المؤلفون: Drakakis, G, Wafford, KA, Brewerton, SC, Bodkin, MJ, Evans, DA, Bender, A

المساهمون: Drakakis, Georgios [0000-0002-6635-9273], Bender, Andreas [0000-0002-6683-7546], Apollo - University of Cambridge Repository

مصطلحات موضوعية: Biomedical Research, Polypharmacology, Imidazoles, Animals, Hypnotics and Sedatives, Computer Simulation, Benzazepines, Rats

وصف الملف: application/pdf

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bb16c08119a05b6f1f49d0f08f4fae1

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

لا يتم عرض هذه النتيجة على الضيوف.
تسجيل الدخول للوصول الكامل.

المؤلفون: Dear AJ; WaveBreak Therapeutics Ltd, Chemistry of Health Lensfield Road Cambridge CB2 1EW UK georg.meisl@googlemail.com., Teng X; WaveBreak Therapeutics Ltd, Chemistry of Health Lensfield Road Cambridge CB2 1EW UK georg.meisl@googlemail.com., Ball SR; WaveBreak Therapeutics Ltd, Chemistry of Health Lensfield Road Cambridge CB2 1EW UK georg.meisl@googlemail.com., Lewin J; WaveBreak Therapeutics Ltd, Chemistry of Health Lensfield Road Cambridge CB2 1EW UK georg.meisl@googlemail.com., Horne RI; WaveBreak Therapeutics Ltd, Chemistry of Health Lensfield Road Cambridge CB2 1EW UK georg.meisl@googlemail.com., Clow D; WaveBreak Therapeutics Ltd, Chemistry of Health Lensfield Road Cambridge CB2 1EW UK georg.meisl@googlemail.com., Stevenson A; Department of Biology, Institute of Biochemistry, ETH Zurich Otto Stern Weg 3 8093 Zurich Switzerland.; Bringing Materials to Life Initiative, ETH Zurich Switzerland., Harper N; WaveBreak Therapeutics Ltd, Chemistry of Health Lensfield Road Cambridge CB2 1EW UK georg.meisl@googlemail.com., Yahya K; WaveBreak Therapeutics Ltd, Chemistry of Health Lensfield Road Cambridge CB2 1EW UK georg.meisl@googlemail.com., Yang X; WaveBreak Therapeutics Ltd, Chemistry of Health Lensfield Road Cambridge CB2 1EW UK georg.meisl@googlemail.com., Brewerton SC; WaveBreak Therapeutics Ltd, Chemistry of Health Lensfield Road Cambridge CB2 1EW UK georg.meisl@googlemail.com., Thomson J; WaveBreak Therapeutics Ltd, Chemistry of Health Lensfield Road Cambridge CB2 1EW UK georg.meisl@googlemail.com., Michaels TCT; Department of Biology, Institute of Biochemistry, ETH Zurich Otto Stern Weg 3 8093 Zurich Switzerland.; Bringing Materials to Life Initiative, ETH Zurich Switzerland., Linse S; WaveBreak Therapeutics Ltd, Chemistry of Health Lensfield Road Cambridge CB2 1EW UK georg.meisl@googlemail.com.; Biochemistry and Structural Biology, Lund University Lund Sweden., Knowles TPJ; Yusuf Hamied Department of Chemistry, University of Cambridge Cambridge UK.; Cavendish Laboratory, University of Cambridge Cambridge UK., Habchi J; WaveBreak Therapeutics Ltd, Chemistry of Health Lensfield Road Cambridge CB2 1EW UK georg.meisl@googlemail.com., Meisl G; WaveBreak Therapeutics Ltd, Chemistry of Health Lensfield Road Cambridge CB2 1EW UK georg.meisl@googlemail.com.

المصدر: Chemical science [Chem Sci] 2024 Apr 22; Vol. 15 (19), pp. 7229-7242. Date of Electronic Publication: 2024 Apr 22 (Print Publication: 2024).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101545951 Publication Model: eCollection Cited Medium: Print ISSN: 2041-6520 (Print) Linking ISSN: 20416520 NLM ISO Abbreviation: Chem Sci Subsets: PubMed not MEDLINE

المؤلفون: Drakakis G; Centre for Molecular Informatics, Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge CB2 1EW, United Kingdom., Wafford KA; Eli Lilly U.K. , Erl Wood Manor, Windlesham, Surrey GU206PH, United Kingdom., Brewerton SC; Eli Lilly U.K. , Erl Wood Manor, Windlesham, Surrey GU206PH, United Kingdom., Bodkin MJ; Eli Lilly U.K. , Erl Wood Manor, Windlesham, Surrey GU206PH, United Kingdom., Evans DA; Eli Lilly U.K. , Erl Wood Manor, Windlesham, Surrey GU206PH, United Kingdom., Bender A; Centre for Molecular Informatics, Department of Chemistry, University of Cambridge , Lensfield Road, Cambridge CB2 1EW, United Kingdom.

المصدر: ACS chemical biology [ACS Chem Biol] 2017 Jun 16; Vol. 12 (6), pp. 1593-1602. Date of Electronic Publication: 2017 May 01.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

مواضيع طبية MeSH: Polypharmacology*, Hypnotics and Sedatives/*pharmacology, Animals ; Benzazepines/pharmacology ; Biomedical Research/methods ; Computer Simulation ; Hypnotics and Sedatives/classification ; Imidazoles/pharmacology ; Rats

المؤلفون: Telenti A; Human Longevity Inc., San Diego, CA 92121; J. Craig Venter Institute, La Jolla, CA 92037., Pierce LC; Human Longevity Inc., San Diego, CA 92121; Human Longevity Inc., Mountain View, CA 94041., Biggs WH; Human Longevity Inc., San Diego, CA 92121., di Iulio J; Human Longevity Inc., San Diego, CA 92121; J. Craig Venter Institute, La Jolla, CA 92037., Wong EH; Human Longevity Inc., San Diego, CA 92121., Fabani MM; Human Longevity Inc., San Diego, CA 92121., Kirkness EF; Human Longevity Inc., San Diego, CA 92121., Moustafa A; Human Longevity Inc., San Diego, CA 92121., Shah N; Human Longevity Inc., San Diego, CA 92121., Xie C; Human Longevity Singapore Pte. Ltd., Singapore 138542., Brewerton SC; Human Longevity Singapore Pte. Ltd., Singapore 138542., Bulsara N; Human Longevity Inc., San Diego, CA 92121., Garner C; Human Longevity Inc., San Diego, CA 92121., Metzker G; Human Longevity Inc., San Diego, CA 92121., Sandoval E; Human Longevity Inc., San Diego, CA 92121., Perkins BA; Human Longevity Inc., San Diego, CA 92121., Och FJ; Human Longevity Inc., San Diego, CA 92121; Human Longevity Inc., Mountain View, CA 94041., Turpaz Y; Human Longevity Inc., San Diego, CA 92121; Human Longevity Singapore Pte. Ltd., Singapore 138542., Venter JC; Human Longevity Inc., San Diego, CA 92121; J. Craig Venter Institute, La Jolla, CA 92037; jcventer@humanlongevity.com.

المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2016 Oct 18; Vol. 113 (42), pp. 11901-11906. Date of Electronic Publication: 2016 Oct 04.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

مواضيع طبية MeSH: Genome, Human* , Genomics*/methods , Whole Genome Sequencing*, Chromosome Mapping ; Computational Biology/methods ; Databases, Nucleic Acid ; Genetic Predisposition to Disease ; Genetic Variation ; Humans ; Open Reading Frames ; Polymorphism, Single Nucleotide ; Reproducibility of Results ; Untranslated Regions

المؤلفون: Drakakis G, Koutsoukas A, Brewerton SC, Bodkin MJ, Evans DA, Bender A; Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK. ab454@cam.ac.uk.

المصدر: Combinatorial chemistry & high throughput screening [Comb Chem High Throughput Screen] 2015; Vol. 18 (3), pp. 323-30.

نوع المنشور: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 9810948 Publication Model: Print Cited Medium: Internet ISSN: 1875-5402 (Electronic) Linking ISSN: 13862073 NLM ISO Abbreviation: Comb Chem High Throughput Screen Subsets: MEDLINE

مواضيع طبية MeSH: Proteins/*chemistry , Small Molecule Libraries/*chemistry, Algorithms ; Bayes Theorem ; Humans ; Ligands ; Proteins/metabolism ; Small Molecule Libraries/pharmacology

المؤلفون: Ravindranath AC; Unilever Centre for Molecular Science Informatics, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK. ab454@cam.ac.uk., Perualila-Tan N, Kasim A, Drakakis G, Liggi S, Brewerton SC, Mason D, Bodkin MJ, Evans DA, Bhagwat A, Talloen W, Göhlmann HW, Shkedy Z, Bender A

مؤلفون مشاركون: QSTAR Consortium

المصدر: Molecular bioSystems [Mol Biosyst] 2015 Jan; Vol. 11 (1), pp. 86-96. Date of Electronic Publication: 2014 Sep 25.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101251620 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1742-2051 (Electronic) Linking ISSN: 17422051 NLM ISO Abbreviation: Mol Biosyst Subsets: MEDLINE

مواضيع طبية MeSH: Computer Simulation* , Drug Discovery*/methods , Gene Expression Regulation*/drug effects , Gene Regulatory Networks* , Transcriptome*, Computational Biology/*methods, Algorithms ; Anti-Inflammatory Agents/pharmacology ; Antineoplastic Agents/pharmacology ; Antipsychotic Agents/pharmacology ; Cell Line, Tumor ; Cluster Analysis ; Databases, Genetic ; Humans ; Hypoglycemic Agents/pharmacology ; Signal Transduction

المؤلفون: Liggi S; Centre for Molecular Informatics, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK., Drakakis G, Koutsoukas A, Cortes-Ciriano I, Martínez-Alonso P, Malliavin TE, Velazquez-Campoy A, Brewerton SC, Bodkin MJ, Evans DA, Glen RC, Carrodeguas JA, Bender A

المصدر: Future medicinal chemistry [Future Med Chem] 2014; Vol. 6 (18), pp. 2029-56.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Future Science Country of Publication: England NLM ID: 101511162 Publication Model: Print Cited Medium: Internet ISSN: 1756-8927 (Electronic) Linking ISSN: 17568919 NLM ISO Abbreviation: Future Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Computational Biology* , Computer Simulation*, Small Molecule Libraries/*metabolism, Animals ; Apoptosis/drug effects ; Mice ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/toxicity ; Stem Cells/cytology ; Stem Cells/drug effects

المؤلفون: Liggi S; Unilever Centre for Molecular Science Informatics, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK telephone: +44(0)1223 762983; fax: +44 (0)1223 763076., Drakakis G; Unilever Centre for Molecular Science Informatics, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK telephone: +44(0)1223 762983; fax: +44 (0)1223 763076., Hendry AE; School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK., Hanson KM; School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK., Brewerton SC; Eli Lilly U.K. Erl Wood Manor, Windlesham, Surrey GU206PH, UK., Wheeler GN; School of Biological Sciences, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK., Bodkin MJ; Eli Lilly U.K. Erl Wood Manor, Windlesham, Surrey GU206PH, UK., Evans DA; Eli Lilly U.K. Erl Wood Manor, Windlesham, Surrey GU206PH, UK., Bender A; Unilever Centre for Molecular Science Informatics, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, UK telephone: +44(0)1223 762983; fax: +44 (0)1223 763076. ab454@cam.ac.uk.

المصدر: Molecular informatics [Mol Inform] 2013 Dec; Vol. 32 (11-12), pp. 1009-24. Date of Electronic Publication: 2013 Oct 18.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 101529315 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1868-1743 (Print) Linking ISSN: 18681743 NLM ISO Abbreviation: Mol Inform Subsets: PubMed not MEDLINE