المؤلفون: Shannon E. Leggieri, William A. Elyea, Matthew J. Nemec, Ellen Mihaich, Brad P. Hirakawa, Do Hyung Kim, Ann de Peyster

المصدر: Toxicology. 319:23-37

مصطلحات موضوعية: Male, Methyl Ethers, medicine.medical_specialty, tert-Butyl Alcohol, medicine.drug_class, medicine.medical_treatment, Toxicology, Rats, Sprague-Dawley, chemistry.chemical_compound, Aromatase, Internal medicine, Testis, medicine, Animals, Testosterone, Estradiol, biology, Leydig cell, Androgen, Rats, Androgen receptor, Steroid hormone, Endocrinology, medicine.anatomical_structure, Liver, chemistry, Receptors, Androgen, Estrogen, biology.protein, Corticosterone, Methyl tert-butyl ether

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::129e5476a55f9d513c58ba000c2abd43
https://doi.org/10.1016/j.tox.2014.01.015

المؤلفون: Eric L. Reyner, Caroline A. Lee, Harma Ellens, Kirsten M Mease, Cory A Watson, Rucha S. Sane, Liangfu Chen, Mitchell E. Taub, Márton Jani, Brad P Hirakawa

المصدر: Drug Metabolism and Disposition. 39:2093-2102

مصطلحات موضوعية: Digoxin, medicine.medical_specialty, Organic anion transporter 1, Organic Anion Transporters, Pharmaceutical Science, ATP-binding cassette transporter, CHO Cells, Organic Anion Transporters, Sodium-Independent, Pharmacology, Substrate Specificity, Solute Carrier Organic Anion Transporter Family Member 1B3, Cricetinae, Internal medicine, polycyclic compounds, medicine, Animals, Humans, Drug Interactions, ATP Binding Cassette Transporter, Subfamily B, Member 1, RNA, Messenger, cardiovascular diseases, IC50, Cells, Cultured, Cardiac glycoside, biology, Liver-Specific Organic Anion Transporter 1, Chemistry, Sodium, digestive, oral, and skin physiology, Biological Transport, Transporter, carbohydrates (lipids), Organic anion-transporting polypeptide, HEK293 Cells, Endocrinology, biology.protein, Efflux, medicine.drug

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb255ff616c4c03a727fc8dda083f781
https://doi.org/10.1124/dmd.111.040816

المؤلفون: Kevin J. Tomaselli, Julia Herrmann, Robert O. Sayers, Joe C. Wu, Lalitha Kodandapani, Kathy G. Jahangiri, Craig D. Fisher, David T. Winn, Edward D. Robinson, Steven P. Meduna, Robert J. Ternansky, Pauline Yeo, Karen L. Valentino, Jose-Luis Diaz, Vincent J. Kalish, Steven D. Linton, Kristen Sebring, Robert A. Armstrong, Joseph F. Krebs, Niel C. Hoglen, Alfred P. Spada, Brad P. Hirakawa, Ning Chen, Brett R. Ullman, Brett Weylan Ching, Cheng-zhi Zhang, Xu Bai, Xin Gu, Kip Nalley, Long-Shiuh Chen, Patricia L. Gladstone, Jeff McQuiston, Teresa Aja, Todd Groessl, Donald S. Karanewsky, Suzanne Weeks, Lawrence C. Fritz, Patricia C. Contreras

المصدر: Journal of Medicinal Chemistry. 48:6779-6782

مصطلحات موضوعية: Adult, Biological Availability, Phases of clinical research, Apoptosis, Pharmacology, Jurkat Cells, Mice, Structure-Activity Relationship, Liver disease, Pharmacokinetics, In vivo, Drug Discovery, medicine, Animals, Humans, Aspartate Aminotransferases, Pentanoic Acids, Caspase, Liver injury, Cholestasis, Clinical Trials, Phase I as Topic, biology, Caspase 3, Chemistry, Liver Diseases, Alanine Transaminase, Hepatitis C, Chronic, medicine.disease, Caspase Inhibitors, In vitro, Rats, Liver, Biochemistry, Enzyme inhibitor, Hepatocytes, biology.protein, Molecular Medicine, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc05f6b9f812322c1ff557485178cfdb
https://doi.org/10.1021/jm050307e

المؤلفون: Niel C. Hoglen, Patricia C. Contreras, Brad P. Hirakawa, Long-Shiuh Chen, Todd Groessl, Craig D. Fisher

المصدر: Journal of Pharmacology and Experimental Therapeutics. 309:634-640

مصطلحات موضوعية: Male, Pharmacology, Rats, Sprague-Dawley, Mice, Liver disease, Pharmacokinetics, In vivo, Oral administration, medicine, Animals, Potency, Enzyme Inhibitors, Pentanoic Acids, Caspase, Liver injury, Mice, Inbred BALB C, biology, business.industry, medicine.disease, Caspase Inhibitors, Rats, Apoptosis, Models, Animal, biology.protein, Molecular Medicine, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78cd6072fda815132c80b024022dc888
https://doi.org/10.1124/jpet.103.062034

المؤلفون: Karen L. Valentino, Niel C. Hoglen, Craig D. Fisher, Patricia C. Contreras, Brad P. Hirakawa, David Shapiro

المصدر: Hepatology. 38:579-579

مصطلحات موضوعية: Caspase inhibitors, Hepatology, business.industry, Apoptosis, Cancer research, Medicine, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::29b3360dc7096cd3aaa9385b4e55b45c
https://doi.org/10.1016/s0270-9139(03)80913-8