لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

المؤلفون: Seo JE; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA., Le Y; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA., Revollo J; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA., Miranda-Colon J; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA., Xu H; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA., McKinzie P; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA., Mei N; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA., Chen T; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA., Heflich RH; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA., Zhou T; Center for Veterinary Medicine, U.S. Food and Drug Administration, Rockville, MD, 20855, USA., Robison T; Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, 20993, USA., Bonzo JA; Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, 20993, USA., Guo X; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, 72079, USA. Xiaoqing.Guo@fda.hhs.gov.

المصدر: Archives of toxicology [Arch Toxicol] 2024 Jun; Vol. 98 (6), pp. 1919-1935. Date of Electronic Publication: 2024 Apr 07.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Springer-Verlag Country of Publication: Germany NLM ID: 0417615 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-0738 (Electronic) Linking ISSN: 03405761 NLM ISO Abbreviation: Arch Toxicol Subsets: MEDLINE

مواضيع طبية MeSH: Dimethylnitrosamine*/toxicity , High-Throughput Nucleotide Sequencing* , Comet Assay*/methods , Micronucleus Tests*/methods , Mutagens*/toxicity , DNA Damage*/drug effects, Humans ; Spheroids, Cellular/drug effects ; Mutagenicity Tests/methods ; Cell Culture Techniques ; Cell Line ; Hepatocytes/drug effects ; Mutagenesis/drug effects ; Mutation ; Dose-Response Relationship, Drug

المؤلفون: Tomlinson L; Global Pathology, Pfizer Inc., Cambridge, MA, 02140, USA., Ramsden D; DMPK Oncology, AstraZeneca, Boston, MA, 02451, USA., Leite SB; European Commission Joint Research Centre, Ispra, 21027, Italy., Beken S; Federal Agency for Medicines and Health Products, Brussels, 1210, Belgium., Bonzo JA; Center for Drug Evaluation and Research, Office of New Drugs, U.S. Food and Drug Administration, Silver Spring, MD, 20993, USA., Brown P; Center for Drug Evaluation and Research, Office of New Drugs, U.S. Food and Drug Administration, Silver Spring, MD, 20993, USA., Candarlioglu PL; Complex In Vitro Models, GSK, Stevenage, SG1 2NY, UK., Chan TS; Drug Metabolism and Pharmacokinetics, Boehringer Ingelheim Pharmaceuticals Inc., Ridgefield, CT, 06877, USA., Chen E; DMPK, Genentech, South San Francisco, CA, 94080, USA., Choi CK; Preclinical Safety, Biogen, Cambridge, MA, 02142, USA., David R; Clinical Pharmacology & Safety Sciences, AstraZeneca, Cambridge, CB2 0AA, UK., Delrue N; Organisation for Economic Co-operation and Development, Paris, 75016, France., Devine PJ; Discovery Toxicology, Bristol Myers Squibb, San Diego, CA, 09130, USA., Ford K; Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, 20993, USA., Garcia MI; Division of Applied Regulatory Science, Office of Clinical Pharmacology, Office of Translational Science, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, 20993, USA., Gosset JR; DMPK, Pfizer Inc., Cambridge, MA, 02139, USA., Hewitt P; Chemical and Preclinical Safety, Merck Healthcare KGaA, 64293, Darmstadt, Germany., Homan K; Complex in Vitro Systems Group, Genentech, South San Francisco, CA, 94080, USA., Irrechukwu O; Preclinical Sciences and Translational Safety, Johnson and Johnson Innovation Medicine, Spring House, PA, 19002, USA., Kopec AK; Drug Safety Research & Development, Pfizer Inc., Groton, CT, 06340, USA., Liras JL; Pharmacokinetics, Dynamics & Metabolism-Medicine Design, Pfizer, Cambridge, MA, 02139, USA., Mandlekar S; Clinical Pharmacology, Genentech, South San Francisco, CA, 94080, USA., Raczynski A; Preclinical Safety Assessment, Vertex Pharmaceuticals Inc., Boston, MA, 02210, USA., Sadrieh N; Center for Drug Evaluation and Research, Office of New Drugs, U.S. Food and Drug Administration, Silver Spring, MD, 20993, USA., Sakatis MZ; Non-Clinical Safety, In Vitro/In Vivo Translation, GSK R&D, Ware, SG12 9TJ, UK., Siegel J; Center for Drug Evaluation and Research, Office of New Drugs, U.S. Food and Drug Administration, Silver Spring, MD, 20993, USA., Sung K; Center for Biologics Evaluation and Research, Office of Cellular Therapy and Human Tissue, Cellular and Tissue Therapy Branch, U.S. Food and Drug Administration, Silver Spring, MD, 20993, USA., Sunyovszki I; Translational Cellular Sciences, Biogen, Cambridge, MA, 02142, USA., Van Vleet TR; AbbVie, Inc., North Chicago, IL, 60064, USA., Ekert JE; UCB Pharma, Cambridge, MA, 02140, USA., Hardwick RN; Discovery Toxicology, Bristol Myers Squibb, San Diego, CA, 09130, USA.

المصدر: Advanced biology [Adv Biol (Weinh)] 2023 Oct 09, pp. e2300131. Date of Electronic Publication: 2023 Oct 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-VCH GmbH Country of Publication: Germany NLM ID: 101775319 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2701-0198 (Electronic) Linking ISSN: 27010198 NLM ISO Abbreviation: Adv Biol (Weinh) Subsets: MEDLINE

المؤلفون: Zolfaghari R; Department of Nutritional Sciences, Pennsylvania State University, University Park, PA 16802, USA., Bonzo JA; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20814, USA., Gonzalez FJ; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20814, USA., Ross AC; Department of Nutritional Sciences, Pennsylvania State University, University Park, PA 16802, USA.

المصدر: International journal of molecular sciences [Int J Mol Sci] 2023 May 11; Vol. 24 (10). Date of Electronic Publication: 2023 May 11.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

مواضيع طبية MeSH: Hepatocyte Nuclear Factor 4*/genetics , Hepatocyte Nuclear Factor 4*/metabolism , Hepatocytes*/metabolism , Tretinoin*/pharmacology , Receptors, Retinoic Acid*/genetics, Animals ; Humans ; Mice ; Glucose ; Lipids ; Retinoic Acid Receptor alpha/genetics

المؤلفون: Boyce M; Center for Computational Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, Durham, NC, United States., Favela KA; Southwest Research Institute, San Antonio, TX, United States., Bonzo JA; Thermo Fisher Scientific, South San Francisco, CA, United States., Chao A; Center for Computational Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, Durham, NC, United States., Lizarraga LE; Center for Public Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Cincinnati, OH, United States., Moody LR; Thermo Fisher Scientific, South San Francisco, CA, United States., Owens EO; Center for Public Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Cincinnati, OH, United States., Patlewicz G; Center for Computational Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, Durham, NC, United States., Shah I; Center for Computational Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, Durham, NC, United States., Sobus JR; Center for Computational Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, Durham, NC, United States., Thomas RS; Center for Computational Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, Durham, NC, United States., Williams AJ; Center for Computational Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, Durham, NC, United States., Yau A; Southwest Research Institute, San Antonio, TX, United States., Wambaugh JF; Center for Computational Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, Durham, NC, United States.

المصدر: Frontiers in toxicology [Front Toxicol] 2023 Jan 18; Vol. 5, pp. 1051483. Date of Electronic Publication: 2023 Jan 18 (Print Publication: 2023).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101777990 Publication Model: eCollection Cited Medium: Internet ISSN: 2673-3080 (Electronic) Linking ISSN: 26733080 NLM ISO Abbreviation: Front Toxicol Subsets: PubMed not MEDLINE

المؤلفون: Li X; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA., Li Y; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA., Ning KG; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA.; Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, MD, USA., Chen S; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA., Guo L; Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA., Bonzo JA; Division of Pharmacology/Toxicology for Immunology and Inflammation, Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA., Mei N; Division of Genetic and Molecular Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA.

المصدر: Journal of environmental science and health. Part C, Toxicology and carcinogenesis [J Environ Sci Health C Toxicol Carcinog] 2022; Vol. 40 (1), pp. 106-118. Date of Electronic Publication: 2022 Mar 11.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

بيانات الدورية: Publisher: Taylor & Francis Group Country of Publication: United States NLM ID: 101766761 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2689-6591 (Electronic) NLM ISO Abbreviation: J Environ Sci Health C Toxicol Carcinog Subsets: MEDLINE

مواضيع طبية MeSH: DNA Damage* , Mammals*, Activation, Metabolic ; Animals ; Cell Line ; Humans ; Mutagenicity Tests/methods

المؤلفون: Franzosa JA; Center for Computational Toxicology and Exposure, Office of Research and Development, U.S. EPA, Research Triangle Park, NC, 27711, USA., Bonzo JA; Cell Biology, Biosciences Division, Thermo Fisher Scientific, Frederick, MD, 21703, USA., Jack J; Center for Computational Toxicology and Exposure, Office of Research and Development, U.S. EPA, Research Triangle Park, NC, 27711, USA., Baker NC; Leidos, Research Triangle Park, NC, 27711, USA., Kothiya P; Center for Computational Toxicology and Exposure, Office of Research and Development, U.S. EPA, Research Triangle Park, NC, 27711, USA., Witek RP; Cell Biology, Biosciences Division, Thermo Fisher Scientific, Frederick, MD, 21703, USA., Hurban P; Expression Analysis, Durham, NC, 27713, USA., Siferd S; Expression Analysis, Durham, NC, 27713, USA., Hester S; Center for Computational Toxicology and Exposure, Office of Research and Development, U.S. EPA, Research Triangle Park, NC, 27711, USA., Shah I; Center for Computational Toxicology and Exposure, Office of Research and Development, U.S. EPA, Research Triangle Park, NC, 27711, USA., Ferguson SS; Division of National Toxicology Program, National Institutes of Environmental Health Sciences of National Institutes of Health, Durham, NC, 27709, USA., Houck KA; Center for Computational Toxicology and Exposure, Office of Research and Development, U.S. EPA, Research Triangle Park, NC, 27711, USA., Wambaugh JF; Center for Computational Toxicology and Exposure, Office of Research and Development, U.S. EPA, Research Triangle Park, NC, 27711, USA. Wambaugh.john@epa.gov.

المصدر: NPJ systems biology and applications [NPJ Syst Biol Appl] 2021 Jan 27; Vol. 7 (1), pp. 7. Date of Electronic Publication: 2021 Jan 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group in partnership with SBI, The Systems Biology Institute Country of Publication: England NLM ID: 101677786 Publication Model: Electronic Cited Medium: Internet ISSN: 2056-7189 (Electronic) Linking ISSN: 20567189 NLM ISO Abbreviation: NPJ Syst Biol Appl Subsets: MEDLINE

مواضيع طبية MeSH: Hepatocytes/*drug effects , High-Throughput Screening Assays/*methods , Toxicogenetics/*methods, Bayes Theorem ; Cell Culture Techniques ; Cell Line ; Humans ; Liver/cytology ; Small Molecule Libraries ; Transcription Factors/drug effects ; Transcriptome/genetics

المؤلفون: Brocker CN; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20814, USA., Kim D; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20814, USA., Melia T; Department of Biology and Bioinformatics Program, Boston University, Boston, MA, 02215, USA., Karri K; Department of Biology and Bioinformatics Program, Boston University, Boston, MA, 02215, USA., Velenosi TJ; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20814, USA., Takahashi S; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20814, USA.; Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC, 20057, USA., Aibara D; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20814, USA., Bonzo JA; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20814, USA., Levi M; Biochemistry and Molecular & Cellular Biology, Georgetown University, Washington, DC, 20057, USA., Waxman DJ; Department of Biology and Bioinformatics Program, Boston University, Boston, MA, 02215, USA., Gonzalez FJ; Laboratory of Metabolism, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20814, USA. gonzalef@mail.nih.gov.

المصدر: Nature communications [Nat Commun] 2020 Nov 17; Vol. 11 (1), pp. 5847. Date of Electronic Publication: 2020 Nov 17.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Inflammasomes/*genetics , Liver/*pathology , PPAR alpha/*agonists , RNA, Long Noncoding/*metabolism, Animals ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Cells, Cultured ; Fasting ; Gene Expression Regulation ; HEK293 Cells ; Humans ; Inflammasomes/metabolism ; Liver/drug effects ; Liver/metabolism ; Male ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; PPAR alpha/genetics ; PPAR alpha/metabolism ; Peroxisome Proliferators/pharmacology ; Promoter Regions, Genetic ; Pyrimidines/pharmacology ; RNA, Long Noncoding/genetics ; Thioredoxins/genetics ; Thioredoxins/metabolism

المؤلفون: Avila AM; Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD, 20903, United States., Bebenek I; Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD, 20903, United States., Bonzo JA; Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD, 20903, United States., Bourcier T; Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD, 20903, United States., Davis Bruno KL; Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD, 20903, United States., Carlson DB; Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD, 20903, United States., Dubinion J; Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD, 20903, United States., Elayan I; Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD, 20903, United States., Harrouk W; Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD, 20903, United States., Lee SL; Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD, 20903, United States., Mendrick DL; National Center for Toxicological Research, US Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD, 20903, United States., Merrill JC; Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD, 20903, United States., Peretz J; Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD, 20903, United States., Place E; Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD, 20903, United States., Saulnier M; Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD, 20903, United States., Wange RL; Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD, 20903, United States., Yao J; Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD, 20903, United States., Zhao D; Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD, 20903, United States., Brown PC; Center for Drug Evaluation and Research, US Food and Drug Administration, 10903 New Hampshire Ave., Silver Spring, MD, 20903, United States. Electronic address: Paul.Brown@fda.hhs.gov.

المصدر: Regulatory toxicology and pharmacology : RTP [Regul Toxicol Pharmacol] 2020 Jul; Vol. 114, pp. 104662. Date of Electronic Publication: 2020 Apr 20.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8214983 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0295 (Electronic) Linking ISSN: 02732300 NLM ISO Abbreviation: Regul Toxicol Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Pharmaceutical Preparations/*chemistry, Animals ; Drug Development ; Humans ; Risk Assessment ; United States ; United States Food and Drug Administration

المؤلفون: Muthusamy S; Division of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago , Chicago, Illinois., Jeong JJ; Division of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago , Chicago, Illinois., Cheng M; Division of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago , Chicago, Illinois., Bonzo JA; Center for Cancer Research, National Cancer Institute , Bethesda, Maryland., Kumar A; Division of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago , Chicago, Illinois., Gonzalez FJ; Center for Cancer Research, National Cancer Institute , Bethesda, Maryland., Borthakur A; Division of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago , Chicago, Illinois., Dudeja PK; Division of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago , Chicago, Illinois.; Jesse Brown Veterans Affairs Medical Center , Chicago, Illinois., Saksena S; Division of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago , Chicago, Illinois.; Jesse Brown Veterans Affairs Medical Center , Chicago, Illinois., Malakooti J; Jesse Brown Veterans Affairs Medical Center , Chicago, Illinois.

المصدر: American journal of physiology. Gastrointestinal and liver physiology [Am J Physiol Gastrointest Liver Physiol] 2018 Jan 01; Vol. 314 (1), pp. G14-G21. Date of Electronic Publication: 2017 Sep 07.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901227 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1547 (Electronic) Linking ISSN: 01931857 NLM ISO Abbreviation: Am J Physiol Gastrointest Liver Physiol Subsets: MEDLINE

مواضيع طبية MeSH: Hepatocyte Nuclear Factor 4/*metabolism , Intestinal Mucosa/*metabolism , Sodium-Hydrogen Exchanger 3/*metabolism, Binding Sites ; Caco-2 Cells ; Gene Expression Regulation ; HCT116 Cells ; Hepatocyte Nuclear Factor 4/genetics ; Humans ; Promoter Regions, Genetic ; Protein Binding ; Sodium-Hydrogen Exchanger 3/genetics