المؤلفون: Venkadakrishnan VB; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Presser AG; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Singh R; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Booker MA; Department of Informatics and Analytics, Dana-Farber Cancer Institute, Boston, MA, USA., Traphagen NA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Weng K; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Boston College, Chestnut Hill, MA, USA., Voss NCE; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Belmont Hill School, Belmont, MA, USA., Mahadevan NR; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA., Mizuno K; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Puca L; Department of Medicine, Weill Cornell Medicine, New York, NY, USA., Idahor O; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard University, Cambridge, MA, USA., Ku SY; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Bakht MK; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA., Borah AA; The Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Urology, University of California at San Francisco, San Francisco, CA, USA.; Arc Institute, Palo Alto, CA, USA., Herbert ZT; Molecular Biology Core Facilities, Dana-Farber Cancer Institute, Boston, MA, USA., Tolstorukov MY; Department of Informatics and Analytics, Dana-Farber Cancer Institute, Boston, MA, USA., Barbie DA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA., Rickman DS; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA., Brown M; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA, USA., Beltran H; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. himisha_beltran@dfci.harvard.edu.; Harvard Medical School, Boston, MA, USA. himisha_beltran@dfci.harvard.edu.; The Broad Institute of MIT and Harvard, Cambridge, MA, USA. himisha_beltran@dfci.harvard.edu.

المصدر: Nature communications [Nat Commun] 2024 Aug 08; Vol. 15 (1), pp. 6779. Date of Electronic Publication: 2024 Aug 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Enhancer of Zeste Homolog 2 Protein*/metabolism , Enhancer of Zeste Homolog 2 Protein*/genetics , Gene Expression Regulation, Neoplastic* , Prostatic Neoplasms*/genetics , Prostatic Neoplasms*/metabolism , Prostatic Neoplasms*/pathology, Male ; Humans ; Cell Line, Tumor ; Animals ; Adenocarcinoma/genetics ; Adenocarcinoma/metabolism ; Adenocarcinoma/pathology ; Drug Resistance, Neoplasm/genetics ; Cell Differentiation ; Prostatic Neoplasms, Castration-Resistant/genetics ; Prostatic Neoplasms, Castration-Resistant/metabolism ; Prostatic Neoplasms, Castration-Resistant/pathology ; Prostatic Neoplasms, Castration-Resistant/drug therapy ; Mice ; Cell Lineage

المؤلفون: Venkadakrishnan VB; Dana-Farber Cancer Institute., Presser AG; Dana-Farber Cancer Institute., Singh R; Weill Cornell Medicine., Booker MA; Dana-Farber Cancer Institute., Traphagen NA; Dana-Farber Cancer Institute., Weng K; Dana-Farber Cancer Institute., Voss NC; Dana-Farber Cancer Institute., Mahadevan NR; Dana-Farber Cancer Institute., Mizuno K; Dana Farber Cancer Institute., Puca L; Division of Medical Oncology, Weill Cornell Medicine., Idahor O; Dana-Farber Cancer Institute., Ku SY; Dana-Farber Cancer Institute., Bakht MK; Dana-Farber Cancer Institute., Borah AA; Broad Institute of Harvard and MIT., Herbert ZT; Dana-Farber Cancer Institute., Tolstorukov MY; Dana-Farber Cancer Institute., Barbie DA; Dana-Farber Cancer Institute., Rickman DS; Weill Cornell Medicine., Brown M; Dana-Farber Cancer Institute., Beltran H; Dana-Farber Cancer Institute.

المصدر: Research square [Res Sq] 2024 Mar 04. Date of Electronic Publication: 2024 Mar 04.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet ISSN: 2693-5015 (Electronic) Linking ISSN: 26935015 NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE

المؤلفون: Krill-Burger JM; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Dempster JM; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Borah AA; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Paolella BR; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Root DE; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Golub TR; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., Boehm JS; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Hahn WC; Broad Institute of Harvard and MIT, Cambridge, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA., McFarland JM; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Vazquez F; Broad Institute of Harvard and MIT, Cambridge, MA, USA. vazquez@broadinstitute.org.; Dana-Farber Cancer Institute, Boston, MA, USA. vazquez@broadinstitute.org., Tsherniak A; Broad Institute of Harvard and MIT, Cambridge, MA, USA.

المصدر: Genome biology [Genome Biol] 2023 Aug 23; Vol. 24 (1), pp. 192. Date of Electronic Publication: 2023 Aug 23.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 100960660 Publication Model: Electronic Cited Medium: Internet ISSN: 1474-760X (Electronic) Linking ISSN: 14747596 NLM ISO Abbreviation: Genome Biol Subsets: MEDLINE

مواضيع طبية MeSH: CRISPR-Cas Systems* , Neoplasms*/genetics, Humans ; Genetic Techniques ; RNA Interference ; Cell Line

المؤلفون: Cervia LD; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts., Shibue T; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Borah AA; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Gaeta B; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., He L; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Leung L; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Li N; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts., Moyer SM; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts., Shim BH; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts., Dumont N; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Gonzalez A; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Bick NR; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Kazachkova M; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Dempster JM; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Krill-Burger JM; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Piccioni F; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Udeshi ND; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Olive ME; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Carr SA; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Root DE; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., McFarland JM; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Vazquez F; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Hahn WC; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.

المصدر: Cancer discovery [Cancer Discov] 2023 Mar 01; Vol. 13 (3), pp. 766-795.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE

مواضيع طبية MeSH: Carcinoma*, Humans ; Ubiquitination ; Cell Line ; Signal Transduction ; Ubiquitins

المؤلفون: Pan J; Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02215, USA., Kwon JJ; Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02215, USA., Talamas JA; Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02215, USA., Borah AA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Vazquez F; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Boehm JS; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Tsherniak A; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Zitnik M; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Department of Biomedical Informatics, Boston, MA 02215, USA; Harvard University, Data Science Initiative, Cambridge, MA 02138, USA., McFarland JM; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Hahn WC; Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02215, USA; Brigham and Women's Hospital and Harvard Medical School, Department of Medicine, Boston, MA 02215, USA. Electronic address: william_hahn@dfci.harvard.edu.

المصدر: Cell systems [Cell Syst] 2022 Apr 20; Vol. 13 (4), pp. 286-303.e10. Date of Electronic Publication: 2022 Jan 31.

نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101656080 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2405-4720 (Electronic) Linking ISSN: 24054712 NLM ISO Abbreviation: Cell Syst Subsets: MEDLINE

مواضيع طبية MeSH: Genomics*/methods, Humans

المؤلفون: Raghavan S; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Winter PS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: pswinter@mit.edu., Navia AW; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Williams HL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA., DenAdel A; Center for Computational Molecular Biology, Brown University, Providence, RI 02912, USA; Division of Applied Mathematics, Brown University, Providence, RI 02912, USA., Lowder KE; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Galvez-Reyes J; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Kalekar RL; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Mulugeta N; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Kapner KS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Raghavan MS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Borah AA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Liu N; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Väyrynen SA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA., Costa AD; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA., Ng RWS; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Wang J; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Hill EK; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Ragon DY; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Brais LK; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Jaeger AM; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Spurr LF; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Li YY; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Cherniack AD; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA., Booker MA; Department of Informatics and Analytics, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Cohen EF; Department of Informatics and Analytics, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Tolstorukov MY; Department of Informatics and Analytics, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Wakiro I; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Rotem A; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Johnson BE; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA 02215, USA., McFarland JM; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Sicinska ET; Harvard Medical School, Boston, MA 02115, USA; Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Jacks TE; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA., Sullivan RJ; Harvard Medical School, Boston, MA 02115, USA; Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA., Shapiro GI; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Clancy TE; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Surgery, Brigham and Women's Hospital, Boston, MA 02115, USA., Perez K; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Rubinson DA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Ng K; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Cleary JM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Crawford L; Center for Computational Molecular Biology, Brown University, Providence, RI 02912, USA; Department of Biostatistics, Brown University, Providence, RI 02912, USA; Microsoft Research New England, Cambridge, MA 02142, USA., Manalis SR; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02142, USA., Nowak JA; Harvard Medical School, Boston, MA 02115, USA; Center for Cancer Genomics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA., Wolpin BM; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Hahn WC; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA., Aguirre AJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA. Electronic address: andrew_aguirre@dfci.harvard.edu., Shalek AK; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Harvard Medical School, Boston, MA 02115, USA; Institute for Medical Engineering & Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA 02139, USA. Electronic address: shalek@mit.edu.

المصدر: Cell [Cell] 2021 Dec 09; Vol. 184 (25), pp. 6119-6137.e26.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

مواضيع طبية MeSH: Tumor Microenvironment*, Biomarkers, Tumor/*metabolism , Carcinoma, Pancreatic Ductal/*metabolism , Pancreatic Neoplasms/*metabolism, Adult ; Aged ; Cell Line, Tumor ; Female ; Gene Expression Regulation, Neoplastic ; Humans ; Male ; Middle Aged ; Single-Cell Analysis

المؤلفون: van Wietmarschen N; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Sridharan S; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Nathan WJ; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA.; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK., Tubbs A; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Chan EM; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Callen E; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Wu W; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Belinky F; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Tripathi V; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Wong N; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA., Foster K; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Noorbakhsh J; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Garimella K; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Cruz-Migoni A; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK., Sommers JA; Laboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, MD, USA., Huang Y; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Borah AA; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Smith JT; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Kalfon J; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Kesten N; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Harvard Medical School, Cambridge, MA, USA., Fugger K; DNA Recombination and Repair Laboratory, The Francis Crick Institute, London, UK., Walker RL; Genetics Branch, National Cancer Institute, NIH, Bethesda, MD, USA., Dolzhenko E; Illumina Inc., San Diego, CA, USA., Eberle MA; Illumina Inc., San Diego, CA, USA., Hayward BE; Laboratory of Cell and Molecular Biology, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, MD, USA., Usdin K; Laboratory of Cell and Molecular Biology, National Institute of Diabetes, Digestive and Kidney Diseases, NIH, Bethesda, MD, USA., Freudenreich CH; Department of Biology, Tufts University, Medford, MA, USA., Brosh RM Jr; Laboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, MD, USA., West SC; DNA Recombination and Repair Laboratory, The Francis Crick Institute, London, UK., McHugh PJ; Department of Oncology, MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, UK., Meltzer PS; Genetics Branch, National Cancer Institute, NIH, Bethesda, MD, USA., Bass AJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.; Broad Institute of Harvard and MIT, Cambridge, MA, USA., Nussenzweig A; Laboratory of Genome Integrity, National Cancer Institute, NIH, Bethesda, MD, USA. andre_nussenzweig@nih.gov.

المصدر: Nature [Nature] 2020 Oct; Vol. 586 (7828), pp. 292-298. Date of Electronic Publication: 2020 Sep 30.

نوع المنشور: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: DNA Breaks, Double-Stranded*, DNA Repeat Expansion/*genetics , Dinucleotide Repeats/*genetics , Neoplasms/*genetics , Werner Syndrome Helicase/*metabolism, Ataxia Telangiectasia Mutated Proteins/metabolism ; Cell Line, Tumor ; Chromosomes, Human/genetics ; Chromosomes, Human/metabolism ; Chromothripsis ; DNA Cleavage ; DNA Replication ; DNA-Binding Proteins/metabolism ; Endodeoxyribonucleases/metabolism ; Endonucleases/metabolism ; Genomic Instability ; Humans ; Recombinases/metabolism