المؤلفون: Taliun D; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Harris DN; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.; Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Kessler MD; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.; Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Carlson J; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Department of Genome Sciences, University of Washington, Seattle, WA, USA., Szpiech ZA; Department of Biology, Pennsylvania State University, University Park, PA, USA.; Institute for Computational and Data Sciences, Pennsylvania State University, University Park, PA, USA., Torres R; Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA, USA., Taliun SAG; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Corvelo A; New York Genome Center, New York, NY, USA., Gogarten SM; Department of Biostatistics, University of Washington, Seattle, WA, USA., Kang HM; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Pitsillides AN; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., LeFaive J; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Lee SB; Department of Genome Sciences, University of Washington, Seattle, WA, USA., Tian X; Department of Biostatistics, University of Washington, Seattle, WA, USA., Browning BL; Department of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, USA., Das S; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Emde AK; New York Genome Center, New York, NY, USA., Clarke WE; New York Genome Center, New York, NY, USA., Loesch DP; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.; Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Shetty AC; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.; Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Blackwell TW; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Smith AV; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Wong Q; Department of Biostatistics, University of Washington, Seattle, WA, USA., Liu X; USF Genomics, College of Public Health, University of South Florida, Tampa, FL, USA., Conomos MP; Department of Biostatistics, University of Washington, Seattle, WA, USA., Bobo DM; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Aguet F; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Albert C; Massachusetts General Hospital, Boston, MA, USA., Alonso A; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Ardlie KG; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Arking DE; McKusick-Nathans Institute, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Aslibekyan S; University of Alabama, Birmingham, AL, USA., Auer PL; Zilber School of Public Health, University of Wisconsin Milwaukee, Milwaukee, WI, USA., Barnard J; Cleveland Clinic, Cleveland, OH, USA., Barr RG; Department of Medicine, Columbia University Medical Center, New York, NY, USA.; Department of Epidemiology, Columbia University Medical Center, New York, NY, USA., Barwick L; The Emmes Corporation, Rockville, MD, USA., Becker LC; Johns Hopkins University, Baltimore, MD, USA., Beer RL; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Benjamin EJ; Department of Medicine, Boston University School of Medicine, Boston, MA, USA.; Department of Epidemiology, Boston University School of Public Health, Boston, MA, USA.; Framingham Heart Study, Framingham, MA, USA., Bielak LF; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA., Blangero J; Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Boehnke M; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Bowden DW; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Brody JA; Department of Medicine, University of Washington, Seattle, WA, USA.; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA., Burchard EG; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA.; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA., Cade BE; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Casella JF; Department of Pediatrics, Johns Hopkins University, Baltimore, MD, USA.; Division of Pediatric Hematology, Johns Hopkins University, Baltimore, MD, USA., Chalazan B; Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada., Chasman DI; Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Chen YI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA, USA., Cho MH; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Choi SH; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Chung MK; Department of Cardiovascular Medicine, Heart & Vascular Institute, Cleveland Clinic, Cleveland, OH, USA.; Department of Cardiovascular and Metabolic Sciences, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA., Clish CB; Metabolomics Platform, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Correa A; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA.; Department of Pediatrics, University of Mississippi Medical Center, Jackson, MS, USA.; Department of Population Health Science, University of Mississippi Medical Center, Jackson, MS, USA., Curran JE; Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA.; South Texas Diabetes and Obesity Institute, University of Texas Rio Grande Valley School of Medicine, Brownsville, TX, USA., Custer B; Vitalant Research Institute, San Francisco, CA, USA.; Department of Laboratory Medicine, University of California, San Francisco, San Francisco, CA, USA., Darbar D; Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA., Daya M; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., de Andrade M; Mayo Clinic, Rochester, MN, USA., DeMeo DL; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Dutcher SK; McDonnell Genome Institute, Washington University, St Louis, MO, USA.; Department of Genetics, Washington University, St Louis, MO, USA., Ellinor PT; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Emery LS; Department of Biostatistics, University of Washington, Seattle, WA, USA., Eng C; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA., Fatkin D; Molecular Cardiology Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia.; Faculty of Medicine, University of New South Wales, Kensington, New South Wales, Australia.; Cardiology Department, St Vincent's Hospital, Darlinghurst, New South Wales, Australia., Fingerlin T; National Jewish Health, Center for Genes, Environment and Health, Denver, CO, USA., Forer L; Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University of Innsbruck, Innsbruck, Austria., Fornage M; Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA., Franceschini N; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA., Fuchsberger C; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.; Institute for Biomedicine, Eurac Research, Bolzano, Italy., Fullerton SM; Department of Bioethics & Humanities, University of Washington School of Medicine, Seattle, WA, USA., Germer S; New York Genome Center, New York, NY, USA., Gladwin MT; Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.; Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Gottlieb DJ; VA Boston Healthcare System, Boston, MA, USA.; Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, USA., Guo X; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA, USA., Hall ME; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA., He J; Department of Epidemiology, Tulane University, New Orleans, LA, USA.; Tulane University Translational Science Institute, Tulane University, New Orleans, LA, USA., Heard-Costa NL; Framingham Heart Study, Framingham, MA, USA.; Department of Neurology, Boston University School of Medicine, Boston, MA, USA., Heckbert SR; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA., Irvin MR; Department of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, USA., Johnsen JM; Department of Medicine, University of Washington, Seattle, WA, USA.; Bloodworks Northwest Research Institute, Seattle, WA, USA., Johnson AD; Framingham Heart Study, Framingham, MA, USA.; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, MA, USA., Kaplan R; Albert Einstein College of Medicine, New York, NY, USA., Kardia SLR; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA., Kelly T; Department of Epidemiology, Tulane University, New Orleans, LA, USA., Kelly S; Department of Epidemiology, Vitalant Research Institute, San Francisco, CA, USA.; Department of Pediatrics, UCSF Benioff Children's Hospital, Oakland, CA, USA.; Division of Pediatric Hematology, UCSF Benioff Children's Hospital, Oakland, CA, USA., Kenny EE; Icahn School of Medicine at Mount Sinai, New York, NY, USA., Kiel DP; The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Hinda and Arthur Marcus Institute for Aging Research, Hebrew SeniorLife, Boston, MA, USA.; Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Klemmer R; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Konkle BA; Department of Medicine, University of Washington, Seattle, WA, USA.; Bloodworks Northwest Research Institute, Seattle, WA, USA., Kooperberg C; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Köttgen A; Department of Epidemiology, Johns Hopkins University, Baltimore, MD, USA.; Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany., Lange LA; Department of Medicine, University of Colorado at Denver, Aurora, CO, USA., Lasky-Su J; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Brigham and Women's Hospital, Boston, MA, USA., Levy D; Department of Medicine, Boston University School of Medicine, Boston, MA, USA.; Framingham Heart Study, Framingham, MA, USA.; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, MA, USA., Lin X; Biostatistics and Statistics, Harvard University, Boston, MA, USA., Lin KH; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Liu C; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Loos RJF; The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Garman L; Department of Genes and Human Disease, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA., Gerszten R; Beth Israel Deaconess Medical Center, Boston, MA, USA., Lubitz SA; Massachusetts General Hospital, Boston, MA, USA., Lunetta KL; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Mak ACY; Department of Medicine, University of California, San Francisco, San Francisco, CA, USA., Manichaikul A; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.; Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA., Manning AK; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Clinical and Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital, Boston, MA, USA.; Metabolism Program, The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Mathias RA; Department of Medicine, Johns Hopkins University, Baltimore, MD, USA., McManus DD; Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, MA, USA., McGarvey ST; International Health Institute, Brown University, Providence, RI, USA.; Department of Epidemiology, Brown University, Providence, RI, USA.; Department of Anthropology, Brown University, Providence, RI, USA., Meigs JB; Division of General Internal Medicine, Massachusetts General Hospital, Harvard Medical School, The Broad Institute of MIT and Harvard, Boston, MA, USA., Meyers DA; University of Arizona, Tucson, AZ, USA., Mikulla JL; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Minear MA; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Mitchell BD; Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD, USA., Mohanty S; Texas Cardiac Arrhythmia Institute, St David's Medical Center, Austin, TX, USA.; Department of Internal Medicine, Dell Medical School, Austin, TX, USA., Montasser ME; Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Montgomery C; Department of Genes and Human Disease, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA., Morrison AC; Human Genetics Center, Department of Epidemiology, Human Genetics, and Environmental Sciences, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA., Murabito JM; Department of Medicine, Boston University School of Medicine, Boston, MA, USA., Natale A; Texas Cardiac Arrhythmia Institute, St David's Medical Center, Austin, TX, USA., Natarajan P; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA., Nelson SC; Department of Biostatistics, University of Washington, Seattle, WA, USA., North KE; Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA., O'Connell JR; Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA., Palmer ND; Department of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA., Pankratz N; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA., Peloso GM; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Peyser PA; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA., Pleiness J; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Post WS; Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA., Psaty BM; Department of Medicine, University of Washington, Seattle, WA, USA.; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Department of Health Services, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA., Rao DC; Division of Biostatistics, Washington University in St Louis, St Louis, MO, USA., Redline S; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Reiner AP; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA., Roden D; Vanderbilt University Medical Center, Nashville, TN, USA., Rotter JI; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA, USA., Ruczinski I; Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA., Sarnowski C; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA., Schoenherr S; Institute of Genetic Epidemiology, Department of Genetics and Pharmacology, Medical University of Innsbruck, Innsbruck, Austria., Schwartz DA; University of Colorado at Denver, Denver, CO, USA., Seo JS; Precision Medicine Center, Seoul National University Bundang Hospital, Seongnam, Republic of Korea.; Macrogen Inc, Seoul, Republic of Korea.; Gong Wu Genomic Medicine Institute, Seoul National University Bundang Hospital, Seongnam, Republic of Korea., Seshadri S; Framingham Heart Study, Framingham, MA, USA.; Glenn Biggs Institute for Alzheimer's and Neurodegenerative Diseases, University of Texas Health Sciences Center at San Antonio, San Antonio, TX, USA., Sheehan VA; Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA.; Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA, USA., Sheu WH; Taichung Veterans General Hospital Taiwan, Taichung City, Taiwan., Shoemaker MB; Vanderbilt University Medical Center, Nashville, TN, USA., Smith NL; Department of Epidemiology, University of Washington, Seattle, WA, USA.; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.; Seattle Epidemiologic Research and Information Center, Department of Veterans Affairs Office of Research and Development, Seattle, WA, USA., Smith JA; Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA., Sotoodehnia N; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA., Stilp AM; Department of Biostatistics, University of Washington, Seattle, WA, USA., Tang W; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA., Taylor KD; The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation, Harbor-UCLA Medical Center, Torrance, CA, USA., Telen M; Duke University, Durham, NC, USA., Thornton TA; Department of Biostatistics, University of Washington, Seattle, WA, USA., Tracy RP; Department of Pathology & Laboratory Medicine, University of Vermont Larner College of Medicine, Burlington, VT, USA., Van Den Berg DJ; Center for Genetic Epidemiology, Department of Preventive Medicine, University of Southern California, Los Angeles, CA, USA., Vasan RS; Department of Medicine, Boston University School of Medicine, Boston, MA, USA.; Framingham Heart Study, Framingham, MA, USA., Viaud-Martinez KA; Illumina Laboratory Services, Illumina Inc, San Diego, CA, USA., Vrieze S; Department of Psychology, University of Minnesota, Minneapolis, MN, USA., Weeks DE; Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Weir BS; Department of Biostatistics, University of Washington, Seattle, WA, USA., Weiss ST; Department of Medicine, Harvard Medical School, Boston, MA, USA.; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.; Brigham and Women's Hospital, Boston, MA, USA., Weng LC; Massachusetts General Hospital, Boston, MA, USA., Willer CJ; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA.; Department of Internal Medicine-Cardiology, University of Michigan, Ann Arbor, MI, USA.; Department of Human Genetics, University of Michigan, Ann Arbor, MI, USA., Zhang Y; Pittsburgh Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA.; Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Zhao X; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA., Arnett DK; Department of Epidemiology, University of Kentucky, Lexington, KY, USA., Ashley-Koch AE; Duke Molecular Physiology Institute, Duke University Medical Center, Durham, NC, USA., Barnes KC; Division of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA., Boerwinkle E; University of Texas Health Science Center at Houston, Houston, TX, USA.; Baylor College of Medicine Human Genome Sequencing Center, Houston, TX, USA., Gabriel S; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Gibbs R; Baylor College of Medicine Human Genome Sequencing Center, Houston, TX, USA., Rice KM; Department of Biostatistics, University of Washington, Seattle, WA, USA., Rich SS; Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA.; Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA., Silverman EK; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Qasba P; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Gan W; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Papanicolaou GJ; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA., Nickerson DA; Department of Genome Sciences, University of Washington, Seattle, WA, USA.; Northwest Genomics Center, Seattle, WA, USA.; Brotman Baty Institute, Seattle, WA, USA., Browning SR; Department of Biostatistics, University of Washington, Seattle, WA, USA., Zody MC; New York Genome Center, New York, NY, USA., Zöllner S; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Center for Statistical Genetics, University of Michigan School of Public Health, Ann Arbor, MI, USA.; Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA., Wilson JG; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA., Cupples LA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. adrienne@bu.edu.; Framingham Heart Study, Framingham, MA, USA. adrienne@bu.edu., Laurie CC; Department of Biostatistics, University of Washington, Seattle, WA, USA. cclaurie@uw.edu., Jaquish CE; National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. jaquishc@nhlbi.nih.gov., Hernandez RD; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA. ryan.hernandez@mcgill.ca.; Department of Human Genetics, McGill University, Montreal, Quebec, Canada. ryan.hernandez@mcgill.ca.; Quantitative Biosciences Institute, University of California, San Francisco, San Francisco, CA, USA. ryan.hernandez@mcgill.ca.; Institute for Human Genetics, University of California, San Francisco, San Francisco, CA, USA. ryan.hernandez@mcgill.ca.; Bakar Computational Health Sciences Institute, University of California, San Francisco, San Francisco, CA, USA. ryan.hernandez@mcgill.ca., O'Connor TD; Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA. timothydoconnor@gmail.com.; Program in Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. timothydoconnor@gmail.com.; Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. timothydoconnor@gmail.com., Abecasis GR; Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA. goncalo@umich.edu.

مؤلفون مشاركون: NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium

المصدر: Nature [Nature] 2021 Feb; Vol. 590 (7845), pp. 290-299. Date of Electronic Publication: 2021 Feb 10.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Genomics* , National Heart, Lung, and Blood Institute (U.S.)* , Precision Medicine*/standards, Genetic Variation/*genetics , Genome, Human/*genetics, Cytochrome P-450 CYP2D6/genetics ; Haplotypes/genetics ; Heterozygote ; Humans ; INDEL Mutation ; Loss of Function Mutation ; Mutagenesis ; Phenotype ; Polymorphism, Single Nucleotide ; Population Density ; Quality Control ; Sample Size ; United States ; Whole Genome Sequencing/standards

المؤلفون: Atkinson EG; Department of Ecology and Evolution, Stony Brook University, Stony Brook, NY, USA. Electronic address: eatkinso@broadinstitute.org., Audesse AJ; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA; Neuroscience Graduate Program, Brown University, Providence, RI 02912, USA., Palacios JA; Department of Ecology and Evolutionary Biology and Center for Computational Molecular Biology, Brown University, Providence, RI 02912, USA; Department of Statistics and Department of Biomedical Data Science, Stanford University, Stanford, CA 94305, USA., Bobo DM; Department of Ecology and Evolution, Stony Brook University, Stony Brook, NY, USA., Webb AE; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, RI 02912, USA; Carney Institute for Brain Science, Brown University, Providence, RI 02912, USA., Ramachandran S; Department of Ecology and Evolutionary Biology and Center for Computational Molecular Biology, Brown University, Providence, RI 02912, USA., Henn BM; Department of Ecology and Evolution, Stony Brook University, Stony Brook, NY, USA; Department of Anthropology and the Genome Center, University of California, Davis, Davis, CA 95616, USA. Electronic address: bmhenn@ucdavis.edu.

المصدر: Cell [Cell] 2018 Sep 06; Vol. 174 (6), pp. 1424-1435.e15. Date of Electronic Publication: 2018 Aug 02.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Forkhead Transcription Factors/*genetics, Brain/cytology ; Brain/metabolism ; Cell Line ; Databases, Genetic ; Exons ; Female ; Genome, Human ; Haplotypes ; Humans ; Introns ; Male ; Markov Chains ; Polymorphism, Single Nucleotide ; Prefrontal Cortex/metabolism

المؤلفون: Hofmanová Z; Palaeogenetics Group, Johannes Gutenberg University Mainz, 55099 Mainz, Germany;, Kreutzer S; Palaeogenetics Group, Johannes Gutenberg University Mainz, 55099 Mainz, Germany;, Hellenthal G; Department of Genetics, Evolution, and Environment, University College London, London WC1E 6BT, United Kingdom;, Sell C; Palaeogenetics Group, Johannes Gutenberg University Mainz, 55099 Mainz, Germany;, Diekmann Y; Department of Genetics, Evolution, and Environment, University College London, London WC1E 6BT, United Kingdom;, Díez-Del-Molino D; Department of Genetics, Evolution, and Environment, University College London, London WC1E 6BT, United Kingdom;, van Dorp L; Department of Genetics, Evolution, and Environment, University College London, London WC1E 6BT, United Kingdom;, López S; Department of Genetics, Evolution, and Environment, University College London, London WC1E 6BT, United Kingdom;, Kousathanas A; Department of Biology, University of Fribourg, 1700 Fribourg, Switzerland; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland;, Link V; Department of Biology, University of Fribourg, 1700 Fribourg, Switzerland; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland;, Kirsanow K; Palaeogenetics Group, Johannes Gutenberg University Mainz, 55099 Mainz, Germany;, Cassidy LM; Molecular Population Genetics, Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland;, Martiniano R; Molecular Population Genetics, Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland;, Strobel M; Palaeogenetics Group, Johannes Gutenberg University Mainz, 55099 Mainz, Germany;, Scheu A; Palaeogenetics Group, Johannes Gutenberg University Mainz, 55099 Mainz, Germany; Molecular Population Genetics, Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland;, Kotsakis K; Faculty of Philosophy, School of History and Archaeology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece;, Halstead P; Department of Archaeology, University of Sheffield, Sheffield S1 4ET, United Kingdom;, Triantaphyllou S; Faculty of Philosophy, School of History and Archaeology, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece;, Kyparissi-Apostolika N; Honorary Ephor of Antiquities, Hellenic Ministry of Culture & Sports, 106 82 Athens, Greece;, Urem-Kotsou D; Department of History and Ethnology, Democritus University of Thrace, 69100 Komotini, Greece;, Ziota C; Ephorate of Antiquities of Florina, Hellenic Ministry of Culture & Sports, 106 82 Athens, Greece;, Adaktylou F; Ephorate of Antiquities of Chalkidiki and Mount Athos, Hellenic Ministry of Culture & Sports, 106 82 Athens, Greece;, Gopalan S; Department of Ecology and Evolution, Stony Brook University, Stony Brook, New York 11794-5245;, Bobo DM; Department of Ecology and Evolution, Stony Brook University, Stony Brook, New York 11794-5245;, Winkelbach L; Palaeogenetics Group, Johannes Gutenberg University Mainz, 55099 Mainz, Germany;, Blöcher J; Palaeogenetics Group, Johannes Gutenberg University Mainz, 55099 Mainz, Germany;, Unterländer M; Palaeogenetics Group, Johannes Gutenberg University Mainz, 55099 Mainz, Germany;, Leuenberger C; Department of Mathematics, University of Fribourg, 1700 Fribourg, Switzerland;, Çilingiroğlu Ç; Department of Protohistory and Near Eastern Archeology, Faculty of Letters, Ege University, 35100 Bornova, Izmir, Turkey;, Horejs B; Institute of Oriental and European Archaeology, Austrian Academy of Sciences, 1010 Vienna, Austria;, Gerritsen F; Netherlands Institute in Turkey, Beyoglu 34433, Istanbul, Turkey;, Shennan SJ; Institute of Archaeology, University College London, London WC1H 0PY, United Kingdom;, Bradley DG; Molecular Population Genetics, Smurfit Institute of Genetics, Trinity College Dublin, Dublin 2, Ireland;, Currat M; Anthropology Unit, Department of Genetics & Evolution, University of Geneva, 1211 Geneva, Switzerland;, Veeramah KR; Department of Ecology and Evolution, Stony Brook University, Stony Brook, New York 11794-5245;, Wegmann D; Department of Biology, University of Fribourg, 1700 Fribourg, Switzerland; Swiss Institute of Bioinformatics, 1015 Lausanne, Switzerland;, Thomas MG; Department of Genetics, Evolution, and Environment, University College London, London WC1E 6BT, United Kingdom;, Papageorgopoulou C; Laboratory of Anthropology, Department of History and Ethnology, Democritus University of Thrace, 69100 Komotini, Greece cpapage@he.duth.gr jburger@uni-mainz.de., Burger J; Palaeogenetics Group, Johannes Gutenberg University Mainz, 55099 Mainz, Germany; cpapage@he.duth.gr jburger@uni-mainz.de.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2016 Jun 21; Vol. 113 (25), pp. 6886-91. Date of Electronic Publication: 2016 Jun 06.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Agriculture* , Anthropology*, Europe ; Genetics, Population ; Humans ; Mediterranean Region ; Principal Component Analysis