemistry, Enzyme inhibitor, Drug Design, Checkpoint Kinase 1, biology.protein, Molecular Medicine, Hydrophobic and Hydrophilic Interactions, Protein Kinases
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5
المؤلفون: Kenneth L. Arrington, Keith W. Rickert, Bob Drakas, Mari Ikuta, Sanjeev Munshi, Robert M. Garbaccio, Steven M. Stirdivant, Edward J. Brnardic, Mark E. Fraley, Stephen C. Beck, Eileen S. Walsh, Carolyn A. Buser, Lawrence C. Kuo, Weikang Tao, George D. Hartman, Kelly Hamilton, Laura Sepp-Lorenzino, Youwei Yan, Vadim Y. Dudkin, Constantine Kreatsoulas, Justin T. Steen, Edward S. Tasber, Robert B. Lobell, James Hardwick, Xianzhi Mao
المصدر: Bioorganicmedicinal chemistry letters. 17(21)
مصطلحات موضوعية: Models, Molecular, animal structures, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Quinolones, Ring (chemistry), Crystallography, X-Ray, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Structure-Activity Relationship, Drug Discovery, Structure–activity relationship, Transferase, Moiety, Molecular Biology, Protein Kinase Inhibitors, biology, Organic Chemistry, chemistry, Enzyme inhibitor, Checkpoint Kinase 1, Lactam, biology.protein, Molecular Medicine, Amine gas treating, biological phenomena, cell phenomena, and immunity, Protein Kinases