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المؤلفون: Jason C. Rech, Bruce L. Grasberger, Michael A. Letavic, Jinquan Luo, Changlu Liu, Jichun Ma, Michael P. Maher, Renee L. DesJarlais, Jeffrey Schoellerman, Rebecca Hagan, Yi Liu, Robyn L. Miller, David Lin
المصدر: Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Communications Biologyمصطلحات موضوعية: 0301 basic medicine, Gene isoform, Protein Conformation, QH301-705.5, Medicine (miscellaneous), Peptide, Gating, CHO Cells, General Biochemistry, Genetics and Molecular Biology, Article, Membrane Potentials, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, 0302 clinical medicine, Cricetulus, Membrane Transport Modulators, Psalmotoxin, Animals, Binding site, Tachyphylaxis, Biology (General), Ion channel, Acid-sensing ion channel, X-ray crystallography, Ion transport, chemistry.chemical_classification, Binding Sites, Small molecule, Acid Sensing Ion Channels, Kinetics, 030104 developmental biology, chemistry, Mutation, Biophysics, General Agricultural and Biological Sciences, Ion Channel Gating, 030217 neurology & neurosurgery, Protein Binding
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2
المؤلفون: Donald William Ludovici, Gilles Bignan, Carsten Schubert, Erwin Fraiponts, Karine Smans, Norbert Esser, Danielle Peeters, Michael H. Parker, Maxwell D. Cummings, Peter Vermeulen, Lieven Meerpoel, Sabine De Breucker, Tianbao Lu, Luc Van Nuffel, Richard Alexander, Bruce L. Grasberger, James R. Bischoff, Christian Rocaboy, Ron Gilissen, Christophe Meyer, Boudewijn Janssens, Peter J. Connolly
المصدر: Bioorganic & Medicinal Chemistry Letters. 28:2159-2164
مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Cell type, Oral treatment, Clinical Biochemistry, Cancer therapy, Pharmaceutical Science, Antineoplastic Agents, Pharmacology, Biochemistry, Mice, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Oral administration, Drug Discovery, medicine, Animals, Humans, Enzyme Inhibitors, Molecular Biology, Cell Proliferation, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Organic Chemistry, Imidazoles, Cancer, Neoplasms, Experimental, medicine.disease, Bioavailability, Fatty Acid Synthase, Type I, Fatty acid synthase, 030104 developmental biology, Drug Design, 030220 oncology & carcinogenesis, Pharmacodynamics, biology.protein, Molecular Medicine, Drug Screening Assays, Antitumor
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المؤلفون: Frank A. Lewandowski, Li Liu, Jose Clemente, Charles H. Reynolds, Bruce L. Grasberger, Renee L. DesJarlais, Mark J. Macielag, Celine Schalk-Hihi, Christopher M. Flores, Mcdonnell Mark E, Richard S. Alexander, Shariff Bayoumy, Hongchang Ma, Ingrid Deckman, Diane M. Maguire, Keli C. Dzordzorme, Robyn L. Miller, Tara Mezzasalma Haarlander, Carsten Schubert, Lawrence C. Kuo, James K. Kranz, Cindy Milligan
المصدر: Protein Science. 20:670-683
مصطلحات موضوعية: biology, Chemistry, Stereochemistry, Glyceride, Plasma protein binding, Biochemistry, Monoacylglycerol lipase, chemistry.chemical_compound, Monomer, Membrane, Catalytic cycle, Static electricity, biology.protein, Lipase, Molecular Biology
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المؤلفون: Pierre Raboisson, Raul R. Calvo, Rose Tominovich, Louis V. LaFrance, Karen L. Milkiewicz, Dana L. Johnson, Anna C. Maroney, Shuyuan Zhao, Robert R. Donatelli, Maxwell D. Cummings, Bruce L. Grasberger, Christopher J. Molloy, Tianbao Lu, Juan J. Marugan, Daniel J. Parks, Kristi A. Leonard, Carol F. Franks, Joan Gushue, Holly K. Koblish
المصدر: Molecular Cancer Therapeutics. 5:160-169
مصطلحات موضوعية: Cancer Research, Mutant, Mice, Nude, Apoptosis, Biology, Benzodiazepines, Mice, Liver Neoplasms, Experimental, In vivo, Cell Line, Tumor, Antineoplastic Combined Chemotherapy Protocols, Tumor Cells, Cultured, medicine, Animals, Humans, Doxorubicin, Cell Proliferation, Benzodiazepinones, Cell growth, Choriocarcinoma, Drug Synergism, Proto-Oncogene Proteins c-mdm2, medicine.disease, Xenograft Model Antitumor Assays, Molecular biology, In vitro, Oncology, Cell culture, Multiprotein Complexes, Mutation, Female, Drug Screening Assays, Antitumor, Tumor Suppressor Protein p53, medicine.drug
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30835600d455b26ccf94cf87ed7132f4
https://doi.org/10.1158/1535-7163.mct-05-0199 -
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المؤلفون: Jennifer Lattanze, Tianbao Lu, Karen L. Milkiewicz, Bruce L. Grasberger, Theodore E. Carver, Louis V. LaFrance, Daniel J. Parks, Kannan Ramachandren, Varsha Gupta, Raul R. Calvo, Diane M. Maguire, Eugene C. Petrella, Maxwell D. Cummings
المصدر: Bioorganic & Medicinal Chemistry Letters. 15:765-770
مصطلحات موضوعية: medicine.drug_class, Stereochemistry, Carboxylic acid, Clinical Biochemistry, Pharmaceutical Science, Fluorescence Polarization, Peptide, Biochemistry, Chemical synthesis, Benzodiazepines, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Proto-Oncogene Proteins, Drug Discovery, medicine, Combinatorial Chemistry Techniques, Humans, Binding site, Molecular Biology, chemistry.chemical_classification, Benzodiazepine, Binding Sites, Organic Chemistry, Nuclear Proteins, Proto-Oncogene Proteins c-mdm2, Small molecule, chemistry, Lactam, Molecular Medicine, Tumor Suppressor Protein p53, Fluorescence anisotropy, Protein Binding
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6Discovery and Cocrystal Structure of Benzodiazepinedione HDM2 Antagonists That Activate p53 in Cells
المؤلفون: Tianbao Lu, Jennifer Lattanze, Ingrid Deckman, Marie Zhang, Bruce L. Grasberger, Carl L. Manthey, and Christopher J. Molloy, John C. Spurlino, Diane M. Maguire, Eugene C. Petrella, Kannan Ramachandren, Holly K. Koblish, Shuyuan Zhao, Bruce E. Tomczuk, Gwendolyn R. Bylebyl, Louis V. LaFrance, Carsten Schubert, Daniel J. Parks, Karen L. Milkiewicz, Carol F. Franks, Theodore E. Carver, Roger F. Bone, Anna C. Maroney, Maxwell D. Cummings, Raul R. Calvo, W. Michael Avondale Pantoliano
المصدر: Journal of Medicinal Chemistry. 48:909-912
مصطلحات موضوعية: Models, Molecular, Molecular model, Crystallography, X-Ray, Cocrystal, Benzodiazepines, Structure-Activity Relationship, Transactivation, Proto-Oncogene Proteins c-mdm2, Cell Line, Tumor, Proto-Oncogene Proteins, Drug Discovery, Combinatorial Chemistry Techniques, Humans, Structure–activity relationship, Binding site, Transcription factor, chemistry.chemical_classification, DNA ligase, Binding Sites, Molecular Structure, Molecular Mimicry, Nuclear Proteins, Stereoisomerism, chemistry, Biochemistry, Biophysics, Molecular Medicine, Tumor Suppressor Protein p53
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المؤلفون: Carl R. Illig, Ingrid Deckman, Troy Randle, Kenneth J. Wilson, Frank A. Lewandowski, Bruce L. Grasberger, Renee L. DesJarlais, M. Jonathan Rudolph, James B. Hoffman, Marie Zhang, Carl L. Manthey, David Green, Zhao Zhou, Diane M. Maguire, Nalin L. Subasinghe, Christopher J. Molloy, Celia Sharp, Roger F. Bone, John C. Spurlino, Richard Soll
المصدر: Bioorganic & Medicinal Chemistry Letters. 12:491-495
مصطلحات موضوعية: Serine Proteinase Inhibitors, Alkylation, Stereochemistry, Clinical Biochemistry, Heteroatom, Amidines, Pharmaceutical Science, Thiophenes, Biochemistry, Chemical synthesis, Amidine, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Thiophene, medicine, Molecular Biology, Alkyl, Urokinase, chemistry.chemical_classification, biology, Organic Chemistry, Urokinase-Type Plasminogen Activator, Combinatorial chemistry, Thiazoles, chemistry, Enzyme inhibitor, Lithium Compounds, biology.protein, Molecular Medicine, Indicators and Reagents, Plasminogen activator, Protein Binding, medicine.drug
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المؤلفون: Troy Randle, Ingrid Deckman, Frank A. Lewandowski, Christopher J. Molloy, Celia Sharp, Marie Zhang, Renee L. DesJarlais, Carl L. Manthey, Roger F. Bone, Nalin L. Subasinghe, Zhau Zhou, David Green, M. Jonathan Rudolph, John C. Spurlino, Bruce L. Grasberger, Carl R. Illig, Diane M. Maguire, Richard Soll, Carl Crysler, James B. Hoffman, Kenneth J. Wilson
المصدر: Bioorganic & Medicinal Chemistry Letters. 11:1379-1382
مصطلحات موضوعية: Antimetabolites, Angiogenesis, Clinical Biochemistry, Pharmaceutical Science, Thiophenes, Biochemistry, Metastasis, Structure-Activity Relationship, Drug Discovery, medicine, Humans, Molecular Biology, chemistry.chemical_classification, Serine protease, Binding Sites, biology, Organic Chemistry, Active site, medicine.disease, Urokinase-Type Plasminogen Activator, In vitro, Urokinase receptor, Enzyme, chemistry, Enzyme inhibitor, biology.protein, Molecular Medicine
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المؤلفون: John C. Spurlino, Renee L. DesJarlais, Bruce L. Grasberger, Richard Soll, David Green, Nalin L. Subasinghe, Zhao Zhou, Christopher J. Molloy, Frank A. Lewandowski, Celia Sharp, James B. Hoffman, Kenneth J. Wilson, Troy Randall, Marie Zhang, Diane M. Maguire, Roger F. Bone, Carl R. Illig, M. Jonathan Rudolph
المصدر: Bioorganic & Medicinal Chemistry Letters. 11:915-918
مصطلحات موضوعية: Stereochemistry, Clinical Biochemistry, Amidines, Drug Evaluation, Preclinical, Pharmaceutical Science, Thiophenes, Biochemistry, Chemical synthesis, Amidine, Plasminogen Activators, Structure-Activity Relationship, chemistry.chemical_compound, Drug Discovery, Thiophene, medicine, Molecular Biology, chemistry.chemical_classification, Serine protease, Urokinase, biology, Organic Chemistry, Urokinase-Type Plasminogen Activator, Thiazoles, Enzyme, chemistry, Enzyme inhibitor, Drug Design, biology.protein, Molecular Medicine, Amine gas treating, medicine.drug
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المؤلفون: Danielle Peeters, Michael H. Parker, Donald William Ludovici, Christophe Meyer, Richard Alexander, Bruce L. Grasberger, S. de Breucker, Christian Rocaboy, Norbert Esser, Lieven Meerpoel, Tianbao Lu, Ronaldus Arnodus Hendrika Joseph Gilissen, Maxwell D. Cummings, Peter J. Connolly, James R. Bischoff, Gilles Bignan, Erwin Fraiponts, Boudewijn Janssens, Karine Smans, Carsten Schubert
المصدر: European Journal of Cancer. 50:141-142
مصطلحات موضوعية: Cancer Research, Oncology, Chemistry, Stereochemistry, Domain (software engineering)