المؤلفون: Coskun T; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Sloop KW; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Loghin C; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Alsina-Fernandez J; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Urva S; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Bokvist KB; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Cui X; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Briere DA; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Cabrera O; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Roell WC; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Kuchibhotla U; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Moyers JS; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Benson CT; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., Gimeno RE; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA., D'Alessio DA; Division of Endocrinology, Metabolism, and Nutrition, Duke University Medical Center, Durham, NC, USA., Haupt A; Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA. Electronic address: haupt_axel@lilly.com.

المصدر: Molecular metabolism [Mol Metab] 2018 Dec; Vol. 18, pp. 3-14. Date of Electronic Publication: 2018 Oct 03.

نوع المنشور: Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-8778 (Electronic) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: MEDLINE

مواضيع طبية MeSH: Diabetes Mellitus, Type 2/*drug therapy , Gastric Inhibitory Polypeptide/*therapeutic use , Glucagon-Like Peptide-1 Receptor/*agonists , Hypoglycemic Agents/*therapeutic use , Incretins/*therapeutic use , Receptors, Gastrointestinal Hormone/*agonists, Adult ; Animals ; Appetite/drug effects ; Blood Glucose/metabolism ; Body Weight ; Diarrhea/etiology ; Female ; Gastric Inhibitory Polypeptide/adverse effects ; Gastric Inhibitory Polypeptide/pharmacology ; Humans ; Hypoglycemic Agents/adverse effects ; Hypoglycemic Agents/pharmacology ; Incretins/adverse effects ; Incretins/pharmacology ; Male ; Mice ; Mice, Inbred C57BL ; Middle Aged ; Vomiting/etiology

المؤلفون: Templin AT; Department of Medicine, VA Puget Sound Health Care System, 1660 S. Columbian Way, Seattle, WA, 98108, USA. templin@uw.edu.; University of Washington, Seattle, WA, USA. templin@uw.edu., Meier DT; Department of Medicine, VA Puget Sound Health Care System, 1660 S. Columbian Way, Seattle, WA, 98108, USA.; University of Washington, Seattle, WA, USA., Willard JR; Department of Medicine, VA Puget Sound Health Care System, 1660 S. Columbian Way, Seattle, WA, 98108, USA.; University of Washington, Seattle, WA, USA., Wolden-Hanson T; Department of Medicine, VA Puget Sound Health Care System, 1660 S. Columbian Way, Seattle, WA, 98108, USA., Conway K; Avid Radiopharmaceuticals, Inc., Philadelphia, PA, USA., Lin YG; Avid Radiopharmaceuticals, Inc., Philadelphia, PA, USA., Gillespie PJ; Eli Lilly Research Laboratories, Indianapolis, IN, USA., Bokvist KB; Eli Lilly Research Laboratories, Indianapolis, IN, USA., Attardo G; Avid Radiopharmaceuticals, Inc., Philadelphia, PA, USA., Kahn SE; Department of Medicine, VA Puget Sound Health Care System, 1660 S. Columbian Way, Seattle, WA, 98108, USA.; University of Washington, Seattle, WA, USA., Scheuner D; Eli Lilly Research Laboratories, Indianapolis, IN, USA., Hull RL; Department of Medicine, VA Puget Sound Health Care System, 1660 S. Columbian Way, Seattle, WA, 98108, USA.; University of Washington, Seattle, WA, USA.

المصدر: Diabetologia [Diabetologia] 2018 Oct; Vol. 61 (10), pp. 2215-2224. Date of Electronic Publication: 2018 Jul 25.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0006777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0428 (Electronic) Linking ISSN: 0012186X NLM ISO Abbreviation: Diabetologia Subsets: MEDLINE

مواضيع طبية MeSH: Positron-Emission Tomography*, Amyloid/*chemistry , Aniline Compounds/*pharmacology , Ethylene Glycols/*pharmacology , Islets of Langerhans/*diagnostic imaging, Animals ; Body Composition ; Calorimetry, Indirect ; Fluorine Radioisotopes/pharmacology ; Gene Expression Regulation ; Glucose Clamp Technique ; Glucose Tolerance Test ; Hypothalamus/metabolism ; Insulin/metabolism ; Insulin Resistance ; Ligands ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Polymerase Chain Reaction ; Protein Tyrosine Phosphatase, Non-Receptor Type 1/metabolism ; Signal Transduction

المؤلفون: Farb TB; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Adeva M; Centro de Investigacion Lilly, Eli Lilly and Company, 28108-Alcobendas, Madrid, Spain., Beauchamp TJ; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Cabrera O; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Coates DA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Meredith TD; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Droz BA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Efanov A; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Ficorilli JV; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Gackenheimer SL; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Martinez-Grau MA; Centro de Investigacion Lilly, Eli Lilly and Company, 28108-Alcobendas, Madrid, Spain., Molero V; Centro de Investigacion Lilly, Eli Lilly and Company, 28108-Alcobendas, Madrid, Spain., Ruano G; Centro de Investigacion Lilly, Eli Lilly and Company, 28108-Alcobendas, Madrid, Spain., Statnick MA; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Suter TM; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Syed SK; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Toledo MA; Centro de Investigacion Lilly, Eli Lilly and Company, 28108-Alcobendas, Madrid, Spain., Willard FS; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Zhou X; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Bokvist KB; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285., Barrett DG; Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285.

المصدر: Endocrinology [Endocrinology] 2017 Nov 01; Vol. 158 (11), pp. 3859-3873.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375040 Publication Model: Print Cited Medium: Internet ISSN: 1945-7170 (Electronic) Linking ISSN: 00137227 NLM ISO Abbreviation: Endocrinology Subsets: MEDLINE

مواضيع طبية MeSH: Benzoates/*pharmacology , Glucagon-Like Peptide 1/*metabolism , Hypoglycemic Agents/*pharmacology , Insulin/*metabolism , Islets of Langerhans/*drug effects , Receptors, Somatostatin/*antagonists & inhibitors , Spiro Compounds/*pharmacology, Animals ; CHO Cells ; Cells, Cultured ; Cricetinae ; Cricetulus ; HEK293 Cells ; Humans ; Insulin Secretion ; Islets of Langerhans/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Rats ; Rats, Sprague-Dawley ; Rats, Zucker ; Receptors, Somatostatin/genetics ; Secretory Pathway/drug effects