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1
المؤلفون: Neng-Yang Shih, Joseph A. Maddry, Xiao Tong, Subramaniam Ananthan, Cheng Li, Jeremy Clark, Feng Geng, Hollis S. Kezar, Cecil D. Kwong, John J. Piwinski, Abhijit Roychowdhury, Robert C. Reynolds, Anita T. Fowler, Ashok Arasappan, Hsueh-Cheng Huang, John A. Secrist, F. George Njoroge, Boris Feld
المصدر: Bioorganic & Medicinal Chemistry Letters. 22:1160-1164
مصطلحات موضوعية: Clinical Biochemistry, Substituent, Pharmaceutical Science, RNA-dependent RNA polymerase, Stereoisomerism, Hepacivirus, Microbial Sensitivity Tests, Virus Replication, Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, In vivo, Drug Discovery, Animals, Potency, Structure–activity relationship, Moiety, Replicon, Molecular Biology, Dose-Response Relationship, Drug, Molecular Structure, Organic Chemistry, Hepatitis C, Virology, Rats, Pyrimidines, chemistry, Molecular Medicine
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2
المؤلفون: Boris Feld, Robert A. Ogert, John A. Howe, Andrew Prongay, Yan Hou, Debra E. Mcguinness, Charles A. Lunn, Paul Ingravallo
المصدر: SLAS Discovery. 13:406-414
مصطلحات موضوعية: Drug Evaluation, Preclinical, HIV Integrase, Biochemistry, Analytical Chemistry, Core domain, Protein–protein interaction, Acquired immunodeficiency syndrome (AIDS), medicine, Humans, HIV Integrase Inhibitors, Dna viral, DNA Primers, Base Sequence, biology, Chemistry, Assay, virus diseases, medicine.disease, Virology, Integrase, biology.protein, Intercellular Signaling Peptides and Proteins, Molecular Medicine, Biotechnology, Binding domain
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7428660800eae98ffa5a03704f229052
https://doi.org/10.1177/1087057108317060 -
3
المؤلفون: Cynthia Kravec, John Pichardo, Patricia McMonagle, E. Barrabee, Lynn Miesel, Alan Tianpei Xin, Boris Feld, Robert E. Palermo, Sarah Ma
المصدر: Analytical Biochemistry. 366:9-17
مصطلحات موضوعية: Adenosine, DNA Ligases, Biophysics, Biotin, Eukaryotic DNA replication, Biology, Ligands, Biochemistry, Chemistry Techniques, Analytical, chemistry.chemical_compound, Adenosine Triphosphate, Escherichia coli, Enzyme Inhibitors, Ligase chain reaction, Molecular Biology, chemistry.chemical_classification, DNA ligase, Base Sequence, Reproducibility of Results, DNA, Cell Biology, NAD, Adenosine Monophosphate, Sequencing by ligation, Kinetics, Scintillation proximity assay, chemistry, Phosphodiester bond, Scintillation Counting, Streptavidin, NAD+ kinase
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4
المؤلفون: Kevin J. Curran, Boris Feld, Amar S. Prashad, Anita Y. M. Howe, John O'Connell, Martin Joseph Digrandi, Atul Agarwal, Alan G. Sutherland, Bloom Jonathan David, Bernard Dean Johnson, Thomas Nittoli, Shabana Insaf, Rajiv Chopra, Mark Orlowski, Karen L. Wheless, M. Brawner Floyd, Tarek S. Mansour
المصدر: Journal of Medicinal Chemistry. 50:2108-2116
مصطلحات موضوعية: Models, Molecular, Molecular model, Stereochemistry, viruses, Hepatitis C virus, Allosteric regulation, Hepacivirus, Viral Nonstructural Proteins, Crystallography, X-Ray, Virus Replication, medicine.disease_cause, Antiviral Agents, Cell Line, Structure-Activity Relationship, chemistry.chemical_compound, Allosteric Regulation, Drug Discovery, Anthranilic acid, medicine, Humans, ortho-Aminobenzoates, NS5B, chemistry.chemical_classification, Binding Sites, biology, virus diseases, Active site, biochemical phenomena, metabolism, and nutrition, digestive system diseases, Enzyme, chemistry, Biochemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Replicon
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5
المؤلفون: John O'Connell, Kevin J. Curran, Kristine Svenson, Anita Y. M. Howe, Kitae Lim, Steven F. Sukits, Mengxiao Shi, Ariamala Gopalsamy, Boris Feld, Girija Krishnamurthy, Rajiv Chopra, Tarek S. Mansour, Atul Agarwal, Mark Orlowski, Joel Bard, John W. Ellingboe, Gregory Ciszewski
المصدر: Journal of Medicinal Chemistry. 49:3052-3055
مصطلحات موضوعية: Models, Molecular, Proline, Hepatitis C virus, Molecular Conformation, Viral Nonstructural Proteins, Crystallography, X-Ray, medicine.disease_cause, Antiviral Agents, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, medicine, Transferase, Binding site, NS5B, chemistry.chemical_classification, Sulfonamides, Binding Sites, biology, virus diseases, Active site, Molecular biology, digestive system diseases, Enzyme, chemistry, Biochemistry, Enzyme inhibitor, RNA Polymerase Inhibitor, biology.protein, Molecular Medicine
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6
المؤلفون: Srinivas K. Chunduru, John W. Ellingboe, Huiming Cheng, Boris Feld, John O'Connell, Carl J. Baldick, Matthew W. Olson, Ian J. Thompson, Tarek S. Mansour, Michelle L. Kimberland, Marja van Zeijl, Girija Krisnamurthy, Christopher A. Benetatos, Joel S. Christensen, Dorothy C. Young, Ariamala Gopalsamy, Mark Orlowski, Steve Swanberg, Glen A. Coburn, Megan Thorn, Alfred M. Del Vecchio, Johnathan Bloom, Xiaoqun Jiang, S V Johann, Janis Upeslacis, Marc S. Collett, William P. Gorczyca, Anita Y. M. Howe, Steve Herrmann
المصدر: Antimicrobial Agents and Chemotherapy
مصطلحات موضوعية: Indoles, Hepatitis C virus, Drug Evaluation, Preclinical, RNA-dependent RNA polymerase, DNA-Directed DNA Polymerase, Hepacivirus, Viral Nonstructural Proteins, Biology, medicine.disease_cause, Antiviral Agents, Virus, Substrate Specificity, chemistry.chemical_compound, Cytopathogenic Effect, Viral, RNA polymerase, Chlorocebus aethiops, Escherichia coli, medicine, Animals, Humans, Pharmacology (medical), Enzyme Inhibitors, Vero Cells, NS5B, Cells, Cultured, Polymerase, Pyrans, Pharmacology, Interferon-alpha, virus diseases, RNA, RNA-Dependent RNA Polymerase, Virology, Molecular biology, HIV Reverse Transcriptase, digestive system diseases, Reverse transcriptase, Spectrometry, Fluorescence, Infectious Diseases, chemistry, biology.protein, Replicon
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b3750639fe4a595b533d24806055005
https://doi.org/10.1128/aac.48.12.4813-4821.2004 -
7
المؤلفون: Gregory Ciszewski, John W. Ellingboe, Yelena Pyatski, Ariamala Gopalsamy, Tarek S. Mansour, Kaapjoo Park, Girija Krishnamurthy, Anita Y. M. Howe, Murthy Damarla, Janis Upeslacis, Douglas M. Ho, Boris Feld, Bloom Jonathan David, Kitae Lim, John O'Connell, Mark Orlowski, Shabana Insaf
المصدر: Journal of Medicinal Chemistry. 47:6603-6608
مصطلحات موضوعية: Indoles, viruses, Hepatitis C virus, Hepacivirus, Viral Nonstructural Proteins, Crystallography, X-Ray, medicine.disease_cause, Antiviral Agents, Structure-Activity Relationship, chemistry.chemical_compound, RNA polymerase, Drug Discovery, medicine, Replicon, NS5B, Pyrans, Indole test, chemistry.chemical_classification, virus diseases, Stereoisomerism, DNA-Directed RNA Polymerases, biochemical phenomena, metabolism, and nutrition, Nucleotidyltransferase, digestive system diseases, In vitro, Enzyme, chemistry, Biochemistry, Molecular Medicine
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8
المؤلفون: Boris Feld, Emily B. Norton, Russell Dushin, Kevin J. Curran, Ross Adma Antonia, Stanley A. Lang, Terefenko Eugene Anthony, Martin Joseph Digrandi, Thomas R. Jones, Bloom Jonathan David, Fran Donahue
المصدر: Bioorganic & Medicinal Chemistry Letters. 14:3401-3406
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Cytomegalovirus, Pharmaceutical Science, medicine.disease_cause, Antiviral Agents, Biochemistry, Chemical synthesis, Virus, Herpesviridae, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Betaherpesvirinae, Drug Discovery, medicine, Humans, Molecular Biology, IC50, Cells, Cultured, biology, Chemistry, Organic Chemistry, Thiourea, virus diseases, Drug Resistance, Microbial, biology.organism_classification, Virology, In vitro, Molecular Medicine
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9
المؤلفون: Vladimir I. Razinkov, Bloom Jonathan David, John O'Connell, S V Johann, Shi-Wu Lee, Robert J. Visalli, Boris Feld, Thomas R. Jones
المصدر: Journal of Virology. 78:1289-1300
مصطلحات موضوعية: Human cytomegalovirus, viruses, Immunology, Mutant, Cytomegalovirus, Biology, Antiviral Agents, Membrane Fusion, Microbiology, Virus, Chemical library, Cell membrane, Mice, chemistry.chemical_compound, Viral Envelope Proteins, Virology, Vaccines and Antiviral Agents, medicine, Animals, Humans, Cells, Cultured, chemistry.chemical_classification, Mice, Inbred BALB C, Dose-Response Relationship, Drug, Cell Membrane, Thiourea, Virion, Lipid bilayer fusion, Fibroblasts, medicine.disease, Small molecule, Molecular biology, Molecular Weight, medicine.anatomical_structure, chemistry, Insect Science, Glycoprotein
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::512df6be00f3a351628f8aed9d89757f
https://doi.org/10.1128/jvi.78.3.1289-1300.2004 -
10
المؤلفون: S V Johann, Morin John Edward, Bloom Jonathan David, Larocque James Paul, Boris Feld, Bryan Mark O'hara, Jeanette Fairhurst, Steven K. Vernon, Marja van Zeijl, Thomas R. Jones
المصدر: Journal of Virology. 74:9054-9061
مصطلحات موضوعية: viruses, Immunology, Herpesvirus 1, Human, Virus Replication, medicine.disease_cause, Microbiology, Virus, Viral Proteins, chemistry.chemical_compound, Capsid, Viral envelope, Virology, Vaccines and Antiviral Agents, Chlorocebus aethiops, medicine, Animals, Humans, Point Mutation, Vero Cells, Gene, Polymerase, biology, Nucleoside analogue, Thiourea, Drug Resistance, Microbial, Herpes Simplex, Herpes simplex virus, chemistry, Thymidine kinase, Insect Science, DNA, Viral, biology.protein, Capsid Proteins, DNA, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::983d4b882d843db3e2731003e87bc938
https://doi.org/10.1128/jvi.74.19.9054-9061.2000