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1
المؤلفون: Kenneth L. Clark, Paul Martin Gore, Panayiotis A. Procopiou, Simon Teanby Hodgson, Alison J. Ford, Clarissa J. Watts, Robert J. Slack, Duncan S. Holmes, Brian Edgar Looker, Ken A. Saunders, Ashley Paul Hancock, Sadie Vile
المصدر: Bioorganic & Medicinal Chemistry Letters. 27:4914-4919
مصطلحات موضوعية: 0301 basic medicine, CYP3A4, Chemistry, Organic Chemistry, Clinical Biochemistry, Sulfonamide (medicine), Pharmaceutical Science, Sulfanilamide, Histamine H1 receptor, Pharmacology, Histamine H1 Antagonists, Biochemistry, Azelastine, Bioavailability, 03 medical and health sciences, 030104 developmental biology, Drug Discovery, medicine, Molecular Medicine, Nasal administration, Molecular Biology, medicine.drug
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2
المؤلفون: Robert J. Slack, Brian Edgar Looker, Sadie Vile, Duncan S. Holmes, Kenneth L. Clark, Clarissa J. Watts, Simon Teanby Hodgson, Panayiotis A. Procopiou, Paul Martin Gore, Ken A. Saunders, Alison J. Ford, James E. Rowedder
المصدر: ACS Medicinal Chemistry Letters. 8:577-581
مصطلحات موضوعية: 0301 basic medicine, Histamine H1 Receptor Antagonists, medicine.medical_specialty, 010405 organic chemistry, Chemistry, Organic Chemistry, Pharmacology, 01 natural sciences, Biochemistry, Azelastine, In vitro, 0104 chemical sciences, Bioavailability, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, Endocrinology, In vivo, Internal medicine, Amide, Drug Discovery, medicine, Nasal administration, Dosing, medicine.drug
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3
المؤلفون: Steven Philip Keeling, Nigel J. Parr, Simon Teanby Hodgson, Ashley Paul Hancock, Duncan S. Holmes, Panayiotis A. Procopiou, James E. Rowedder, Brian Edgar Looker, Robert J. Slack, Paul Martin Gore, Rachael A. Ancliff
المصدر: Bioorganic & Medicinal Chemistry Letters. 26:5855-5859
مصطلحات موضوعية: 0301 basic medicine, Stereochemistry, Clinical Biochemistry, hERG, Pharmaceutical Science, Histamine Receptor Antagonists, Pharmacology, 01 natural sciences, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, medicine, Potency, Receptor, Molecular Biology, biology, Chemistry, Organic Chemistry, Quinoline, Azelastine, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, 030104 developmental biology, biology.protein, Molecular Medicine, Nasal administration, medicine.drug
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4
المؤلفون: Brian Edgar Looker, Victoria J. Barrett, Gillian Elizabeth Lunniss, Alison J. Ford, Claire E. Smith, Deborah Needham, Panayiotis A. Procopiou, Graham Somers
المصدر: Bioorganic & Medicinal Chemistry. 19:6026-6032
مصطلحات موضوعية: medicine.medical_specialty, Adrenergic receptor, Clinical Biochemistry, Pharmaceutical Science, Pharmacology, Biochemistry, Guinea pig, chemistry.chemical_compound, In vivo, Internal medicine, Drug Discovery, medicine, Molecular Biology, Organic Chemistry, respiratory system, In vitro, respiratory tract diseases, Bioavailability, Endocrinology, chemistry, Urea, Microsome, Molecular Medicine, Salmeterol, hormones, hormone substitutes, and hormone antagonists, medicine.drug
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5
المؤلفون: Claire E. Smith, Rossana Perciaccante, Peter R. Butchers, Alison J. Ford, Gillian Elizabeth Lunniss, Richard Conroy, Séverine Jeulin, Brian Edgar Looker, Graham Somers, Valerie S. Morrison, Amanda Emmons, Panayiotis A. Procopiou, Nicola Bevan, Victoria J. Barrett, Mark Ruston, Peter J. Mutch
المصدر: Bioorganic & Medicinal Chemistry. 19:4192-4201
مصطلحات موضوعية: Organic Chemistry, Clinical Biochemistry, Pharmaceutical Science, Hydantoin, Adrenergic, Uracil, Pharmacology, Biochemistry, In vitro, Bioavailability, Guinea pig, chemistry.chemical_compound, chemistry, In vivo, Drug Discovery, Microsome, Molecular Medicine, Molecular Biology
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6
المؤلفون: Peter R. Butchers, Claire E. Smith, Iain M. McLay, Rosemary Sasse, Keith Biggadike, Peter J. Mutch, Panayiotis A. Procopiou, Stephen A. Richards, Richard Conroy, Diane M. Coe, Edney Dean David, Stephen Barry Guntrip, Alison J. Ford, Rita Field, Brian Edgar Looker, Nicola Bevan, Michael John Monteith, Victoria J. Barrett, Valerie S. Morrison
المصدر: Journal of Medicinal Chemistry. 52:2280-2288
مصطلحات موضوعية: Models, Molecular, Agonist, Stereochemistry, medicine.drug_class, Guinea Pigs, Administration, Oral, Biological Availability, Bronchi, CHO Cells, In Vitro Techniques, Chemical synthesis, Guinea pig, Structure-Activity Relationship, Cricetulus, Dogs, In vivo, Oral administration, Cricetinae, Microsomes, Drug Discovery, Cyclic AMP, medicine, Animals, Humans, Structure–activity relationship, Albuterol, Adrenergic beta-2 Receptor Agonists, Salmeterol Xinafoate, chemistry.chemical_classification, 2-Hydroxyphenethylamine, Sulfonamides, Chemistry, Muscle, Smooth, Stereoisomerism, In vitro, Rats, Sulfonamide, Trachea, Molecular Medicine, Muscle Contraction
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7
المؤلفون: Peter R. Butchers, Victoria J. Barrett, Peter J. Mutch, Andrew P. Craven, Sara C Hughes, Mark Ruston, Duncan S. Holmes, Alison J. Ford, Keith Biggadike, Brian Edgar Looker, Stephen Barry Guntrip, Anne Jones, Deborah Needham, Panayiotis A. Procopiou, Claire E. Smith
المصدر: Journal of medicinal chemistry. 57(1)
مصطلحات موضوعية: Agonist, Adrenergic receptor, medicine.drug_class, Guinea Pigs, CHO Cells, Pharmacology, Drug Administration Schedule, Sulfone, Hydroxylation, chemistry.chemical_compound, Cricetulus, Dogs, In vivo, Cricetinae, Drug Discovery, medicine, Animals, Humans, Sulfones, Adrenergic beta-2 Receptor Agonists, respiratory system, Bioavailability, Rats, Trachea, chemistry, Toxicity, Hepatocytes, Molecular Medicine, Salmeterol, medicine.drug
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8
المؤلفون: Linda J. Russell, Paul Martin Gore, Simon Teanby Hodgson, Ashley Paul Hancock, Robert J. Slack, Jennifer M. Buckley, Sadie Vile, Michael Kranz, Steven L. Sollis, Kenneth L. Clark, Brian Edgar Looker, Panayiotis A. Procopiou, Clarissa J. Watts, Duncan S. Holmes, Christopher Browning, Lise C. Fechner, Daniel L. Parton, Karen M. L. Morriss
المصدر: Journal of medicinal chemistry. 54(7)
مصطلحات موضوعية: Models, Molecular, Protein Conformation, Administration, Oral, Nasal congestion, Pharmacology, Drug Discovery, medicine, Potency, Humans, Receptors, Histamine H3, Receptors, Histamine H1, Receptor, Administration, Intranasal, Rhinitis, Chemistry, Azelastine, Bioavailability, Blockade, Immunology, Histamine H1 Antagonists, Molecular Medicine, Phthalazines, Nasal administration, medicine.symptom, Antagonism, medicine.drug, Histamine H3 Antagonists
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9
المؤلفون: Brian Edgar Looker, Peter R. Butchers, Peter J. Mutch, Iain Mcfarlane Mclay, Alison J. Ford, Duncan S. Holmes, Claire E. Smith, Philip Charles Box, Inderjit Singh Mann, Helen Tracey Horsley, Richard Conroy, Valerie S. Morrison, Fern Kerr, Nicola Bevan, Amanda Emmons, Victoria J. Barrett, Panayiotis A. Procopiou, Anne-Marie Li-Kwai-Cheung, Paula Tomlin, Diane Mary Coe, Keith Biggadike
المصدر: Journal of medicinal chemistry. 53(11)
مصطلحات موضوعية: Agonist, Models, Molecular, medicine.medical_specialty, medicine.drug_class, Protein Conformation, CHO Cells, Alkylation, Pharmacology, Chlorobenzenes, Guinea pig, Structure-Activity Relationship, Cricetulus, In vivo, Internal medicine, Cricetinae, Drug Discovery, medicine, Potency, Animals, Humans, Adrenergic beta-2 Receptor Agonists, Benzyl Alcohols, Chemistry, Chinese hamster ovary cell, Adrenergic beta-Agonists, In vitro, Bioavailability, Rats, Endocrinology, Molecular Medicine, Receptors, Adrenergic, beta-2, Benzyl Alcohol
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10
المؤلفون: Gemma Victoria White, Helen E. Connor, Elizabeth Pickup, David Matthew Wilson, Clarissa J. Watts, Christopher Browning, Sanjeet Singh Sehmi, Karen M. L. Morriss, Mark James Bamford, Christopher A. Parr, Susannah Davies, Brian Edgar Looker, Panayiotis A. Procopiou, Simon Teanby Hodgson, Fogden Yvonne C, Rachael A. Ancliff, Woodrow Michael David, Duncan S. Holmes
المصدر: Journal of medicinal chemistry. 50(26)
مصطلحات موضوعية: Male, ERG1 Potassium Channel, Stereochemistry, Guinea Pigs, Administration, Oral, CHO Cells, In Vitro Techniques, Chemical synthesis, Piperazines, Rats, Sprague-Dawley, chemistry.chemical_compound, Radioligand Assay, Structure-Activity Relationship, Cricetulus, Dogs, Cytochrome P-450 Enzyme System, Ileum, Cricetinae, Isometric Contraction, Drug Discovery, Animals, Humans, Receptor, Cerebral Cortex, Chemistry, Brain, Muscle, Smooth, Penetration (firestop), Ether-A-Go-Go Potassium Channels, Bioavailability, Rats, Isoenzymes, Blood-Brain Barrier, Molecular Medicine, Amine gas treating, Histamine H3 receptor, Selectivity, Histamine, Histamine H3 Antagonists