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المؤلفون: Hansen MK, McVey MJ, White RF, Legos JJ, Brusq JM, Grillot DA, Issandou M, Barone FC

المصدر: Journal of Cardiovascular Pharmacology & Therapeutics; Jun2010, Vol. 15 Issue 2, p196-202, 7p

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المؤلفون: Finger JN; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville, PA, USA., Brusq JM; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville, PA, USA., Campobasso N; Structural and Biophysical Sciences, GlaxoSmithKline, Collegeville, PA, USA., Cook MN; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville, PA, USA., Deutsch J; Integrated Biological Platform Sciences, GlaxoSmithKline, Collegeville, PA, USA., Haag H; Integrated Biological Platform Sciences, GlaxoSmithKline, Collegeville, PA, USA., Harris PA; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville, PA, USA., Jenkins EL; Integrated Biological Platform Sciences, GlaxoSmithKline, Collegeville, PA, USA., Joglekar D; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville, PA, USA., Lich JD; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville, PA, USA., Maguire S; Integrated Biological Platform Sciences, GlaxoSmithKline, Collegeville, PA, USA., Nagilla R; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville, PA, USA., Rivera EJ; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville, PA, USA., Sun H; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville, PA, USA., Votta BJ; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville, PA, USA., Bertin J; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville, PA, USA., Gough PJ; Pattern Recognition Receptor DPU, GlaxoSmithKline, Collegeville, PA, USA.

المصدر: Pharmacology research & perspectives [Pharmacol Res Perspect] 2017 Dec; Vol. 5 (6).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: John Wiley & Sons Ltd, British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics Country of Publication: United States NLM ID: 101626369 Publication Model: Print Cited Medium: Internet ISSN: 2052-1707 (Electronic) Linking ISSN: 20521707 NLM ISO Abbreviation: Pharmacol Res Perspect Subsets: MEDLINE

مواضيع طبية MeSH: Antibodies/*metabolism , Protein Kinase Inhibitors/*pharmacology , Receptor-Interacting Protein Serine-Threonine Kinases/*metabolism, Animals ; HT29 Cells ; Humans ; Immunoassay ; Macaca fascicularis ; Male ; Protein Binding/drug effects ; Receptor-Interacting Protein Serine-Threonine Kinases/immunology ; Small Molecule Libraries/pharmacology

المؤلفون: Smith SH; Discovery and Preclinical Development, Stiefel, a GSK company, Research Triangle Park, North Carolina, United States of America., Peredo CE; Discovery and Preclinical Development, Stiefel, a GSK company, Research Triangle Park, North Carolina, United States of America., Takeda Y; Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America., Bui T; Discovery and Preclinical Development, Stiefel, a GSK company, Research Triangle Park, North Carolina, United States of America., Neil J; Discovery and Preclinical Development, Stiefel, a GSK company, Research Triangle Park, North Carolina, United States of America., Rickard D; MDR/PTS, GlaxoSmithKline, Research Triangle Park, North Carolina, United States of America., Millerman E; Discovery and Preclinical Development, Stiefel, a GSK company, Research Triangle Park, North Carolina, United States of America., Therrien JP; Discovery and Preclinical Development, Stiefel, a GSK company, Research Triangle Park, North Carolina, United States of America., Nicodeme E; Flexible Discovery Unit, GlaxoSmithKline, Les Ulis Cedex, France., Brusq JM; Flexible Discovery Unit, GlaxoSmithKline, Les Ulis Cedex, France., Birault V; Respiratory Therapeutic Area, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, United Kingdom., Viviani F; Flexible Discovery Unit, GlaxoSmithKline, Les Ulis Cedex, France., Hofland H; Discovery and Preclinical Development, Stiefel, a GSK company, Research Triangle Park, North Carolina, United States of America., Jetten AM; Immunity, Inflammation and Disease Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina, United States of America., Cote-Sierra J; Discovery and Preclinical Development, Stiefel, a GSK company, Research Triangle Park, North Carolina, United States of America.

المصدر: PloS one [PLoS One] 2016 Feb 12; Vol. 11 (2), pp. e0147979. Date of Electronic Publication: 2016 Feb 12 (Print Publication: 2016).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

مواضيع طبية MeSH: Immunologic Factors/*pharmacology , Interleukin-17/*antagonists & inhibitors , Nuclear Receptor Subfamily 1, Group F, Member 3/*antagonists & inhibitors , Psoriasis/*drug therapy , Skin/*drug effects , Small Molecule Libraries/*pharmacology, Administration, Cutaneous ; Aminoquinolines ; Animals ; Drug Evaluation, Preclinical ; Female ; Gene Expression ; Genes, Reporter ; Humans ; Imiquimod ; Immunologic Factors/chemical synthesis ; Interleukin-17/genetics ; Interleukin-17/immunology ; Jurkat Cells ; Luciferases/genetics ; Luciferases/metabolism ; Mice ; Mice, Inbred BALB C ; Nuclear Receptor Subfamily 1, Group F, Member 3/genetics ; Nuclear Receptor Subfamily 1, Group F, Member 3/immunology ; Permeability ; Primary Cell Culture ; Psoriasis/chemically induced ; Psoriasis/immunology ; Psoriasis/pathology ; Skin/immunology ; Skin/pathology ; Small Molecule Libraries/chemical synthesis ; Th17 Cells/drug effects ; Th17 Cells/immunology ; Th17 Cells/pathology ; Translational Research, Biomedical

المؤلفون: Sujobert P; INSERM U1016, Institut Cochin, 75014 Paris, France; CNRS UMR8104, 75014 Paris, France; Université Paris Descartes, Faculté de Médecine Sorbonne Paris Cité, 75005 Paris, France; Equipe Labellisée Ligue Nationale Contre le Cancer (LNCC), 75013 Paris, France., Poulain L; INSERM U1016, Institut Cochin, 75014 Paris, France; CNRS UMR8104, 75014 Paris, France; Université Paris Descartes, Faculté de Médecine Sorbonne Paris Cité, 75005 Paris, France; Equipe Labellisée Ligue Nationale Contre le Cancer (LNCC), 75013 Paris, France., Paubelle E; INSERM UMR 1163, Laboratory of cellular and molecular mechanisms of hematological disorders and therapeutic implications, 75015 Paris, France; Paris Descartes-Sorbonne Paris Cité University, Imagine Institute, 75015 Paris, France; CNRS ERL 8254, 75015 Paris, France; Laboratory of Excellence GR-Ex, 75015 Paris, France., Zylbersztejn F; INSERM UMR 1163, Laboratory of cellular and molecular mechanisms of hematological disorders and therapeutic implications, 75015 Paris, France; Paris Descartes-Sorbonne Paris Cité University, Imagine Institute, 75015 Paris, France; CNRS ERL 8254, 75015 Paris, France; Laboratory of Excellence GR-Ex, 75015 Paris, France., Grenier A; INSERM U1016, Institut Cochin, 75014 Paris, France; CNRS UMR8104, 75014 Paris, France; Université Paris Descartes, Faculté de Médecine Sorbonne Paris Cité, 75005 Paris, France; Equipe Labellisée Ligue Nationale Contre le Cancer (LNCC), 75013 Paris, France., Lambert M; INSERM U1016, Institut Cochin, 75014 Paris, France; CNRS UMR8104, 75014 Paris, France; Université Paris Descartes, Faculté de Médecine Sorbonne Paris Cité, 75005 Paris, France; Equipe Labellisée Ligue Nationale Contre le Cancer (LNCC), 75013 Paris, France., Townsend EC; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA., Brusq JM; GlaxoSmithKline Research Center, 91490 Les Ulis, France., Nicodeme E; GlaxoSmithKline Research Center, 91490 Les Ulis, France., Decrooqc J; INSERM UMR 1163, Laboratory of cellular and molecular mechanisms of hematological disorders and therapeutic implications, 75015 Paris, France; Paris Descartes-Sorbonne Paris Cité University, Imagine Institute, 75015 Paris, France; CNRS ERL 8254, 75015 Paris, France; Laboratory of Excellence GR-Ex, 75015 Paris, France., Nepstad I; Division for Hematology, Department of Medicine, Haukeland University Hospital, N-5021 Bergen, Norway., Green AS; INSERM U1016, Institut Cochin, 75014 Paris, France; CNRS UMR8104, 75014 Paris, France; Université Paris Descartes, Faculté de Médecine Sorbonne Paris Cité, 75005 Paris, France; Equipe Labellisée Ligue Nationale Contre le Cancer (LNCC), 75013 Paris, France., Mondesir J; INSERM U1016, Institut Cochin, 75014 Paris, France; CNRS UMR8104, 75014 Paris, France; Université Paris Descartes, Faculté de Médecine Sorbonne Paris Cité, 75005 Paris, France; Equipe Labellisée Ligue Nationale Contre le Cancer (LNCC), 75013 Paris, France., Hospital MA; INSERM U1016, Institut Cochin, 75014 Paris, France; CNRS UMR8104, 75014 Paris, France; Université Paris Descartes, Faculté de Médecine Sorbonne Paris Cité, 75005 Paris, France; Equipe Labellisée Ligue Nationale Contre le Cancer (LNCC), 75013 Paris, France., Jacque N; INSERM U1016, Institut Cochin, 75014 Paris, France; CNRS UMR8104, 75014 Paris, France; Université Paris Descartes, Faculté de Médecine Sorbonne Paris Cité, 75005 Paris, France; Equipe Labellisée Ligue Nationale Contre le Cancer (LNCC), 75013 Paris, France., Christodoulou A; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA., Desouza TA; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA., Hermine O; INSERM UMR 1163, Laboratory of cellular and molecular mechanisms of hematological disorders and therapeutic implications, 75015 Paris, France; Paris Descartes-Sorbonne Paris Cité University, Imagine Institute, 75015 Paris, France; CNRS ERL 8254, 75015 Paris, France; Laboratory of Excellence GR-Ex, 75015 Paris, France., Foretz M; INSERM U1016, Institut Cochin, 75014 Paris, France; CNRS UMR8104, 75014 Paris, France; Université Paris Descartes, Faculté de Médecine Sorbonne Paris Cité, 75005 Paris, France; Laboratory of Excellence GR-Ex, 75015 Paris, France., Viollet B; INSERM U1016, Institut Cochin, 75014 Paris, France; CNRS UMR8104, 75014 Paris, France; Université Paris Descartes, Faculté de Médecine Sorbonne Paris Cité, 75005 Paris, France; Laboratory of Excellence GR-Ex, 75015 Paris, France., Lacombe C; INSERM U1016, Institut Cochin, 75014 Paris, France; CNRS UMR8104, 75014 Paris, France; Université Paris Descartes, Faculté de Médecine Sorbonne Paris Cité, 75005 Paris, France; Equipe Labellisée Ligue Nationale Contre le Cancer (LNCC), 75013 Paris, France., Mayeux P; INSERM U1016, Institut Cochin, 75014 Paris, France; CNRS UMR8104, 75014 Paris, France; Université Paris Descartes, Faculté de Médecine Sorbonne Paris Cité, 75005 Paris, France; Equipe Labellisée Ligue Nationale Contre le Cancer (LNCC), 75013 Paris, France., Weinstock DM; Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA., Moura IC; INSERM UMR 1163, Laboratory of cellular and molecular mechanisms of hematological disorders and therapeutic implications, 75015 Paris, France; Paris Descartes-Sorbonne Paris Cité University, Imagine Institute, 75015 Paris, France; CNRS ERL 8254, 75015 Paris, France; Laboratory of Excellence GR-Ex, 75015 Paris, France., Bouscary D; INSERM U1016, Institut Cochin, 75014 Paris, France; CNRS UMR8104, 75014 Paris, France; Université Paris Descartes, Faculté de Médecine Sorbonne Paris Cité, 75005 Paris, France; Equipe Labellisée Ligue Nationale Contre le Cancer (LNCC), 75013 Paris, France., Tamburini J; INSERM U1016, Institut Cochin, 75014 Paris, France; CNRS UMR8104, 75014 Paris, France; Université Paris Descartes, Faculté de Médecine Sorbonne Paris Cité, 75005 Paris, France; Equipe Labellisée Ligue Nationale Contre le Cancer (LNCC), 75013 Paris, France. Electronic address: jerome.tamburini@inserm.fr.

المصدر: Cell reports [Cell Rep] 2015 Jun 09; Vol. 11 (9), pp. 1446-57. Date of Electronic Publication: 2015 May 21.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

مواضيع طبية MeSH: AMP-Activated Protein Kinases/*metabolism , Antineoplastic Agents/*pharmacology , Enzyme Activation/*drug effects , Imidazoles/*pharmacology , Leukemia, Myeloid, Acute/*metabolism , Multiprotein Complexes/*agonists , Pyrimidinones/*pharmacology, Animals ; Fluorescent Antibody Technique ; Heterografts ; Humans ; Mechanistic Target of Rapamycin Complex 1 ; Mice ; Mice, Nude ; Microscopy, Electron, Transmission ; Oligonucleotide Array Sequence Analysis ; Polymerase Chain Reaction ; RNA Interference ; Signal Transduction/drug effects ; TOR Serine-Threonine Kinases

المؤلفون: Gosmini R; Candidate Discovery, ‡Discovery Biology, §DMPK, GlaxoSmithKline Les Ulis, Centre de Recherches François Hyafil, GlaxoSmithKline R&D , 25 Avenue du Québec, 91140 Villebon-sur-Yvette, France., Nguyen VL, Toum J, Simon C, Brusq JM, Krysa G, Mirguet O, Riou-Eymard AM, Boursier EV, Trottet L, Bamborough P, Clark H, Chung CW, Cutler L, Demont EH, Kaur R, Lewis AJ, Schilling MB, Soden PE, Taylor S, Walker AL, Walker MD, Prinjha RK, Nicodème E

المصدر: Journal of medicinal chemistry [J Med Chem] 2014 Oct 09; Vol. 57 (19), pp. 8111-31. Date of Electronic Publication: 2014 Sep 24.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Aminoquinolines/*chemical synthesis , Anti-Inflammatory Agents/*chemical synthesis , Apolipoprotein A-I/*metabolism , Benzoates/*chemical synthesis , Nuclear Proteins/*antagonists & inhibitors , Protein Serine-Threonine Kinases/*antagonists & inhibitors , Quinolines/*chemical synthesis , Transcription Factors/*antagonists & inhibitors, Aminoquinolines/pharmacokinetics ; Aminoquinolines/pharmacology ; Animals ; Anti-Inflammatory Agents/pharmacokinetics ; Anti-Inflammatory Agents/pharmacology ; Benzoates/pharmacokinetics ; Benzoates/pharmacology ; Cell Cycle Proteins ; Drug Discovery ; Humans ; Mice ; Quinolines/pharmacokinetics ; Quinolines/pharmacology ; Structure-Activity Relationship

المؤلفون: Mirguet O; Centre de Recherches François Hyafil, GlaxoSmithKline R&D , 25 Avenue du Québec, 91140 Villebon-sur-Yvette, France., Gosmini R, Toum J, Clément CA, Barnathan M, Brusq JM, Mordaunt JE, Grimes RM, Crowe M, Pineau O, Ajakane M, Daugan A, Jeffrey P, Cutler L, Haynes AC, Smithers NN, Chung CW, Bamborough P, Uings IJ, Lewis A, Witherington J, Parr N, Prinjha RK, Nicodème E

المصدر: Journal of medicinal chemistry [J Med Chem] 2013 Oct 10; Vol. 56 (19), pp. 7501-15. Date of Electronic Publication: 2013 Sep 25.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

مواضيع طبية MeSH: Antineoplastic Agents/*pharmacology , Benzodiazepines/*pharmacology , Nuclear Proteins/*antagonists & inhibitors , Transcription Factors/*antagonists & inhibitors, Animals ; Anti-Inflammatory Agents/chemical synthesis ; Anti-Inflammatory Agents/pharmacokinetics ; Anti-Inflammatory Agents/pharmacology ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/pharmacokinetics ; Apolipoprotein A-I/biosynthesis ; Benzodiazepines/chemical synthesis ; Benzodiazepines/pharmacokinetics ; Cell Cycle Proteins ; Dogs ; Epigenesis, Genetic ; Humans ; Macaca fascicularis ; Mice ; Models, Molecular ; Permeability ; Protein Structure, Tertiary ; Rats ; Stereoisomerism ; Structure-Activity Relationship

المؤلفون: Mirguet O; Centre de Recherches François Hyafil, GlaxoSmithKline R&D , 25 avenue du Québec, 91140 Villebon-sur-Yvette, France., Sautet S; Centre de Recherches François Hyafil, GlaxoSmithKline R&D , 25 avenue du Québec, 91140 Villebon-sur-Yvette, France., Clément CA; Centre de Recherches François Hyafil, GlaxoSmithKline R&D , 25 avenue du Québec, 91140 Villebon-sur-Yvette, France., Toum J; Centre de Recherches François Hyafil, GlaxoSmithKline R&D , 25 avenue du Québec, 91140 Villebon-sur-Yvette, France., Donche F; Centre de Recherches François Hyafil, GlaxoSmithKline R&D , 25 avenue du Québec, 91140 Villebon-sur-Yvette, France., Marques C; Centre de Recherches François Hyafil, GlaxoSmithKline R&D , 25 avenue du Québec, 91140 Villebon-sur-Yvette, France., Rondet E; Centre de Recherches François Hyafil, GlaxoSmithKline R&D , 25 avenue du Québec, 91140 Villebon-sur-Yvette, France., Pizzonero M; Centre de Recherches François Hyafil, GlaxoSmithKline R&D , 25 avenue du Québec, 91140 Villebon-sur-Yvette, France., Beaufils B; Centre de Recherches François Hyafil, GlaxoSmithKline R&D , 25 avenue du Québec, 91140 Villebon-sur-Yvette, France., Dudit Y; Centre de Recherches François Hyafil, GlaxoSmithKline R&D , 25 avenue du Québec, 91140 Villebon-sur-Yvette, France., Huet P; Centre de Recherches François Hyafil, GlaxoSmithKline R&D , 25 avenue du Québec, 91140 Villebon-sur-Yvette, France., Trottet L; Centre de Recherches François Hyafil, GlaxoSmithKline R&D , 25 avenue du Québec, 91140 Villebon-sur-Yvette, France., Grondin P; Centre de Recherches François Hyafil, GlaxoSmithKline R&D , 25 avenue du Québec, 91140 Villebon-sur-Yvette, France., Brusq JM; Centre de Recherches François Hyafil, GlaxoSmithKline R&D , 25 avenue du Québec, 91140 Villebon-sur-Yvette, France., Boursier E; Centre de Recherches François Hyafil, GlaxoSmithKline R&D , 25 avenue du Québec, 91140 Villebon-sur-Yvette, France., Saintillan Y; Centre de Recherches François Hyafil, GlaxoSmithKline R&D , 25 avenue du Québec, 91140 Villebon-sur-Yvette, France., Nicodeme E; Centre de Recherches François Hyafil, GlaxoSmithKline R&D , 25 avenue du Québec, 91140 Villebon-sur-Yvette, France.

المصدر: ACS medicinal chemistry letters [ACS Med Chem Lett] 2013 May 17; Vol. 4 (7), pp. 632-6. Date of Electronic Publication: 2013 May 17 (Print Publication: 2013).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE