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    المؤلفون: Morfopoulou S; Infection, Immunity and Inflammation Department, Great Ormond Street Institute of Child Health, University College London, London, UK.; Section for Paediatrics, Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, UK., Buddle S; Infection, Immunity and Inflammation Department, Great Ormond Street Institute of Child Health, University College London, London, UK., Torres Montaguth OE; Infection, Immunity and Inflammation Department, Great Ormond Street Institute of Child Health, University College London, London, UK., Atkinson L; Department of Microbiology, Virology and Infection Control, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Guerra-Assunção JA; Infection, Immunity and Inflammation Department, Great Ormond Street Institute of Child Health, University College London, London, UK., Moradi Marjaneh M; Section for Paediatrics, Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, UK.; Section of Virology, Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, UK., Zennezini Chiozzi R; University College London Mass Spectrometry Science Technology Platform, Division of Biosciences, University College London, London, UK., Storey N; Department of Microbiology, Virology and Infection Control, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Campos L; Histopathology Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Hutchinson JC; Histopathology Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Counsell JR; Research Department of Targeted Intervention, Division of Surgery and Interventional Science, University College London, London, UK., Pollara G; Division of Infection and Immunity, University College London, London, UK., Roy S; Infection, Immunity and Inflammation Department, Great Ormond Street Institute of Child Health, University College London, London, UK., Venturini C; Infection, Immunity and Inflammation Department, Great Ormond Street Institute of Child Health, University College London, London, UK., Antinao Diaz JF; Research Department of Targeted Intervention, Division of Surgery and Interventional Science, University College London, London, UK., Siam A; Research Department of Targeted Intervention, Division of Surgery and Interventional Science, University College London, London, UK.; Gene Transfer Technology Group, EGA-Institute for Women's Health, University College London, London, UK., Tappouni LJ; Research Department of Targeted Intervention, Division of Surgery and Interventional Science, University College London, London, UK., Asgarian Z; Research Department of Targeted Intervention, Division of Surgery and Interventional Science, University College London, London, UK., Ng J; Gene Transfer Technology Group, EGA-Institute for Women's Health, University College London, London, UK., Hanlon KS; Research Department of Targeted Intervention, Division of Surgery and Interventional Science, University College London, London, UK., Lennon A; Department of Microbiology, Virology and Infection Control, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., McArdle A; Section for Paediatrics, Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, UK., Czap A; Division of Infection and Immunity, University College London, London, UK., Rosenheim J; Division of Infection and Immunity, University College London, London, UK., Andrade C; Histopathology Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Anderson G; Histopathology Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Lee JCD; Department of Microbiology, Virology and Infection Control, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Williams R; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK., Williams CA; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK., Tutill H; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK., Bayzid N; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK., Martin Bernal LM; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK., Macpherson H; Department of Neurodegenerative Disease, Queen Square Institute of Neurology, University College London, London, UK., Montgomery KA; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK.; Department of Neurodegenerative Disease, Queen Square Institute of Neurology, University College London, London, UK., Moore C; Wales Specialist Virology Centre, Public Health Wales Microbiology Cardiff, University Hospital of Wales, Cardiff, UK., Templeton K; Department of Medical Microbiology, Edinburgh Royal Infirmary, Edinburgh, UK., Neill C; Public Health Agency Northern Ireland, Belfast, UK., Holden M; School of Medicine, University of St. Andrews, St. Andrews, UK.; Public Health Scotland, Edinburgh, UK., Gunson R; West of Scotland Specialist Virology Centre, Glasgow, UK., Shepherd SJ; West of Scotland Specialist Virology Centre, Glasgow, UK., Shah P; Section for Paediatrics, Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, UK., Cooray S; Section for Paediatrics, Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, UK., Voice M; Micropathology Ltd, University of Warwick Science Park, Coventry, UK., Steele M; Micropathology Ltd, University of Warwick Science Park, Coventry, UK., Fink C; Micropathology Ltd, University of Warwick Science Park, Coventry, UK., Whittaker TE; Molecular and Cellular Immunology, Great Ormond Street Institute of Child Health, University College London, London, UK., Santilli G; Molecular and Cellular Immunology, Great Ormond Street Institute of Child Health, University College London, London, UK., Gissen P; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK., Kaufer BB; Institute of Virology, Freie Universität Berlin, Berlin, Germany., Reich J; Institute of Virology, Freie Universität Berlin, Berlin, Germany., Andreani J; Nuffield Department of Medicine, University of Oxford, Oxford, UK.; Centre Hospitalier Universitaire (CHU) Grenoble-Alpes, Grenoble, France., Simmonds P; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Alrabiah DK; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK.; National Centre for Biotechnology, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia., Castellano S; Genetics and Genomic Medicine Department, Great Ormond Street Institute of Child Health, University College London, London, UK.; University College London Genomics, University College London, London, UK., Chikowore P; Roslin Institute, University of Edinburgh, Edinburgh, UK., Odam M; Roslin Institute, University of Edinburgh, Edinburgh, UK., Rampling T; Division of Infection and Immunity, University College London, London, UK.; UK Health Security Agency, London, UK.; Hospital for Tropical Diseases, University College London Hospitals NHS Foundation Trust, London, UK., Houlihan C; Division of Infection and Immunity, University College London, London, UK.; UK Health Security Agency, London, UK.; Department of Clinical Virology, University College London Hospitals, London, UK., Hoschler K; UK Health Security Agency, London, UK., Talts T; UK Health Security Agency, London, UK., Celma C; UK Health Security Agency, London, UK., Gonzalez S; UK Health Security Agency, London, UK., Gallagher E; UK Health Security Agency, London, UK., Simmons R; UK Health Security Agency, London, UK., Watson C; UK Health Security Agency, London, UK., Mandal S; UK Health Security Agency, London, UK., Zambon M; UK Health Security Agency, London, UK., Chand M; UK Health Security Agency, London, UK., Hatcher J; Department of Microbiology, Virology and Infection Control, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., De S; Department of Microbiology, Virology and Infection Control, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Baillie K; Roslin Institute, University of Edinburgh, Edinburgh, UK., Semple MG; Pandemic Institute, University of Liverpool, Liverpool, UK.; Respiratory Medicine, Alder Hey Children's Hospital NHS Foundation Trust, Liverpool, UK., Martin J; Centre for Genomics and Child Health, The Blizard Institute, Queen Mary University of London, London, UK., Ushiro-Lumb I; NHS Blood and Transplant, Bristol, UK., Noursadeghi M; Division of Infection and Immunity, University College London, London, UK., Deheragoda M; King's College Hospital, London, UK., Hadzic N; King's College Hospital, London, UK., Grammatikopoulos T; King's College Hospital, London, UK., Brown R; Department of Cellular Pathology, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK., Kelgeri C; Liver Unit, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK., Thalassinos K; University College London Mass Spectrometry Science Technology Platform, Division of Biosciences, University College London, London, UK.; Institute of Structural and Molecular Biology, Division of Biosciences, University College London, London, UK.; Institute of Structural and Molecular Biology, Birkbeck College, University of London, London, UK., Waddington SN; Gene Transfer Technology Group, EGA-Institute for Women's Health, University College London, London, UK.; Medical Research Council Antiviral Gene Therapy Research Unit, Faculty of Health Sciences, University of the Witswatersrand, Johannesburg, South Africa., Jacques TS; Histopathology Department, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.; Developmental Biology and Cancer Department, Great Ormond Street Institute of Child Health, University College London, London, UK., Thomson E; Medical Research Council-University of Glasgow Centre for Virus Research, Glasgow, UK., Levin M; Section for Paediatrics, Department of Infectious Diseases, Faculty of Medicine, Imperial College London, London, UK., Brown JR; Department of Microbiology, Virology and Infection Control, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK., Breuer J; Infection, Immunity and Inflammation Department, Great Ormond Street Institute of Child Health, University College London, London, UK. j.breuer@ucl.ac.uk.; Department of Microbiology, Virology and Infection Control, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK. j.breuer@ucl.ac.uk.

    المصدر: Nature [Nature] 2023 May; Vol. 617 (7961), pp. 564-573. Date of Electronic Publication: 2023 Mar 30.

    نوع المنشور: Journal Article

    بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

    SCR Organism: Adeno-associated virus-2