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1دورية أكاديمية
المؤلفون: Aristos J Alexandrou, Adam R Brown, Mark L Chapman, Mark Estacion, Jamie Turner, Malgorzata A Mis, Anna Wilbrey, Elizabeth C Payne, Alex Gutteridge, Peter J Cox, Rachel Doyle, David Printzenhoff, Zhixin Lin, Brian E Marron, Christopher West, Nigel A Swain, R Ian Storer, Paul A Stupple, Neil A Castle, James A Hounshell, Mirko Rivara, Andrew Randall, Sulayman D Dib-Hajj, Douglas Krafte, Stephen G Waxman, Manoj K Patel, Richard P Butt, Edward B Stevens
المصدر: PLoS ONE, Vol 11, Iss 4, p e0152405 (2016)
وصف الملف: electronic resource
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المؤلفون: Rachel M Dick, Mark E. Gurney, Lester S Manly, Victor W. Pike, Sami S. Zoghbi, Nugent Richard, Janice A. Sindac, Jinsoo Hong, Jeih San Liow, Cheryl L. Morse, Emily C. D’Amato, Robert B. Innis, Xuesheng Mo, Sanjay Telu, Robert L. Gladding, Yuichi Wakabayashi, Brian E. Marron, Masahiro Fujita, Maarten Ooms
المصدر: ACS Chem Neurosci
مصطلحات موضوعية: Physiology, Cognitive Neuroscience, Hippocampus, Pharmacology, Biochemistry, Article, 03 medical and health sciences, 0302 clinical medicine, medicine, Radioligand, Carbon Radioisotopes, Prefrontal cortex, Rolipram, 030304 developmental biology, Temporal cortex, 0303 health sciences, medicine.diagnostic_test, Chemistry, Phosphodiesterase, Brain, Cell Biology, General Medicine, Human brain, Cyclic Nucleotide Phosphodiesterases, Type 4, medicine.anatomical_structure, Positron emission tomography, Positron-Emission Tomography, Radiopharmaceuticals, 030217 neurology & neurosurgery, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be97eda4c5f7f24c27268d008983b6e4
https://europepmc.org/articles/PMC7444660/ -
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المؤلفون: Jianmin Sun, Thomas Ryckmans, David Fengas, Colin R. Rose, M. Scott Johnson, Matthew Corbett, David James Rawson, Nigel Alan Swain, Joseph S. Warmus, Lyn H. Jones, Brian E. Marron, Aristos J. Alexandrou, David Printzenhoff, C. Elizabeth Payne, Bruce M. Bechle, Rubben Torella, Neil A. Castle, Jonathan W. Theile, Elaine Tseng, David C. Blakemore, Andrew Pike, R. Ian Storer, Neil J. Flanagan, Alan Daniel Brown
المصدر: Bioorganic & Medicinal Chemistry Letters. 27:4805-4811
مصطلحات موضوعية: 0301 basic medicine, Voltage-gated ion channel, Chemistry, Sodium channel, Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, In vivo, Drug Discovery, NAV1, Molecular Medicine, Potency, Molecular Biology, 030217 neurology & neurosurgery, Ion channel, Conjugate, ADME
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المؤلفون: Christopher William West, Nigel Alan Swain, Peter J. Cox, Joseph S. Warmus, Kiyoyuki Omoto, David C. Pryde, George Salvatore Amato, Steven Michael Reister, Jamie Turner, Brett M Antonio, Aaron C. Gerlach, Brian E. Marron, Karen Padilla, Katrina Yoger, John H. Mahoney
المصدر: ACS Medicinal Chemistry Letters. 8:666-671
مصطلحات موضوعية: 0301 basic medicine, Indazole, Stereochemistry, Organic Chemistry, Pharmacology, Inflammatory pain, Biochemistry, In vitro, 03 medical and health sciences, Transient receptor potential channel, chemistry.chemical_compound, 030104 developmental biology, chemistry, In vivo, Docking (molecular), Drug Discovery, Moiety
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المؤلفون: David C. Pryde, Brian E. Marron, Peter J. Cox, C. J. Markworth, Joseph S. Warmus, Christopher William West, David Printzenhoff, S. McMurray, Stupple Paul Anthony, Zhixin Lin, Nigel Alan Swain, Mark L. Chapman, C. E. Payne, Ryoichi Suzuki, Gareth Waldron
المصدر: MedChemComm. 8:1255-1267
مصطلحات موضوعية: 0301 basic medicine, Pharmacology, Chemistry, Organic Chemistry, Pharmaceutical Science, Ether, Biochemistry, Combinatorial chemistry, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, Pharmacokinetics, Voltage sensor, Drug Discovery, Molecular Medicine, 030217 neurology & neurosurgery
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::686aba00c31c3db790fd73e2323a9e86
https://doi.org/10.1039/c7md00131b -
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المؤلفون: Joseph S. Warmus, Sarah Elizabeth Skerratt, Steven M Reister, David C. Pryde, Thomas Ryckmans, J. Turner, Karen M. Padilla, Katrina E. Yoger, A. C. Gerlach, Nigel Alan Swain, G. Amato, Peter J. Cox, C. G. West, Brian E. Marron, David C. Blakemore
المصدر: MedChemComm. 7:2145-2158
مصطلحات موضوعية: 0301 basic medicine, Pharmacology, medicine.drug_class, Chemistry, Organic Chemistry, Pharmaceutical Science, Carboxamide, Atopic dermatitis, medicine.disease, Biochemistry, Combinatorial chemistry, 03 medical and health sciences, 030104 developmental biology, Pharmacokinetics, Drug Discovery, medicine, Molecular Medicine
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::646aab78dfcb415f3cbbd6666b75f640
https://doi.org/10.1039/c6md00387g -
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المصدر: Channels
مصطلحات موضوعية: voltage-gated sodium channels Electrophysiology screening, Sodium, sodium channel structure, Molecular Sequence Data, Biophysics, chemistry.chemical_element, Review, sodium channel toxins, Voltage-Gated Sodium Channels, Pharmacology, Biochemistry, Sodium channel blocker, Drug Discovery, Animals, Humans, Amino Acid Sequence, Ion channel, Membrane potential, Analgesics, Chemistry, Drug discovery, Sodium channel, Anticonvulsants, Anti-Arrhythmia Agents, Intracellular, sodium channel drugs, Sodium Channel Blockers
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المؤلفون: R Ian, Storer, Andy, Pike, Nigel A, Swain, Aristos J, Alexandrou, Bruce M, Bechle, David C, Blakemore, Alan D, Brown, Neil A, Castle, Matthew S, Corbett, Neil J, Flanagan, David, Fengas, M Scott, Johnson, Lyn H, Jones, Brian E, Marron, C Elizabeth, Payne, David, Printzenhoff, David J, Rawson, Colin R, Rose, Thomas, Ryckmans, Jianmin, Sun, Jonathan W, Theile, Rubben, Torella, Elaine, Tseng, Joseph S, Warmus
المصدر: Bioorganicmedicinal chemistry letters. 27(21)
مصطلحات موضوعية: Voltage-Gated Sodium Channel Blockers, Sulfonamides, Binding Sites, Pyridines, NAV1.7 Voltage-Gated Sodium Channel, Pain, Protein Structure, Tertiary, Rats, Molecular Docking Simulation, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, Dogs, Piperidines, Thiadiazoles, Hepatocytes, Microsomes, Liver, Animals, Humans, Infusions, Intravenous, Half-Life, Protein Binding
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المؤلفون: Bruce M. Bechle, Stephen Martin Denton, Sebastien Galan, David James Rawson, Marcel J. de Groot, Brian E. Marron, Matthew S Johnson, Jo Hannam, Shoko Nakagawa, Dave Batchelor, Nigel Alan Swain, Steven M Reister, David Ellis, Mark L. Chapman, David Printzenhoff, Sarah J Ransley, Beaudoin Serge, David S. Millan, Christopher W. West, Kenneth John Butcher, R. Ian Storer, Stephen M Gaulier, Stupple Paul Anthony, Andrew Pike, Alan Daniel Brown, Christopher John Markworth, Bruce Brown, Zhixin Lin, Sasaki Kosuke, Paul A. Bradley, Ian Gurrell, Richard P. Butt, Mel Glossop, Ben S. Greener
المصدر: Journal of medicinal chemistry. 60(16)
مصطلحات موضوعية: 0301 basic medicine, Cytochrome P-450 CYP2C9 Inhibitors, Stereochemistry, Cell Line, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, MicroDose, Pharmacokinetics, Drug Discovery, Structure–activity relationship, Cytochrome P-450 CYP3A, Humans, Cytochrome P-450 CYP2C9, Voltage-Gated Sodium Channel Blockers, Sulfonamides, biology, Chemistry, Aryl, Phenyl Ethers, NAV1.7 Voltage-Gated Sodium Channel, PF-05089771, Cytochrome P450, In vitro, 030104 developmental biology, Drug Design, biology.protein, Microsome, Microsomes, Liver, Molecular Medicine, Cytochrome P-450 CYP3A Inhibitors
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المؤلفون: Sharan K. Bagal, Nigel Alan Swain, R. Ian Storer, Mark L. Chapman, Brian E. Marron, Rebecca L. Prime
المصدر: Bioorganic & Medicinal Chemistry Letters. 24(16):3690-3699
مصطلحات موضوعية: Drug discovery, Chemistry, Sodium channel, Organic Chemistry, Clinical Biochemistry, Pain, Genetic data, Pharmaceutical Science, Pharmacology, Sodium channel toxins, Biochemistry, Sodium channel drugs, Sodium channel structure, Drug Discovery, Animals, Humans, Molecular Medicine, Electrophysiology screening, Voltage-gated sodium channels, Neuroscience, Molecular Biology, Ion channel, Sodium Channel Blockers