المؤلفون: Rees, MG, Seashore-Ludlow, B, Cheah, JH, Adams, DJ, Price, EV, Gill, S, Javaid, S, Coletti, ME, Jones, VL, Bodycombe, NE, Soule, CK, Alexander, B, Li, A, Montgomery, P, Kotz, JD, Hon, CSY, Munoz, B, Liefeld, T, Dancik, V, Haber, DA, Clish, CB, Bittker, JA, Palmer, M, Wagner, BK, Clemons, PA, Shamji, AF, Schreiber, SL

المصدر: Nature chemical biology. 12(2):109

مصطلحات موضوعية: Medicin och hälsovetenskap

URL الوصول: http://kipublications.ki.se/Default.aspx?queryparsed=id:132916551

المؤلفون: Bray MA; Imaging Platform., Gustafsdottir SM; Chemical Biology and Therapeutics Science Program., Rohban MH; Imaging Platform., Singh S; Imaging Platform., Ljosa V; Imaging Platform., Sokolnicki KL; Imaging Platform., Bittker JA; Center for the Development of Therapeutics., Bodycombe NE; Chemical Biology and Therapeutics Science Program., Dancík V; Chemical Biology and Therapeutics Science Program., Hasaka TP; Center for the Development of Therapeutics., Hon CS; Chemical Biology and Therapeutics Science Program., Kemp MM; Chemical Biology and Therapeutics Science Program., Li K; Chemical Biology and Therapeutics Science Program., Walpita D; Chemical Biology and Therapeutics Science Program., Wawer MJ; Chemical Biology and Therapeutics Science Program., Golub TR; Cancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA, 02142., Schreiber SL; Chemical Biology and Therapeutics Science Program., Clemons PA; Chemical Biology and Therapeutics Science Program., Shamji AF; Chemical Biology and Therapeutics Science Program., Carpenter AE; Imaging Platform.

المصدر: GigaScience [Gigascience] 2017 Dec 01; Vol. 6 (12), pp. 1-5.

نوع المنشور: Dataset; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 101596872 Publication Model: Print Cited Medium: Internet ISSN: 2047-217X (Electronic) Linking ISSN: 2047217X NLM ISO Abbreviation: Gigascience Subsets: MEDLINE

مواضيع طبية MeSH: Image Processing, Computer-Assisted* , Small Molecule Libraries*, Cell Line ; Cells/drug effects ; Cells/ultrastructure ; Humans

المؤلفون: Zhang F; Rare Disease Research Unit., Bodycombe NE; Medicine Design, Worldwide Research and Development, Pfizer, Cambridge, MA 02139, USA., Haskell KM; Pharmacokinetics, Dynamics and Metabolism - New Chemical Entities, Worldwide Research and Development, Pfizer, CT 06340, USA., Sun YL; Rare Disease Research Unit., Wang ET; Center for Neurogenetics, University of Florida, Gainesville, FL 32610, USA., Morris CA; Rare Disease Research Unit., Jones LH; Medicine Design, Worldwide Research and Development, Pfizer, Cambridge, MA 02139, USA., Wood LD; Rare Disease Research Unit., Pletcher MT; Rare Disease Research Unit.

المصدر: Human molecular genetics [Hum Mol Genet] 2017 Aug 15; Vol. 26 (16), pp. 3056-3068.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print Cited Medium: Internet ISSN: 1460-2083 (Electronic) Linking ISSN: 09646906 NLM ISO Abbreviation: Hum Mol Genet Subsets: MEDLINE

مواضيع طبية MeSH: Myotonic Dystrophy/*drug therapy , Myotonic Dystrophy/*metabolism , Myotonin-Protein Kinase/*genetics , RNA-Binding Proteins/*biosynthesis , RNA-Binding Proteins/*genetics , Small Molecule Libraries/*pharmacology, 3' Untranslated Regions ; Alternative Splicing ; Exons ; Flow Cytometry/methods ; HeLa Cells ; Humans ; Myotonic Dystrophy/genetics ; Myotonin-Protein Kinase/metabolism ; RNA Precursors/metabolism ; RNA Splicing/drug effects ; RNA-Binding Proteins/metabolism ; Trinucleotide Repeat Expansion ; Trinucleotide Repeats

المؤلفون: Seashore-Ludlow B; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Rees MG; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Cheah JH; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Cokol M; Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul, Turkey., Price EV; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Coletti ME; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Jones V; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Bodycombe NE; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Soule CK; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Gould J; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Alexander B; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Li A; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Montgomery P; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Wawer MJ; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Kuru N; Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul, Turkey., Kotz JD; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Hon CS; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Munoz B; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Liefeld T; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Dančík V; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Bittker JA; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Palmer M; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts., Bradner JE; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts. Cancer Biology and Medical Oncology, Harvard Medical School, Boston, Massachusetts., Shamji AF; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts. pclemons@broadinstitute.org stuart_schreiber@harvard.edu ashamji@broadinstitute.org., Clemons PA; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts. pclemons@broadinstitute.org stuart_schreiber@harvard.edu ashamji@broadinstitute.org., Schreiber SL; Center for the Science of Therapeutics, Broad Institute, Cambridge, Massachusetts.

المصدر: Cancer discovery [Cancer Discov] 2015 Nov; Vol. 5 (11), pp. 1210-23. Date of Electronic Publication: 2015 Oct 19.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE

مواضيع طبية MeSH: Drug Screening Assays, Antitumor* , Small Molecule Libraries*, Computational Biology/*methods , Drug Resistance, Neoplasm/*genetics , Gene Expression Regulation, Neoplastic/*drug effects , Neoplasms/*genetics, Antineoplastic Agents/pharmacology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Cluster Analysis ; Datasets as Topic ; Dose-Response Relationship, Drug ; Drug Synergism ; Humans ; Mutation ; Neoplasms/drug therapy ; Protein Kinase Inhibitors/pharmacology

المؤلفون: Wawer MJ; Center for the Science of Therapeutics., Li K; Center for the Science of Therapeutics., Gustafsdottir SM; Center for the Science of Therapeutics., Ljosa V; Imaging Platform., Bodycombe NE; Center for the Science of Therapeutics., Marton MA; Genomics Platform., Sokolnicki KL; Imaging Platform., Bray MA; Imaging Platform., Kemp MM; Center for the Science of Therapeutics., Winchester E; Genomics Platform., Taylor B; Genomics Platform., Grant GB; Genomics Platform., Hon CS; Center for the Science of Therapeutics., Duvall JR; Center for the Development of Therapeutics, and., Wilson JA; Center for the Science of Therapeutics., Bittker JA; Center for the Development of Therapeutics, and., Dančík V; Center for the Science of Therapeutics,Mathematical Institute of the Slovak Academy of Sciences, 04001 Košice, Slovak Republic., Narayan R; Cancer Program, Broad Institute, Cambridge, MA 02142; and., Subramanian A; Cancer Program, Broad Institute, Cambridge, MA 02142; and., Winckler W; Genomics Platform., Golub TR; Cancer Program, Broad Institute, Cambridge, MA 02142; and., Carpenter AE; Imaging Platform., Shamji AF; Center for the Science of Therapeutics., Schreiber SL; Center for the Science of Therapeutics, stuart_schreiber@harvard.edu pclemons@broadinstitute.org., Clemons PA; Center for the Science of Therapeutics, stuart_schreiber@harvard.edu pclemons@broadinstitute.org.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2014 Jul 29; Vol. 111 (30), pp. 10911-6. Date of Electronic Publication: 2014 Jul 14.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Gene Expression Profiling*, Drug Evaluation, Preclinical/*methods , Gene Expression Regulation/*drug effects, Cell Line, Tumor ; Humans

المؤلفون: Dančík V; Center for the Science of Therapeutics, Broad Institute of Harvard and MIT, Cambridge, MA, USA Mathematical Institute of the Slovak Academy of Sciences, Košice, Slovakia (on leave)., Carrel H; Center for the Science of Therapeutics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Bodycombe NE; Center for the Science of Therapeutics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Seiler KP; Center for the Science of Therapeutics, Broad Institute of Harvard and MIT, Cambridge, MA, USA Champlain College, Division of Information Technology & Sciences, Burlington, VT, USA., Fomina-Yadlin D; Center for the Science of Therapeutics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Kubicek ST; Center for the Science of Therapeutics, Broad Institute of Harvard and MIT, Cambridge, MA, USA CeMM Research Center for Molecular Medicine, Vienna, Austria., Hartwell K; Cancer Program, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Shamji AF; Center for the Science of Therapeutics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Wagner BK; Center for the Science of Therapeutics, Broad Institute of Harvard and MIT, Cambridge, MA, USA., Clemons PA; Center for the Science of Therapeutics, Broad Institute of Harvard and MIT, Cambridge, MA, USA pclemons@broadinstitute.org.

المصدر: Journal of biomolecular screening [J Biomol Screen] 2014 Jun; Vol. 19 (5), pp. 771-81. Date of Electronic Publication: 2014 Jan 24.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Sage Publications Country of Publication: United States NLM ID: 9612112 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-454X (Electronic) Linking ISSN: 10870571 NLM ISO Abbreviation: J Biomol Screen Subsets: MEDLINE

مواضيع طبية MeSH: Drug Evaluation, Preclinical/*methods , High-Throughput Screening Assays/*methods , Small Molecule Libraries/*chemistry, Algorithms ; Animals ; Bayes Theorem ; Cell Line, Tumor ; Cluster Analysis ; Humans ; Membrane Potential, Mitochondrial ; Mice ; Models, Molecular ; Phenotype ; Reproducibility of Results

المؤلفون: Basu A; The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Bodycombe NE; The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Cheah JH; The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Price EV; The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Liu K; The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Schaefer GI; The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Ebright RY; The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Stewart ML; The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Ito D; The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Wang S; The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Bracha AL; The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Liefeld T; The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Wawer M; The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Gilbert JC; The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Wilson AJ; Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Stransky N; The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Kryukov GV; The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Dancik V; The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Barretina J; The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Garraway LA; The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Hon CS; The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Munoz B; The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Bittker JA; The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Stockwell BR; Columbia University, New York, NY 10027, USA., Khabele D; Vanderbilt University School of Medicine, Nashville, TN 37232, USA., Stern AM; The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA., Clemons PA; The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: pclemons@broadinstitute.org., Shamji AF; The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: ashamji@broadinstitute.org., Schreiber SL; The Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA. Electronic address: stuart_schreiber@harvard.edu.

المصدر: Cell [Cell] 2013 Aug 29; Vol. 154 (5), pp. 1151-1161.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Databases, Pharmaceutical* , Drug Discovery*, Neoplasms/*drug therapy, Antineoplastic Agents/chemistry ; Cell Line, Tumor ; Humans ; Neoplasms/genetics

المؤلفون: Swamidass SJ; Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA. swamidass@wustl.edu, Calhoun BT, Bittker JA, Bodycombe NE, Clemons PA

المصدر: Journal of chemical information and modeling [J Chem Inf Model] 2012 Jan 23; Vol. 52 (1), pp. 29-37. Date of Electronic Publication: 2011 Dec 20.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101230060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-960X (Electronic) Linking ISSN: 15499596 NLM ISO Abbreviation: J Chem Inf Model Subsets: MEDLINE

مواضيع طبية MeSH: Caenorhabditis elegans Proteins/*antagonists & inhibitors , Chromosomal Proteins, Non-Histone/*antagonists & inhibitors , Drug Discovery/*methods , Jumonji Domain-Containing Histone Demethylases/*antagonists & inhibitors, Algorithms ; Animals ; Caenorhabditis elegans ; Caenorhabditis elegans Proteins/chemistry ; Chromosomal Proteins, Non-Histone/chemistry ; High-Throughput Screening Assays ; Humans ; Jumonji Domain-Containing Histone Demethylases/chemistry ; Models, Molecular ; Small Molecule Libraries

المؤلفون: Seiler KP; The Broad Institute, Chemical Biology Program, Cambridge, MA 02140, USA., Bodycombe NE, Hawkins T, Shell R, Lemon A, de Souza A, Clemons PA

المصدر: Combinatorial chemistry & high throughput screening [Comb Chem High Throughput Screen] 2011 Nov; Vol. 14 (9), pp. 749-56.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 9810948 Publication Model: Print Cited Medium: Internet ISSN: 1875-5402 (Electronic) Linking ISSN: 13862073 NLM ISO Abbreviation: Comb Chem High Throughput Screen Subsets: MEDLINE

مواضيع طبية MeSH: Information Storage and Retrieval*, Drug Discovery ; Models, Theoretical

المؤلفون: Wagner BK, Gilbert TJ, Hanai J, Imamura S, Bodycombe NE, Bon RS, Waldmann H, Clemons PA, Sukhatme VP, Mootha VK

المصدر: ACS chemical biology [ACS Chem Biol] 2011 Sep 16; Vol. 6 (9), pp. 900-4. Date of Electronic Publication: 2011 Jul 15.

نوع المنشور: Letter; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: High-Throughput Screening Assays/*methods , Hydroxymethylglutaryl-CoA Reductase Inhibitors/*adverse effects , Muscular Diseases/*chemically induced , Muscular Diseases/*prevention & control, Animals ; Carbazoles/pharmacology ; Cell Line ; Humans ; Molecular Structure ; Molecular Weight ; Muscle Fibers, Skeletal/drug effects ; Muscle Fibers, Skeletal/pathology ; Muscular Diseases/pathology ; Zebrafish