المؤلفون: Rodrigo R.R. Duarte, Sandrine Thuret, Timothy R. Powell, Demelza Smeeth, Ioanna Kourouzidou

المصدر: Neuroscience

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_specialty, prolactin, medicine.drug_class, Neurogenesis, 4-OHT, 4-hydroxytamoxifen, Biology, Hippocampal formation, Hippocampus, PRLR, prolactin receptor, 03 medical and health sciences, DCX, Doublecortin, MAP2, microtubule-associated protein 2, 0302 clinical medicine, Internal medicine, estradiol, medicine, AHN, adult hippocampal neurogenesis, Animals, Humans, Testosterone, ESR1, Estrogen Receptor 1, Progenitor cell, neural stem cells, Cell Proliferation, ESR2, Estrogen Receptor 2, General Neuroscience, HPC, hippocampal progenitor cell, Estrogens, BrdU, Bromodeoxyuridine, hippocampal neurogenesis, Neural stem cell, Prolactin, Doublecortin, 030104 developmental biology, Endocrinology, Bromodeoxyuridine, Estrogen, embryonic structures, biology.protein, ICC, immunocytochemistry, AR, androgen receptor, Female, 030217 neurology & neurosurgery, hormones, hormone substitutes, and hormone antagonists, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79be9ca5ba6757d62536be1fef095375
http://europepmc.org/articles/PMC7839971

المؤلفون: Iulia Oancea, Andy Wu, Michael A. McGuckin, Sumaira Z. Hasnain, Rabina Giri, John D. Hooper, Veronika Schreiber, Brett C McWhinney, Julie M. Davies, Jakob Begun, Yonghua Sheng, David P. Fairlie, Saleh Y. Alabbas, Gregor Kijanka, Yaowu He, Ramya Movva, Andrew J. Lucke, Timothy H. Florin

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 1, Pp 33-53 (2021)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: rac1 GTP-Binding Protein, 0301 basic medicine, TGTP, thioguanine nucleotide triphosphate, TCF/LEF, T-cell factor/lymphoid enhancer factor, Colorectal cancer, MP, mercaptopurine, TGN, thioguanine nucleotides, medicine.disease_cause, Autophagy-Related Protein 7, Inflammatory bowel disease, BrdU, bromodeoxyuridine, Mice, chemistry.chemical_compound, AOM, azoxymethane, 0302 clinical medicine, GTP, guanosine triphosphate, GTPase, guanosine triphosphatase, DSS, dextran sodium sulfate, Intestinal Mucosa, Wnt Signaling Pathway, beta Catenin, Original Research, GDP, guanosine diphosphate, IBD, inflammatory bowel disease, Colon Cancer, Mercaptopurine, Dextran Sulfate, Gastroenterology, Wnt signaling pathway, Colitis, Atg7ΔIEC, intestinal epithelial cell–specific deletion of autophagy related 7 gene, Editorial, Gene Knockdown Techniques, CRC, colorectal cancer, 030211 gastroenterology & hepatology, Colon, β-Catenin, CAC, colitis-associated cancer, Azoxymethane, Mice, Transgenic, DAI, disease activity index scores, IMPDH, inosine-5′-monophosphate dehydrogenase, 03 medical and health sciences, Administration, Rectal, Anseriformes, medicine, Autophagy, Animals, Humans, lcsh:RC799-869, Thioguanine, IC50, inhibitory concentration of 50%, Hepatology, business.industry, Neuropeptides, Cancer, DMEM, Dulbecco modified Eagle medium, PBS-T, phosphate-buffered saline with 0.1% Tween-20, HCT116 Cells, medicine.disease, WT, wild-type, TG, thioguanine, 030104 developmental biology, chemistry, siRNA, small interfering RNA, Cancer research, BSA, bovine serum albumin, lcsh:Diseases of the digestive system. Gastroenterology, Caco-2 Cells, Colitis-Associated Neoplasms, business, Carcinogenesis, HPRT, hypoxanthine phosphoribosyltransferase gene

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f601ccce23a182b6171ce5a7c5598ec
http://www.sciencedirect.com/science/article/pii/S2352345X20300886

المؤلفون: Yulong He, Jianbo Xu, Peng Shi, Xinde Ou, Wen Zhou, Shirong Cai, Jin Li, Yujie Yuan, Jianjun Peng, Taiqiang Su, Liangliang Lin, Qinbo Cai

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 3, Pp 857-880 (2021)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: 0301 basic medicine, Chemokine, Atrophic gastritis, RELA, RELA proto-oncogene, nuclear factor-κB subunit, TP53, tumor protein p53, BrdU, bromodeoxyuridine, Chemokine receptor, 0302 clinical medicine, CG, chronic gastritis, GSEA, gene set enrichment analysis, CXCL, C-X-C motif chemokine ligand, GEO, Gene Expression Omnibus, CXC chemokine receptors, Helicobacter, MOI, multiplicity of infection, Original Research, biology, H pylori, Gastroenterology, IM, intestinal metaplasia, MNU, N-methyl-N-nitrosourea, mRNA, messenger RNA, PMSS1, pre-mouse Sydney strain 1, ChIP, chromatin immunoprecipitation, medicine.anatomical_structure, CXCR2, C-X-C motif chemokine receptor 2, qPCR, quantitative polymerase chain reaction, 030211 gastroenterology & hepatology, CagA, cytotoxin-associated gene A, CDKN, cyclin-dependent kinase inhibitor, Gastritis, Atrophic, Senescence, PBS, phosphate-buffered saline, IHC, immunohistochemical, NF-κB, nuclear factor-κB, SASP, senescence-associated secretory phenotype, C-X-C Motif Chemokine Receptor 2, NFKB1, nuclear factor-κB subunit 1, Helicobacter Infections, Senescent Cell, 03 medical and health sciences, Gastric mucosa, medicine, Humans, lcsh:RC799-869, Helicobacter pylori, Hepatology, Mucosa Atrophy, AG, atrophic gastritis, biology.organism_classification, medicine.disease, IL, interleukin, 030104 developmental biology, biology.protein, Cancer research, lcsh:Diseases of the digestive system. Gastroenterology, DP, dysplasia, Atrophy

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d51feee4d86b3f3b985a29b089d53c44
http://www.sciencedirect.com/science/article/pii/S2352345X2030179X

المؤلفون: Shanshan Zhang, Antonio Cigliano, Xianqiong Liu, Xinhua Song, Jie Zhang, Pan Wang, Yong Zeng, Xin Chen, Matthias Evert, Haichuan Wang, Ke Liu, Diego F. Calvisi, Jingxiao Wang, Hong Wu, Jiaoyuan Jia, Silvia Ribback, Li Che

المصدر: Cellular and Molecular Gastroenterology and Hepatology
Cellular and molecular gastroenterology and hepatology, vol 11, iss 4
Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1095-1117 (2021)

مصطلحات موضوعية: Male, TAZ, 0301 basic medicine, Neuroblastoma RAS viral oncogene homolog, YAP, yes-associated protein, Cell Cycle Proteins, law.invention, BrdU, bromodeoxyuridine, Mice, LATS1/2, large tumor-suppressor kinase 1/2, 0302 clinical medicine, law, NEDD4, developmentally down-regulated protein 4, siYT, small interfering RNA targeting yes-associated protein/transcriptional co-activator with PDZ-binding motif, Original Research, Mice, Knockout, siTAZ, small interfering targeting transcriptional co-activator with PDZ-binding motif, TCGA, the cancer genome atlas, ICC, intrahepatic cholangiocarcinoma, pCMV, cytomegalovirus promoter, V12, mutation at position 12 replacing amino acid glycine with valine, Liver Neoplasms, Cell Cycle, Gastroenterology, Hepatitis B, PTX3, pentraxin 3, mRNA, messenger RNA, NRas, Neuroblastoma Ras viral oncogene homolog, Knockout mouse, qPCR, quantitative polymerase chain reaction, Female, 030211 gastroenterology & hepatology, YAP, IHC, immunohistochemistry, TEAD, TEA domain, Hepatitis B virus, Carcinoma, Hepatocellular, TAZ, transcriptional co-activator with PDZ-binding motif, Biology, 03 medical and health sciences, Neuroblastoma, KEGG, Kyoto encyclopedia of genes and genomes, medicine, Animals, Humans, Gene silencing, lcsh:RC799-869, Gene, Protein kinase B, Aged, KO, knockout, Hepatology, myr-Akt-HA, myristoylated-protein kinase B-hemagglutinin tag, p-Erk1/2, phosphorylated extracellular regulated kinase 1/2, YAP-Signaling Proteins, Hepatocellular Carcinoma, HCCS, siSC, scrambled small interfering RNA, medicine.disease, 030104 developmental biology, siYAP, small interfering RNA targeting yes-associated protein, siRNA, small interfering RNA, Ct, cycle threshold, Akt, protein kinase B, Cancer research, Suppressor, lcsh:Diseases of the digestive system. Gastroenterology, HCC, hepatocellular carcinoma, Acyltransferases, MAPK, mitogen-activated protein kinase, Transcription Factors

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::447d7bcd8df00ed9b5b307b5d9e85371
https://doi.org/10.1016/j.jcmgh.2020.11.008

المؤلفون: Yajie Wen, Jiahong Sun, Panpan Chen, Wenzhou Li, Tingying Jiao, Huichang Bi, Yanying Zhou, Yixin Chen, Lihuan Guan, Pan Chen, Fan Xiaomei, Yiming Jiang, Min Huang

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 1, Pp 89-99 (2021)

مصطلحات موضوعية: GSTα, glutathianone S-transferase α, NAPQI, N-acetyl p-benzoquinone imine, AST, aspartate aminotransferase, Pharmacology, medicine.disease_cause, BrdU, bromodeoxyuridine, CDK4, cyclin-dependent kinase 4, 0302 clinical medicine, AAV, adeno-associated virus, ECL, electrochemiluminescence, GSTμ, glutathione S-transferase μ, GSH, glutathione, General Pharmacology, Toxicology and Pharmaceutics, HO-1, heme oxygenase-1, Liver injury, 0303 health sciences, Gene knockdown, biology, LDH, lactate dehydrogenase, Chemistry, CYP450, cytochromes P450, digestive, oral, and skin physiology, SIRT6, sirtuin 6, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Hepatocyte, Sirtuin, NRF2, nuclear factor erythroid 2-related factor 2, KEAP1, Kelch-like ECH-associated protein 1, Original Article, SIRT6, DNA damage, APAP, acetaminophen, ARE, antioxidant response element, NRF2, ALT, serum alanine aminotransferase, 03 medical and health sciences, H3K9ac, histone H3 Nε-acetyl-lysines 9, CCK-8, cell counting kit-8, ROS, reactive oxygen species, ALF, acute liver failure, Dox, doxorubicin, H3K56ac, histone H3 Nε-acetyl-lysines 56, medicine, Viability assay, 030304 developmental biology, Acetaminophen, P53, CCND1, cyclin D1, lcsh:RM1-950, Hepatotoxicity, medicine.disease, BCA, bicinchoninic acid, lcsh:Therapeutics. Pharmacology, DCF, dichlorofluorescein, siRNA, small interfering RNA, biology.protein, H&E, hematoxylin and eosin, CCNA1, cyclin A1, NQO1, NAD(P)H quinone dehydrogenase 1, Co-IP, co-immunoprecipitation, Oxidative stress

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73bdb116a375dde7c9f1a71079b6d0f0
http://europepmc.org/articles/PMC7838028

المؤلفون: Johanna McChord, Katharina Ganss, Christian Krautz, Sebastian Hempel, Klaus-Peter Knoch, Michele Solimena, Robert Grützmann, Philippe Ravassard, Kamal Chowdhury, Jürgen Weitz, Stephan Kersting, Christian Pilarsky, Hassan Mziaut, Steffen Wolk, Georg Henniger

المساهمون: Helmholtz-Zentrum Dresden-Rossendorf (HZDR), Technische Universität Dresden = Dresden University of Technology (TU Dresden), Max-Planck-Institut für Biophysikalische Chemie - Max Planck Institute for Biophysical Chemistry [Göttingen], Max-Planck-Gesellschaft, Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Sorbonne Université (SU), Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Max Planck Institute of Molecular Cell Biology and Genetics (MPI-CBG)

المصدر: Molecular metabolism
Molecular metabolism, Elsevier, 2020, 31, pp.150-162. ⟨10.1016/j.molmet.2019.11.012⟩
Molecular Metabolism, Vol 31, Iss, Pp 150-162 (2020)
Molecular Metabolism
Mol. Metab. 31, 150-162 (2020)

مصطلحات موضوعية: Male, 0301 basic medicine, Pten, phosphatase and tensin homolog, Pi3k, phosphatidylinositol-4,5-bisphosphate 3-kinase, Apoptosis, [SDV.BC.BC]Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC], miR-132, microRNA 132, miR-132, Creb, cAMP response element-binding protein, BrdU, bromodeoxyuridine, Mice, 0302 clinical medicine, Insulin-Secreting Cells, miRNA, microRNA, Raf, rapidly accelerated fibrosarcoma, Cells, Cultured, Mice, Knockout, Gene knockdown, Forkhead Box Protein O3, FOXO3, Original Article, β cell regeneration, Beta cell, Signal Transduction, lcsh:Internal medicine, Cell Survival, T2D, type 2 diabetes, 030209 endocrinology & metabolism, Biology, Fgfr3, fibroblast growth factor receptor 3, GSIS, glucose-stimulated insulin secretion, 03 medical and health sciences, RT-PCR, reverse transcription polymerase chain reaction, Pancreatectomy, Nras, neuroblastoma RAS viral oncogene homolog, Downregulation and upregulation, Pten/Akt/Foxo3a, [SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Genomics [q-bio.GN], microRNA, Animals, Humans, PTEN, Gnb, G protein subunit beta, lcsh:RC31-1245, Molecular Biology, Protein kinase B, Gnb1, G protein subunit beta 1, IPA, Ingenuity Pathway Analysis, Cell Proliferation, Mir-132, Beta Cell Regeneration, Pten/akt/foxo3a, pHH3, phosphohistone H3, Mapk1, mitogen-activated protein kinase 1, PTEN Phosphohydrolase, Cell Biology, LCM, laser capture microscopy, Mice, Inbred C57BL, MicroRNAs, HEK293 Cells, 030104 developmental biology, Ras, rat sarcoma, Pik3r1, phosphoinositide-3 kinase regulatory subunit 1, Akt, protein kinase B, Cancer research, biology.protein, Foxo3a, Forkhead box O3a, Sos1, Son of Sevenless homolog 1, Proto-Oncogene Proteins c-akt

وصف الملف: application/pdf; application/zip

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ac233ce670f178447662777e657c669
https://doi.org/10.1016/j.molmet.2019.11.012

المؤلفون: Sander Meisner, Agnès Ribeiro, Vanesa Muncan, Manon E. Wildenberg, Jarom Heijmans, Christine Jones, Jan Koster, Gijs R. van den Brink, Jacqueline L.M. Vermeulen, Jonathan H. M. van der Meer, François Boudreau, Paula S. Montenegro-Miranda

المساهمون: Gastroenterology and Hepatology, Graduate School, Tytgat Institute for Liver and Intestinal Research, AGEM - Digestive immunity, AGEM - Re-generation and cancer of the digestive system, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Oncogenomics, General Internal Medicine

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 10, Iss 2, Pp 209-223 (2020)
Cellular and Molecular Gastroenterology and Hepatology
Cellular and molecular gastroenterology and hepatology, 10(2), 209-223. Elsevier Inc.

مصطلحات موضوعية: 0301 basic medicine, Male, qRT-PCR, quantitative reverse transcription polymerase chain reaction, Primary Cell Culture, Regulator, EdU, 5-ethynyl-2’-deoxyuridine, PBS, phosphate-buffered saline, Transcript profiling, Biology, Lgr5, leucine-rich repeat-containing G-protein–coupled receptor 5, HNF4α, hepatocyte nuclear factor 4α, BrdU, bromodeoxyuridine, 03 medical and health sciences, Mice, 0302 clinical medicine, Intestine, Small, Organoid, Animals, Regeneration, Olfm4, olfactomedin 4, Intestinal Mucosa, lcsh:RC799-869, Cells, Cultured, Original Research, Epithelial barrier, Mice, Knockout, Hepatology, Regeneration (biology), Gastroenterology, Intestinal organoids, IPA, ingenuity pathway analysis, ENR, epidermal growth factor, Noggin, and R-spondin, Cell biology, Organoids, Hepatocyte nuclear factors, Radiation Injuries, Experimental, 030104 developmental biology, Hepatocyte Nuclear Factor 4, 030211 gastroenterology & hepatology, TUNEL, terminal deoxynucleotidyl transferase–mediated deoxyuridine triphosphate nick-end labeling, Irradiation, lcsh:Diseases of the digestive system. Gastroenterology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5f98bd5feac0564f9b5ecfa8b528cf
http://www.sciencedirect.com/science/article/pii/S2352345X20300345

المؤلفون: Anisa Shaker

المصدر: Cellular and Molecular Gastroenterology and Hepatology, Vol 11, Iss 4, Pp 1204-1206 (2021)
Cellular and Molecular Gastroenterology and Hepatology

مصطلحات موضوعية: HDC, histidine decarboxylase, iDTR, inducible diphtheria toxin receptor, Male, Histidine Decarboxylase, Bioinformatics, BrdU, bromodeoxyuridine, Mice, CreERT, tamoxifen-inducible recombinase Cre system, Bone Marrow, FACS, fluorescence-activated cell sorting, Medicine, Myeloid Cells, Myeloid Cell, Original Research, GFP, green fluorescent protein, Mice, Knockout, IBD, inflammatory bowel disease, MB-HSC, myeloid-biased hematopoietic stem cell, Stem Cells, Gastroenterology, Colitis, mRNA, messenger RNA, Intestines, Editorial, LPS, lipopolysaccharide, Stem cell, H2-Receptor (H2R) Agonist, GM-CSF, granulocyte-macrophage colony-stimulating factor, TLR, Toll-like receptor, Histamine, Signal Transduction, Hematopoietic Stem Cell (HSC), MEDLINE, PBS, phosphate-buffered saline, Intestine Inflammation, H2R, H2-receptor, Therapeutic approach, Text mining, HSC, hematopoietic stem cell, DSS, dextran sulfate sodium, Humans, Animals, lcsh:RC799-869, Inflammation, Hepatology, business.industry, HSPC, hematopoietic stem and progenitor cells, medicine.disease, Hematopoietic Stem Cells, WT, wild-type, qRT-PCR, quantitative reverse-transcription polymerase chain reaction, IL, interleukin, Mice, Inbred C57BL, ABX, antibiotics, BAC, bacterial artificial chromosome, BM, bone marrow, lcsh:Diseases of the digestive system. Gastroenterology, business, Histidine Decarboxylase (HDC)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c7e2d6f725474d357ecdeaa0aacf2e2
http://www.sciencedirect.com/science/article/pii/S2352345X20302009

المؤلفون: Nada Mohamed, Ting Zhang, Justin Molitoris, Krishna Prasadan, Mohamed Saleh, Yan Wang, Anuradha Sehrawat, Ranjeet Kalsi, Madison Thomas, George K. Gittes

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: insulin secretion, HFD, high-fat diet, medicine.medical_treatment, glucose metabolism, Smad2 Protein, Carbohydrate metabolism, Diet, High-Fat, SMAD transcription factor, TGF-β, transforming growth factor-beta, Biochemistry, transforming growth factor beta (TGF-β), BrdU, bromodeoxyuridine, ER, endoplasmic reticulum, GSIS, glucose-stimulated insulin secretion, Mice, Downregulation and upregulation, PPX, partial pancreatectomy, Diabetes mellitus, Insulin-Secreting Cells, medicine, Animals, Molecular Biology, IPITT, intraperitoneal insulin tolerance testing, Mice, Knockout, biology, Chemistry, Cell growth, smad2-βKO, deletion of smad2 protein in ins1cre, smad2fx/fx, Insulin, RIP, rat insulin promoter, Type 2 Diabetes Mellitus, Cell Biology, Transforming growth factor beta, T2DM, type 2 diabetes mellitus, medicine.disease, β-cell, Cell biology, Hyperglycemia, HOMA-IR, homeostatic model assessment–estimated insulin resistance, biology.protein, Signal transduction, HbA1c, glycated hemoglobin, RT-PCR, real-time PCR, IHC, immunohistochemistry, Signal Transduction, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9bf2363f38cde8af23f109fca39a28ff
https://pubmed.ncbi.nlm.nih.gov/34582892

المؤلفون: Rohit N. Kulkarni, Hyunki Kim, Kimitaka Shibue, Jiang Hu, Shusheng Lu, Manoj K. Gupta, Morris F. White, Jun Shirakawa, Tomozumi Takatani, Robert T. Kennedy

المصدر: The Journal of Biological Chemistry

مصطلحات موضوعية: 0301 basic medicine, metabolic disorder, Male, IRS1, Biochemistry, Alpha cell, BrdU, bromodeoxyuridine, IRS2, insulin receptor substrate 2, Mice, Insulin receptor substrate, insulin receptor, Phosphorylation, Mice, Knockout, pancreatic alpha cell, biology, Chemistry, Glucagon secretion, Cell biology, IRS1, insulin receptor substrate 1, Female, type 2 diabetes, alphaIRS1KD, IRS1 knockdown, Research Article, Signal Transduction, endocrine system, alphaIRS2KD, IRS2 knockdown, Glucagon, lphaIRS2KO, alpha cell-specific IRS2 knockout, 03 medical and health sciences, CHX, cycloheximide, Glucose Intolerance, Animals, Molecular Biology, Protein kinase B, peptide secretion, 030102 biochemistry & molecular biology, insulin receptor substrate 1, Cell Biology, pancreatic islet, IRS2, Insulin receptor, 030104 developmental biology, alphaIRS1KO, alpha cell-specific IRS1-knockout, Glucagon-Secreting Cells, biology.protein, glycemic control, Insulin Receptor Substrate Proteins, Insulin Resistance

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::106c075826eb5ca48491acd6d97497ae
http://europepmc.org/articles/PMC8131928