المؤلفون: Trevor J Wardill, Tsai-Wen Chen, Eric R Schreiter, Jeremy P Hasseman, Getahun Tsegaye, Benjamin F Fosque, Reza Behnam, Brenda C Shields, Melissa Ramirez, Bruce E Kimmel, Rex A Kerr, Vivek Jayaraman, Loren L Looger, Karel Svoboda, Douglas S Kim

المصدر: PLoS ONE, Vol 8, Iss 10, p e77728 (2013)

مصطلحات موضوعية: Medicine, Science

وصف الملف: electronic resource

Relation: http://europepmc.org/articles/PMC3796516?pdf=render; https://doaj.org/toc/1932-6203

URL الوصول: https://doaj.org/article/260c05b0e92b4cd0a03c4417df7ccb10

المؤلفون: Eiji Shigetomi, Sevinç Mutlu, Andrew Gordus, Florian Engert, Loren L. Looger, John J. Macklin, Eric R. Schreiter, Aman Aggarwal, Nicole Carreras Calderón, Bruce E. Kimmel, Samuel S.-H. Wang, Douglas S. Kim, Herwig Baier, Leon Lagnado, Sebastian Kracun, Karel Svoboda, Baljit S. Khakh, Xiaonan Richard Sun, Trevor J. Wardill, Ruben Portugues, Lin Tian, Cornelia I. Bargmann, Vivek Jayaraman, Federico Esposti, Bart G. Borghuis, Jonathan S. Marvin, Alessandro Filosa, Tsai Wen Chen, Ryousuke Takagi, Michael B. Orger, Jasper Akerboom, Rex Kerr

المساهمون: Akerboom, J, Chen, Tw, Wardill, Tj, Tian, L, Marvin, J, Mutlu, S, Calderon, Nc, Esposti, Federico, Borghuis, Bg, Sun, Xr, Gordus, A, Orger, Mb, Portugues, R, Engert, F, Macklin, Jj, Filosa, A, Aggarwal, A, Kerr, Ra, Takagi, R, Kracun, S, Shigetomi, E, Khakh, B, Baier, H, Lagnado, L, Wang, Ssh, Bargmann, Ci, Kimmel, Be, Jayaraman, V, Svoboda, K, Kim, D, Schreiter, Er, Looger, Ll

المصدر: The Journal of Neuroscience. 32:13819-13840

مصطلحات موضوعية: Models, Molecular, Retinal Bipolar Cells, Neuropil, Protein Conformation, Recombinant Fusion Proteins, Genetic Vectors, Green Fluorescent Proteins, Neuromuscular Junction, Neuroimaging, Biology, Crystallography, X-Ray, Hippocampus, Synaptic Transmission, Olfactory Receptor Neurons, Article, Mice, In vivo, Genes, Synthetic, medicine, Animals, Humans, Premovement neuronal activity, Fluorometry, Calcium Signaling, Caenorhabditis elegans, Zebrafish, Fluorescent Dyes, Neurons, Systems neuroscience, Lasers, General Neuroscience, Rats, Electrophysiology, Drosophila melanogaster, HEK293 Cells, Visual cortex, medicine.anatomical_structure, Astrocytes, Larva, GCaMP, Mutagenesis, Site-Directed, Female, Peptides, Tectum, Neuroscience, Photic Stimulation, Preclinical imaging

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f129ce07ec26e102a535bad97cbf711
https://doi.org/10.1523/jneurosci.2601-12.2012

المؤلفون: Bruce E. Kimmel, Richard D. DiMarchi, Joel Berger, Anthony Manibusan, Zhihua Li, Qing Dallas-Yang, Margaret Wu, Dennis M. Zaller, Stuart Bussell, Jun Yao, Heather Myler, Anna-Maria A. Hays Putnam, James Mu, Nina Li, Bei B. Zhang, Thea Norman, Douglas W. Axelrod, Carlos G. Rodriguez, Jason Pinkstaff, Joseph M. Metzger, Darin Lee, Lillian Skidmore

المصدر: Diabetes

مصطلحات موضوعية: Male, FGF21, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Adipose tissue, Biology, Pharmacology, Polyethylene Glycols, Rats, Sprague-Dawley, Mice, Insulin resistance, Internal Medicine, medicine, Animals, Humans, Hypoglycemic Agents, Protein kinase B, geography, geography.geographical_feature_category, Insulin, Body Weight, Islet, medicine.disease, Pharmacology and Therapeutics, Rats, Fibroblast Growth Factors, HEK293 Cells, Delayed-Action Preparations, PEGylation, Phosphorylation, Insulin Resistance, Energy Metabolism

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e334765339a6145bf9956f15fddc608
http://europepmc.org/articles/PMC3266413

المؤلفون: Thea Norman, Tsotne Javahishvili, Stuart Bussell, David C. Litzinger, Stephanie Chu, Bruce E. Kimmel, Ricky Lieu, Sami Kaphle, Bee-Cheng Sim, Peter G. Schultz, Thomas L. Daniel, Mike Ong, Anna-Maria A. Hays Putnam, Zhenwei Maio, Ying Buechler, Richard D. DiMarchi, Ho Cho, Andrew R. Hoffman, Guillermo Viramontes, Paola Castiglioni, Douglas W. Axelrod, Becky Gc, Vadim Kraynov, Nick Knudsen

المصدر: Proceedings of the National Academy of Sciences. 108:9060-9065

مصطلحات موضوعية: Male, Polymers, Phenylalanine, Mutant, Polyethylene glycol, Biology, Protein Engineering, medicine.disease_cause, Polyethylene Glycols, Rats, Sprague-Dawley, chemistry.chemical_compound, Residue (chemistry), Endocrinology, PEG ratio, Genetic variation, medicine, Animals, Humans, Expanded genetic code, chemistry.chemical_classification, Mutation, Multidisciplinary, Dose-Response Relationship, Drug, Human Growth Hormone, Genetic Variation, Biological Sciences, Rats, Amino acid, chemistry, Biochemistry, Peptides, Ribosomes

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5b5edb326f7ee27edbdf4cea0830975
https://doi.org/10.1073/pnas.1100387108

المؤلفون: Douglas S. Reed, T.L. Clements, R.P. Dirmeier, Randal J. Schoepp, Gary Woodnutt, K. Wong, M. Keller, J. Li, E.C. Tozer, Bruce E. Kimmel, L.M. Lewis, J.Q. Li, Xuqiu Tan, Gerhard Frey, Jeff Rogers, O. Schröder, T.F. Holland

المصدر: Protein Engineering, Design and Selection
Protein Engineering Design and Selection

مصطلحات موضوعية: Mutagenesis (molecular biology technique), Bioengineering, Complementarity determining region, Antibodies, Viral, Severe Acute Respiratory Syndrome, Communicable Diseases, Emerging, Biochemistry, Virus, Neutralization, Mice, Antibody Specificity, Neutralization Tests, Chlorocebus aethiops, Drug Discovery, Animals, Humans, Point Mutation, Vero Cells, Molecular Biology, Mice, Inbred BALB C, antibody discovery, humanized, biology, Drug discovery, Point mutation, fungi, SARS-CoV, Original Articles, optimized, Virology, Severe acute respiratory syndrome-related coronavirus, biology.protein, Vero cell, Directed Molecular Evolution, Antibody, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65cef199ed1a9dd9aa6c21036f7be8da
https://doi.org/10.1093/protein/gzn027

المؤلفون: Bruce E. Kimmel, Gary Woodnutt, Mangala Hariharan, Geneviève Hansen, Marikka Elia, Ping Jin, Jay M. Short, Michael Dudley, Stephen J Demarest, Jared Salbato, Colin Bird

المصدر: mAbs. 2(2)

مصطلحات موضوعية: Diarrhea, medicine.drug_class, Immunology, Bacterial Toxins, Clostridium difficile toxin A, Clostridium difficile toxin B, CHO Cells, Biology, medicine.disease_cause, Monoclonal antibody, Neutralization, Epitope, Microbiology, Enterotoxins, Mice, Cricetulus, Bacterial Proteins, Cricetinae, medicine, Immunology and Allergy, Animals, Humans, Enterocolitis, Pseudomembranous, Toxin, Clostridioides difficile, Antibodies, Monoclonal, Drug Combinations, Epitope mapping, biology.protein, Antitoxins, Binding Sites, Antibody, Antibody, Epitope Mapping, Protein Binding, Reports

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::355688b463cba1fc38539a499b41ce40
https://pubmed.ncbi.nlm.nih.gov/20150758

المؤلفون: Noelle D. Dwyer, Piali Sengupta, Bruce E. Kimmel, Heather A. Colbert, Cornelia I. Bargmann

المصدر: Ciba Foundation Symposium 179-The Molecular Basis of Smell and Taste Transduction

مصطلحات موضوعية: Nervous system, Mutation, musculoskeletal, neural, and ocular physiology, Mutant, Sensory system, Chemotaxis, Biology, medicine.disease_cause, biology.organism_classification, medicine.anatomical_structure, medicine, Signal transduction, Neuroscience, psychological phenomena and processes, Function (biology), Caenorhabditis elegans

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::4b2afdee0b358bbd8c556ad6851ee918
https://doi.org/10.1002/9780470514511.ch15

المؤلفون: John Poland, David Gustafson, Ken Wong, Marikka Elia, Bruce E. Kimmel, Jay M. Short, Jane Wu, Stephen J. Demarest, Xuqiu Tan, Geneviève Hansen, Gang Chen, Jared Salbato

المصدر: Protein engineering, designselection : PEDS. 19(7)

مصطلحات موضوعية: Protein Denaturation, Protein Folding, Time Factors, Immunoglobulin Variable Region, Bioengineering, Immunoglobulin domain, medicine.disease_cause, Protein Engineering, Biochemistry, Pattern Recognition, Automated, Immunoglobulin Fab Fragments, Peptide Library, medicine, Escherichia coli, Humans, Saturated mutagenesis, Peptide library, Molecular Biology, biology, Protein engineering, Molecular biology, Gene Expression Regulation, Immunoglobulin G, Mutation, biology.protein, Thermodynamics, Protein folding, Antibody, Biotechnology

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b47474aa71c546fd6d3a94335805b4e
https://pubmed.ncbi.nlm.nih.gov/16672248

المؤلفون: Gary Woodnutt, Stephen J. Demarest, Jingping Zhong, Katie Kline, Marikka Elia, Bruce E. Kimmel, Geneviève Hansen, Theresa Morrow, Trevin Holland, Jared Salbato

المصدر: Journal of molecular biology. 346(5)

مصطلحات موضوعية: Cell, Bacterial Toxins, Molecular Sequence Data, Clostridium difficile toxin A, Apoptosis, CHO Cells, Biology, medicine.disease_cause, Cell wall, Enterotoxins, Bacterial Proteins, Structural Biology, Cell Wall, AB toxin, Cricetinae, medicine, Extracellular, Animals, Amino Acid Sequence, Cloning, Molecular, Molecular Biology, Sequence Homology, Amino Acid, Toxin, Clostridioides difficile, Chinese hamster ovary cell, Clostridium difficile, Molecular biology, Protein Structure, Tertiary, medicine.anatomical_structure, Streptococcus pneumoniae, Biochemistry, Calcium, Protein Binding

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::287fc4958385cb187761c6f649bc2184
https://pubmed.ncbi.nlm.nih.gov/15713474

المؤلفون: Benjamin F. Fosque, Vivek Jayaraman, Douglas S. Kim, Getahun Tsegaye, Tsai Wen Chen, Karel Svoboda, Loren L. Looger, Bruce E. Kimmel, Jeremy P. Hasseman, Rex Kerr, Reza Behnam, Eric R. Schreiter, Brenda C. Shields, Melissa H. Ramirez, Trevor J. Wardill

المصدر: PLoS ONE
PLoS ONE, Vol 8, Iss 10, p e77728 (2013)

مصطلحات موضوعية: Fluorescence-lifetime imaging microscopy, lcsh:Medicine, Action Potentials, Glutamic Acid, chemistry.chemical_element, Calcium, Bioinformatics, Fluorescence, Calcium imaging, Receptors, GABA, Genes, Reporter, medicine, Animals, Humans, Premovement neuronal activity, Calcium Signaling, lcsh:Science, Cells, Cultured, Calcium signaling, Neurons, Calcium metabolism, Multidisciplinary, lcsh:R, Glutamate receptor, Electric Stimulation, Rats, Solutions, medicine.anatomical_structure, nervous system, chemistry, lcsh:Q, Indicators and Reagents, Neuron, Neuroscience, Research Article

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b37ca05ea2c33cc80dc0e38df12042
https://doi.org/10.1371/journal.pone.0077728