المؤلفون: Kettle, JG, Bagal, SK, Barratt, D, Bodnarchuk, MS, Boyd, S, Braybrooke, E, Breed, J, Cassar, DJ, Cosulich, S, Davies, M, Davies, NL, Deng, C, Eatherton, A, Evans, L, Feron, LJ, Fillery, S, Gleave, ES, Goldberg, FW, Gonzalez, MAC, Guerot, C, Haider, A, Harlfinger, S, Howells, R, Jackson, A, Johnstrom, P, Kemmitt, PD, Koers, A, Kondrashov, M, Lamont, GM, Lamont, S, Lewis, HJ, Liu, LB, Mylrea, M, Nash, S, Niedbala, MJ, Peter, A, Phillips, C, Pike, K, Raubo, P, Robb, GR, Ross, S, Sanders, MG, Schou, M, Simpson, I, Steward, O

المصدر: Journal of medicinal chemistry. 66(13):9147-9160

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:153054564

المؤلفون: Suruzhon M; School of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, United Kingdom., Abdel-Maksoud K; School of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, United Kingdom., Bodnarchuk MS; Computational Chemistry, R&D Oncology, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Ciancetta A; Sygnature Discovery Limited, Nottingham NG1 1GR, United Kingdom., Wall ID; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, United Kingdom., Essex JW; School of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, United Kingdom.

المصدر: The Journal of chemical physics [J Chem Phys] 2024 Apr 21; Vol. 160 (15).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Institute of Physics Country of Publication: United States NLM ID: 0375360 Publication Model: Print Cited Medium: Internet ISSN: 1089-7690 (Electronic) Linking ISSN: 00219606 NLM ISO Abbreviation: J Chem Phys Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Hargreaves D; Discovery Sciences, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Carbajo RJ; Chemistry, Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Bodnarchuk MS; Chemistry, Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Embrey K; Discovery Sciences, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Rawlins PB; Discovery Sciences, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Packer M; Chemistry, Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Degorce SL; Discovery Sciences, AstraZeneca, Waltham, MA 02451., Hird AW; Discovery Sciences, AstraZeneca, Waltham, MA 02451., Johannes JW; Discovery Sciences, AstraZeneca, Waltham, MA 02451., Chiarparin E; Chemistry, Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Schade M; Chemistry, Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 May 23; Vol. 120 (21), pp. e2221967120. Date of Electronic Publication: 2023 May 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Naphthalenes* , Apoptosis*, Models, Molecular ; Myeloid Cell Leukemia Sequence 1 Protein/metabolism ; Ligands

المؤلفون: Petrović D; Hit Discovery, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg 431 50, Sweden., Scott JS; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Bodnarchuk MS; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Lorthioir O; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Boyd S; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, United Kingdom., Hughes GM; Discovery Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge CB2 0AA, United Kingdom., Lane J; Discovery Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge CB2 0AA, United Kingdom., Wu A; Mechanistic and Structural Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Waltham, Massachusetts 02451, United States., Hargreaves D; Mechanistic and Structural Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge CB2 0AA, United Kingdom., Robinson J; Mechanistic and Structural Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge CB2 0AA, United Kingdom., Sadowski J; Hit Discovery, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Gothenburg 431 50, Sweden.

المصدر: Journal of chemical information and modeling [J Chem Inf Model] 2022 Aug 22; Vol. 62 (16), pp. 3832-3843. Date of Electronic Publication: 2022 Aug 03.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101230060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-960X (Electronic) Linking ISSN: 15499596 NLM ISO Abbreviation: J Chem Inf Model Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma, Non-Small-Cell Lung* , Lung Neoplasms*, Cloud Computing ; Drug Evaluation, Preclinical ; Humans ; Molecular Docking Simulation ; Prospective Studies ; Protein Kinase Inhibitors/chemistry ; Protein Kinase Inhibitors/pharmacology ; Protein-Tyrosine Kinases ; Proto-Oncogene Proteins ; Receptor Protein-Tyrosine Kinases

المؤلفون: Suruzhon M; School of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, U.K., Bodnarchuk MS; Computational Chemistry, R&D Oncology, AstraZeneca, Cambridge CB4 0WG, U.K., Ciancetta A; Sygnature Discovery, Bio City, Pennyfoot Street, Nottingham NG1 1GR, U.K.; Department of Chemical, Pharmaceutical and Agricultural Sciences─DOCPAS, University of Ferrara, Via Fossato di Mortara 17/19, 44121 Ferrara, Italy., Wall ID; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, U.K., Essex JW; School of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, U.K.

المصدر: Journal of chemical theory and computation [J Chem Theory Comput] 2022 Jun 14; Vol. 18 (6), pp. 3894-3910. Date of Electronic Publication: 2022 May 19.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101232704 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-9626 (Electronic) Linking ISSN: 15499618 NLM ISO Abbreviation: J Chem Theory Comput Subsets: MEDLINE

مواضيع طبية MeSH: Proteins*, Ligands ; Monte Carlo Method

المؤلفون: Kettle JG; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Bagal SK; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Bickerton S; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Bodnarchuk MS; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Boyd S; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Breed J; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Carbajo RJ; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Cassar DJ; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Chakraborty A; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Cosulich S; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Cumming I; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Davies M; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Davies NL; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Eatherton A; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Evans L; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Feron L; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Fillery S; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Gleave ES; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Goldberg FW; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Hanson L; Oncology R&D, AstraZeneca, Alderley Park SK10 4TG, U.K., Harlfinger S; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Howard M; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Howells R; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Jackson A; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Kemmitt P; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Lamont G; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Lamont S; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Lewis HJ; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Liu L; Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing 100176, P. R. China., Niedbala MJ; Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States., Phillips C; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Polanski R; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Raubo P; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Robb G; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Robinson DM; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Ross S; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Sanders MG; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Tonge M; Discovery Sciences, R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Whiteley R; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Wilkinson S; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Yang J; Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing 100176, P. R. China., Zhang W; Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing 100176, P. R. China.

المصدر: Journal of medicinal chemistry [J Med Chem] 2022 May 12; Vol. 65 (9), pp. 6940-6952. Date of Electronic Publication: 2022 Apr 26.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents*/pharmacology , Lung Neoplasms*/drug therapy, Drug Design ; Humans ; Mutation ; Proto-Oncogene Proteins p21(ras)/genetics ; Quinazolines/pharmacology ; Structure-Activity Relationship

المؤلفون: Bodnarchuk MS; Oncology R&D, AstraZeneca Cambridge CB4 0WG UK Michael.bodnarchuk@astrazeneca.com., Cassar DJ; Oncology R&D, AstraZeneca Cambridge CB4 0WG UK Michael.bodnarchuk@astrazeneca.com., Kettle JG; Oncology R&D, AstraZeneca Cambridge CB4 0WG UK Michael.bodnarchuk@astrazeneca.com., Robb G; Oncology R&D, AstraZeneca Cambridge CB4 0WG UK Michael.bodnarchuk@astrazeneca.com., Ward RA; Oncology R&D, AstraZeneca Cambridge CB4 0WG UK Michael.bodnarchuk@astrazeneca.com.

المصدر: RSC medicinal chemistry [RSC Med Chem] 2021 Mar 29; Vol. 12 (4), pp. 609-614. Date of Electronic Publication: 2021 Mar 29 (Print Publication: 2021).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101759460 Publication Model: eCollection Cited Medium: Internet ISSN: 2632-8682 (Electronic) Linking ISSN: 26328682 NLM ISO Abbreviation: RSC Med Chem Subsets: PubMed not MEDLINE

المؤلفون: Suruzhon M; School of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, U.K., Bodnarchuk MS; Computational Chemistry, R&D Oncology, AstraZeneca, Cambridge CB4 0WG, U.K., Ciancetta A; Sygnature Discovery Limited, BioCity, Pennyfoot St, Nottingham NG1 1GR, U.K., Viner R; Syngenta, Jealott's Hill International Research Centre, Bracknell RG42 6EY, U.K., Wall ID; GSK Medicines Research Centre, Gunnels Wood Road, Stevenage SG1 2NY, U.K., Essex JW; School of Chemistry, University of Southampton, Highfield, Southampton SO17 1BJ, U.K.

المصدر: Journal of chemical theory and computation [J Chem Theory Comput] 2021 Mar 09; Vol. 17 (3), pp. 1806-1821. Date of Electronic Publication: 2021 Feb 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101232704 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-9626 (Electronic) Linking ISSN: 15499618 NLM ISO Abbreviation: J Chem Theory Comput Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Leiris S; Antabio SAS, 436 rue Pierre et Marie Curie, 31670 Labège, France., Davies DT; Antabio SAS, 436 rue Pierre et Marie Curie, 31670 Labège, France., Sprynski N; Antabio SAS, 436 rue Pierre et Marie Curie, 31670 Labège, France., Castandet J; Antabio SAS, 436 rue Pierre et Marie Curie, 31670 Labège, France., Beyria L; Antabio SAS, 436 rue Pierre et Marie Curie, 31670 Labège, France., Bodnarchuk MS; Charles River Laboratories, Harlow CM19 5TR, U.K., Sutton JM; Charles River Laboratories, Harlow CM19 5TR, U.K., Mullins TMG; Charles River Laboratories, Harlow CM19 5TR, U.K., Jones MW; Charles River Laboratories, Harlow CM19 5TR, U.K., Forrest AK; Charles River Laboratories, Harlow CM19 5TR, U.K., Pallin TD; Charles River Laboratories, Harlow CM19 5TR, U.K., Karunakar P; GVK Biosciences Private Limited, Plot No. 28 A, IDA Nacharam, Hyderabad 500076, India., Martha SK; GVK Biosciences Private Limited, Plot No. 28 A, IDA Nacharam, Hyderabad 500076, India., Parusharamulu B; GVK Biosciences Private Limited, Plot No. 28 A, IDA Nacharam, Hyderabad 500076, India., Ramula R; GVK Biosciences Private Limited, Plot No. 28 A, IDA Nacharam, Hyderabad 500076, India., Kotha V; GVK Biosciences Private Limited, Plot No. 28 A, IDA Nacharam, Hyderabad 500076, India., Pottabathini N; GVK Biosciences Private Limited, Plot No. 28 A, IDA Nacharam, Hyderabad 500076, India., Pothukanuri S; GVK Biosciences Private Limited, Plot No. 28 A, IDA Nacharam, Hyderabad 500076, India., Lemonnier M; Antabio SAS, 436 rue Pierre et Marie Curie, 31670 Labège, France., Everett M; Antabio SAS, 436 rue Pierre et Marie Curie, 31670 Labège, France.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2021 Jan 15; Vol. 12 (2), pp. 217-227. Date of Electronic Publication: 2021 Jan 15 (Print Publication: 2021).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

المؤلفون: McAulay K; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Hoyt EA; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K., Thomas M; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Schimpl M; Discovery Sciences, R&D BioPharmaceuticals, AstraZeneca, Cambridge CB4 0WG, U.K., Bodnarchuk MS; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Lewis HJ; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Barratt D; Discovery Sciences, R&D BioPharmaceuticals, AstraZeneca, Cambridge CB4 0WG, U.K., Bhavsar D; Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States., Robinson DM; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Deery MJ; Cambridge Centre for Proteomics, Department of Biochemistry, University of Cambridge, Cambridge CB2 1QW, U.K., Ogg DJ; Discovery Sciences, R&D BioPharmaceuticals, AstraZeneca, Cambridge CB4 0WG, U.K., Bernardes GJL; Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.; Instituto de Medicina Molecular, Faculdade de Medicina de Universidad de Lisboa, Avenida Prof. Egas Moniz, 1649-028 Lisboa, Portugal., Ward RA; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K., Waring MJ; Northern Institute for Cancer Research, Chemistry, School of Natural and Environmental Sciences, Newcastle University, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K., Kettle JG; Oncology R&D, AstraZeneca, Cambridge CB4 0WG, U.K.

المصدر: Journal of the American Chemical Society [J Am Chem Soc] 2020 Jun 10; Vol. 142 (23), pp. 10358-10372. Date of Electronic Publication: 2020 Jun 02.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

مواضيع طبية MeSH: Benzoxazines/*pharmacology , Janus Kinase 3/*antagonists & inhibitors , Protein Kinase Inhibitors/*pharmacology , Quinazolines/*pharmacology, Benzoxazines/chemical synthesis ; Benzoxazines/chemistry ; Humans ; Janus Kinase 3/metabolism ; Models, Molecular ; Molecular Structure ; Protein Kinase Inhibitors/chemical synthesis ; Protein Kinase Inhibitors/chemistry ; Quinazolines/chemical synthesis ; Quinazolines/chemistry