المؤلفون: Buravchenko GI; Gause Institute of New Antibiotics 11 B. Pirogovskaya Street Moscow 119021 Russia buravchenkogi@gmail.com krymov.s.k@gmail.com gzatonsk@gmail.com shchekotikhin@mail.ru shchekotikhin@gause-inst.ru., Scherbakov AM; Department of Experimental Tumor Biology, Institute of Carcinogenesis, Blokhin N.N. National Medical Research Center of Oncology Kashirskoe sh. 24 115522 Moscow Russia dianasalnikova08@yandex.ru alex.scherbakov@gmail.com., Krymov SK; Gause Institute of New Antibiotics 11 B. Pirogovskaya Street Moscow 119021 Russia buravchenkogi@gmail.com krymov.s.k@gmail.com gzatonsk@gmail.com shchekotikhin@mail.ru shchekotikhin@gause-inst.ru., Salnikova DI; Department of Experimental Tumor Biology, Institute of Carcinogenesis, Blokhin N.N. National Medical Research Center of Oncology Kashirskoe sh. 24 115522 Moscow Russia dianasalnikova08@yandex.ru alex.scherbakov@gmail.com., Zatonsky GV; Gause Institute of New Antibiotics 11 B. Pirogovskaya Street Moscow 119021 Russia buravchenkogi@gmail.com krymov.s.k@gmail.com gzatonsk@gmail.com shchekotikhin@mail.ru shchekotikhin@gause-inst.ru., Schols D; Rega Institute for Medical Research, KU Leuven 3000 Leuven Belgium dominique.schols@kuleuven.be., Vullo D; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence Florence Italy daniela.vullo@unifi.it claudiu.supuran@unifi.it., Supuran CT; Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence Florence Italy daniela.vullo@unifi.it claudiu.supuran@unifi.it., Shchekotikhin AE; Gause Institute of New Antibiotics 11 B. Pirogovskaya Street Moscow 119021 Russia buravchenkogi@gmail.com krymov.s.k@gmail.com gzatonsk@gmail.com shchekotikhin@mail.ru shchekotikhin@gause-inst.ru.

المصدر: RSC advances [RSC Adv] 2024 Jul 23; Vol. 14 (32), pp. 23257-23272. Date of Electronic Publication: 2024 Jul 23 (Print Publication: 2024).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101581657 Publication Model: eCollection Cited Medium: Internet ISSN: 2046-2069 (Electronic) Linking ISSN: 20462069 NLM ISO Abbreviation: RSC Adv Subsets: PubMed not MEDLINE

المؤلفون: Frolova SG; Laboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 119333 Moscow, Russia.; Phystech School of Biological and Medical Physics, Moscow Institute of Physics and Technology (State University), 141701 Dolgoprudny, Russia.; Institute for Regenerative Medicine, Department of Dermatology and Venereology, Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia., Vatlin AA; Laboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 119333 Moscow, Russia.; Institute of Ecology, Peoples' Friendship University of Russia (RUDN University), 117198 Moscow, Russia., Maslov DA; Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA., Yusuf B; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.; University of Chinese Academy of Sciences, Beijing 100049, China.; Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Diseases, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.; China-New Zealand Joint Laboratory on Biomedicine and Health, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China., Buravchenko GI; Gause Institute of New Antibiotics, 119021 Moscow, Russia., Bekker OB; Laboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 119333 Moscow, Russia., Klimina KM; Laboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 119333 Moscow, Russia.; Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency (Lopukhin FRCC PCM), 119435 Moscow, Russia., Smirnova SV; Laboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 119333 Moscow, Russia., Shnakhova LM; Institute for Regenerative Medicine, Department of Dermatology and Venereology, Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia., Malyants IK; Lopukhin Federal Research and Clinical Center of Physical-Chemical Medicine of Federal Medical Biological Agency (Lopukhin FRCC PCM), 119435 Moscow, Russia., Lashkin AI; Federal Research and Clinical Center of Physical-Сhemical Medicine, 119435 Moscow, Russia.; Laboratory of Molecular Oncology, Department of Bioorganic Chemistry, Faculty of Biology, Lomonosov Moscow State University, 119991 Moscow, Russia., Tian X; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.; University of Chinese Academy of Sciences, Beijing 100049, China.; Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Diseases, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.; China-New Zealand Joint Laboratory on Biomedicine and Health, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China., Alam MS; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.; University of Chinese Academy of Sciences, Beijing 100049, China.; Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Diseases, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.; China-New Zealand Joint Laboratory on Biomedicine and Health, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China., Zatonsky GV; Gause Institute of New Antibiotics, 119021 Moscow, Russia., Zhang T; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.; University of Chinese Academy of Sciences, Beijing 100049, China.; Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Diseases, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.; China-New Zealand Joint Laboratory on Biomedicine and Health, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China., Shchekotikhin AE; Gause Institute of New Antibiotics, 119021 Moscow, Russia., Danilenko VN; Laboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 119333 Moscow, Russia.

المصدر: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2023 Nov 06; Vol. 16 (11). Date of Electronic Publication: 2023 Nov 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238453 Publication Model: Electronic Cited Medium: Print ISSN: 1424-8247 (Print) Linking ISSN: 14248247 NLM ISO Abbreviation: Pharmaceuticals (Basel) Subsets: PubMed not MEDLINE

المؤلفون: Buravchenko GI; Gause Institute of New Antibiotics, 119021 Moscow, Russia., Shchekotikhin AE; Gause Institute of New Antibiotics, 119021 Moscow, Russia.

المصدر: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2023 Aug 17; Vol. 16 (8). Date of Electronic Publication: 2023 Aug 17.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238453 Publication Model: Electronic Cited Medium: Print ISSN: 1424-8247 (Print) Linking ISSN: 14248247 NLM ISO Abbreviation: Pharmaceuticals (Basel) Subsets: PubMed not MEDLINE

المؤلفون: Perera WH; CAMAG Scientific, Inc., 515 Cornelius Harnett Drive, Wilmington, NC 28401, USA., Scherbakov AM; Department of Experimental Tumor Biology, Blokhin N.N. National Medical Research Center of Oncology, 24 Kashirskoye sh., 115522 Moscow, Russia., Buravchenko GI; Laboratory of Chemical Transformations of Antibiotics, Gause Institute of New Antibiotics, 11 B. Pirogovskaya St., 119021 Moscow, Russia.; Organic Chemistry Department, Faculty of Natural Sciences, Mendeleyev University of Chemical Technology, 9 Miusskaya Square, 125190 Moscow, Russia., Mikhaevich EI; Department of Experimental Tumor Biology, Blokhin N.N. National Medical Research Center of Oncology, 24 Kashirskoye sh., 115522 Moscow, Russia., Leitão SG; Faculty of Pharmacy, Federal University of Rio de Janeiro, CCS, Bl. A, Ilha do Fundão, Rio de Janeiro 21941-902, Brazil.; Research Network Natural Products against Neglected Diseases (ResNetNPND), University of Münster, 48149 Münster, Germany., Cos P; Research Network Natural Products against Neglected Diseases (ResNetNPND), University of Münster, 48149 Münster, Germany.; Laboratory for Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, 2610 Antwerp, Belgium., Shchekotikhin AE; Laboratory of Chemical Transformations of Antibiotics, Gause Institute of New Antibiotics, 11 B. Pirogovskaya St., 119021 Moscow, Russia., Monzote L; Research Network Natural Products against Neglected Diseases (ResNetNPND), University of Münster, 48149 Münster, Germany.; Parasitology Department, Institute of Tropical Medicine 'Pedro Kouri', Havana 10400, Cuba., Setzer WN; Research Network Natural Products against Neglected Diseases (ResNetNPND), University of Münster, 48149 Münster, Germany.; Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA.; Aromatic Plant Research Center, 230 N 1200 E, Suite 100, Lehi, UT 84043, USA.

المصدر: Molecules (Basel, Switzerland) [Molecules] 2022 Mar 16; Vol. 27 (6). Date of Electronic Publication: 2022 Mar 16.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE

مواضيع طبية MeSH: Baccharis* , Lippia* , Oils, Volatile*/pharmacology , Trypanosoma cruzi*, Animals ; Brazil ; Mice

المؤلفون: Buravchenko GI; Gause Institute of New Antibiotics, 119021 Moscow, Russia., Maslov DA; Laboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 119333 Moscow, Russia., Alam MS; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.; China-New Zealand Joint Laboratory on Biomedicine and Health, Guangzhou 510530, China.; Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Diseases, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Grammatikova NE; Gause Institute of New Antibiotics, 119021 Moscow, Russia., Frolova SG; Laboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 119333 Moscow, Russia.; Phystech School of Biological and Medical Physics, Moscow Institute of Physics and Technology (State University), 141701 Dolgoprudny, Russia., Vatlin AA; Laboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 119333 Moscow, Russia.; Institute of Ecology, Peoples' Friendship University of Russia (RUDN University), 117198 Moscow, Russia., Tian X; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.; China-New Zealand Joint Laboratory on Biomedicine and Health, Guangzhou 510530, China.; Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Diseases, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Ivanov IV; Gause Institute of New Antibiotics, 119021 Moscow, Russia.; Organic Chemistry Department, Faculty of Natural Sciences, Mendeleyev University of Chemical Technology, 9 Miusskaya Square, 125190 Moscow, Russia., Bekker OB; Laboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 119333 Moscow, Russia., Kryakvin MA; Chemistry Department, Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119991 Moscow, Russia., Dontsova OA; Chemistry Department, Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, 119991 Moscow, Russia.; Center of Life Sciences, Skolkovo Institute of Science and Technology, 143028 Skolkovo, Russia.; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, 117997 Moscow, Russia., Danilenko VN; Laboratory of Bacterial Genetics, Vavilov Institute of General Genetics, Russian Academy of Sciences, 119333 Moscow, Russia., Zhang T; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.; China-New Zealand Joint Laboratory on Biomedicine and Health, Guangzhou 510530, China.; Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Diseases, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.; University of Chinese Academy of Sciences, Beijing 100049, China., Shchekotikhin AE; Gause Institute of New Antibiotics, 119021 Moscow, Russia.

المصدر: Pharmaceuticals (Basel, Switzerland) [Pharmaceuticals (Basel)] 2022 Jan 27; Vol. 15 (2). Date of Electronic Publication: 2022 Jan 27.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101238453 Publication Model: Electronic Cited Medium: Print ISSN: 1424-8247 (Print) Linking ISSN: 14248247 NLM ISO Abbreviation: Pharmaceuticals (Basel) Subsets: PubMed not MEDLINE

المؤلفون: Buravchenko GI; Gause Institute of New Antibiotics 11 B. Pirogovskaya Street Moscow 119021 Russia shchekotikhin@mail.ru.; Mendeleyev University of Chemical Technology 9 Miusskaya Square Moscow 125190 Russia., Scherbakov AM; Blokhin National Medical Research Center of Oncology 24 Kashirskoye Sh. Moscow 115522 Russia., Dezhenkova LG; Gause Institute of New Antibiotics 11 B. Pirogovskaya Street Moscow 119021 Russia shchekotikhin@mail.ru., Monzote L; Department of Parasitology, Pedro Kouri Tropical Medicine Institute Havana Cuba., Shchekotikhin AE; Gause Institute of New Antibiotics 11 B. Pirogovskaya Street Moscow 119021 Russia shchekotikhin@mail.ru.

المصدر: RSC advances [RSC Adv] 2021 Dec 03; Vol. 11 (61), pp. 38782-38795. Date of Electronic Publication: 2021 Dec 03 (Print Publication: 2021).

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101581657 Publication Model: eCollection Cited Medium: Internet ISSN: 2046-2069 (Electronic) Linking ISSN: 20462069 NLM ISO Abbreviation: RSC Adv Subsets: PubMed not MEDLINE

المؤلفون: Buravchenko GI; Gause Institute of New Antibiotics, 11 B. Pirogovskaya Street, Moscow 119021, Russia; Mendeleyev University of Chemical Technology, 9 Miusskaya Square, Moscow 125190, Russia. Electronic address: buravchenkogi@gmail.com., Scherbakov AM; Blokhin National Medical Research Center of Oncology, 24 Kashirskoye sh., Moscow 115522, Russia. Electronic address: alex.scherbakov@gmail.com., Dezhenkova LG; Gause Institute of New Antibiotics, 11 B. Pirogovskaya Street, Moscow 119021, Russia. Electronic address: dezhenkovalg@yahoo.com., Bykov EE; Gause Institute of New Antibiotics, 11 B. Pirogovskaya Street, Moscow 119021, Russia., Solovieva SE; Gause Institute of New Antibiotics, 11 B. Pirogovskaya Street, Moscow 119021, Russia., Korlukov AA; Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilova St., Moscow 119991, Russia., Sorokin DV; Blokhin National Medical Research Center of Oncology, 24 Kashirskoye sh., Moscow 115522, Russia. Electronic address: dsorokin2018@gmail.com., Monzote Fidalgo L; Department of Parasitology, Pedro Kouri Tropical Medicine Institute, Havana, Cuba. Electronic address: monzote@ipk.sld.cu., Shchekotikhin AE; Gause Institute of New Antibiotics, 11 B. Pirogovskaya Street, Moscow 119021, Russia. Electronic address: shchekotikhin@mail.ru.

المصدر: Bioorganic chemistry [Bioorg Chem] 2020 Nov; Vol. 104, pp. 104324. Date of Electronic Publication: 2020 Sep 28.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE

مواضيع طبية MeSH: Drug Discovery*, Antineoplastic Agents/*pharmacology , Cell Hypoxia/*drug effects , Hypoxia-Inducible Factor 1, alpha Subunit/*antagonists & inhibitors , Nitriles/*pharmacology , Quinoxalines/*pharmacology , Receptors, Estrogen/*antagonists & inhibitors, Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Dose-Response Relationship, Drug ; Drug Screening Assays, Antitumor ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/genetics ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Molecular Structure ; Nitriles/chemical synthesis ; Nitriles/chemistry ; Quinoxalines/chemical synthesis ; Quinoxalines/chemistry ; Receptors, Estrogen/metabolism ; Structure-Activity Relationship

المؤلفون: Buravchenko GI; Gause Institute of New Antibiotics, 11 B. Pirogovskaya Street, Moscow 119021, Russian Federation.; Mendeleyev University of Chemical Technology, 9 Miusskaya Square, Moscow 125190, Russian Federation., Scherbakov AM; Blokhin National Medical Research Center of Oncology, 24 Kashirskoye sh., Moscow 115522, Russian Federation., Korlukov AА; Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 28 Vavilova St., Moscow 119991, Russian Federation.; Pirogov Russian National Research Medical University, 1 Ostrovitianov str., Moscow 117997, Russian Federation., Dorovatovskii PV; National Research Center 'Kurchatov Institute', 1 Akademika Kurchatova pl., Moscow 123182, Russian Federation., Shchekotikhin AE; Gause Institute of New Antibiotics, 11 B. Pirogovskaya Street, Moscow 119021, Russian Federation.; Mendeleyev University of Chemical Technology, 9 Miusskaya Square, Moscow 125190, Russian Federation.

المصدر: Current organic synthesis [Curr Org Synth] 2020; Vol. 17 (1), pp. 29-39.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Bentham Science Publishers Country of Publication: United Arab Emirates NLM ID: 101208457 Publication Model: Print Cited Medium: Internet ISSN: 1570-1794 (Print) Linking ISSN: 15701794 NLM ISO Abbreviation: Curr Org Synth Subsets: MEDLINE

مواضيع طبية MeSH: Acetonitriles/*chemistry , Antineoplastic Agents/*pharmacology , Benzoxazoles/*chemistry , Cell Hypoxia/*physiology , Cyclic N-Oxides/*pharmacology , Quinoxalines/*pharmacology, Antineoplastic Agents/chemical synthesis ; Cell Proliferation/drug effects ; Cyclic N-Oxides/chemical synthesis ; Drug Screening Assays, Antitumor ; Humans ; MCF-7 Cells ; Quinoxalines/chemical synthesis

المؤلفون: Scherbakov AM; a Department of Experimental Tumor Biology , Blokhin N.N. National Medical Research Center of Oncology , Moscow , Russia., Borunov AM; b Laboratory of Chemical Transformations of Antibiotics , Gause Institute of New Antibiotics , Moscow , Russia.; c Organic Chemistry Department , Mendeleyev University of Chemical Technology of Russia , Moscow , Russia., Buravchenko GI; b Laboratory of Chemical Transformations of Antibiotics , Gause Institute of New Antibiotics , Moscow , Russia.; c Organic Chemistry Department , Mendeleyev University of Chemical Technology of Russia , Moscow , Russia., Andreeva OE; a Department of Experimental Tumor Biology , Blokhin N.N. National Medical Research Center of Oncology , Moscow , Russia., Kudryavtsev IA; a Department of Experimental Tumor Biology , Blokhin N.N. National Medical Research Center of Oncology , Moscow , Russia., Dezhenkova LG; b Laboratory of Chemical Transformations of Antibiotics , Gause Institute of New Antibiotics , Moscow , Russia., Shchekotikhin AE; b Laboratory of Chemical Transformations of Antibiotics , Gause Institute of New Antibiotics , Moscow , Russia.; c Organic Chemistry Department , Mendeleyev University of Chemical Technology of Russia , Moscow , Russia.

المصدر: Cancer investigation [Cancer Invest] 2018 Mar 16; Vol. 36 (3), pp. 199-209. Date of Electronic Publication: 2018 Apr 06.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Taylor & Francis Country of Publication: England NLM ID: 8307154 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-4192 (Electronic) Linking ISSN: 07357907 NLM ISO Abbreviation: Cancer Invest Subsets: MEDLINE

مواضيع طبية MeSH: Down-Regulation*, Drug Resistance, Neoplasm/*drug effects , Hypoxia-Inducible Factor 1, alpha Subunit/*genetics , Nitriles/*chemical synthesis , Quinoxalines/*chemistry, Cell Line, Tumor ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Drug Synergism ; Gene Expression Regulation, Neoplastic/drug effects ; HCT116 Cells ; Humans ; K562 Cells ; MCF-7 Cells ; Metformin/pharmacology ; Molecular Structure ; Nitriles/chemistry ; Nitriles/pharmacology ; Reactive Oxygen Species/metabolism