المؤلفون: Williams HL; Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Dias Costa A; Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Zhang J; Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Raghavan S; Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Winter PS; Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts.; Institute for Medical Engineering and Science, Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts., Kapner KS; Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Ginebaugh SP; Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Väyrynen SA; Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Väyrynen JP; Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.; Cancer and Translational Medicine Research Unit, Medical Research Center Oulu, Oulu University Hospital, University of Oulu, Oulu, Finland., Yuan C; Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Navia AW; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts.; Institute for Medical Engineering and Science, Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts., Wang J; Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Yang A; Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Bosse TL; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Kalekar RL; Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Lowder KE; Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Lau MC; Department of Pathology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts., Elganainy D; Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Morales-Oyarvide V; Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Rubinson DA; Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Singh H; Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Perez K; Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Cleary JM; Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Clancy TE; Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts., Wang J; Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts., Mancias JD; Department of Radiation Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.; Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts., Brais LK; Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Hill ER; Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Kozak MM; Department of Radiation Oncology, Stanford Cancer Institute, Stanford, California., Linehan DC; Department of Surgery, University of Rochester Medical Center, Rochester, New York., Dunne RF; Department of Medicine, Division of Hematology and Oncology, Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, New York., Chang DT; Department of Radiation Oncology, Stanford Cancer Institute, Stanford, California., Koong AC; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas., Hezel AF; Department of Medicine, Division of Hematology and Oncology, Wilmot Cancer Institute, University of Rochester Medical Center, Rochester, New York., Hahn WC; Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Shalek AK; Broad Institute of MIT and Harvard, Cambridge, Massachusetts.; Ragon Institute of MGH, MIT, and Harvard, Cambridge, Massachusetts.; Institute for Medical Engineering and Science, Department of Chemistry, and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts., Aguirre AJ; Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.; Broad Institute of MIT and Harvard, Cambridge, Massachusetts., Nowak JA; Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts., Wolpin BM; Department of Medical Oncology, Dana-Farber Cancer Institute, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

المصدر: Cancer research [Cancer Res] 2023 Feb 03; Vol. 83 (3), pp. 441-455.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

مواضيع طبية MeSH: Pancreatic Neoplasms*/pathology , Carcinoma, Pancreatic Ductal*/genetics , Carcinoma, Pancreatic Ductal*/pathology, Humans ; Prognosis ; Phenotype ; RNA ; Gene Expression Regulation, Neoplastic ; Claudins

المؤلفون: Sulahian R; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Kwon JJ; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Walsh KH; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Pailler E; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Bosse TL; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Thaker M; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Almanza D; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Dempster JM; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Pan J; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Piccioni F; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Dumont N; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Gonzalez A; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Rennhack J; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA., Nabet B; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA., Bachman JA; Laboratory of Systems Pharmacology, Harvard Medical School, 200 Longwood Ave., Boston, MA 02115, USA., Goodale A; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Lee Y; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Bagul M; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Liao R; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Navarro A; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Yuan TL; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Ng RWS; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Raghavan S; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA., Gray NS; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA., Tsherniak A; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Vazquez F; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Root DE; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA., Firestone AJ; Calico Life Sciences, South San Francisco, CA 94080, USA., Settleman J; Calico Life Sciences, South San Francisco, CA 94080, USA., Hahn WC; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, MA. Electronic address: william_hahn@dfci.harvard.edu., Aguirre AJ; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, MA. Electronic address: andrew_aguirre@dfci.harvard.edu.

المصدر: Cell reports [Cell Rep] 2019 Oct 01; Vol. 29 (1), pp. 118-134.e8.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

مواضيع طبية MeSH: Intracellular Signaling Peptides and Proteins/*metabolism , MAP Kinase Signaling System/*physiology , Mitogen-Activated Protein Kinases/*metabolism , Neoplasms/*metabolism , ras Proteins/*metabolism, A549 Cells ; Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Proliferation/physiology ; HCT116 Cells ; Humans ; MAP Kinase Signaling System/drug effects ; Mice ; Mice, Hairless ; Mice, SCID ; Neoplasms/drug therapy ; Protein Kinase Inhibitors/pharmacology ; Signal Transduction/drug effects ; Signal Transduction/physiology

المؤلفون: Neville KE; Department of Biology, Providence College., Bosse TL; Department of Biology, Providence College., Klekos M; Department of Biology, Providence College., Mills JF; Department of Biology, Providence College., Tipping M; Department of Biology, Providence College; mtipping@providence.edu.

المصدر: Journal of visualized experiments : JoVE [J Vis Exp] 2018 Aug 07 (138). Date of Electronic Publication: 2018 Aug 07.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Video-Audio Media

بيانات الدورية: Publisher: MYJoVE Corporation Country of Publication: United States NLM ID: 101313252 Publication Model: Electronic Cited Medium: Internet ISSN: 1940-087X (Electronic) Linking ISSN: 1940087X NLM ISO Abbreviation: J Vis Exp Subsets: MEDLINE

مواضيع طبية MeSH: Brain/*metabolism , Drosophila melanogaster/*metabolism , Larva/*metabolism, Animals

المؤلفون: Neville KE; Department of Biology, Providence College, 1 Cunningham Square, Providence, RI 02918, United States. Electronic address: kneville@friars.providence.edu., Bosse TL; Department of Biology, Providence College, 1 Cunningham Square, Providence, RI 02918, United States. Electronic address: tbosse@friars.providence.edu., Klekos M; Department of Biology, Providence College, 1 Cunningham Square, Providence, RI 02918, United States. Electronic address: mklekos@friars.providence.edu., Mills JF; Department of Biology, Providence College, 1 Cunningham Square, Providence, RI 02918, United States. Electronic address: jmills4@friars.providence.edu., Weicksel SE; Department of Biology, Providence College, 1 Cunningham Square, Providence, RI 02918, United States. Electronic address: sweickse@providence.edu., Waters JS; Department of Biology, Providence College, 1 Cunningham Square, Providence, RI 02918, United States. Electronic address: jwaters2@providence.edu., Tipping M; Department of Biology, Providence College, 1 Cunningham Square, Providence, RI 02918, United States. Electronic address: mtipping@providence.edu.

المصدر: Journal of neuroscience methods [J Neurosci Methods] 2018 Feb 15; Vol. 296, pp. 32-43. Date of Electronic Publication: 2017 Dec 26.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7905558 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-678X (Electronic) Linking ISSN: 01650270 NLM ISO Abbreviation: J Neurosci Methods Subsets: MEDLINE

مواضيع طبية MeSH: Models, Animal*, Brain/*metabolism , Tissue Culture Techniques/*instrumentation, Animals ; Animals, Genetically Modified ; Brain/drug effects ; Brain/growth & development ; Caenorhabditis elegans ; Drosophila melanogaster ; Enzyme Inhibitors/pharmacology ; Equipment Design ; Extracellular Space/metabolism ; Female ; Hydrogen-Ion Concentration ; Male ; Mitochondrial Proton-Translocating ATPases/antagonists & inhibitors ; Mitochondrial Proton-Translocating ATPases/metabolism ; Oligomycins/pharmacology ; Oxygen Consumption