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1
المؤلفون: Brian M. Glass, Padmaja Polam, Tom Emm, Kevin Bowman, Jordan S. Fridman, Holly Koblish, Richard Wynn, Michael Hansbury, Yanlong Li, Eddy W. Yue, Brian Metcalf, Michael J. Bower, Min Wei, Richard B. Sparks, Peggy Scherle, Xiangdong Liu, Andrew P. Combs, Timothy Burn, Dilip P. Modi, Brian Wayland, Qian Wang, Lynn Leffet, Brent Douty, Wenyu Zhu, Amy Takvorian, Joseph Glenn
المصدر: ACS Medicinal Chemistry Letters
مصطلحات موضوعية: 0301 basic medicine, Letter, Organic Chemistry, data-centric medicinal chemistry, Pembrolizumab, Pharmacology, Furazan, Biochemistry, Small molecule, In vitro, Bioavailability, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, IDO1, chemistry, INCB24360, 030220 oncology & carcinogenesis, Drug Discovery, Epacadostat, Indoleamine 2,3-dioxygenase, immuno-oncology, Sulfamide, ADME
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2
المؤلفون: Swamy Yeleswaram, Thomas Maduskuie, Brian Wayland, Hao Feng, Patricia Feldman, Niu Shin, Yanlong Li, Chu-Biao Xue, Peggy Scherle, Song Mei, Kathy Wang, Maryanne Covington, Wenqing Yao, Padmaja Polam, Richard B. Sparks, Wenyu Zhu, Xin He, Sharon Diamond, Eddy W. Yue, Chunhong He, Brian Metcalf, Holly Koblish, Ke Zhang, Nikoo Falahatpisheh, Brent Douty, Leslie Hall, Yu Li, Andrew P. Combs, Joseph Glenn, Kamna Katiyar, Yun-Long Li
المصدر: ACS Med Chem Lett
مصطلحات موضوعية: Purine, Phosphoinositide 3-kinase, biology, 010405 organic chemistry, Organic Chemistry, Pharmacology, 01 natural sciences, Biochemistry, Duvelisib, Pyrazolopyrimidine, 0104 chemical sciences, 010404 medicinal & biomolecular chemistry, chemistry.chemical_compound, chemistry, Pharmacokinetics, In vivo, Drug Discovery, biology.protein, Idelalisib, ADME
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3
المؤلفون: Erin McLaughlin, Richard Wynn, Brent Douty, Brian Wayland, Andrew P. Combs, Mary Becker-Pasha, Amy Takvorian, Brian M. Glass, Lucie Gonneville, Eddy W. Yue, Timothy Burn, Matthew L. Crawley, Richard B. Sparks, Gregory Hollis, Milton Hillman, Paul J. Ala, Padmaja Polam
المصدر: Journal of Biological Chemistry. 281:38013-38021
مصطلحات موضوعية: Models, Molecular, Benzimidazole, Protein Conformation, Stereochemistry, Static Electricity, In Vitro Techniques, Crystallography, X-Ray, Ring (chemistry), Biochemistry, Structure-Activity Relationship, chemistry.chemical_compound, Catalytic Domain, Amide, Humans, Moiety, Enzyme Inhibitors, Molecular Biology, Protein Tyrosine Phosphatase, Non-Receptor Type 1, chemistry.chemical_classification, biology, Chemistry, Hydrogen bond, Aryl, Active site, Hydrogen Bonding, Cell Biology, Recombinant Proteins, Sulfonamide, Thiazoles, Drug Design, biology.protein, Protein Tyrosine Phosphatases
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dc56472deabeab69da8f0d1a3343f0e
https://doi.org/10.1074/jbc.m607913200 -
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المؤلفون: Brian Wayland, Andrew P. Combs, Matthew L. Crawley, Amy Takvorian, Yanlong Li, Eddy W. Yue, Lucie Gonneville, Brent Douty, Erin McLaughlin, Min Wei, Zelda Wasserman, Michael J. Bower, Phillip Liu, Richard Wynn, Timothy Burn, Paul J. Ala
المصدر: Bioorganic & Medicinal Chemistry. 14:5833-5849
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Protein Tyrosine Phosphatase, Non-Receptor Type 11, Peptide, Protein tyrosine phosphatase, Biochemistry, Chemical synthesis, Structure-Activity Relationship, chemistry.chemical_compound, Suzuki reaction, Drug Discovery, Escherichia coli, Humans, Molecular Biology, Protein Tyrosine Phosphatase, Non-Receptor Type 1, chemistry.chemical_classification, Dipeptide, Molecular Structure, biology, Protein Tyrosine Phosphatase, Non-Receptor Type 6, Organic Chemistry, Intracellular Signaling Peptides and Proteins, Active site, Thiazoles, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine, Protein Tyrosine Phosphatases, Peptides
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المؤلفون: Brian Wayland, Brian M. Glass, Padmaja Polam, Wenyu Zhu, Amy Takvorian, Milton Hillman, Yanlong Li, Lucie Gonneville, Matthew L. Crawley, Brian Metcalf, Richard B. Sparks, Mary Becker-Pasha, Eddy W. Yue, Reid Huber, Laurine G. Galya, Erin McLaughlin, Dilip P. Modi, Richard Wynn, Brent Douty, Timothy Burn, Brian Reid, Michael J. Bower, Andrew P. Combs, Mei Li, Zelda Wasserman, Phillip Liu, Ronald M. Klabe, Min Wei, Karl F Blom, Paul J. Ala, James Russell Pruitt, Lori L. Bostrom, Gregory Hollis
المصدر: Journal of Medicinal Chemistry. 48:6544-6548
مصطلحات موضوعية: Models, Molecular, Molecular model, medicine.drug_class, Stereochemistry, In silico, Quantitative Structure-Activity Relationship, Peptide, Carboxamide, Protein tyrosine phosphatase, Crystallography, X-Ray, chemistry.chemical_compound, Drug Discovery, medicine, Peptide synthesis, Phosphotyrosine, Protein Tyrosine Phosphatase, Non-Receptor Type 1, chemistry.chemical_classification, biology, Molecular Mimicry, Stereoisomerism, Dipeptides, Thiazoles, Enzyme, chemistry, Biochemistry, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Protein Tyrosine Phosphatases
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المؤلفون: Xiangdong Liu, Andrew P. Combs, Min Wei, Changnian Liu, Peggy Scherle, Kevin Bowman, Timothy Burn, Jordan S. Fridman, Yanlong Li, Brian Wayland, Richard Wynn, Brent Douty, Holly Koblish, Brian Metcalf, Michael J. Bower, Lynn Leffet, Michael Hansbury, Qian Wang, Eddy W. Yue
المصدر: Journal of medicinal chemistry. 52(23)
مصطلحات موضوعية: Models, Molecular, Amidines, Molecular Conformation, Pharmacology, Binding, Competitive, HeLa, chemistry.chemical_compound, Inhibitory Concentration 50, Mice, Non-competitive inhibition, In vivo, Drug Discovery, Animals, Humans, Indoleamine-Pyrrole 2,3,-Dioxygenase, Enzyme Inhibitors, Indoleamine 2,3-dioxygenase, IC50, Melanoma, biology, Chemistry, biology.organism_classification, Gene Expression Regulation, Neoplastic, Disease Models, Animal, Biochemistry, Enzyme inhibitor, biology.protein, Disease Progression, Molecular Medicine, Pharmacophore, Kynurenine, HeLa Cells
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المؤلفون: Richard Wynn, Brian Wayland, Ronald M. Klabe, Brent Douty, Andrew P. Combs, Eddy W. Yue, Min Wei, Lucie Gonneville, Paul J. Ala, Timothy Burn, Lori L. Bostrom, Michael J. Bower, Phillip Liu, James Russell Pruitt
المصدر: Bioorganicmedicinal chemistry letters. 18(1)
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Clinical Biochemistry, Pharmaceutical Science, Imidazoline derivatives, Crystallography, X-Ray, Biochemistry, Chemical synthesis, Structure-Activity Relationship, Drug Discovery, Hydrolase, Enzyme Inhibitors, Imidazolines, Molecular Biology, chemistry.chemical_classification, Protein Tyrosine Phosphatase, Non-Receptor Type 1, biology, Organic Chemistry, Imidazoles, Sulfonamide, Thiazoles, Enzyme, chemistry, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Isothiazolidinone
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المؤلفون: Milton Hillman, Andrew P. Combs, Paul J. Ala, Ronald M. Klabe, Brian Wayland, Brent Douty, Michael J. Bower, Min Wei, Eddy W. Yue, Brian Reid, Mary Becker-Pasha, Gregory Hollis, Timothy Burn, Lucie Gonneville, Padmaja Polam, Richard Wynn, Zelda Wasserman
المصدر: The Journal of biological chemistry. 281(43)
مصطلحات موضوعية: Models, Molecular, Stereochemistry, Protein Conformation, Phosphatase, Organophosphonates, Ring (chemistry), Crystallography, X-Ray, Biochemistry, Protein Structure, Secondary, Catalysis, Substrate Specificity, chemistry.chemical_compound, Inhibitory Concentration 50, Structure-Activity Relationship, Catalytic Domain, Hydrolase, Side chain, Escherichia coli, Moiety, Humans, Molecular Biology, Protein Tyrosine Phosphatase, Non-Receptor Type 1, Binding Sites, Molecular Structure, Hydrogen bond, Hydrolysis, Molecular Mimicry, Water, Hydrogen Bonding, Cell Biology, Phosphonate, Protein Structure, Tertiary, Kinetics, Thiazoles, chemistry, Protein Tyrosine Phosphatases
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26917bc8c3c72958fbfd5b19d9ebd2f2
https://pubmed.ncbi.nlm.nih.gov/16916797 -
9دورية أكاديمية
المؤلفون: Eddy W. Yue, Brent Douty, Brian Wayland, Michael Bower, Xiangdong Liu, Lynn Leffet, Qian Wang, Kevin J. Bowman, Michael J. Hansbury, Changnian Liu, Min Wei, Yanlong Li, Richard Wynn, Timothy C. Burn, Holly K. Koblish, Jordan S. Fridman, Brian Metcalf, Peggy A. Scherle, Andrew P. Combs
المصدر: Journal of Medicinal Chemistry; Dec2009, Vol. 52 Issue 23, p7364-7367, 4p