المؤلفون: Adrian D. Hobson, Russell A. Judge, Ana L. Aguirre, Brian S. Brown, Yifang Cui, Ping Ding, Eric Dominguez, Enrico DiGiammarino, David A. Egan, Gail M. Freiberg, Sujatha M. Gopalakrishnan, Christopher M. Harris, Marie P. Honore, Karen L. Kage, Nicolas J. Kapecki, Christopher Ling, Junli Ma, Helmut Mack, Mulugeta Mamo, Stefan Maurus, Bradford McRae, Nigel S. Moore, Bernhard K. Mueller, Reinhold Mueller, Marian T. Namovic, Kaushal Patel, Steve D. Pratt, C. Brent Putman, Kara L. Queeney, Kathy K. Sarris, Lisa M. Schaffter, Vincent Stoll, Anil Vasudevan, Lei Wang, Lu Wang, William Wirthl, Kimberly Yach

المصدر: Journal of Medicinal Chemistry. 61:11074-11100

مصطلحات موضوعية: 0301 basic medicine, rho-Associated Kinases, Cytochrome P-450 CYP2C9 Inhibitors, Drug Evaluation, Preclinical, Administration, Oral, Biological Availability, Crystallography, X-Ray, Mice, Inbred C57BL, Rats, Sprague-Dawley, Structure-Activity Relationship, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Drug Design, Optic Nerve Injuries, 030220 oncology & carcinogenesis, Drug Discovery, Animals, Cytochrome P-450 CYP3A Inhibitors, Humans, Molecular Medicine, Protein Kinase Inhibitors, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba127f0c7da3013553a7215d8180f4bd
https://doi.org/10.1021/acs.jmedchem.8b01098

المؤلفون: Luciana Tissi, Bradford McRae, Tariq Ghayur, Christina von Hunolstein, Graziella Orefici, Francesco Bistoni, Manuela Puliti

المصدر: Arthritis & Rheumatism; Jun2004, Vol. 50 Issue 6, p2005-2013, 9p

مصطلحات موضوعية: INTERLEUKINS, ARTHRITIS, SEPSIS, STREPTOCOCCUS, LABORATORY mice, THERAPEUTICS