المؤلفون: Leslie, J, Macia, MG, Luli, S, Worrell, JC, Reilly, WJ, Paish, HL, Knox, A, Barksby, BS, Gee, LM, Zaki, MYW, Collins, AL, Burgoyne, RA, Cameron, R, Bragg, C, Xu, X, Chung, GW, Brown, CDA, Blanchard, AD, Nanthakumar, CB, Karsdal, M, Robinson, SM, Manas, DM, Sen, G, French, J, White, SA, Murphy, S, Trost, M, Zakrzewski, JL, Klein, U, Schwabe, RF, Mederacke, I, Nixon, C, Bird, T, Teuwen, L-A, Schoonjans, L, Carmeliet, P, Mann, J, Fisher, AJ, Sheerin, NS, Borthwick, LA, Mann, DA, Oakley, F

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المؤلفون: Gee LMV; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom., Barron-Millar B; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom., Leslie J; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom., Richardson C; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom., Zaki MYW; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom; Biochemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt., Luli S; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom., Burgoyne RA; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom., Cameron RIT; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom., Smith GR; Bioinformatics Support Unit, Newcastle University, Newcastle upon Tyne, United Kingdom., Brain JG; Liver Unit, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom., Innes B; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom., Jopson L; Liver Unit, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom., Dyson JK; Liver Unit, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom., McKay KRC; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom., Pechlivanis A; Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, United Kingdom., Holmes E; Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, United Kingdom., Berlinguer-Palmini R; Newcastle Bioimaging Unit, Newcastle University, Newcastle upon Tyne, United Kingdom., Victorelli S; Department of Physiology and Biomedical Engineering, Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota., Mells GF; Academic Department of Medical Genetics, University of Cambridge, Cambridge, United Kingdom., Sandford RN; Academic Department of Medical Genetics, University of Cambridge, Cambridge, United Kingdom., Palmer J; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom., Kirby JA; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom., Kiourtis C; Cancer Research UK Beatson Institute, Glasgow, United Kingdom., Mokochinski J; MRC London Institute of Medical Sciences, London, United Kingdom., Hall Z; Division of Systems Medicine, Department of Metabolism, Digestion and Reproduction, Imperial College London, Hammersmith Hospital Campus, London, United Kingdom., Bird TG; Cancer Research UK Beatson Institute, Glasgow, United Kingdom; MRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom., Borthwick LA; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom., Morris CM; Medical Toxicology Centre, Newcastle University, Newcastle upon Tyne, United Kingdom., Hanson PS; Medical Toxicology Centre, Newcastle University, Newcastle upon Tyne, United Kingdom., Jurk D; Department of Physiology and Biomedical Engineering, Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota., Stoll EA; Western Institute for Advanced Study, Denver, Colorado., LeBeau FEN; Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom., Jones DEJ; Liver Unit, Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom; Translational and Clinical Research Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom., Oakley F; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom. Electronic address: fiona.oakley@newcastle.ac.uk.

المصدر: The American journal of pathology [Am J Pathol] 2023 Jan; Vol. 193 (1), pp. 11-26. Date of Electronic Publication: 2022 Oct 13.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 0370502 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-2191 (Electronic) Linking ISSN: 00029440 NLM ISO Abbreviation: Am J Pathol Subsets: MEDLINE

مواضيع طبية MeSH: Memory, Short-Term* , Cholestasis*/drug therapy, Humans ; Mice ; Animals ; Chenodeoxycholic Acid/pharmacology ; Bile Ducts/surgery ; Liver ; Ligation

المؤلفون: Wilkinson AL; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., John AE; Margaret Turner Warwick Centre for Fibrosing Lung Disease, National Heart and Lung Institute, Imperial College London, Guy Scadding Building, Cale Street, London, UK., Barrett JW; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Gower E; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Morrison VS; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Man Y; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Pun KT; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Roper JA; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Luckett JC; Nottingham Respiratory Research Unit, University of Nottingham, Nottingham, UK., Borthwick LA; Fibrosis Research Group, Newcastle University Biosciences Institute, Newcastle University Translational and Clinical Research Institute, Newcastle Upon Tyne, UK., Barksby BS; Fibrosis Research Group, Newcastle University Biosciences Institute, Newcastle University Translational and Clinical Research Institute, Newcastle Upon Tyne, UK., Burgoyne RA; Fibrosis Research Group, Newcastle University Biosciences Institute, Newcastle University Translational and Clinical Research Institute, Newcastle Upon Tyne, UK., Barnes R; Fibrosis Research Group, Newcastle University Biosciences Institute, Newcastle University Translational and Clinical Research Institute, Newcastle Upon Tyne, UK., Fisher AJ; Fibrosis Research Group, Newcastle University Biosciences Institute, Newcastle University Translational and Clinical Research Institute, Newcastle Upon Tyne, UK; Institute of Transplantation, Freeman Hospital, Newcastle Upon Tyne Hospitals NHS, Foundation Trust, Newcastle Upon Tyne, UK., Procopiou PA; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Hatley RJD; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Barrett TN; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Marshall RP; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Macdonald SJF; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Jenkins RG; Margaret Turner Warwick Centre for Fibrosing Lung Disease, National Heart and Lung Institute, Imperial College London, Guy Scadding Building, Cale Street, London, UK., Slack RJ; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK. Electronic address: RJSlack@galecto.com.

المصدر: European journal of pharmacology [Eur J Pharmacol] 2021 Dec 15; Vol. 913, pp. 174618. Date of Electronic Publication: 2021 Nov 08.

نوع المنشور: Journal Article

بيانات الدورية: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 1254354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0712 (Electronic) Linking ISSN: 00142999 NLM ISO Abbreviation: Eur J Pharmacol Subsets: MEDLINE

مواضيع طبية MeSH: Antifibrotic Agents/*pharmacology , Integrins/*antagonists & inhibitors , Pulmonary Fibrosis/*drug therapy, Administration, Oral ; Animals ; Antifibrotic Agents/chemistry ; Antifibrotic Agents/therapeutic use ; Antigens, Neoplasm/chemistry ; Antigens, Neoplasm/metabolism ; Biological Availability ; Bleomycin/administration & dosage ; Bleomycin/toxicity ; Cells, Cultured ; Disease Models, Animal ; Epithelial Cells/drug effects ; Epithelial Cells/pathology ; Humans ; Integrins/chemistry ; Integrins/metabolism ; Lung/drug effects ; Lung/pathology ; Lysosomes/metabolism ; Male ; Mice ; Oligopeptides/chemistry ; Primary Cell Culture ; Proteolysis/drug effects ; Pulmonary Fibrosis/chemically induced ; Pulmonary Fibrosis/pathology ; Transforming Growth Factor beta/metabolism

المؤلفون: Garcia-Macia M; Newcastle Fibrosis Research Group, Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.; Institute of Biomedical Research of Salamanca, University Hospital of Salamanca, Salamanca, Spain.; Institute of Functional Biology and Genomics, University of Salamanca, CSIC, Salamanca, Spain.; Centro de Investigación Biomédica en Red sobre Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain., Santos-Ledo A; E.U.E Dacio Crespo (Universidad de Valladolid), Palencia, Spain., Leslie J; Newcastle Fibrosis Research Group, Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Paish HL; Newcastle Fibrosis Research Group, Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Collins AL; Newcastle Fibrosis Research Group, Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Scott RS; Newcastle Fibrosis Research Group, Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.; FibroFind Ltd, William Leech Building, Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom., Watson A; FibroFind Ltd, William Leech Building, Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom., Burgoyne RA; Newcastle Fibrosis Research Group, Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., White S; Department of Hepatobiliary Surgery, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom., French J; Department of Hepatobiliary Surgery, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom., Hammond J; Department of Hepatobiliary Surgery, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom., Borthwick LA; Newcastle Fibrosis Research Group, Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Mann J; Newcastle Fibrosis Research Group, Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Bolaños JP; Institute of Biomedical Research of Salamanca, University Hospital of Salamanca, Salamanca, Spain.; Institute of Functional Biology and Genomics, University of Salamanca, CSIC, Salamanca, Spain.; Centro de Investigación Biomédica en Red sobre Fragilidad y Envejecimiento Saludable (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain., Korolchuk VI; Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Oakley F; Newcastle Fibrosis Research Group, Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Mann DA; Newcastle Fibrosis Research Group, Biosciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.

المصدر: Hepatology (Baltimore, Md.) [Hepatology] 2021 Dec; Vol. 74 (6), pp. 3441-3459. Date of Electronic Publication: 2021 Sep 21.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 8302946 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-3350 (Electronic) Linking ISSN: 02709139 NLM ISO Abbreviation: Hepatology Subsets: MEDLINE

مواضيع طبية MeSH: Autophagy* , Signal Transduction*, Fatty Liver/*metabolism , Hepatocytes/*metabolism , Mechanistic Target of Rapamycin Complex 1/*metabolism , Perilipin-3/*metabolism, Animals ; Humans ; Male ; Mice ; Mice, Inbred C57BL

المؤلفون: Burgoyne RA; Fibrosis Research Group, Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK., Fisher AJ; Regenerative Medicine, Stem Cells and Transplantation Theme, Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.; Institute of Transplantation, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne NE7 7DN, UK., Borthwick LA; Fibrosis Research Group, Biosciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.; Fibrofind, Medical School, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.

المصدر: Cells [Cells] 2021 Oct 15; Vol. 10 (10). Date of Electronic Publication: 2021 Oct 15.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't; Review

بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE

مواضيع طبية MeSH: COVID-19/*immunology , Epithelium/*immunology , Idiopathic Pulmonary Fibrosis/*immunology , Lung/*immunology, Alarmins ; Animals ; Cellular Senescence ; Coculture Techniques ; Epithelial Cells/cytology ; Epithelial Cells/metabolism ; Fibroblasts/cytology ; Fibroblasts/metabolism ; Fibrosis/metabolism ; Humans ; Idiopathic Pulmonary Fibrosis/metabolism ; Immunity ; Inflammation/metabolism ; Ligands ; Necroptosis ; Necrosis/pathology ; Pulmonary Disease, Chronic Obstructive ; SARS-CoV-2 ; Signal Transduction

المؤلفون: Leslie J; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK. jack.leslie@newcastle.ac.uk., Macia MG; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Luli S; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Worrell JC; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Reilly WJ; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Paish HL; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Knox A; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Barksby BS; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Gee LM; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Zaki MYW; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Biochemistry Department, Faculty of Pharmacy, Minia University, Minia, Egypt., Collins AL; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Burgoyne RA; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Cameron R; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Bragg C; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Xu X; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Chung GW; Newcells Biotech, The Biosphere, Newcastle Helix, Newcastle upon Tyne, UK., Brown CDA; Newcells Biotech, The Biosphere, Newcastle Helix, Newcastle upon Tyne, UK., Blanchard AD; Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Stevenage, UK., Nanthakumar CB; Fibrosis Discovery Performance Unit, Respiratory Therapy Area, Medicines Research Centre, GlaxoSmithKline R&D, Stevenage, UK., Karsdal M; Nordic Bioscience A/S, Biomarkers & Research, Herlev, Denmark., Robinson SM; Department of Hepatobiliary Surgery, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Manas DM; Department of Hepatobiliary Surgery, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Sen G; Department of Hepatobiliary Surgery, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., French J; Department of Hepatobiliary Surgery, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., White SA; Department of Hepatobiliary Surgery, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Murphy S; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Trost M; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Zakrzewski JL; Center for Discovery and Innovation and John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, NJ, USA., Klein U; Division of Haematology & Immunology, Leeds Institute of Medical Research at St. James's, University of Leeds, Leeds, UK., Schwabe RF; Department of Medicine, Columbia University, New York, NY, USA., Mederacke I; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany., Nixon C; Cancer Research UK Beatson Institute, Garscube Estate, Glasgow, UK., Bird T; Cancer Research UK Beatson Institute, Garscube Estate, Glasgow, UK.; Institute of Cancer Sciences, University of Glasgow, Garscube Estate, Glasgow, UK.; MRC Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Teuwen LA; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, Leuven, Belgium., Schoonjans L; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, Leuven, Belgium., Carmeliet P; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, VIB, Leuven, Belgium.; Laboratory of Angiogenesis and Vascular Metabolism, Center for Cancer Biology, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, Leuven, Belgium., Mann J; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Fibrofind, Medical School, Newcastle University, Newcastle upon Tyne, UK., Fisher AJ; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Institute of Transplantation, The Freeman Hospital, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK., Sheerin NS; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK., Borthwick LA; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Fibrofind, Medical School, Newcastle University, Newcastle upon Tyne, UK., Mann DA; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.; Fibrofind, Medical School, Newcastle University, Newcastle upon Tyne, UK., Oakley F; Newcastle Fibrosis Research Group, Biosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK. fiona.oakley@newcastle.ac.uk.; Fibrofind, Medical School, Newcastle University, Newcastle upon Tyne, UK. fiona.oakley@newcastle.ac.uk.

المصدر: Nature metabolism [Nat Metab] 2020 Nov; Vol. 2 (11), pp. 1350-1367. Date of Electronic Publication: 2020 Nov 09.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE

مواضيع طبية MeSH: Epithelium/*pathology , Liver Cirrhosis/*genetics , Liver Cirrhosis/*pathology , Macrophages/*pathology , Proto-Oncogene Proteins c-rel/*genetics, Animals ; Cell Polarity/genetics ; Gene Targeting ; Hepatocytes/pathology ; Hydroxyproline/metabolism ; Liver Cirrhosis/prevention & control ; Liver Regeneration/genetics ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Mitosis/genetics ; Paracrine Communication/genetics ; Phosphofructokinase-2/genetics ; Proto-Oncogene Proteins c-rel/antagonists & inhibitors ; Proto-Oncogene Proteins c-rel/metabolism

المؤلفون: John AE; Respiratory Medicine NIHR Biomedical Research Centre, University of Nottingham, Nottingham, UK., Graves RH; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Pun KT; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Vitulli G; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Forty EJ; Centre for Inflammation and Tissue Repair, University College London, London, UK., Mercer PF; Centre for Inflammation and Tissue Repair, University College London, London, UK., Morrell JL; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Barrett JW; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Rogers RF; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Hafeji M; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Bibby LI; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Gower E; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Morrison VS; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Man Y; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Roper JA; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Luckett JC; Radiological Sciences, University of Nottingham, Nottingham, UK., Borthwick LA; Fibrosis Research Group, Newcastle University Biosciences Institute and Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK., Barksby BS; Fibrosis Research Group, Newcastle University Biosciences Institute and Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK., Burgoyne RA; Fibrosis Research Group, Newcastle University Biosciences Institute and Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK., Barnes R; Fibrosis Research Group, Newcastle University Biosciences Institute and Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK., Le J; Drug Design and Selection - Molecular Design, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Flint DJ; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK., Pyne S; Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, Glasgow, UK., Habgood A; Respiratory Medicine NIHR Biomedical Research Centre, University of Nottingham, Nottingham, UK., Organ LA; Respiratory Medicine NIHR Biomedical Research Centre, University of Nottingham, Nottingham, UK., Joseph C; Respiratory Medicine NIHR Biomedical Research Centre, University of Nottingham, Nottingham, UK., Edwards-Pritchard RC; Respiratory Medicine NIHR Biomedical Research Centre, University of Nottingham, Nottingham, UK., Maher TM; NIHR Respiratory Clinical Research Facility, Royal Brompton Hospital, London, UK.; Fibrosis Research Group, National Heart and Lung Institute, Imperial College, London, UK., Fisher AJ; Fibrosis Research Group, Newcastle University Biosciences Institute and Newcastle University Translational and Clinical Research Institute, Newcastle upon Tyne, UK.; Institute of Transplantation, Freeman Hospital, Newcastle Upon Tyne Hospitals NHS, Foundation Trust, Newcastle upon Tyne, UK., Gudmann NS; Nordic Bioscience A/S, Biomarkers and Research, Herlev Hovedgade 205-207, Herlev, Denmark., Leeming DJ; Nordic Bioscience A/S, Biomarkers and Research, Herlev Hovedgade 205-207, Herlev, Denmark., Chambers RC; Centre for Inflammation and Tissue Repair, University College London, London, UK., Lukey PT; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Marshall RP; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Macdonald SJF; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK., Jenkins RG; Respiratory Medicine NIHR Biomedical Research Centre, University of Nottingham, Nottingham, UK. gisli.jenkins@nottingham.ac.uk., Slack RJ; Fibrosis DPU, Respiratory TAU, GlaxoSmithKline, Stevenage, Hertfordshire, UK.

المصدر: Nature communications [Nat Commun] 2020 Sep 16; Vol. 11 (1), pp. 4659. Date of Electronic Publication: 2020 Sep 16.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

مواضيع طبية MeSH: Butyrates/*pharmacology , Idiopathic Pulmonary Fibrosis/*drug therapy , Integrins/*antagonists & inhibitors , Naphthyridines/*pharmacology , Pyrazoles/*pharmacology , Pyrrolidines/*pharmacology, Administration, Inhalation ; Animals ; Antigens, Neoplasm/metabolism ; Bleomycin/toxicity ; Butyrates/administration & dosage ; Butyrates/metabolism ; Butyrates/pharmacokinetics ; Collagen/metabolism ; Disease Models, Animal ; Epithelial Cells/drug effects ; Humans ; Idiopathic Pulmonary Fibrosis/chemically induced ; Idiopathic Pulmonary Fibrosis/pathology ; Integrins/metabolism ; Male ; Mice, Inbred C57BL ; Molecular Docking Simulation ; Naphthyridines/administration & dosage ; Naphthyridines/metabolism ; Naphthyridines/pharmacokinetics ; Pyrazoles/administration & dosage ; Pyrazoles/metabolism ; Pyrazoles/pharmacokinetics ; Pyrrolidines/administration & dosage ; Pyrrolidines/metabolism ; Pyrrolidines/pharmacokinetics ; Small Molecule Libraries/chemistry ; Small Molecule Libraries/pharmacology ; Tomography, Emission-Computed, Single-Photon ; Transforming Growth Factor beta/metabolism ; Translational Research, Biomedical

المؤلفون: Leslie J; Newcastle Fibrosis Research Group and., Millar BJ; Newcastle Fibrosis Research Group and., Del Carpio Pons A; Newcastle Fibrosis Research Group and., Burgoyne RA; Newcastle Fibrosis Research Group and., Frost JD; Newcastle Fibrosis Research Group and., Barksby BS; Newcastle Fibrosis Research Group and., Luli S; Newcastle Fibrosis Research Group and., Scott J; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom., Simpson AJ; Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom.; Interstitial Lung Disease Clinic, Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom., Gauldie J; Firestone Institute for Respiratory Health, Saint Joseph's Healthcare and Department of Pathology and Molecular Medicine, McMaster University Hamilton, Hamilton, Ontario, Canada., Murray LA; MedImmune Ltd., Cambridge, United Kingdom., Finch DK; MedImmune Ltd., Cambridge, United Kingdom., Carruthers AM; MedImmune Ltd., Cambridge, United Kingdom., Ferguson J; MedImmune Ltd., Cambridge, United Kingdom., Sleeman MA; MedImmune Ltd., Cambridge, United Kingdom., Rider D; MedImmune Ltd., Cambridge, United Kingdom., Howarth R; Newcastle Fibrosis Research Group and., Fox C; Newcastle Fibrosis Research Group and., Oakley F; Newcastle Fibrosis Research Group and., Fisher AJ; Newcastle Fibrosis Research Group and.; Institute of Transplantation, Freeman Hospital, Newcastle upon Tyne, United Kingdom., Mann DA; Newcastle Fibrosis Research Group and., Borthwick LA; Newcastle Fibrosis Research Group and.

المصدر: JCI insight [JCI Insight] 2020 Feb 27; Vol. 5 (4). Date of Electronic Publication: 2020 Feb 27.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 101676073 Publication Model: Electronic Cited Medium: Internet ISSN: 2379-3708 (Electronic) Linking ISSN: 23793708 NLM ISO Abbreviation: JCI Insight Subsets: MEDLINE

مواضيع طبية MeSH: Neutrophil Infiltration/*physiology , Pulmonary Fibrosis/*physiopathology , Receptors, Formyl Peptide/*physiology, Animals ; Bleomycin/toxicity ; Humans ; Ligands ; Mice, Inbred C57BL ; Mice, Knockout ; Pulmonary Fibrosis/chemically induced ; Pulmonary Fibrosis/pathology ; Receptors, Formyl Peptide/genetics ; Receptors, Formyl Peptide/metabolism