-
1دورية أكاديمية
المؤلفون: Yun Wang, Kelvin Zhang, Peter Georgiev, Steven Wells, Haiyan Xu, Brian M Lacey, Zangwei Xu, Jason Laskey, Robbie Mcleod, Joey L Methot, Mark Bittinger, Alexander Pasternak, Sheila Ranganath
المصدر: PLoS ONE, Vol 15, Iss 12, p e0243145 (2020)
وصف الملف: electronic resource
Relation: https://doaj.org/toc/1932-6203
-
2
المؤلفون: Joey L. Methot, David A Candito, Sheila Ranganath, Zangwei Xu, Xavier Fradera, Abdelghani Achab, Erin F. DiMauro, Haiyan Xu, Samuel M. Levi, Brandon A. Vara, Brian M. Lacey, Mark Bittinger, Jennifer Piesvaux, Dustin M Smith, Alexander Pasternak, Jongwon Lim, David Jonathan Bennett, J. Richard Miller, Charles A. Lesburg, Shuhei Kawamura
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: 010405 organic chemistry, Chemistry, medicine.drug_class, Kinase, medicine.medical_treatment, T cell, Organic Chemistry, T-cell receptor, Carboxamide, 01 natural sciences, Biochemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, Cytokine, medicine.anatomical_structure, Diaminopyrimidine, Drug Discovery, Cancer research, medicine, Kinome, B cell
-
3
المؤلفون: Dustin M Smith, Zangwei Xu, Joey L. Methot, Xavier Fradera, Alexander Pasternak, Elsie C Yu, Jennifer Piesvaux, Phieng Siliphaivanh, Brian M. Lacey, Mark Bittinger, Shuhei Kawamura, Charles A. Lesburg, J. Richard Miller, Ping Liu, Haiyan Xu
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Indazole, 010405 organic chemistry, Chemistry, Kinase, Organic Chemistry, Signal transducing adaptor protein, 01 natural sciences, Biochemistry, 0104 chemical sciences, Bioavailability, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, In vivo, Drug Discovery, Potency, Phosphorylation, Salt bridge
-
4
المؤلفون: Wonsuk Chang, Michael D. Altman, Charles A. Lesburg, Samanthi A. Perera, Jennifer A. Piesvaux, Gottfried K. Schroeder, Daniel F. Wyss, Saso Cemerski, Yiping Chen, Edward DiNunzio, Andrew M. Haidle, Thu Ho, Ilona Kariv, Ian Knemeyer, Johnny E. Kopinja, Brian M. Lacey, Jason Laskey, Jongwon Lim, Brian J. Long, Yanhong Ma, Matthew L. Maddess, Bo-Sheng Pan, Jeremy P. Presland, Edward Spooner, Dietrich Steinhuebel, Quang Truong, Zhibo Zhang, Jianmin Fu, George H. Addona, Alan B. Northrup, Emma Parmee, James R. Tata, David Jonathan Bennett, Jared N. Cumming, Tony Siu, B. Wesley Trotter
المصدر: Journal of medicinal chemistry. 65(7)
مصطلحات موضوعية: Mice, Neoplasms, Drug Discovery, Molecular Medicine, Animals, Cytokines, Humans, Membrane Proteins, Immunotherapy, Interferons
-
5
المؤلفون: My Sam Mansueto, Brooke M Swalm, Patrick S. Fier, Rachel L. Palte, Sandra Lee, Kristin Geddes, Josep Saurí, Michael H. Reutershan, Charles S. Yeung, Benjamin Nicholson, David J. Witter, Murray Wan, Robert P Hayes, Haiyan Xu, David L. Sloman, Nicole Follmer, Daniel S. Spellman, Danica A. Rankic, Pierre Daublain, Timothy J. Henderson, Jongwon Lim, Dapeng Chen, Erik Munsell, Guo Feng, Steven M. Silverman, Ryan V Quiroz, Doug Linn, Sulagna Sanyal, Michelle R. Machacek, Craig R. Gibeau, Shuhei Kawamura, Yuanwei Gao, Jonathan M E Hughes, Sebastian Schneider, Phieng Siliphaivanh, Yingchun Ye, Brian M. Lacey
المصدر: Journal of medicinal chemistry. 64(7)
مصطلحات موضوعية: Protein-Arginine N-Methyltransferases, DNA repair, Antineoplastic Agents, Plasma protein binding, Computational biology, Mice, SCID, 01 natural sciences, 03 medical and health sciences, Structure-Activity Relationship, Transcription (biology), Neoplasms, Drug Discovery, Structure–activity relationship, Animals, Humans, Enzyme Inhibitors, 030304 developmental biology, Cell Proliferation, 0303 health sciences, Bicyclic molecule, Molecular Structure, Chemistry, Protein arginine methyltransferase 5, Nucleosides, 0104 chemical sciences, Molecular Docking Simulation, 010404 medicinal & biomolecular chemistry, Docking (molecular), Drug Design, RNA splicing, Aminoquinolines, Molecular Medicine, Female, Protein Binding
-
6
المؤلفون: Laura Price, Samanthi A. Perera, Daniel F. Wyss, Johnny E. Kopinja, Saso Cemerski, Sharad K. Sharma, Timothy J. Henderson, Serena Xu, Andrew M. Haidle, Min Lu, George H. Addona, Greg O’Donnell, Berengere Sauvagnat, Gottfried K. Schroeder, Ilona Kariv, Larissa Rakhilina, Sriram Tyagarajan, Bo-Sheng Pan, Hyun Chong Woo, Brian Long, Jared N. Cumming, Brandon Cash, Yiping Chen, Ryan D. Otte, B. Wesley Trotter, Jeremy Presland, Jennifer Piesvaux, Brian M. Lacey, Rui Liang, Peter J. Dandliker, Ellen C. Minnihan, Charles A. Lesburg, Ian Knemeyer, Yanhong Ma, Guo Feng, David Jonathan Bennett, Michael D. Altman, Alexei V. Buevich, Jason Laskey, James P. Jewell, Wonsuk Chang
المصدر: Signal Transduction and Targeted Therapy
مصطلحات موضوعية: Agonist, Tumor microenvironment, Multidisciplinary, Innate immune system, Chemistry, medicine.drug_class, Administration, Oral, Membrane Proteins, Antineoplastic Agents, Pharmacology, Research Highlight, Target validation, nervous system diseases, Sting, Drug screening, stomatognathic system, Interferon, Stimulator of interferon genes, Systemic administration, medicine, Animals, Humans, Secretion, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93434b3ed8c750bce8ca979d455db02c
https://doi.org/10.1126/science.aba6098 -
7Pharmacological inhibition of hematopoietic progenitor kinase 1 positively regulates T-cell function
المؤلفون: Steven Wells, Jason Laskey, Robbie L. McLeod, Brian M. Lacey, Joey L. Methot, Alexander Pasternak, Yun Wang, Mark Bittinger, Kelvin Xi Zhang, Sheila Ranganath, Haiyan Xu, Zangwei Xu, Peter Georgiev
المصدر: PLoS ONE, Vol 15, Iss 12, p e0243145 (2020)
PLoS ONEمصطلحات موضوعية: Adenosine, Physiology, medicine.medical_treatment, T-Lymphocytes, Cancer Treatment, Glycobiology, Lymphocyte Activation, Biochemistry, White Blood Cells, Cancer immunotherapy, Interferon, Animal Cells, Immune Physiology, Medicine and Health Sciences, Cytotoxic T cell, Innate Immune System, Multidisciplinary, Chemistry, T Cells, Nucleosides, Glycosylamines, medicine.anatomical_structure, Oncology, Cytokines, Medicine, Female, Immunotherapy, Signal transduction, Cellular Types, medicine.drug, Research Article, T cell, Immune Cells, Science, Immunology, Cytotoxic T cells, Protein Serine-Threonine Kinases, Research and Analysis Methods, Cancer Immunotherapy, Immune system, medicine, Animals, Kinase activity, Molecular Biology Techniques, Protein Kinase Inhibitors, Molecular Biology, Secretion, Blood Cells, Biology and Life Sciences, Cell Biology, Molecular Development, Mice, Inbred C57BL, Immune System, Cancer research, Clinical Immunology, Clinical Medicine, Physiological Processes, Developmental Biology, Cloning
-
8
المؤلفون: Christopher Sondey, Michael D. Altman, Sebastian Schneider, Michelle R. Machacek, Yingchun Ye, Robert P Hayes, Zangwei Xu, Phieng Siliphaivanh, Brian M. Lacey, Shuhei Kawamura, Haiyan Xu, Michael H. Reutershan, Rachel L. Palte, My Sam Mansueto
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Methyltransferase, biology, Arginine, 010405 organic chemistry, Chemistry, Protein arginine methyltransferase 5, Organic Chemistry, Allosteric regulation, Methylation, 01 natural sciences, Biochemistry, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, Histone, Drug Discovery, Histone methylation, biology.protein, Binding site
-
9
المؤلفون: Federica Orvieto, Mark J Demma, Canada Keith A, Alycia V Shoultz, Alessia Santoprete, Kuanchang Chen, Amy Bittner Mccracken, Xiaohong Zhu, Scott A. Johnson, Claudio Mapelli, Iman Farasat, Brian M. Lacey, Zachary Z Brown, Abbas Walji, Robert M. Garbaccio, Jennifer O'Neil, Elisabetta Bianchi
المصدر: The Journal of organic chemistry. 85(3)
مصطلحات موضوعية: chemistry.chemical_classification, Coiled coil, 010405 organic chemistry, Organic Chemistry, Mutagenesis, Cell, Peptide, DNA, 010402 general chemistry, Native chemical ligation, 01 natural sciences, Peptide Fragments, 0104 chemical sciences, Amino acid, Cell biology, Cell Line, Proto-Oncogene Proteins c-myc, chemistry.chemical_compound, medicine.anatomical_structure, chemistry, medicine, Peptide synthesis, Protein Binding
-
10
المؤلفون: Gottfried K. Schroeder, T. Ho, Altman, James P. Jewell, Matthew Lloyd Childers, Tony Siu, H. Hatch, Bo-Sheng Pan, J.M. Ellis, Brian M. Lacey, Hakan Gunaydin, Berengere Sauvagnat, G.A. Baltus, Shiyao Xu, Charles A. Lesburg
مصطلحات موضوعية: 010404 medicinal & biomolecular chemistry, Sting, 010405 organic chemistry, Chemistry, Ligand, Organic Chemistry, Drug Discovery, Druggability, 01 natural sciences, Biochemistry, Combinatorial chemistry, 0104 chemical sciences
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c62c0515a878b2ef55a30a0a5889e743
https://europepmc.org/articles/PMC6331172/