المؤلفون: Kayhanian H; UCL Cancer Institute, University College London, London, UK., Cross W; UCL Cancer Institute, University College London, London, UK.; Cancer Mechanisms and Biomarker Discovery Group, School of Life Sciences, University of Westminster, London, UK., van der Horst SEM; Oncode Institute, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., Barmpoutis P; UCL Cancer Institute, University College London, London, UK.; UCL Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK., Lakatos E; Department of Mathematical Sciences, Chalmers University of Technology and University of Gothenburg, Gothenburg, Sweden., Caravagna G; Department of Mathematics, Informatics and Geosciences, University of Trieste, Trieste, Italy., Zapata L; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Van Hoeck A; Oncode Institute, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., Middelkamp S; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Litchfield K; UCL Cancer Institute, University College London, London, UK., Steele C; UCL Cancer Institute, University College London, London, UK., Waddingham W; UCL Cancer Institute, University College London, London, UK., Patel D; UCL Cancer Institute, University College London, London, UK., Milite S; Department of Mathematics, Informatics and Geosciences, University of Trieste, Trieste, Italy., Jin C; UCL Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK., Baker AM; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK., Alexander DC; UCL Centre for Medical Image Computing, Department of Computer Science, University College London, London, UK., Khan K; Department of Oncology, UCL Cancer Institute, University College London, London, UK., Hochhauser D; UCL Cancer Institute, University College London, London, UK.; Department of Oncology, UCL Cancer Institute, University College London, London, UK., Novelli M; UCL Cancer Institute, University College London, London, UK.; Department of Pathology, University College London Hospital, London, UK., Werner B; Centre for Cancer Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., van Boxtel R; Oncode Institute, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.; Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands., Hageman JH; Oncode Institute, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., Buissant des Amorie JR; Oncode Institute, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands., Linares J; HSL-AD, London, UK., Ligtenberg MJL; Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands., Nagtegaal ID; Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands., Laclé MM; Department of Pathology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Moons LMG; Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands., Brosens LAA; Department of Pathology, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands., Pillay N; UCL Cancer Institute, University College London, London, UK., Sottoriva A; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Computational Biology Research Centre, Human Technopole, Milan, Italy., Graham TA; Centre for Evolution and Cancer, The Institute of Cancer Research, London, UK.; Centre for Cancer Genomics and Computational Biology, Barts Cancer Institute, Queen Mary University of London, London, UK., Rodriguez-Justo M; UCL Cancer Institute, University College London, London, UK.; Department of Pathology, University College London Hospital, London, UK., Shiu KK; UCL Cancer Institute, University College London, London, UK.; Department of Oncology, UCL Cancer Institute, University College London, London, UK., Snippert HJG; Oncode Institute, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands. h.j.g.snippert@umcutrecht.nl., Jansen M; UCL Cancer Institute, University College London, London, UK. m.jansen@ucl.ac.uk.; Department of Pathology, University College London Hospital, London, UK. m.jansen@ucl.ac.uk.

المصدر: Nature genetics [Nat Genet] 2024 Jul; Vol. 56 (7), pp. 1420-1433. Date of Electronic Publication: 2024 Jul 03.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE

مواضيع طبية MeSH: Colorectal Neoplasms*/genetics , DNA Mismatch Repair*/genetics , Microsatellite Instability*, Humans ; DNA-Binding Proteins/genetics ; Mutation ; MutS Homolog 3 Protein/genetics ; Mutation Rate ; Frameshift Mutation/genetics

المؤلفون: Bollen Y; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, the Netherlands.; Oncode Institute, Utrecht, the Netherlands.; Medical Cell Biophysics, TechMed Centre, University of Twente, Enschede, the Netherlands., Hageman JH; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., van Leenen P; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Derks LLM; Oncode Institute, Utrecht, the Netherlands.; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Ponsioen B; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Buissant des Amorie JR; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Verlaan-Klink I; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., van den Bos M; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, the Netherlands.; Oncode Institute, Utrecht, the Netherlands., Terstappen LWMM; Medical Cell Biophysics, TechMed Centre, University of Twente, Enschede, the Netherlands., van Boxtel R; Oncode Institute, Utrecht, the Netherlands.; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands., Snippert HJG; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, the Netherlands.; Oncode Institute, Utrecht, the Netherlands.

المصدر: PLoS biology [PLoS Biol] 2022 Jan 28; Vol. 20 (1), pp. e3001527. Date of Electronic Publication: 2022 Jan 28 (Print Publication: 2022).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE

مواضيع طبية MeSH: Genetic Loci* , Recombinational DNA Repair*, DNA/*genetics , Deoxyribonuclease I/*metabolism , Organoids/*metabolism , Staining and Labeling/*methods, Alleles ; Base Sequence ; CRISPR-Associated Protein 9/genetics ; CRISPR-Associated Protein 9/metabolism ; Colon/cytology ; Colon/metabolism ; DNA/metabolism ; DNA End-Joining Repair ; Deoxyribonuclease I/genetics ; Electroporation/methods ; Epithelial Cells/cytology ; Epithelial Cells/metabolism ; Fluorescent Dyes/chemistry ; Fluorescent Dyes/metabolism ; Gene Knock-In Techniques ; Genetic Vectors ; Genome, Human ; Heterozygote ; Humans ; Organoids/cytology

المؤلفون: Ponsioen B; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., Post JB; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., Buissant des Amorie JR; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., Laskaris D; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., van Ineveld RL; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., Kersten S; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., Bertotti A; Laboratory of Translational Cancer Medicine, Candiolo Cancer Institute - FPO IRCCs, Candiolo, Torino, Italy.; Department of Oncology, University of Torino School of Medicine, Candiolo, Torino, Italy., Sassi F; Laboratory of Translational Cancer Medicine, Candiolo Cancer Institute - FPO IRCCs, Candiolo, Torino, Italy., Sipieter F; Molecular Signaling and Cell Death Unit, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.; Molecular Signaling and Cell Death Unit, Center for Inflammation Research (IRC), a VIB-UGent department, Ghent, Belgium.; Institut Jacques Monod, CNRS UMR 7592, Université Paris Diderot, Paris, France., Cappe B; Molecular Signaling and Cell Death Unit, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.; Molecular Signaling and Cell Death Unit, Center for Inflammation Research (IRC), a VIB-UGent department, Ghent, Belgium., Mertens S; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., Verlaan-Klink I; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., Boj SF; Foundation Hubrecht Organoid Technology (HUB), Utrecht, Netherlands., Vries RGJ; Foundation Hubrecht Organoid Technology (HUB), Utrecht, Netherlands., Rehmann H; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands., Vandenabeele P; Molecular Signaling and Cell Death Unit, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.; Molecular Signaling and Cell Death Unit, Center for Inflammation Research (IRC), a VIB-UGent department, Ghent, Belgium., Riquet FB; Molecular Signaling and Cell Death Unit, Department of Biomedical Molecular Biology, Ghent University, Ghent, Belgium.; Molecular Signaling and Cell Death Unit, Center for Inflammation Research (IRC), a VIB-UGent department, Ghent, Belgium.; University of Lille, Villeneuve d'Ascq, France., Trusolino L; Laboratory of Translational Cancer Medicine, Candiolo Cancer Institute - FPO IRCCs, Candiolo, Torino, Italy.; Department of Oncology, University of Torino School of Medicine, Candiolo, Torino, Italy., Bos JL; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.; Oncode Institute, Utrecht, Netherlands., Snippert HJG; Molecular Cancer Research, Center for Molecular Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands. h.j.g.snippert@umcutrecht.nl.; Oncode Institute, Utrecht, Netherlands. h.j.g.snippert@umcutrecht.nl.

المصدر: Nature cell biology [Nat Cell Biol] 2021 Apr; Vol. 23 (4), pp. 377-390. Date of Electronic Publication: 2021 Apr 01.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE

مواضيع طبية MeSH: Colorectal Neoplasms/*drug therapy , Protein Kinase Inhibitors/*pharmacology , Proto-Oncogene Proteins B-raf/*genetics , Proto-Oncogene Proteins p21(ras)/*genetics, Cell Line, Tumor ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/pathology ; ErbB Receptors/genetics ; Gene Expression Regulation, Neoplastic/drug effects ; Humans ; MAP Kinase Signaling System/drug effects ; Mitogen-Activated Protein Kinase Kinases/genetics ; Mutation ; Organoids/metabolism ; Organoids/pathology ; Single-Cell Analysis