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المؤلفون: Robert Godemann, Kathleen Knüppel, Christian A.G.N. Montalbetti, Stefan Steinbacher, Myron Smith, Lawren C. Wu, Swathi Sujatha-Bhaskar, Jianwen Feng, Maureen Beresini, Jacob Z. Chen, Christine Everett, Pawan Bir Kohli, Susan Krüger, Joachim Kraemer, David A. Roberts, Sarah G. Hymowitz, Ryan Takahashi, Hans Brightbill, Paul A. McEwan, Nobuhiko Kayagaki, Yamin Zhang, Pui Loke, Georgette Castanedo, Charles Eigenbrot, Hai-Feng Cui, Nicole Blaquiere, Steven T. Staben, Brandon J. Bravo, Adam R. Johnson, Emily B. Gogol, Xiaolu Wang
المصدر: Journal of Medicinal Chemistry. 60:627-640
مصطلحات موضوعية: 0301 basic medicine, P50, High selectivity, Active Transport, Cell Nucleus, Protein Serine-Threonine Kinases, Heterocyclic Compounds, 4 or More Rings, Nf κb inducing kinase, Mice, 03 medical and health sciences, Dogs, 0302 clinical medicine, NF-kappa B p52 Subunit, Drug Discovery, Animals, Humans, Oxazoles, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Phosphoinositide-3 Kinase Inhibitors, Cell Nucleus, chemistry.chemical_classification, Binding Sites, Phosphoinositide 3-kinase, biology, Kinase, Imidazoles, NF-kappa B p50 Subunit, Isoxazoles, Heterocyclic Compounds, Bridged-Ring, Oxazepines, HEK293 Cells, 030104 developmental biology, chemistry, Biochemistry, 030220 oncology & carcinogenesis, biology.protein, Molecular Medicine, Structure based, HeLa Cells, Signal Transduction, Tricyclic
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المؤلفون: Wendy Sandoval, Barbara J. Brandhuber, Brandon J. Bravo, Wilson Phung, Sarah G. Hymowitz, Steve Sideris, Darin Smith, Alexandre Masselot, Jacob R. Haling, Tony Morales, Shiva Malek, Ivana Yen, Ariana Peck, Anthony M. Giannetti, Jawahar Sudhamsu
المصدر: Cancer Cell. 26(3):402-413
مصطلحات موضوعية: MAPK/ERK pathway, Models, Molecular, Proto-Oncogene Proteins B-raf, Cancer Research, endocrine system diseases, MAP Kinase Kinase 1, Mutation, Missense, Biology, medicine.disease_cause, Crystallography, X-Ray, Protein Structure, Secondary, Proto-Oncogene Proteins p21(ras), Catalytic Domain, Proto-Oncogene Proteins, medicine, Humans, Point Mutation, Kinase activity, skin and connective tissue diseases, Protein Structure, Quaternary, neoplasms, Mutation, Point mutation, Cell Biology, HCT116 Cells, digestive system diseases, enzymes and coenzymes (carbohydrates), HEK293 Cells, Protein kinase domain, Oncology, Cancer research, ras Proteins, Phosphorylation, KRAS, Signal transduction, Signal Transduction
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المؤلفون: Erin McNamara, Chudi Ndubaku, Ping Wu, Steven Magnuson, Lesley J. Murray, Anthony M. Giannetti, Kristina West, Weilan Ye, Stanley Mark S, Seth F. Harris, Jason Boggs, Brandon J. Bravo, Tanya Smyczek, Jim Nonomiya, Kelly J. Delatorre, Stephen E. Gould, Philip Vitorino, Stephen Schmidt, Huifen Chen, Lan Wang, Terry Crawford, Amy Sambrone
المصدر: Journal of Medicinal Chemistry. 57:3484-3493
مصطلحات موضوعية: Models, Molecular, Ligand efficiency, Drug discovery, Stereochemistry, Chemistry, Kinase, Intracellular Signaling Peptides and Proteins, Protein Serine-Threonine Kinases, Serine, Mice, Structure-Activity Relationship, Pyrimidines, Biochemistry, In vivo, Drug Discovery, Animals, Molecular Medicine, Structure–activity relationship, Female, Threonine, Protein kinase A, Protein Kinase Inhibitors
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المؤلفون: Thomas O'Brien, Peter S. Dragovich, Brandon J. Bravo, Xiaozhang Zheng, Chengcheng Wang, Weiru Wang, Nicholas J. Skelton, Qiang Zhao, Yunli Wang, Mark Zak, Angela Oh, Guangkun Li, Yen-Ching Ho, Anthony M. Giannetti, Guiling Zhao, Yuen Po-Wai, Xiaolei Ma, Yang Xiao, Rongbao Hua, Xiaorong Liang, Timm Baumeister
المصدر: Bioorganic & Medicinal Chemistry Letters. 24:954-962
مصطلحات موضوعية: Models, Molecular, 3-Aminopyridine, Stereochemistry, Clinical Biochemistry, Nicotinamide phosphoribosyltransferase, Aminopyridines, Pharmaceutical Science, Antineoplastic Agents, Crystallography, X-Ray, Biochemistry, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Amide, Drug Discovery, Humans, Moiety, Enzyme Inhibitors, Nicotinamide Phosphoribosyltransferase, Molecular Biology, IC50, Cells, Cultured, Cell Proliferation, chemistry.chemical_classification, Organic Chemistry, Biochemical Activity, Amides, Enzyme Activation, Enzyme, chemistry, Cell culture, Cytokines, Molecular Medicine
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المؤلفون: Micah Steffek, Frederick Cohen, Christine Pozniak, Preeti Chugha, Joe Lewcock, Brandon J. Bravo, Yinyan Tang, Adam R. Renslo, Xianrui Zhao, Brian R. Hearn, Jeremy Murray, Michelle R. Arkin, John A. Flygare, Priyadarshini Jaishankar, Christine Tam, Cuong Ly, Paul Gibbons, Anthony M. Giannetti
المصدر: ChemMedChem. 9:73-77
مصطلحات موضوعية: Stereochemistry, Dimer, Allosteric regulation, Caspase 6, Crystallography, X-Ray, Biochemistry, Small Molecule Libraries, chemistry.chemical_compound, Zymogen, Drug Discovery, Transition Temperature, General Pharmacology, Toxicology and Pharmaceutics, Surface plasmon resonance, Caspase, Pharmacology, Enzyme Precursors, Binding Sites, biology, Organic Chemistry, Active site, Hydrogen-Ion Concentration, Small molecule, Protein Structure, Tertiary, Molecular Docking Simulation, chemistry, Drug Design, biology.protein, Biophysics, Molecular Medicine, Dimerization, Allosteric Site, Protein Binding
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المؤلفون: Mac Reiter, Keith Pitts, Donald P. Huddler, Houston N. Gilbert, Brandon J. Bravo, Chris Strande, Anthony M. Giannetti
المصدر: Fragment-Based Drug Discovery ISBN: 9781849739085
مصطلحات موضوعية: Flexibility (engineering), Business process discovery, Engineering, Workflow, Software, Lead (geology), Fragment (logic), Software deployment, business.industry, Hit to lead, business, Software engineering, Simulation
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المؤلفون: Jason Boggs, Seth F. Harris, Ping Wu, Jim Nonomiya, Steven Magnuson, Stephen E. Gould, Chudi Ndubaku, Anthony M. Giannetti, Stephen Schmidt, Terry Crawford, Stanley Mark S, Lan Wang, Weilan Ye, Brandon J. Bravo, Huifen Chen, Lesley J. Murray
المصدر: Bioorganicmedicinal chemistry letters. 24(18)
مصطلحات موضوعية: Models, Molecular, Molecular model, Stereochemistry, Clinical Biochemistry, Fragment-based lead discovery, Pharmaceutical Science, Structural diversity, Protein Serine-Threonine Kinases, Crystallography, X-Ray, Ligands, Biochemistry, chemistry.chemical_compound, Mice, Structure-Activity Relationship, In vivo, Drug Discovery, Animals, Humans, Molecular Biology, Protein Kinase Inhibitors, Triazine, Ligand efficiency, Dose-Response Relationship, Drug, Molecular Structure, Fragment (computer graphics), Triazines, Organic Chemistry, Intracellular Signaling Peptides and Proteins, Small molecule, Combinatorial chemistry, chemistry, Molecular Medicine
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المؤلفون: Yuen Po-Wai, Deepak Sampath, Xiaolei Ma, Yongbo Liu, Anthony M. Giannetti, Janet Gunzner-Toste, Guiling Zhao, Xiaozhang Zheng, Weiru Wang, Thomas O'Brien, Nicholas J. Skelton, Yang Xiao, Leslie Wang, Rongbao Hua, Yen-Ching Ho, Yezhen Feng, Peter S. Dragovich, Youming Shen, Qiang Zhao, Chengcheng Wang, Eric Cheng, Brandon J. Bravo, Timm Baumeister, Lisa Crocker, Kenneth W. Bair, Bianca M. Liederer, Mark Zak, Hongxing Wu, Jason Oeh
المصدر: Journal of medicinal chemistry. 57(3)
مصطلحات موضوعية: Cyclopropanes, Models, Molecular, Stereochemistry, Protein Conformation, Pyridines, Nicotinamide phosphoribosyltransferase, Mice, Nude, Stereoisomerism, Antineoplastic Agents, Crystallography, X-Ray, chemistry.chemical_compound, Mice, Structure-Activity Relationship, In vivo, Cell Line, Tumor, Drug Discovery, Potency, Structure–activity relationship, Animals, Humans, Sulfones, Nicotinamide Phosphoribosyltransferase, IC50, chemistry.chemical_classification, Chemistry, Amides, Enzyme, Biochemistry, Cell culture, Molecular Medicine, Heterografts, Drug Screening Assays, Antitumor, Neoplasm Transplantation
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المؤلفون: Yinyan Tang, Cuong Ly, Karen Stanger, John A. Flygare, Priyadarshini Jaishankar, Kinjalkumar Shah, Frederick Cohen, Joseph W. Lewcock, Micah Steffek, Rami N. Hannoush, Xianrui Zhao, Katherine E. Augustyn, Preeti Chugha, Jeremy Murray, Brian R. Hearn, Paul Gibbons, Anthony M. Giannetti, Brandon J. Bravo, Christopher E. Heise, Adam R. Renslo, Michelle R. Arkin
المصدر: PLoS ONE, Vol 7, Iss 12, p e50864 (2012)
PLoS ONEمصطلحات موضوعية: Models, Molecular, Protein Structure, Proteolysis, Molecular Sequence Data, Drug Evaluation, Preclinical, lcsh:Medicine, Plasma protein binding, Caspase 6, Crystallography, X-Ray, Biochemistry, Substrate Specificity, Drug Discovery, Chemical Biology, medicine, Macromolecular Structure Analysis, Amino Acid Sequence, Biomacromolecule-Ligand Interactions, lcsh:Science, Peptide sequence, Ternary complex, Biology, Caspase, Enzyme Kinetics, Multidisciplinary, medicine.diagnostic_test, biology, Drug discovery, Chemistry, lcsh:R, Computational Biology, Reproducibility of Results, Surface Plasmon Resonance, Caspase Inhibitors, Enzyme structure, Enzymes, Kinetics, Small Molecules, Enzyme Structure, biology.protein, lcsh:Q, Medicinal Chemistry, Peptides, Research Article, Protein Binding
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المؤلفون: Vikram Malhi, Stephen E. Gould, Gerrit J. P. Dijkgraaf, Brandon J. Bravo, Richard A. Graham, Harvey Wong, Emile Plise, Anthony M. Giannetti, Daniel F. Ortwine, Bert L. Lum, Erin C. Dueber
المصدر: Journal of medicinal chemistry. 54(8)
مصطلحات موضوعية: Pyridines, Biophysics, Vismodegib, Plasma protein binding, Pharmacology, Cell Line, Species Specificity, Drug Discovery, medicine, Animals, Humans, Anilides, Hedgehog Proteins, chemistry.chemical_classification, Chemistry, Albumin, Half-life, Hedgehog signaling pathway, Rats, Biochemistry, Cell culture, Molecular Medicine, Thermodynamics, Signal transduction, Glycoprotein, medicine.drug, Half-Life, Protein Binding, Signal Transduction
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