نتائج البحث - "Bruce D Jaffee"

1

دورية أكاديمية

AAV-mediated RLBP1 gene therapy improves the rate of dark adaptation in Rlbp1 knockout mice

المصدر: Molecular Therapy: Methods & Clinical Development, Vol 2, Iss , Pp - (2015)

مصطلحات موضوعية: Genetics, QH426-470, Cytology, QH573-671

وصف الملف: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2329050116300341; https://doaj.org/toc/2329-0501

URL الوصول: https://doaj.org/article/543b664ff66b42138de04c51579aee00

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2

Complement factor B is critical for sub-RPE deposit accumulation in a model of Doyne honeycomb retinal dystrophy with features of age-related macular degeneration

المصدر: Human Molecular Genetics. 32:204-217

مصطلحات موضوعية: Genetics, General Medicine, Molecular Biology, Genetics (clinical)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fec58b40ea8387ba6f2edc6bd8b972d3
https://doi.org/10.1093/hmg/ddac187

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Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases

المؤلفون: Nello Mainolfi, Takeru Ehara, Rajeshri G. Karki, Karen Anderson, Aengus Mac Sweeney, Sha-Mei Liao, Upendra A. Argikar, Keith Jendza, Chun Zhang, James Powers, Daniel W. Klosowski, Maura Crowley, Toshio Kawanami, Jian Ding, Myriam April, Cornelia Forster, Michael Serrano-Wu, Michael Capparelli, Rrezarta Ramqaj, Catherine Solovay, Frederic Cumin, Thomas M. Smith, Luciana Ferrara, Wendy Lee, Debby Long, Melissa Prentiss, Andrea De Erkenez, Louis Yang, Fang Liu, Holger Sellner, Finton Sirockin, Eric Valeur, Paulus Erbel, Daniela Ostermeier, Paul Ramage, Bernd Gerhartz, Anna Schubart, Stefanie Flohr, Nathalie Gradoux, Roland Feifel, Barbara Vogg, Christian Wiesmann, Jürgen Maibaum, Jörg Eder, Richard Sedrani, Richard A. Harrison, Muneto Mogi, Bruce D. Jaffee, Christopher M. Adams

المصدر: Journal of Medicinal Chemistry. 63:5697-5722

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::161530bd60ced781537b4b5cf97869fc
https://doi.org/10.1021/acs.jmedchem.9b01870

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4

Amount of Mononuclear Phagocyte Infiltrate Does Not Predict Area of Experimental Choroidal Neovascularization (CNV)

المؤلفون: Stephen Poor, Namrata Kotagiri, Yubin Qiu, Siyuan Shen, Elizabeth Fassbender, Adrian Will-Orrego, Bruce D Jaffee, Jorge Aranda, Sha-Mei Liao, Michael Maker

المصدر: Journal of Ocular Pharmacology and Therapeutics. 34:489-499

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42256ddb597515bd1c1cf0c62faa4631
https://doi.org/10.1089/jop.2017.0131

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Nonclinical Safety Evaluation of scAAV8-RLBP1 for Treatment of RLBP1 Retinitis Pigmentosa

المؤلفون: Timothy K. MacLachlan, Mark N. Milton, Oliver Turner, Francis Tukov, Vivian W. Choi, Jan Penraat, Shawn M. Hanks, Joanna Vrouvlianis, Barrett Leehy, Hui Li, Marie-Hélène Delmotte, Lydia Michaut, Bruce D. Jaffee, Chad E. Bigelow

المصدر: Molecular Therapy: Methods & Clinical Development, Vol 8, Iss C, Pp 105-120 (2018)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb9da079374b6c787861fc32f57b6661
http://www.sciencedirect.com/science/article/pii/S2329050117301262

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6

Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo

المصدر: Journal of Medicinal Chemistry. 60:5717-5735

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e242e3d44a96036addb2cb8f7ea9cefc
https://doi.org/10.1021/acs.jmedchem.7b00425

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7

Long-acting protein drugs for the treatment of ocular diseases

المصدر: Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Male, genetic structures, Recombinant Fusion Proteins, Science, General Physics and Astronomy, Peptide, Angiogenesis Inhibitors, Disease, Pharmacology, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Retinal Diseases, Ranibizumab, medicine, Animals, Humans, Hyaluronic Acid, Receptor, Aflibercept, chemistry.chemical_classification, Multidisciplinary, biology, business.industry, Retinal, General Chemistry, eye diseases, Vascular endothelial growth factor, Bevacizumab, Disease Models, Animal, Macaca fascicularis, 030104 developmental biology, Receptors, Vascular Endothelial Growth Factor, chemistry, Intravitreal Injections, 030221 ophthalmology & optometry, biology.protein, Female, Rabbits, Antibody, business, medicine.drug, Half-Life

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70f28f1f2760d443ab436000b8e2eab1
https://doaj.org/article/f0adf43d440f4267b734d5d4506d7186

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8

Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway

المصدر: Journal of medicinal chemistry. 62(9)

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da588cee5e7843ba124041bcbf4f4b5e
https://pubmed.ncbi.nlm.nih.gov/30995036

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9

Induction of Ocular Complement Activation by Inflammatory Stimuli and Intraocular Inhibition of Complement Factor D in Animal Models

المؤلفون: Karen Anderson, Omar Delgado, Maura Crowley, Sha-Mei Liao, Natasha Buchanan, Bruce D Jaffee, Adrian Will-Orrego, Thaddeus P. Dryja

المصدر: Investigative ophthalmologyvisual science. 59(2)

مصطلحات موضوعية: 0301 basic medicine, Lipopolysaccharides, genetic structures, Lipopolysaccharide, Blotting, Western, Complement Pathway, Alternative, Pharmacology, Complement factor B, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Complement Factor D, Medicine, Animals, RNA, Messenger, Neutralizing antibody, Inflammation, biology, business.industry, Complement C3, Antibodies, Neutralizing, eye diseases, Complement system, Mice, Inbred C57BL, Toll-Like Receptor 4, 030104 developmental biology, chemistry, Intravitreal Injections, Models, Animal, 030221 ophthalmology & optometry, TLR4, biology.protein, Alternative complement pathway, Female, sense organs, Rabbits, Antibody, business, Injections, Intraperitoneal, Complement Factor B

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cea8fcfcd655344a11ce02e80e70cb56
https://pubmed.ncbi.nlm.nih.gov/29450541

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The Discovery of N-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration

المصدر: Journal of medicinal chemistry. 61(4)

مصطلحات موضوعية: 0301 basic medicine, Indoles, genetic structures, medicine.drug_class, VEGF receptors, Administration, Topical, Carboxamide, Rodentia, Pharmacology, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, 0302 clinical medicine, In vivo, Drug Discovery, medicine, Potency, Animals, Protein Kinase Inhibitors, Indole test, Trifluoromethyl, biology, Macular degeneration, medicine.disease, Vascular Endothelial Growth Factor Receptor-2, eye diseases, Choroidal Neovascularization, 030104 developmental biology, Choroidal neovascularization, Pyrimidines, chemistry, 030221 ophthalmology & optometry, biology.protein, Wet Macular Degeneration, Molecular Medicine, Pyrazoles, sense organs, Rabbits, medicine.symptom, Ophthalmic Solutions

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e718fab306483499929412e81aa3c213
https://pubmed.ncbi.nlm.nih.gov/29400470

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