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المؤلفون: Kevin G. McLure, Reena G. Patel, Edward H. van der Horst, Henrik C. Hansen, S. David Brown, Olesya A. Kharenko, Damodharan Lakshminarasimhan, Bryan Cordell Duffy, Cyrus Calosing, Douglas B. Kitchen, Peter Young, André O. White, Robert K. Suto
المصدر: Journal of medicinal chemistry. 61(18)
مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, BRD4, Protein Conformation, Antineoplastic Agents, Cell Cycle Proteins, Crystallography, X-Ray, 01 natural sciences, 03 medical and health sciences, Structure-Activity Relationship, Protein structure, Methionine, Drug Discovery, Tumor Cells, Cultured, Humans, Transcription factor, Molecular Structure, 010405 organic chemistry, Drug discovery, Chemistry, Nuclear Proteins, Small molecule, 0104 chemical sciences, Bromodomain, 030104 developmental biology, Biochemistry, Acetylation, Covalent bond, Drug Design, Hematologic Neoplasms, Molecular Medicine, Transcription Factors
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المؤلفون: Marieke Lamers, Jiffry Ismail, Kevin F. McGee, John Wityak, Gwen Wang, Jonathan Bard, Leticia Toledo-Sherman, Michele Luche, Mei Bai, Michael Conlon, W. Brent Clayton, Michael A. Lynch, Celia Dominguez, James C. Haber, Dawn Yates, Ryan Newell, Pat Wheelan, Ren Hua Song, Susan Deupree, Tania Mead, Macarena Irigoyen, Ignacio Munoz-Sanjuan, Douglas B. Kitchen, Emily Freeman, Kim L. Matthews, Jeff Webster, Bryan Cordell Duffy, IokTeng D. Kuok, Peter C. Michels, Alex S. Kiselyov, Steve Clifton, Lynette Ongeri, David D. Manning, Maria Beconi, Kathy Lyons, Yuri L. Khmelnitsky, Philip Leonard, Claire Wilson, Monica Hultman
المصدر: Journal of Medicinal Chemistry. 58:2967-2987
مصطلحات موضوعية: Pyrimidine, Drug Evaluation, Preclinical, Chemistry Techniques, Synthetic, Pharmacology, Crystallography, X-Ray, Madin Darby Canine Kidney Cells, Inhibitory Concentration 50, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Dogs, Pharmacokinetics, Mitogen-Activated Protein Kinase 10, Drug Discovery, Animals, Cytochrome P-450 Enzyme Inhibitors, Humans, Protein Kinase Inhibitors, ADME, Molecular Structure, Chemistry, Cellular Assay, In vitro, Disease Models, Animal, Huntington Disease, Pyrimidines, Blood-Brain Barrier, Pharmacodynamics, Microsomes, Liver, Microsome, Pyrazoles, Molecular Medicine, Efflux, Half-Life
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المؤلفون: Bryan Cordell Duffy, Leifeng Cheng, Thomas Elebring, Peter R. Guzzo, Ulhas Bhatt
المصدر: Synthetic Communications. 37:2793-2806
مصطلحات موضوعية: chemistry.chemical_compound, chemistry, Aryl, Organic Chemistry, Organic chemistry, Regioselectivity, Pharmacophore, Cycloaddition, Pyrrole
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المؤلفون: Michael Ellis, Robert K. Suto, Ming Min Hsia, Bryan Cordell Duffy, Cheng Guo, Karen Norek, He Zhao, Henrik C. Hansen, Damodharan Lakshminarasimhan, Shuang Liu, Peter Young, Ruifang Wang, Gregory S. Wagner, Douglas B. Kitchen, Andre White, John Frederick Quinn, Kevin G. McLure, Emily M. Gesner, Gregory Scott Martin, Olesya A. Kharenko
المصدر: Bioorganicmedicinal chemistry letters. 25(14)
مصطلحات موضوعية: BRD4, Clinical Biochemistry, Druggability, Drug Evaluation, Preclinical, Pharmaceutical Science, Cell Cycle Proteins, Plasma protein binding, Crystallography, X-Ray, Ligands, Biochemistry, Structure-Activity Relationship, Quinoxalines, Drug Discovery, Humans, Molecular Biology, Virtual screening, Binding Sites, Chemistry, Organic Chemistry, Nuclear Proteins, Combinatorial chemistry, Bromodomain, Protein Structure, Tertiary, Molecular Docking Simulation, Förster resonance energy transfer, Protein–ligand docking, Docking (molecular), Drug Design, Molecular Medicine, Protein Binding, Transcription Factors
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المؤلفون: Douglas B. Kitchen, Lei Zhu, Bryan Cordell Duffy, Hélène Decornez
المصدر: Bioorganicmedicinal chemistry. 20(18)
مصطلحات موضوعية: Informatics, Process (engineering), Clinical Biochemistry, Pharmaceutical Science, Bioinformatics, Machine learning, computer.software_genre, Biochemistry, Structure-Activity Relationship, Drug Discovery, Cluster analysis, Molecular Biology, Virtual screening, Molecular Structure, Chemistry, business.industry, Drug discovery, Organic Chemistry, Hit to lead, High-Throughput Screening Assays, Identification (information), Pharmaceutical Preparations, Cheminformatics, Molecular Medicine, Artificial intelligence, business, computer, Chemical database
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