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المؤلفون: James G. Christensen, Peter Olson, Pasi A. Jänne, Kyriakos P. Papadopoulos, Piro Lito, Sai-Hong Ignatius Ou, Melissa L. Johnson, Igor I. Rybkin, Matthew A. Marx, Douglas P. Cassidy, Emanuel F. Patricoin, Elisa Baldelli, Mariaelena Pierobon, Jeremy Barton, Richard C. Chao, Karen Velastagui, Adam Pavlicek, Julio Fernandez-Banet, Sole Gatto, Yaohua Xue, Guy P. Vigers, John P. Fischer, Jay B. Fell, Michael R. Burkard, Joshua A. Ballard, Brian R. Baer, Vickie Bowcut, Niranjan Sudhakar, David M. Briere, Ruth Aranda, Andrew Calinisan, Lauren Hargis, Lars D. Engstrom, Jill Hallin
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::095624453d8ad8530fb345958c4cd8b6
https://doi.org/10.1158/2159-8290.22535530.v1 -
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المؤلفون: James G. Christensen, Peter Olson, Pasi A. Jänne, Kyriakos P. Papadopoulos, Piro Lito, Sai-Hong Ignatius Ou, Melissa L. Johnson, Igor I. Rybkin, Matthew A. Marx, Douglas P. Cassidy, Emanuel F. Patricoin, Elisa Baldelli, Mariaelena Pierobon, Jeremy Barton, Richard C. Chao, Karen Velastagui, Adam Pavlicek, Julio Fernandez-Banet, Sole Gatto, Yaohua Xue, Guy P. Vigers, John P. Fischer, Jay B. Fell, Michael R. Burkard, Joshua A. Ballard, Brian R. Baer, Vickie Bowcut, Niranjan Sudhakar, David M. Briere, Ruth Aranda, Andrew Calinisan, Lauren Hargis, Lars D. Engstrom, Jill Hallin
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::dd866fa6fe03bc0849986ce88d5870c4
https://doi.org/10.1158/2159-8290.c.6547879.v1 -
3دورية أكاديمية
المؤلفون: Min Lu, Pingping Li, Gautam Bandyopadhyay, William Lagakos, Walter E Dewolf, Taylor Alford, Mark Joseph Chicarelli, Lance Williams, Deborah A Anderson, Brian R Baer, Maralee McVean, Marion Conn, Murielle M Véniant, Peter Coward
المصدر: PLoS ONE, Vol 9, Iss 2, p e88431 (2014)
وصف الملف: electronic resource
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المؤلفون: Joshua Ballard, Harrah Chiang, James G. Christensen, Kenneth Hee, Tony Pisal Tang, Brian R. Baer, Peter Olson, Henry J. Zecca, David Briere, Mark Joseph Chicarelli, Laurence E. Burgess, Karyn Bouhana, Jill Hallin, Matthew A. Marx, Lauren Hanson, Barbara J. Brandhuber, Michael Burkard, Fell Jay Bradford, Pavel Savechenkov, James F. Blake, John P. Fischer, Guy Vigers, Hicken Erik James, Niranjan Sudhakar, Kevin Davidson, Ronald Jay Hinklin, Macedonio J. Mejia, John Gaudino
المصدر: ACS Medicinal Chemistry Letters. 9:1230-1234
مصطلحات موضوعية: 0301 basic medicine, endocrine system diseases, Oncogene, Chemistry, Organic Chemistry, Cancer, medicine.disease_cause, medicine.disease, Biochemistry, Small molecule, digestive system diseases, respiratory tract diseases, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Covalent bond, In vivo, 030220 oncology & carcinogenesis, Drug Discovery, medicine, Cancer research, KRAS, neoplasms, Function (biology), Cysteine
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المؤلفون: Jay B, Fell, John P, Fischer, Brian R, Baer, James F, Blake, Karyn, Bouhana, David M, Briere, Karin D, Brown, Laurence E, Burgess, Aaron C, Burns, Michael R, Burkard, Harrah, Chiang, Mark J, Chicarelli, Adam W, Cook, John J, Gaudino, Jill, Hallin, Lauren, Hanson, Dylan P, Hartley, Erik J, Hicken, Gary P, Hingorani, Ronald J, Hinklin, Macedonio J, Mejia, Peter, Olson, Jennifer N, Otten, Susan P, Rhodes, Martha E, Rodriguez, Pavel, Savechenkov, Darin J, Smith, Niranjan, Sudhakar, Francis X, Sullivan, Tony P, Tang, Guy P, Vigers, Lance, Wollenberg, James G, Christensen, Matthew A, Marx
المصدر: Journal of medicinal chemistry. 63(13)
مصطلحات موضوعية: Models, Molecular, Proto-Oncogene Proteins p21(ras), Mice, Cell Line, Tumor, Drug Design, Mutation, Animals, Humans, Antineoplastic Agents, Drug Screening Assays, Antitumor, Enzyme Inhibitors, Xenograft Model Antitumor Assays
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المؤلفون: Jill, Hallin, Lars D, Engstrom, Lauren, Hargis, Andrew, Calinisan, Ruth, Aranda, David M, Briere, Niranjan, Sudhakar, Vickie, Bowcut, Brian R, Baer, Joshua A, Ballard, Michael R, Burkard, Jay B, Fell, John P, Fischer, Guy P, Vigers, Yaohua, Xue, Sole, Gatto, Julio, Fernandez-Banet, Adam, Pavlicek, Karen, Velastagui, Richard C, Chao, Jeremy, Barton, Mariaelena, Pierobon, Elisa, Baldelli, Emanuel F, Patricoin, Douglas P, Cassidy, Matthew A, Marx, Igor I, Rybkin, Melissa L, Johnson, Sai-Hong Ignatius, Ou, Piro, Lito, Kyriakos P, Papadopoulos, Pasi A, Jänne, Peter, Olson, James G, Christensen
المصدر: Cancer discovery. 10(1)
مصطلحات موضوعية: Acetonitriles, Lung Neoplasms, Pyrrolidines, Mice, Nude, Adenocarcinoma of Lung, Antineoplastic Agents, Apoptosis, Mice, SCID, Piperazines, Proto-Oncogene Proteins p21(ras), Mice, Mice, Inbred NOD, Tumor Cells, Cultured, Animals, Humans, Cell Proliferation, Mice, Inbred BALB C, Clinical Trials, Phase I as Topic, Middle Aged, Prognosis, Xenograft Model Antitumor Assays, Disease Models, Animal, Pyrimidines, Mutation, Female, Signal Transduction
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::1ef3d07a71c1efe4ae1da70ed55065bb
https://pubmed.ncbi.nlm.nih.gov/31919120 -
7
المؤلفون: Allan E. Rettie, Brian R. Baer, Eric F. Johnson, Mei-Hui Hsu
المصدر: Journal of Biological Chemistry. 292:5610-5621
مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, Stereochemistry, Reactive intermediate, Heme, Crystallography, X-Ray, Hydroxylation, Photochemistry, Biochemistry, Substrate Specificity, Conserved sequence, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Animals, Editors' Picks, Molecular Biology, Conserved Sequence, Octane, Binding Sites, 030102 biochemistry & molecular biology, biology, Active site, Cell Biology, Conformational entropy, Octanes, Enzyme structure, 030104 developmental biology, chemistry, Helix, biology.protein, Aryl Hydrocarbon Hydroxylases, Rabbits
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6adc5ee1f72e712b5df9aaaa173240e5
https://doi.org/10.1074/jbc.m117.775494 -
8
المؤلفون: Scott Alan Pratt, Patrice Lee, Thomas Daniel Aicher, John Fischer, Kevin Ronald Condroski, Brian R. Baer, Boyd Steven A, Mark D. Chicarelli, Walter C. Voegtli, Walter E. DeWolf, Francis X. Sullivan, Eli M. Wallace, Nickolas A. Neitzel, Lance A. Williams, Ronald Jay Hinklin, Turner Timothy M, Ajay Singh, Gary P. Hingorani, Michele Frank
المصدر: Bioorganicmedicinal chemistry. 28(1)
مصطلحات موضوعية: Blood Glucose, medicine.medical_treatment, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Enzyme Activators, Type 2 diabetes, Pharmacology, Molecular Dynamics Simulation, Crystallography, X-Ray, 01 natural sciences, Biochemistry, Diabetes Mellitus, Experimental, Mice, Structure-Activity Relationship, Diabetes mellitus, Drug Discovery, Glucokinase, Thiadiazoles, medicine, Glucokinase activator, Animals, Hypoglycemic Agents, Molecular Biology, Binding Sites, 010405 organic chemistry, Chemistry, Insulin, Organic Chemistry, ob/ob mouse, Glucose Tolerance Test, medicine.disease, 0104 chemical sciences, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, Kinetics, medicine.anatomical_structure, Drug Design, Molecular Medicine, Pancreas, Flux (metabolism)
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المؤلفون: James G. Christensen, Macedonia J. Mejia, Tony Pisal Tang, Joshua Ballard, Pavel Y. Savechenkov, Mark Joseph Chicarelli, Guy Vigers, Niranjan Sudhakar, James F. Blake, Peter D. Olson, Brian R. Baer, David Briere, Matthew A. Marx, Fell Jay Bradford, Michael R. Burkhard, Karyn Bouhana, Laurence E. Burgess, Jill Hallin, Harrah Chiang, John P. Fischer
المصدر: Molecular Cancer Research. 18:B30-B30
مصطلحات موضوعية: Cancer Research, Chemistry, Drug discovery, Mutant, medicine.disease_cause, Oncology, Cell culture, Cancer research, medicine, Potency, KRAS, Molecular Biology, IC50, Cysteine, ADME
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::6886a9bb95b32c7a7f0ea987f77aeeb5
https://doi.org/10.1158/1557-3125.ras18-b30 -
10
المؤلفون: David Briere, Lauren Hargis, James G. Christensen, Matthew A. Marx, Jill Hallin, Fell Jay Bradford, Lars D. Engstrom, Niranjan Sudhakar, Peter D. Olson, Andrew Calinisan, Michael R. Burkhard, John P. Fischer, Harrah Chiang, Ruth Aranda, Brian R. Baer
المصدر: Molecular Cancer Research. 18:B23-B23
مصطلحات موضوعية: MAPK/ERK pathway, Cancer Research, Cell, Cancer, Biology, medicine.disease, medicine.disease_cause, medicine.anatomical_structure, Oncology, Downregulation and upregulation, In vivo, medicine, Cancer research, Phosphorylation, KRAS, Molecular Biology, Cell potency
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::1be8c7bdc37581e0db27049ad22395d1
https://doi.org/10.1158/1557-3125.ras18-b23