المؤلفون: Kwartler CS; Division of Medical Genetics, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030., Pedroza AJ; Department of Cardiothoracic Surgery, Stanford University, Stanford, CA 94305., Kaw A; Division of Medical Genetics, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030., Guan P; Division of Medical Genetics, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030., Ma S; Division of Medical Genetics, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030.; Current address: Department Medicine, Michigan State University, East Lansing, MI 48824., Duan XY; Division of Medical Genetics, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030., Kernell C; Division of Medical Genetics, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030., Wang C; Division of Medical Genetics, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030., Pinelo JEE; Division of Medical Genetics, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030., Borthwick MS; Division of Medical Genetics, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030., Chen J; Division of Medical Genetics, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030., Zhong Y; Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957., Sinha S; Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom., Shen X; Institute of Cancer Research, Shenzhen Bay Laboratory, Shenzhen, China., Fischbein MP; Department of Cardiothoracic Surgery, Stanford University, Stanford, CA 94305., Milewicz DM; Division of Medical Genetics, Department of Internal Medicine, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX 77030.

المصدر: Research square [Res Sq] 2023 Feb 28. Date of Electronic Publication: 2023 Feb 28.

نوع المنشور: Preprint

بيانات الدورية: Country of Publication: United States NLM ID: 101768035 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: Res Sq Subsets: PubMed not MEDLINE

المؤلفون: Vellano CP; TRACTION Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., White MG; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Andrews MC; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Medicine, Central Clinical School, Monash University, Melbourne, Victoria, Australia., Chelvanambi M; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Witt RG; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Daniele JR; TRACTION Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Titus M; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., McQuade JL; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Conforti F; Division of Melanoma, Sarcoma, and Rare Tumors, European Institute of Oncology, IRCCS, Milan, Italy., Burton EM; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lastrapes MJ; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Ologun G; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Surgery, Guthrie Courtland Medical Center, Courtland, NY, USA., Cogdill AP; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Immunai, New York, NY, USA., Morad G; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Prieto P; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Surgery, University of Rochester, Rochester, NY, USA., Lazar AJ; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Chu Y; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Han G; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Khan MAW; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Helmink B; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Surgery, Washington University in St Louis, St Louis, MO, USA., Davies MA; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Amaria RN; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Kovacs JJ; TRACTION Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Woodman SE; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Patel S; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Hwu P; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Moffitt Cancer Center, Tampa, FL, USA., Peoples M; TRACTION Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lee JE; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Cooper ZA; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; AstraZeneca, Gaithersburg, MD, USA., Zhu H; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Gao G; TRACTION Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Banerjee H; Clinical Development and Analytics, Novartis Pharmaceuticals, East Hanover, NJ, USA., Lau M; Novartis Pharma, Basel, Switzerland., Gershenwald JE; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lucci A; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Keung EZ; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Ross MI; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Pala L; Division of Melanoma, Sarcoma, and Rare Tumors, European Institute of Oncology, IRCCS, Milan, Italy., Pagan E; Department of Statistics and Quantitative Methods, University of Milan-Bicocca, Milan, Italy., Segura RL; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Liu Q; Department of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Borthwick MS; Department of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lau E; Department of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Yates MS; Department of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Westin SN; Department of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wani K; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Tetzlaff MT; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Pathology, University of California, San Francisco, CA, USA., Haydu LE; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Mahendra M; TRACTION Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Ma X; TRACTION Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Logothetis C; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Kulstad Z; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Johnson S; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Hudgens CW; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Feng N; TRACTION Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Federico L; TRACTION Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Long GV; Melanoma Institute Australia, The University of Sydney, and Royal North Shore and Mater Hospitals, Sydney, New South Wales, Australia., Futreal PA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Arur S; Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Tawbi HA; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Moran AE; Cell, Development & Cancer Biology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA., Wang L; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Heffernan TP; TRACTION Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. TPHeffernan@mdanderson.org., Marszalek JR; TRACTION Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. jrmarszalek@mdanderson.org., Wargo JA; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. jwargo@mdanderson.org.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. jwargo@mdanderson.org.

المصدر: Nature [Nature] 2023 Jan; Vol. 613 (7945), pp. E3.

نوع المنشور: Published Erratum

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: PubMed not MEDLINE; MEDLINE

المؤلفون: Vellano CP; TRACTION Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., White MG; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Andrews MC; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Medicine, Central Clinical School, Monash University, Melbourne, Victoria, Australia., Chelvanambi M; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Witt RG; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Daniele JR; TRACTION Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Titus M; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., McQuade JL; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Conforti F; Division of Melanoma, Sarcomas, and Rare Tumors, European Institute of Oncology, IRCCS, Milan, Italy., Burton EM; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lastrapes MJ; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Ologun G; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Surgery, Guthrie Courtland Medical Center, Courtland, NY, USA., Cogdill AP; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Immunai, New York, NY, USA., Morad G; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Prieto P; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Surgery, University of Rochester, Rochester, NY, USA., Lazar AJ; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Chu Y; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Han G; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Khan MAW; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Helmink B; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Surgery, Washington University in St Louis, St Louis, MO, USA., Davies MA; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Amaria RN; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Kovacs JJ; TRACTION Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Woodman SE; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Patel S; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Hwu P; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Moffitt Cancer Center, Tampa, FL, USA., Peoples M; TRACTION Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lee JE; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Cooper ZA; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; AstraZeneca, Gaithersburg, MD, USA., Zhu H; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Gao G; TRACTION Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Banerjee H; Clinical Development and Analytics, Novartis Pharmaceuticals, East Hanover, NJ, USA., Lau M; Novartis Pharma, Basel, Switzerland., Gershenwald JE; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lucci A; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Keung EZ; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Ross MI; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Pala L; Division of Melanoma, Sarcomas, and Rare Tumors, European Institute of Oncology, IRCCS, Milan, Italy., Pagan E; Department of Statistics and Quantitative Methods, University of Milan-Bicocca, Milan, Italy., Segura RL; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Liu Q; Department of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Borthwick MS; Department of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Lau E; Department of Tumor Biology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA., Yates MS; Department of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Westin SN; Department of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, USA., Wani K; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Tetzlaff MT; Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.; Department of Pathology, University of California, San Francisco, CA, USA., Haydu LE; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Mahendra M; TRACTION Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Ma X; TRACTION Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Logothetis C; Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Kulstad Z; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Johnson S; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Hudgens CW; Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Feng N; TRACTION Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Federico L; TRACTION Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Long GV; Melanoma Institute Australia, The University of Sydney, and Royal North Shore and Mater Hospitals, Sydney, New South Wales, Australia., Futreal PA; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Arur S; Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Tawbi HA; Department of Melanoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Moran AE; Cell, Development & Cancer Biology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA., Wang L; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Heffernan TP; TRACTION Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. TPHeffernan@mdanderson.org., Marszalek JR; TRACTION Platform, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. jrmarszalek@mdanderson.org., Wargo JA; Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. jwargo@mdanderson.org.; Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. jwargo@mdanderson.org.

المصدر: Nature [Nature] 2022 Jun; Vol. 606 (7915), pp. 797-803. Date of Electronic Publication: 2022 Jun 15.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

مواضيع طبية MeSH: Androgen Receptor Antagonists* , Melanoma*/drug therapy , Melanoma*/pathology , Mitogen-Activated Protein Kinase Kinases*/antagonists & inhibitors , Molecular Targeted Therapy* , Proto-Oncogene Proteins B-raf*/antagonists & inhibitors , Receptors, Androgen*/metabolism, Animals ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Female ; Humans ; Male ; Mice ; Protein Kinase Inhibitors/therapeutic use ; Skin Neoplasms/drug therapy ; Skin Neoplasms/pathology ; Survival Analysis

المؤلفون: Dottino JA; Departments of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX., Zhang Q; Departments of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX., Loose DS; Department of Integrative Biology and Pharmacology, University of Texas Health Science Center at Houston, Houston, TX., Fellman B; Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX., Melendez BD; Departments of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX., Borthwick MS; Departments of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX., McKenzie LJ; Departments of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX., Yuan Y; Biostatistics, University of Texas MD Anderson Cancer Center, Houston, TX., Yang RK; Departments of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX., Broaddus RR; Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC., Lu KH; Departments of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX., Soliman PT; Departments of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX., Yates MS; Departments of Gynecologic Oncology and Reproductive Medicine, University of Texas MD Anderson Cancer Center, Houston, TX. Electronic address: msyates@mdanderson.org.

المصدر: American journal of obstetrics and gynecology [Am J Obstet Gynecol] 2021 Mar; Vol. 224 (3), pp. 278.e1-278.e14. Date of Electronic Publication: 2020 Aug 21.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0370476 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-6868 (Electronic) Linking ISSN: 00029378 NLM ISO Abbreviation: Am J Obstet Gynecol Subsets: MEDLINE

مواضيع طبية MeSH: Estrogens/*blood , Obesity/*blood , Premenopause/*blood, Adult ; Biomarkers/blood ; Cohort Studies ; Cross-Sectional Studies ; Endometrial Neoplasms/epidemiology ; Endometrial Neoplasms/etiology ; Endometrium/metabolism ; Endometrium/pathology ; Estrogens/biosynthesis ; Female ; Humans ; Obesity/complications ; Risk Factors