نتائج البحث - "Brooke Rakai"

المساهمون: Experimental Vascular Medicine, Graduate School, Vascular Medicine, ACS - Atherosclerosis & ischemic syndromes, ACS - Microcirculation, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism

المصدر: Clinical Epigenetics
Clinical epigenetics, 12(1):166. Springer Verlag

مصطلحات موضوعية: 0301 basic medicine, Innate immune response, Male, medicine.medical_treatment, Bromodomain, 030204 cardiovascular system & hematology, Cardiovascular, Monocytes, Epigenesis, Genetic, chemistry.chemical_compound, 0302 clinical medicine, Gene expression, Medicine, Receptor, Genetics (clinical), Interleukin-18, Apabetalone, Transcription regulation, Middle Aged, Cytokine, Phenotype, Cardiovascular Diseases, Cytokines, Tumor necrosis factor alpha, Female, musculoskeletal diseases, RVX 208, 03 medical and health sciences, Genetics, Humans, Molecular Biology, Aged, Quinazolinones, Inflammation, Innate immune system, business.industry, Research, Proteins, DNA Methylation, Atherosclerosis, Toll-Like Receptor 2, 030104 developmental biology, chemistry, Diabetes Mellitus, Type 2, Case-Control Studies, Immunology, Cytokine secretion, business, Ex vivo, Developmental Biology, Transcription Factors

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c82def708cf26b958cc587fba2bd35f5
http://europepmc.org/articles/PMC7657365

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7

SO078APABETALONE, A BROMODOMAIN AND EXTRA-TERMINAL (BET) PROTEIN INHIBITOR, REDUCES ALKALINE PHOSPHATASE IN CVD PATIENTS, IN MICE, AND IN CELL CULTURE SYSTEMS

المؤلفون: Christopher Halliday, Ravi Jahagirdar, Dean Gilham, Brooke Rakai, Laura Tsujikawa, Christopher D. Sarsons, Li Fu, Jan Johansson, Mathias Haarhaus, Phoebe Ho, Michael O. Sweeney, Kamyar Kalantar-Zadeh, Ewelina Kulikowski, Stephanie C. Stotz, Sylwia Wasiak, Kenith Lebioda, Norman C.W. Wong

المصدر: Nephrology Dialysis Transplantation. 35

مصطلحات موضوعية: chemistry.chemical_classification, Transplantation, medicine.diagnostic_test, business.industry, Catabolism, Inflammation, Molecular biology, Flow cytometry, Bromodomain, Enzyme, chemistry, Nephrology, Cell culture, Gene expression, Medicine, Alkaline phosphatase, medicine.symptom, business

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::054863eae37172f97653812a1da806dd
https://doi.org/10.1093/ndt/gfaa139.so078

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P0068APABETALONE, A CLINICAL STAGE BET INHIBITOR, REDUCES THE PRO-INFLAMMATORY RESPONSE IN PBMCS FROM FABRY DISEASE PATIENTS ON ERT THERAPY

المؤلفون: Brooke Rakai, Stephanie C. Stotz, Sylwia Wasiak, Michael O. Sweeney, Connie Mohan, Li Fu, Norman C.W. Wong, Jan Johansson, Aneal Khan, Ewelina Kulikowski

المصدر: Nephrology Dialysis Transplantation. 35

مصطلحات موضوعية: BET inhibitor, Transplantation, Nephrology, business.industry, Inflammatory response, Immunology, Medicine, Stage (cooking), business, medicine.disease, Fabry disease, Peripheral blood mononuclear cell

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::3f284900d6c58b905754ed9e4e56e75b
https://doi.org/10.1093/ndt/gfaa142.p0068

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Epigenetic Modulation by Apabetalone Counters Cytokine-Driven Acute Phase Response In Vitro, in Mice and in Patients with Cardiovascular Disease

المؤلفون: Ewelina Kulikowski, Li Fu, Stephanie C. Stotz, Ravi Jahagirdar, Laura Tsujikawa, Sylwia Wasiak, Brooke Rakai, Jan O. Johansson, Norman C.W. Wong, Emily Daze, Dean Gilham, Michael O. Sweeney, Christopher Halliday

المصدر: Cardiovascular Therapeutics
Cardiovascular Therapeutics, Vol 2020 (2020)

مصطلحات موضوعية: 0301 basic medicine, Male, medicine.medical_treatment, Anti-Inflammatory Agents, 030204 cardiovascular system & hematology, Fibrinogen, Epigenesis, Genetic, chemistry.chemical_compound, 0302 clinical medicine, Pharmacology (medical), Promoter Regions, Genetic, Cells, Cultured, Gene knockdown, Acute-phase protein, Ceruloplasmin, Nuclear Proteins, General Medicine, Serum Amyloid P-Component, Cytokine, C-Reactive Protein, Cardiovascular Diseases, Plasminogen activator inhibitor-1, Cytokines, Cardiology and Cardiovascular Medicine, medicine.drug, Research Article, Signal Transduction, BRD4, animal structures, Article Subject, RM1-950, 03 medical and health sciences, Downregulation and upregulation, Plasminogen Activator Inhibitor 1, medicine, Diseases of the circulatory (Cardiovascular) system, Animals, alpha-Macroglobulins, Quinazolinones, Pharmacology, Binding Sites, business.industry, Endotoxemia, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, chemistry, RC666-701, Humanized mouse, Cancer research, Hepatocytes, Therapeutics. Pharmacology, business, Transcription Factors

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URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2efa440120df2aea29495d61c53901a2

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10

P5509Apabetalone (RVX-208) inhibits key drivers of vascular inflammation, calcification, and plaque vulnerability through a BET-dependent epigenetic mechanism

المؤلفون: Christopher Halliday, Sylwia Wasiak, Jan O. Johansson, Laura Tsujikawa, L. Fu, Michael O. Sweeney, Emily Daze, Kristina D. Rinker, Christopher D. Sarsons, Deborah Studer, Brooke Rakai, Norman C. W. Wong, Dean Gilham, Stephanie C. Stotz, Ewelina Kulikowski

المصدر: European Heart Journal. 40

مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Vascular inflammation, business.industry, medicine, Vulnerability, RVX 208, Cardiology and Cardiovascular Medicine, medicine.disease, Bioinformatics, business, Epigenetic Mechanism, Calcification

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4aaed106d657d7aa4e50556b118492ea
https://doi.org/10.1093/eurheartj/ehz746.0459

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