المؤلفون: Brian Chia CS; Experimental Drug Development Centre (EDDC), Agency for Science, Technology and Research (A*STAR), 10 Biopolis Road, Chromos #08-01, Singapore, 138670, Singapore., Pheng Lim S; Experimental Drug Development Centre (EDDC), Agency for Science, Technology and Research (A*STAR), 10 Biopolis Road, Chromos #08-01, Singapore, 138670, Singapore.

المصدر: ChemMedChem [ChemMedChem] 2023 Aug 15; Vol. 18 (16), pp. e202300216. Date of Electronic Publication: 2023 Jun 15.

نوع المنشور: Journal Article; Review; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE

مواضيع طبية MeSH: Papain* , COVID-19*, Humans ; Peptide Hydrolases ; Coronavirus Papain-Like Proteases ; SARS-CoV-2 ; Antiviral Agents/pharmacology ; Protease Inhibitors/pharmacology

المؤلفون: Ng SMS; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos #03-01, Singapore, 138669, Singapore., Yap JM; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos #03-01, Singapore, 138669, Singapore., Lau QY; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos #03-01, Singapore, 138669, Singapore., Ng FM; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos #03-01, Singapore, 138669, Singapore., Ong EHQ; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos #03-01, Singapore, 138669, Singapore., Barkham T; Department of Laboratory Medicine, Tan Tock Seng Hospital, 11 Jalan Tan Tock Seng, 308433, Singapore., Teo JWP; Department of Laboratory Medicine, National University Hospital, 5 Lower Kent Ridge Road, Singapore, 119074, Singapore., Alfatah M; Bioinformatics Institute, 30 Biopolis Street, #07-01, Matrix, 138671, Singapore., Kong KW; Molecular Engineering Lab, 61 Biopolis Drive, #03-12, Proteos, 138673, Singapore., Hoon S; Molecular Engineering Lab, 61 Biopolis Drive, #03-12, Proteos, 138673, Singapore., Arumugam P; Bioinformatics Institute, 30 Biopolis Street, #07-01, Matrix, 138671, Singapore., Hill J; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos #03-01, Singapore, 138669, Singapore., Brian Chia CS; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A*STAR), 31 Biopolis Way, Nanos #03-01, Singapore, 138669, Singapore. Electronic address: cschia@etc.a-star.edu.sg.

المصدر: European journal of medicinal chemistry [Eur J Med Chem] 2018 Apr 25; Vol. 150, pp. 479-490. Date of Electronic Publication: 2018 Mar 09.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antifungal Agents/*pharmacology , Candida albicans/*drug effects , Drug Resistance, Fungal/*drug effects , Fluconazole/*pharmacology , Peptides/*pharmacology, Antifungal Agents/chemical synthesis ; Antifungal Agents/chemistry ; Cell Survival/drug effects ; Dose-Response Relationship, Drug ; Fibroblasts/drug effects ; Humans ; Microbial Sensitivity Tests ; Molecular Structure ; Peptides/chemical synthesis ; Peptides/chemistry ; Structure-Activity Relationship

المؤلفون: Chu JJ; Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore 117597, Singapore. Electronic address: miccjh@nus.edu.sg., Lee RC; Laboratory of Molecular RNA Virology and Antiviral Strategies, Department of Microbiology, Yong Loo Lin School of Medicine, National University Health System, National University of Singapore, Singapore 117597, Singapore., Ang MJ; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), 31 Biopolis Way, Nanos #03-01, Singapore 138669, Singapore., Wang WL; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), 31 Biopolis Way, Nanos #03-01, Singapore 138669, Singapore., Lim HA; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), 31 Biopolis Way, Nanos #03-01, Singapore 138669, Singapore., Wee JL; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), 31 Biopolis Way, Nanos #03-01, Singapore 138669, Singapore., Joy J; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), 31 Biopolis Way, Nanos #03-01, Singapore 138669, Singapore., Hill J; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), 31 Biopolis Way, Nanos #03-01, Singapore 138669, Singapore., Brian Chia CS; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), 31 Biopolis Way, Nanos #03-01, Singapore 138669, Singapore. Electronic address: cschia@etc.a-star.edu.sg.

المصدر: Antiviral research [Antiviral Res] 2015 Jun; Vol. 118, pp. 68-74. Date of Electronic Publication: 2015 Mar 27.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8109699 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9096 (Electronic) Linking ISSN: 01663542 NLM ISO Abbreviation: Antiviral Res Subsets: MEDLINE

مواضيع طبية MeSH: Viral Load*, Anthraquinones/*pharmacology , Antiviral Agents/*pharmacology , Dengue Virus/*enzymology , Protease Inhibitors/*pharmacology , Viral Nonstructural Proteins/*antagonists & inhibitors, Anthraquinones/toxicity ; Antiviral Agents/toxicity ; Cell Line, Tumor ; Cell Survival/drug effects ; Dengue Virus/drug effects ; Dengue Virus/physiology ; Hepatocytes/drug effects ; Hepatocytes/virology ; Humans ; Microbial Sensitivity Tests ; Protease Inhibitors/toxicity ; RNA Helicases/antagonists & inhibitors ; Serine Endopeptidases

المؤلفون: Schüller A; Duke-NUS Graduate Medical School, Program in Emerging Infectious Diseases, 8 College Road, Singapore 169857, Singapore., Yin Z, Brian Chia CS, Doan DN, Kim HK, Shang L, Loh TP, Hill J, Vasudevan SG

المصدر: Antiviral research [Antiviral Res] 2011 Oct; Vol. 92 (1), pp. 96-101. Date of Electronic Publication: 2011 Jul 08.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8109699 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9096 (Electronic) Linking ISSN: 01663542 NLM ISO Abbreviation: Antiviral Res Subsets: MEDLINE

مواضيع طبية MeSH: Dengue Virus/*drug effects , Oligopeptides/*pharmacology , Protease Inhibitors/*pharmacology , Viral Proteins/*antagonists & inhibitors , West Nile virus/*drug effects, Binding Sites ; Dengue Virus/chemistry ; Dengue Virus/enzymology ; Dengue Virus/genetics ; Models, Molecular ; Molecular Structure ; Oligopeptides/chemical synthesis ; Oligopeptides/chemistry ; Peptide Hydrolases/chemistry ; Peptide Hydrolases/metabolism ; Protease Inhibitors/chemical synthesis ; Protease Inhibitors/chemistry ; Protein Binding ; Structure-Activity Relationship ; Viral Proteins/chemistry ; Viral Proteins/metabolism ; West Nile virus/chemistry ; West Nile virus/enzymology ; West Nile virus/genetics