المؤلفون: Vega, Mario I, Shi, Yijiang, Frost, Patrick, Huerta-Yepez, Sara, Antonio-Andres, Gabriela, Hernandez-Pando, Rogelio, Lee, Jihye, Jung, Michael E, Gera, Joseph F, Lichtenstein, Alan

المصدر: Molecular cancer therapeutics. 18(10)

مصطلحات موضوعية: Animals, Antineoplastic Agents: pharmacology, therapeutic use, Apoptosis, Bortezomib: pharmacology, therapeutic use, Cell Line, Tumor, Humans, Intracellular Signaling Peptides and Proteins: metabolism, Mice, Inbred NOD, Mice, SCID, Multiple Myeloma: drug therapy, metabolism, pathology, Proteolysis: drug effects, Treatment Outcome

وصف الملف: application/pdf

URL الوصول: https://escholarship.org/uc/item/7430r0ft

المؤلفون: Ting Lu, Li Qiao, Ye Yang, Ye Hu, Wang Wang, Mengjie Guo, Rui Li, Anja Seckinger, Fenghuang Zhan, Dirk Hose, Rongfang Wei, Miaomiao Shao, Chunyan Gu

المساهمون: Hematology, Basic (bio-) Medical Sciences

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Ubiquitin-Protein Ligases, Multiple Myeloma/drug therapy, Cancer metastasis, Antineoplastic Agents, Aggressive disease, Case-control studies, Gene mutation, Bortezomib, 03 medical and health sciences, 0302 clinical medicine, medicine, Tumor Cells, Cultured, Humans, Ubiquitin-Protein Ligases/genetics, Multiple myeloma, Cyclin-Dependent Kinase Inhibitor p27/genetics, hematology, Philosophy, Ubiquitination, medicine.disease, Prognosis, Proteasome Inhibitors/pharmacology, Gene Expression Regulation, Neoplastic, Transplantation, Survival Rate, 030104 developmental biology, Bortezomib/pharmacology, cell proliferation, Oncology, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Gene Expression Regulation, Neoplastic/drug effects, Proteasome inhibitor, Christian ministry, Multiple Myeloma, Proteasome Inhibitors, Humanities, Resistance (creativity), Antineoplastic Agents/pharmacology, Cyclin-Dependent Kinase Inhibitor p27, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43f1d396323e359453dbfdfee2d99497
https://hdl.handle.net/20.500.14017/4caed97a-4e5f-44c8-9940-e891ed37fe26

المؤلفون: Kirsten Grønbæk, Sara Ek, Venera Kuci Emruli, Christian Winther Eskelund, Roger Olsson, Fredrik Ek, Angelica Johansson, Mats Jerkeman, Catja Freiburghaus

المصدر: BMC Cancer
Freiburghaus, C, Emruli, V K, Johansson, A, Eskelund, C W, Grønbæk, K, Olsson, R, Ek, F, Jerkeman, M & Ek, S 2018, ' Bortezomib prevents cytarabine resistance in MCL, which is characterized by down-regulation of dCK and up-regulation of SPIB resulting in high NF-κB activity ', BMC Cancer, vol. 18, no. 1, 466 . https://doi.org/10.1186/s12885-018-4346-1
BMC Cancer, Vol 18, Iss 1, Pp 1-17 (2018)

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Transcription, Genetic, SPIB, Drug resistance, Lymphoma, Mantle-Cell, Drug Resistance, Neoplasm/drug effects, NF-κB, Bortezomib, 0302 clinical medicine, Signal Transduction/drug effects, Chemistry, Cytarabine, DCK, NF-kappa B, Deoxycytidine kinase, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Cytarabine/pharmacology, DNA-Binding Proteins, Gene Expression Regulation, Neoplastic, Oncology, 030220 oncology & carcinogenesis, Deoxycytidine Kinase/genetics, Antineoplastic Agents/pharmacology, medicine.drug, Research Article, Signal Transduction, Lymphoma, Mantle-Cell/genetics, Transcription Factors/genetics, Antineoplastic Agents, lcsh:RC254-282, 03 medical and health sciences, Downregulation and upregulation, Cell Line, Tumor, Deoxycytidine Kinase, Genetics, medicine, Humans, Nucleoside analogue, Dose-Response Relationship, Drug, Cell growth, Gene Expression Profiling, MCL, medicine.disease, Histone Deacetylase Inhibitors, 030104 developmental biology, Bortezomib/pharmacology, Drug Resistance, Neoplasm, Gene Expression Regulation, Neoplastic/drug effects, NF-kappa B/metabolism, Cancer research, Mantle cell lymphoma, DNA-Binding Proteins/genetics, Histone Deacetylase Inhibitors/pharmacology, Transcription Factors

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c80f56e633be9f10409d3704e33eb842
http://europepmc.org/articles/PMC5918903

المؤلفون: Mariette Matondo, Bernard Monsarrat, Odile Burlet-Schiltz, Marlène Marcellin, Marie-Pierre Bousquet-Dubouch, Karima Chaoui, Anne Gonzalez-de-Peredo

المساهمون: Institut de pharmacologie et de biologie structurale (IPBS), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, The work was supported in part by grants from the Région Midi‐Pyrénées, the 'Fondation pour la Recherche Médicale' (programme Grands Equipements), European Fonds (FEDER), Toulouse metropole, 'Fond Social Européen' (FSE) and the 'Ligue contre le cancer' Grants., We thank Dr. Darragh O'Brien from Institut Pasteur for the careful reading of this manuscript., We thank members of the group for insightful comments related to this work. We would like to thank David Bouyssié for MFPAQ software and technical support. We would like also to thank our collaborators Stephane Manenti, for discussion. We Thanks Pr. Dr. Ruedi Aebersold from IMSB (ETH Zurich) for allowing the SRM measurement on the TSQ Vantage., Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)

المصدر: Proteomics
Proteomics, Wiley-VCH Verlag, 2017, Applications and Developments in Targeted Proteomics, 17 (7), pp.1600089. ⟨10.1002/pmic.201600089⟩

مصطلحات موضوعية: 0301 basic medicine, MESH: Gene Ontology, Technology, Leupeptins, Cellular differentiation, Cell Cycle Proteins, Apoptosis, MESH: Cell Cycle / drug effects, Biochemistry, SILAC, MESH: Interleukins / metabolism, Bortezomib, MESH: Leukocytes / drug effects, Leukocytes, MESH: Interleukins / genetics, MESH: Apoptosis Regulatory Proteins / metabolism, Protein Isoforms, Proteasome inhibitor, Phosphorylation, MESH: Proteasome Endopeptidase Complex / drug effects, Targeted proteomics, Heat-Shock Proteins, MESH: Proteasome Endopeptidase Complex / metabolism, MESH: Computational Biology, Chemistry, Gene Expression Regulation, Leukemic, Cell Cycle, MESH: Apoptosis / drug effects, Cell Differentiation, Cell cycle, MESH: Phosphorylation / drug effects, MESH: Cell Cycle Proteins / metabolism, 3. Good health, Cell biology, MESH: Cell Cycle Proteins / genetics, MESH: Heat-Shock Proteins / genetics, Proteasome Inhibitors, medicine.drug, Research Article, Signal Transduction, MESH: Cell Differentiation, Proteasome Endopeptidase Complex, MESH: Cell Line, Tumor, Quantitative proteomics, MESH: Tumor Suppressor Protein p53 / metabolism, MESH: Protein Isoforms / genetics, MESH: Acetylcysteine / pharmacology, MESH: Molecular Sequence Annotation, MESH: Apoptosis Regulatory Proteins / genetics, MESH: Transcription Factors / genetics, MESH: Protein Isoforms / metabolism, 03 medical and health sciences, MESH: Gene Expression Profiling, MESH: Leukocytes / pathology, Heat shock protein, Cell Line, Tumor, medicine, MESH: Acetylcysteine / analogs & derivatives, Humans, [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, Cell Cycle Protein, Molecular Biology, MESH: Proteasome Inhibitors / pharmacology, MESH: Transcription Factors / metabolism, MESH: Humans, MESH: Leupeptins / pharmacology, Gene Expression Profiling, Interleukins, Computational Biology, Molecular Sequence Annotation, MESH: Bortezomib / pharmacology, MESH: Tumor Suppressor Protein p53 / genetics, MESH: Heat-Shock Proteins / metabolism, MESH: Leukocytes / metabolism, Acetylcysteine, 030104 developmental biology, Gene Ontology, Proteasome, MESH: Gene Expression Regulation, Leukemic / drug effects, Tumor Suppressor Protein p53, Apoptosis Regulatory Proteins, Human acute myeloid leukemia (AML) cells, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b46ca49bbfe534e269c497edfc5fdec0
https://hal-pasteur.archives-ouvertes.fr/pasteur-02619400/document

المؤلفون: De Beule, Nathan, De Veirman, Kim, Maes, Ken, De Bruyne, Elke, Menu, Eline, Breckpot, Karine, De Raeve, Hendrik, Van Rampelbergh, Rian, Van Ginderachter, Jo A, Schots, Henri, Van Valckenborgh, Els, Vanderkerken, Karin

المساهمون: Faculty of Medicine and Pharmacy, Hematology, Basic (bio-) Medical Sciences, Laboratory of Molecullar and Cellular Therapy, Department of Bio-engineering Sciences, Cellular and Molecular Immunology, Immunology and Microbiology, Clinical sciences, Experimental Pathology

مصطلحات موضوعية: Male, Adult, mice, Adolescent, Pyrazoles/pharmacology, tumour-associated macrophages, STAT3 Transcription Factor/genetics, Drug Resistance, Multiple Myeloma/drug therapy, Pathology and Forensic Medicine, STAT3, Macrophages/drug effects, Myeloid Cells/drug effects, Humans, Animals, Pyrimidines/pharmacology, Aged, Macrophage Activation/drug effects, Apoptosis/drug effects, Middle Aged, multiple myeloma, Mice, Inbred C57BL, Disease Models, Animal, Bortezomib/pharmacology, young adult, Female, Biomarkers, Tumor/genetics, aged, 80 and over, TUMOR MICROENVIRONMENT, Antineoplastic Agents/pharmacology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=od______3848::7142218b1216e96a19f14dfcff435e2c
https://biblio.vub.ac.be/vubir/tumourassociated-macrophagemediated-survival-of-myeloma-cells-through-stat3-activation(3a0649bc-6d01-4b53-b21e-c1611190b2d9).html

المؤلفون: Freiburghaus, Catja, Emruli, Venera Kuci, Johansson, Angelica, Eskelund, Christian Winther, Grønbæk, Kirsten, Olsson, Roger, Ek, Fredrik, Jerkeman, Mats, Ek, Sara

المصدر: Freiburghaus , C , Emruli , V K , Johansson , A , Eskelund , C W , Grønbæk , K , Olsson , R , Ek , F , Jerkeman , M & Ek , S 2018 , ' Bortezomib prevents cytarabine resistance in MCL, which is characterized by down-regulation of dCK and up-regulation of SPIB resulting in high NF-κB activity ' , BMC Cancer , vol. 18 , no. 1 , 466 .

مصطلحات الفهرس: Antineoplastic Agents/pharmacology, Bortezomib/pharmacology, Cell Line, Tumor, Cytarabine/pharmacology, DNA-Binding Proteins/genetics, Deoxycytidine Kinase/genetics, Dose-Response Relationship, Drug, Drug Resistance, Neoplasm/drug effects, Gene Expression Profiling, Gene Expression Regulation, Neoplastic/drug effects, Histone Deacetylase Inhibitors/pharmacology, Humans, Lymphoma, Mantle-Cell/genetics, NF-kappa B/metabolism, Signal Transduction/drug effects, Transcription Factors/genetics, Transcription, Genetic, article