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المؤلفون: Samuel Chackalamannil, Yan Xia, Hongwu Wang, Michael W. Miller, Charles Lee Jayne, Sarah W. Li, Jean E. Lachowicz, Andrew Stamford, William J. Greenlee, Jack D. Scott, Timothy J. Kowalski, George Boykow, Ruth A. Duffy, Brian D. Spar
المصدر: Bioorganic & Medicinal Chemistry Letters. 20:1278-1283
مصطلحات موضوعية: Cannabinoid receptor, Stereochemistry, medicine.medical_treatment, Clinical Biochemistry, Mice, Obese, Pharmaceutical Science, Biochemistry, Chemical synthesis, Eating, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Piperidines, Receptor, Cannabinoid, CB1, In vivo, Drug Discovery, medicine, Animals, Potency, Obesity, Receptor, Molecular Biology, Chemistry, Organic Chemistry, Antagonist, Diet, Molecular Medicine, Cannabinoid, Piperidine, Protein Binding
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المؤلفون: William J. Greenlee, Brian E. Hawes, John W. Clader, Brian D. Spar, Mckittrick Brian A, Qian Gang, Jing Su, Timothy J. Kowalski, Duane A. Burnett, Steve Sorota, Haiqun Tang, Huizhong Gu, Blair Weig, Tao Guo, Kim O’Neill
المصدر: Bioorganic & Medicinal Chemistry Letters. 17:4845-4850
مصطلحات موضوعية: congenital, hereditary, and neonatal diseases and abnormalities, Stereochemistry, Chemistry, Pharmaceutical, Clinical Biochemistry, hERG, Drug Evaluation, Preclinical, Pharmaceutical Science, Biochemistry, Chemical synthesis, Heptanes, Mice, chemistry.chemical_compound, Drug Discovery, Animals, Hexanes, Humans, Obesity, Receptors, Somatostatin, cardiovascular diseases, Receptor, Molecular Biology, Heptane, Molecular Structure, biology, Bicyclic molecule, Organic Chemistry, Fishes, In vitro, Melanin-concentrating hormone receptor, Kinetics, Models, Chemical, chemistry, Drug Design, biology.protein, Molecular Medicine, Efflux
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المؤلفون: William J. Greenlee, Jing Su, Kim O’Neill, Duane A. Burnett, Cheng Li, Brian E. Hawes, Brian D. Spar, John W. Clader, Timothy J. Kowalski, Haiqun Tang, Tongtong Liu, Mckittrick Brian A, Steve Sorota, Blair Weig
المصدر: Bioorganic & Medicinal Chemistry. 15:5369-5385
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, hERG, Pharmaceutical Science, Biochemistry, Chemical synthesis, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Transcriptional Regulator ERG, Drug Discovery, Animals, Structure–activity relationship, Phenyl group, Receptors, Pituitary Hormone, Cycloheptanes, Receptor, Molecular Biology, Molecular Structure, biology, Bicyclic molecule, Chemistry, Organic Chemistry, Melanin-concentrating hormone receptor, DNA-Binding Proteins, Trans-Activators, biology.protein, Molecular Medicine, Ex vivo
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المؤلفون: Brian D. Spar, Thavalakulamgara K. Sasikumar, Kim O’Neill, Blair Weig, Li Qiang, William J. Greenlee, Timothy J. Kowalski, Duane A. Burnett, Brian E. Hawes
المصدر: Bioorganic & Medicinal Chemistry Letters. 16:5427-5431
مصطلحات موضوعية: Melanin-concentrating hormone, Ratón, Clinical Biochemistry, Drug Evaluation, Preclinical, Molecular Conformation, Mice, Obese, Pharmaceutical Science, Stereoisomerism, Binding, Competitive, Biochemistry, Eating, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Metabolic Diseases, Pharmacokinetics, Drug Discovery, Animals, Humans, Structure–activity relationship, Obesity, Receptors, Somatostatin, Molecular Biology, Chemistry, Organic Chemistry, Antagonist, Biological activity, respiratory system, Diet, Rats, Disease Models, Animal, Molecular Medicine, Benzimidazoles, Anti-Obesity Agents, hormones, hormone substitutes, and hormone antagonists, Ex vivo
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المؤلفون: Kim O’Neill, Timothy J. Kowalski, Jaroslava Paruchova, Henry Guzik, Brian E. Hawes, Anandan Palani, Ruo Xu, Mark D. McBriar, William J. Greenlee, Daniel J. Weston, John W. Clader, Brian D. Spar, Shengjian Li, Blair Weig, Kathleen Cox
المصدر: Bioorganic & Medicinal Chemistry. 14:3285-3299
مصطلحات موضوعية: Melanin-concentrating hormone, Stereochemistry, Protein subunit, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Biochemistry, Chemical synthesis, Cell Line, Heptanes, Bridged Bicyclo Compounds, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Cricetinae, Drug Discovery, Aminobiphenyl Compounds, Animals, Moiety, Receptors, Pituitary Hormone, Receptor, Molecular Biology, Molecular Structure, Bicyclic molecule, Chemistry, Organic Chemistry, Rats, Melanin-concentrating hormone receptor, Biphenylamine, Molecular Medicine, Mutagens
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المؤلفون: William J. Greenlee, Jaroslava Paruchova, Blair Weig, Brian E. Hawes, John W. Clader, Daniel J. Weston, Mark D. McBriar, Kim O’Neill, Kathleen Cox, Constance Farley, Henry Guzik, Timothy J. Kowalski, Ruo Xu, Anandan Palani, Sherry Shapiro, Brian D. Spar, John Cook
المصدر: Journal of Medicinal Chemistry. 49:2294-2310
مصطلحات موضوعية: Male, medicine.medical_specialty, Melanin-concentrating hormone, Administration, Oral, Biological Availability, CHO Cells, Piperazines, Energy homeostasis, Eating, Radioligand Assay, Structure-Activity Relationship, chemistry.chemical_compound, Cricetulus, Anti-Obesity Agents, Central melanocortin system, In vivo, Cricetinae, Internal medicine, Drug Discovery, medicine, Animals, Urea, Tissue Distribution, Obesity, Receptors, Somatostatin, Receptor, Chemistry, Phenylurea Compounds, Body Weight, Brain, Rats, Melanin-concentrating hormone receptor, medicine.anatomical_structure, Endocrinology, Molecular Medicine, hormones, hormone substitutes, and hormone antagonists, Ex vivo, Half-Life
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المؤلفون: Robert A. Del Vecchio, Brian E. Hawes, Steve Fried, Brian D. Spar, Blair Weig, Henry Guzik, Mark D. McBriar, Timothy J. Kowalski, Kim O’Neill, Constance Farley, Lorraine Ghibaudi, John W. Clader, Joyce J. Hwa, John Cook
المصدر: European Journal of Pharmacology. 535:182-191
مصطلحات موضوعية: Leptin, Male, Receptors, Neuropeptide, Melanin-concentrating hormone, Administration, Oral, Gene Expression, Mice, Obese, Fatty Acids, Nonesterified, Piperazines, Energy homeostasis, Receptors, G-Protein-Coupled, Iodine Radioisotopes, Eating, Mice, chemistry.chemical_compound, Orexin Receptors, Cricetinae, Homeostasis, Insulin, Urea, Neuropeptide Y, Receptors, Somatostatin, Hypothalamic Hormones, Reverse Transcriptase Polymerase Chain Reaction, Intracellular Signaling Peptides and Proteins, Brain, Receptor antagonist, Adipose Tissue, Female, medicine.symptom, Oligopeptides, hormones, hormone substitutes, and hormone antagonists, Protein Binding, medicine.medical_specialty, medicine.drug_class, Hypothalamus, Neuropeptide, Galanin, CHO Cells, Biology, Binding, Competitive, Cricetulus, Internal medicine, Nitriles, Hypophagia, medicine, Animals, Obesity, Triglycerides, Melanins, Pharmacology, Orexins, Dose-Response Relationship, Drug, Body Weight, Neuropeptides, Dietary Fats, Mice, Inbred C57BL, Pituitary Hormones, Endocrinology, chemistry, Energy Metabolism, Diet-induced obese, Weight gain
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المصدر: Obesity Research. 11:845-851
مصطلحات موضوعية: Leptin, Male, medicine.medical_specialty, Calorie, Endocrinology, Diabetes and Metabolism, Meal pattern, Medicine (miscellaneous), Hyperphagia, Satiation, Weight Gain, Rats, Sprague-Dawley, Eating, Endocrinology, Feeding behavior, Hyperinsulinism, Internal medicine, medicine, Animals, Insulin, Genetic Predisposition to Disease, Obesity, Circadian rhythm, Hypertriglyceridemia, Meal, business.industry, Public Health, Environmental and Occupational Health, medicine.disease, Circadian Rhythm, Diet, Rats, Food, Hyperglycemia, Body Composition, Lean body mass, medicine.symptom, Energy Intake, business, Weight gain, Food Science
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المؤلفون: Christopher P. Austin, Doreen E. Cashen, Sheng-Shung Pong, Brian D. Spar, Brett Connolly, Tung Ming Fong, D. Euan MacIntyre, Carina P. Tan, Michael R. Tota, Ravi P. Nargund, R. S. L. Chang, Oksana C. Palyha, Constantin Tamvakopoulos, Deborah L. Drazen, Anthony G. DiLella, Jennifer E. Drisko, David J. Figueroa, Tanya MacNeil, Andreas W. Sailer, David H. Weinberg, Randy J. Nelson, Charles Rosenblum, Cathy R.-R.C. Huang, Rui Tang, Arthur A. Patchett, Xiao-Ming Guan, Hong Yu, George J. Christ, Andrew D. Howard, Lex H.T. Van der Ploeg, William J. Martin, Aurawan Vongs, Iyassu K. Sebhat, Ralph A. Stearns
المصدر: Proceedings of the National Academy of Sciences. 99:11381-11386
مصطلحات موضوعية: Male, Agonist, medicine.medical_specialty, DNA, Complementary, Intracranial Pressure, medicine.drug_class, Blood Pressure, In Vitro Techniques, Biology, Somatosensory system, Mice, Sexual Behavior, Animal, Nerve Fibers, Internal medicine, Copulation, medicine, Animals, Glans, In Situ Hybridization, DNA Primers, Multidisciplinary, Reverse Transcriptase Polymerase Chain Reaction, Human penis, Feeding Behavior, Ribonuclease, Pancreatic, Biological Sciences, Spinal cord, Electric Stimulation, Mice, Inbred C57BL, Melanocortin 4 receptor, medicine.anatomical_structure, Endocrinology, Receptors, Corticotropin, Models, Animal, Receptor, Melanocortin, Type 4, Brainstem, Energy Metabolism, Penis
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::341db11f0e12a0307d07e04176cd4aad
https://doi.org/10.1073/pnas.172378699 -
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المؤلفون: Duane A. Burnett, Chad E. Bennett, Brian E. Hawes, Wen-Lian Wu, Daniel J. Weston, Kim O’Neill, Brian D. Spar, William J. Greenlee, Martin S. Domalski, Mary Ann Caplen, Blair Weig, Timothy J. Kowalski
المصدر: Bioorganicmedicinal chemistry letters. 16(14)
مصطلحات موضوعية: Benzimidazole, Melanin-concentrating hormone, Clinical Biochemistry, Pharmaceutical Science, Administration, Oral, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Structure-Activity Relationship, In vivo, Drug Discovery, Moiety, Animals, Receptors, Pituitary Hormone, Molecular Biology, Organic Chemistry, Body Weight, Antagonist, respiratory system, Melanin-concentrating hormone receptor, Rats, Disease Models, Animal, chemistry, Drug Design, Molecular Medicine, Benzimidazoles, Anti-Obesity Agents, Lead compound, hormones, hormone substitutes, and hormone antagonists
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