المؤلفون: Levinson AL; Department of Pediatrics, University of California, San Francisco, CA., Tjoa K; Department of Pediatrics, University of California, San Francisco, CA., Huang B; Department of Pediatrics, University of California, San Francisco, CA., Meyer LK; Department of Pediatrics, University of California, San Francisco, CA., Kim MO; Department of Epidemiology and Biostatistics, University of California, San Francisco, CA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA., Brady SW; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN., Zhang J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN., Shannon K; Department of Pediatrics, University of California, San Francisco, CA.; Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA., Wandler AM; Department of Pediatrics, University of California, San Francisco, CA.

المصدر: Blood advances [Blood Adv] 2023 Jul 25; Vol. 7 (14), pp. 3479-3484.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society of Hematology Country of Publication: United States NLM ID: 101698425 Publication Model: Print Cited Medium: Internet ISSN: 2473-9537 (Electronic) Linking ISSN: 24739529 NLM ISO Abbreviation: Blood Adv Subsets: MEDLINE

مواضيع طبية MeSH: Precursor T-Cell Lymphoblastic Leukemia-Lymphoma*/drug therapy , Precursor T-Cell Lymphoblastic Leukemia-Lymphoma*/genetics , Precursor T-Cell Lymphoblastic Leukemia-Lymphoma*/metabolism , Precursor Cell Lymphoblastic Leukemia-Lymphoma*/metabolism, Child ; Humans ; Mice ; Animals ; Glucocorticoids/pharmacology ; Glucocorticoids/therapeutic use ; Dexamethasone/pharmacology ; Receptors, Glucocorticoid/genetics ; Recurrence ; Repressor Proteins

المؤلفون: Islam SMA; Department of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA 92093, USA.; Department of Bioengineering, UC San Diego, La Jolla, CA 92093, USA.; Moores Cancer Center, UC San Diego, La Jolla, CA 92037, USA., Díaz-Gay M; Department of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA 92093, USA.; Department of Bioengineering, UC San Diego, La Jolla, CA 92093, USA.; Moores Cancer Center, UC San Diego, La Jolla, CA 92037, USA., Wu Y; Centre for Computational Biology and Programme in Cancer & Stem Cell Biology, Duke NUS Medical School, Singapore 169857, Singapore., Barnes M; Department of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA 92093, USA.; Department of Bioengineering, UC San Diego, La Jolla, CA 92093, USA.; Moores Cancer Center, UC San Diego, La Jolla, CA 92037, USA., Vangara R; Department of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA 92093, USA.; Department of Bioengineering, UC San Diego, La Jolla, CA 92093, USA.; Moores Cancer Center, UC San Diego, La Jolla, CA 92037, USA., Bergstrom EN; Department of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA 92093, USA.; Department of Bioengineering, UC San Diego, La Jolla, CA 92093, USA.; Moores Cancer Center, UC San Diego, La Jolla, CA 92037, USA., He Y; Department of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA 92093, USA.; Department of Bioengineering, UC San Diego, La Jolla, CA 92093, USA.; Moores Cancer Center, UC San Diego, La Jolla, CA 92037, USA., Vella M; NVIDIA Corporation, 2788 San Tomas Expressway, Santa Clara, CA 95051, USA., Wang J; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK., Teague JW; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK., Clapham P; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK., Moody S; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK., Senkin S; Genetic Epidemiology Group, International Agency for Research on Cancer, Cedex 08, 69372 Lyon, France., Li YR; Departments of Radiation Oncology and Cancer Genetics, City of Hope Comprehensive Cancer Center, Duarte, CA, USA., Riva L; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK., Zhang T; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA., Gruber AJ; Big Data Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7LF, UK.; Manchester Cancer Research Centre, The University of Manchester, Manchester M20 4GJ, UK.; Department of Biology, University of Konstanz, Universitaetsstrasse 10, D-78464 Konstanz, Germany., Steele CD; Research Department of Pathology, Cancer Institute, University College London, London WC1E 6BT, UK., Otlu B; Department of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA 92093, USA.; Department of Bioengineering, UC San Diego, La Jolla, CA 92093, USA.; Moores Cancer Center, UC San Diego, La Jolla, CA 92037, USA., Khandekar A; Department of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA 92093, USA.; Department of Bioengineering, UC San Diego, La Jolla, CA 92093, USA.; Moores Cancer Center, UC San Diego, La Jolla, CA 92037, USA., Abbasi A; Department of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA 92093, USA.; Department of Bioengineering, UC San Diego, La Jolla, CA 92093, USA.; Moores Cancer Center, UC San Diego, La Jolla, CA 92037, USA., Humphreys L; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK., Syulyukina N; Department of Bioengineering, UC San Diego, La Jolla, CA 92093, USA., Brady SW; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Alexandrov BS; Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA., Pillay N; Research Department of Pathology, Cancer Institute, University College London, London WC1E 6BT, UK.; Department of Cellular and Molecular Pathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex HA7 4LP, UK., Zhang J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Adams DJ; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK., Martincorena I; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK., Wedge DC; Big Data Institute, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7LF, UK.; Manchester Cancer Research Centre, The University of Manchester, Manchester M20 4GJ, UK., Landi MT; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA., Brennan P; Genetic Epidemiology Group, International Agency for Research on Cancer, Cedex 08, 69372 Lyon, France., Stratton MR; Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Wellcome Genome Campus, Cambridge CB10 1SA, UK., Rozen SG; Centre for Computational Biology and Programme in Cancer & Stem Cell Biology, Duke NUS Medical School, Singapore 169857, Singapore., Alexandrov LB; Department of Cellular and Molecular Medicine, UC San Diego, La Jolla, CA 92093, USA.; Department of Bioengineering, UC San Diego, La Jolla, CA 92093, USA.; Moores Cancer Center, UC San Diego, La Jolla, CA 92037, USA.

المصدر: Cell genomics [Cell Genom] 2022 Nov 09; Vol. 2 (11), pp. None. Date of Electronic Publication: 2022 Nov 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 9918284260106676 Publication Model: Electronic Cited Medium: Internet ISSN: 2666-979X (Electronic) Linking ISSN: 2666979X NLM ISO Abbreviation: Cell Genom Subsets: PubMed not MEDLINE

المؤلفون: Brady SW; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Roberts KG; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA., Gu Z; Department of Computational and Quantitative Medicine & Systems Biology, Beckman Research Institute of City of Hope, Duarte, CA, USA., Shi L; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA., Pounds S; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA., Pei D; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA., Cheng C; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA., Dai Y; Department of Biostatistics, University of Florida, Gainesville, FL, USA., Devidas M; Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, TN, USA., Qu C; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA., Hill AN; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA., Payne-Turner D; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA., Ma X; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Iacobucci I; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA., Baviskar P; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA., Wei L; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Arunachalam S; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Hagiwara K; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Liu Y; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Flasch DA; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Liu Y; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Parker M; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Chen X; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Elsayed AH; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA.; Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, USA., Pathak O; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Li Y; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Fan Y; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Michael JR; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Rusch M; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Wilkinson MR; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Foy S; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Hedges DJ; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Newman S; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Zhou X; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Wang J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Reilly C; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Sioson E; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Rice SV; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Pastor Loyola V; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Wu G; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA., Rampersaud E; Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN, USA., Reshmi SC; Institute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, USA., Gastier-Foster J; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA., Guidry Auvil JM; Office of Cancer Genomics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.; Office of Data Sharing, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Gesuwan P; Office of Cancer Genomics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Smith MA; Cancer Therapeutics Evaluation Program, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Winick N; Department of Pediatric Hematology Oncology and Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA., Carroll AJ; Department of Genetics, University of Alabama at Birmingham, Birmingham, AL, USA., Heerema NA; The Ohio State University, Columbus, OH, USA., Harvey RC; Department of Pathology, University of New Mexico Cancer Center, Albuquerque, NM, USA., Willman CL; Mayo Clinical Comprehensive Cancer Center, Rochester, MN, USA., Larsen E; Department of Pediatrics, Maine Children's Cancer Program, Scarborough, ME, USA., Raetz EA; Department of Pediatrics and Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY, USA., Borowitz MJ; Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD, USA., Wood BL; Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA, USA., Carroll WL; Department of Pediatrics and Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY, USA., Zweidler-McKay PA; ImmunoGen, Inc., Waltham, MA, USA., Rabin KR; Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA., Mattano LA; HARP Pharma Consulting, Mystic, CT, USA., Maloney KW; Department of Pediatrics and Children's Hospital Colorado, University of Colorado, Aurora, CO, USA., Winter SS; Children's Minnesota Research Institute and Cancer and Blood Disorders Program, Minneapolis, MN, USA., Burke MJ; Division of Pediatric Hematology-Oncology, Medical College of Wisconsin, Milwaukee, WI, USA., Salzer W; Uniformed Services University, School of Medicine, Bethesda, MD, USA., Dunsmore KP; Department of Pediatrics, University of Virginia, Charlottesville, VA, USA., Angiolillo AL; Children's National Medical Center, Washington, DC, USA., Crews KR; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA., Downing JR; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA., Jeha S; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA., Pui CH; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA., Evans WE; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA., Yang JJ; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA., Relling MV; Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, USA., Gerhard DS; Office of Cancer Genomics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA., Loh ML; Department of Pediatrics, Benioff Children's Hospital and Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA., Hunger SP; Department of Pediatrics and the Center for Childhood Cancer Research, Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. Hungers@chop.edu., Zhang J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA. jinghui.zhang@stjude.org., Mullighan CG; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA. charles.mullighan@stjude.org.

المصدر: Nature genetics [Nat Genet] 2022 Sep; Vol. 54 (9), pp. 1376-1389. Date of Electronic Publication: 2022 Sep 01.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE

مواضيع طبية MeSH: Precursor Cell Lymphoblastic Leukemia-Lymphoma*/genetics, Child ; Chromosome Aberrations ; Exome/genetics ; Genomics ; Humans ; Mutation

المؤلفون: Arunachalam S; Department of Computational Biology, St. Jude Children's Research Hospital, MS 1135, Room IA6038, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Szlachta K; Department of Computational Biology, St. Jude Children's Research Hospital, MS 1135, Room IA6038, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Brady SW; Department of Computational Biology, St. Jude Children's Research Hospital, MS 1135, Room IA6038, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Ma X; Department of Computational Biology, St. Jude Children's Research Hospital, MS 1135, Room IA6038, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Ju B; Department of Computational Biology, St. Jude Children's Research Hospital, MS 1135, Room IA6038, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Shaner B; Department of Computational Biology, St. Jude Children's Research Hospital, MS 1135, Room IA6038, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Mulder HL; Department of Computational Biology, St. Jude Children's Research Hospital, MS 1135, Room IA6038, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Easton J; Department of Computational Biology, St. Jude Children's Research Hospital, MS 1135, Room IA6038, 262 Danny Thomas Place, Memphis, TN, 38105, USA., Raphael BJ; Department of Computer Science, Princeton University, Princeton, NJ, 08540, USA., Myers M; Department of Computer Science, Princeton University, Princeton, NJ, 08540, USA., Tinkle C; Departments of Radiation Oncology, St. Jude Children's Research Hospital, Memphis, TN, USA., Allen SJ; Thermofisher, Waltham, MA, 02451, USA., Orr BA; Departments of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA., Wetmore CJ; Clinical Development, Neoleukin, 188 East Blaine, Suite 450, Seattle, WA, 98102, USA. cwetmore@neoleukin.com., Baker SJ; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Room M3412, 262 Danny Thomas Place, Memphis, TN, 38105, USA. Suzanne.Baker@StJude.org., Zhang J; Department of Computational Biology, St. Jude Children's Research Hospital, MS 1135, Room IA6038, 262 Danny Thomas Place, Memphis, TN, 38105, USA. Jinghui.Zhang@StJude.org.

المصدر: Acta neuropathologica communications [Acta Neuropathol Commun] 2022 May 31; Vol. 10 (1), pp. 80. Date of Electronic Publication: 2022 May 31.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE

مواضيع طبية MeSH: DNA Copy Number Variations* , Glioma*/drug therapy , Glioma*/genetics , Glioma*/pathology, Child ; Histones/genetics ; Humans ; Mutation/genetics ; Phosphatidylinositol 3-Kinases/genetics ; Phylogeny ; Protein Kinase Inhibitors

المؤلفون: Brady SW; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: samuelw.brady@stjude.org., Gout AM; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Zhang J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: jinghui.zhang@stjude.org.

المصدر: Trends in genetics : TIG [Trends Genet] 2022 Feb; Vol. 38 (2), pp. 194-208. Date of Electronic Publication: 2021 Sep 02.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: Elsevier Trends Journals Country of Publication: England NLM ID: 8507085 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 0168-9525 (Print) Linking ISSN: 01689525 NLM ISO Abbreviation: Trends Genet Subsets: MEDLINE

مواضيع طبية MeSH: Neoplasms*/drug therapy , Neoplasms*/genetics, Humans ; Mutation ; Poly(ADP-ribose) Polymerases ; Prognosis

المؤلفون: Newman S; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Nakitandwe J; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee., Kesserwan CA; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee., Azzato EM; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee., Wheeler DA; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Rusch M; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Shurtleff S; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee., Hedges DJ; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Hamilton KV; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee., Foy SG; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Edmonson MN; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Thrasher A; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Bahrami A; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee., Orr BA; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee., Klco JM; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee., Gu J; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee., Harrison LW; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee., Wang L; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee., Clay MR; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee., Ouma A; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee., Silkov A; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Liu Y; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Zhang Z; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Liu Y; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Brady SW; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Zhou X; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Chang TC; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Pande M; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Davis E; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Becksfort J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Patel A; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Wilkinson MR; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Rahbarinia D; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Kubal M; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee., Maciaszek JL; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee., Pastor V; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Knight J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Gout AM; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Wang J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Gu Z; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee., Mullighan CG; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee., McGee RB; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee., Quinn EA; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee., Nuccio R; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee., Mostafavi R; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee., Gerhardt EL; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee., Taylor LM; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee., Valdez JM; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee., Hines-Dowell SJ; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee., Pappo AS; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee., Robinson G; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee., Johnson LM; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee., Pui CH; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee., Ellison DW; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee., Downing JR; Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee., Zhang J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, Tennessee., Nichols KE; Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee.

المصدر: Cancer discovery [Cancer Discov] 2021 Dec 01; Vol. 11 (12), pp. 3008-3027.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101561693 Publication Model: Print Cited Medium: Internet ISSN: 2159-8290 (Electronic) Linking ISSN: 21598274 NLM ISO Abbreviation: Cancer Discov Subsets: MEDLINE

مواضيع طبية MeSH: Neoplasms*/genetics, Child ; DNA ; Humans ; Mutation ; Sequence Analysis, RNA ; Exome Sequencing

المؤلفون: Wen J; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Rusch M; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Brady SW; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Shao Y; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Edmonson MN; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Shaw TI; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Powers BB; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Tian L; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Easton J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Mullighan CG; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Gruber T; Department of Pediatrics, Stanford University, Palo Alto, California, 94305, USA., Ellison D; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Zhang J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA. Jinghui.Zhang@StJude.org.

المصدر: BMC cancer [BMC Cancer] 2021 Nov 17; Vol. 21 (1), pp. 1233. Date of Electronic Publication: 2021 Nov 17.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 100967800 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2407 (Electronic) Linking ISSN: 14712407 NLM ISO Abbreviation: BMC Cancer Subsets: MEDLINE

مواضيع طبية MeSH: RNA Editing*, Neoplasms/*genetics , Sequence Analysis, RNA/*methods, Brain Neoplasms/genetics ; Child ; DNA, Neoplasm ; Humans ; Immunotherapy ; Neoplasms/metabolism ; Neoplasms/therapy ; Open Reading Frames ; Organ Specificity ; RNA, Neoplasm ; Whole Genome Sequencing

المؤلفون: Pan M; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Wright WC; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Chapple RH; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Zubair A; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Sandhu M; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Batchelder JE; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Huddle BC; The Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, 10065, USA., Low J; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Blankenship KB; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Wang Y; Preclinical Pharmacokinetic Shared Resource, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Gordon B; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Archer P; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Brady SW; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Natarajan S; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Posgai MJ; Departments of Medicine and Human Genetics, The University of Chicago, Chicago, IL, 60637, USA., Schuetz J; Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Miller D; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Kalathur R; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Chen S; Cellular Screening Center, The University of Chicago, Chicago, IL, 60637, USA., Connelly JP; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Babu MM; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Dyer MA; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, 20815, USA., Pruett-Miller SM; Department of Cell and Molecular Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Freeman BB 3rd; Preclinical Pharmacokinetic Shared Resource, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Chen T; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Godley LA; Departments of Medicine and Human Genetics, The University of Chicago, Chicago, IL, 60637, USA., Blanchard SC; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Stewart E; Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.; Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA., Easton J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA. john.easton@stjude.org., Geeleher P; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA. paul.geeleher@stjude.org.

المصدر: Nature communications [Nat Commun] 2021 Nov 09; Vol. 12 (1), pp. 6468. Date of Electronic Publication: 2021 Nov 09.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: DNA Topoisomerases, Type II/*metabolism , Indoles/*therapeutic use , Morpholines/*therapeutic use , Neuroblastoma/*drug therapy , Neuroblastoma/*metabolism , Pyrimidines/*therapeutic use , Sulfonamides/*therapeutic use, Animals ; Benzothiazoles ; Blotting, Western ; Cell Line, Tumor ; Drug Synergism ; Enzyme Activation/drug effects ; Flow Cytometry ; Fluorescent Antibody Technique ; Mice ; Mice, Nude ; Molecular Dynamics Simulation ; Naphthyridines ; Real-Time Polymerase Chain Reaction

المؤلفون: Huang X; Utah Center for Genetic Discovery, University of Utah, Salt Lake City, USA.; Department of Human Genetics, School of Medicine, University of Utah, Salt Lake City, USA., Qiao Y; Utah Center for Genetic Discovery, University of Utah, Salt Lake City, USA.; Department of Human Genetics, School of Medicine, University of Utah, Salt Lake City, USA., Brady SW; Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, USA.; Department of Biomedical Informatics, School of Medicine, University of Utah, Salt Lake City, USA., Factor RE; Department of Pathology, School of Medicine, University of Utah, Salt Lake City, USA., Downs-Kelly E; Department of Pathology, School of Medicine, University of Utah, Salt Lake City, USA., Farrell A; Utah Center for Genetic Discovery, University of Utah, Salt Lake City, USA.; Department of Human Genetics, School of Medicine, University of Utah, Salt Lake City, USA., McQuerry JA; Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, USA.; Department of Oncological Sciences, School of Medicine, University of Utah, Salt Lake City, USA., Shrestha G; Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, USA., Jenkins D; Computational Biomedicine, Department of Medicine, Boston University, Boston, USA., Johnson WE; Computational Biomedicine, Department of Medicine, Boston University, Boston, USA., Cohen AL; Department of Internal Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, USA., Bild AH; Department of Medical Oncology & Therapeutics Research, City of Hope, Duarte, USA., Marth GT; Utah Center for Genetic Discovery, University of Utah, Salt Lake City, USA. gabor.marth@gmail.com.; Department of Human Genetics, School of Medicine, University of Utah, Salt Lake City, USA. gabor.marth@gmail.com.

المصدر: Genome medicine [Genome Med] 2021 Oct 28; Vol. 13 (1), pp. 170. Date of Electronic Publication: 2021 Oct 28.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101475844 Publication Model: Electronic Cited Medium: Internet ISSN: 1756-994X (Electronic) Linking ISSN: 1756994X NLM ISO Abbreviation: Genome Med Subsets: MEDLINE

مواضيع طبية MeSH: Autopsy* , Neoplasm Metastasis*, Breast Neoplasms/*classification , Breast Neoplasms/*genetics, Biopsy ; Evolution, Molecular ; Female ; Humans ; Middle Aged ; Mutation ; Phylogeny

المؤلفون: Yang F; Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Pediatric Translational Medicine Institute, Department of Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Brady SW; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Tang C; Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Pediatric Translational Medicine Institute, Department of Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Sun H; Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Pediatric Translational Medicine Institute, Department of Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Du L; Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Pediatric Translational Medicine Institute, Department of Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Barz MJ; Department of Pediatric Oncology/Hematology, Charite-Universitaetsmedizin Berlin, Berlin, Germany., Ma X; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Chen Y; Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Pediatric Translational Medicine Institute, Department of Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Fang H; Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Pediatric Translational Medicine Institute, Department of Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Li X; Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Pediatric Translational Medicine Institute, Department of Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Kolekar P; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Pathak O; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA., Cai J; Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Pediatric Translational Medicine Institute, Department of Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Ding L; Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Pediatric Translational Medicine Institute, Department of Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Wang T; Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Pediatric Translational Medicine Institute, Department of Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China., von Stackelberg A; Department of Pediatric Oncology/Hematology, Charite-Universitaetsmedizin Berlin, Berlin, Germany., Shen S; Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Pediatric Translational Medicine Institute, Department of Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Eckert C; Department of Pediatric Oncology/Hematology, Charite-Universitaetsmedizin Berlin, Berlin, Germany.; German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany., Klco JM; Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN, USA., Chen H; Department of Pharmacology and Chemical Biology, School of Basic Medicine and Collaborative Innovation Center for Translational Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China., Duan C; Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Pediatric Translational Medicine Institute, Department of Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.; Department of Pharmacology and Chemical Biology, School of Basic Medicine and Collaborative Innovation Center for Translational Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Liu Y; Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Pediatric Translational Medicine Institute, Department of Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Li H; Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Pediatric Translational Medicine Institute, Department of Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Li B; Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Pediatric Translational Medicine Institute, Department of Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Kirschner-Schwabe R; Department of Pediatric Oncology/Hematology, Charite-Universitaetsmedizin Berlin, Berlin, Germany. r.kirschner@charite.de.; German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany. r.kirschner@charite.de., Zhang J; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN, USA. jinghui.zhang@stjude.org., Zhou BS; Key Laboratory of Pediatric Hematology and Oncology Ministry of Health, Pediatric Translational Medicine Institute, Department of Hematology and Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. binbing_s_zhou@yahoo.com.; Department of Pharmacology and Chemical Biology, School of Basic Medicine and Collaborative Innovation Center for Translational Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China. binbing_s_zhou@yahoo.com.

المصدر: Nature cancer [Nat Cancer] 2021 Aug; Vol. 2 (8), pp. 819-834. Date of Electronic Publication: 2021 Jul 22.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101761119 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2662-1347 (Electronic) Linking ISSN: 26621347 NLM ISO Abbreviation: Nat Cancer Subsets: MEDLINE

مواضيع طبية MeSH: Neoplastic Syndromes, Hereditary* , Precursor Cell Lymphoblastic Leukemia-Lymphoma*/genetics, Child ; Humans ; Mutagenesis ; Primary Immunodeficiency Diseases ; Recurrence ; Tumor Suppressor Protein p53/genetics

SCR Disease Name: Turcot syndrome