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المؤلفون: Burke, LK, Darwish, T, Cavanaugh, AR, Virtue, S, Roth, E, Morro, J, Liu, S-M, Xia, J, Dalley, JW, Burling, K, Chua, S, Vidal-Puig, T, Schwartz, GJ, Blouet, C

مصطلحات موضوعية: 2. Zero hunger, Neurons, obesity, medicine, nutrient-sensing, digestive, oral, and skin physiology, brown fat, human biology, Thermogenesis, Mechanistic Target of Rapamycin Complex 1, neuroscience, Mice, nervous system, Adipose Tissue, energy expenditure, Animals, Agouti-Related Protein, hypothalamus, Energy Metabolism, mTORC1, mouse, Signal Transduction

URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_________::f1679e9f46e21a7457ed60999ba4a898

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المؤلفون: Carr TF; Asthma and Airway Disease Research Center, University of Arizona, Tucson, AZ, USA., Moore WC; Department of Internal Medicine, Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest School of Medicine, Winston-Salem, NC, USA., Kraft M; Department of Medicine, Icahn School of Medicine, Mount Sinai Health System, New York, NY, USA., Brusselle G; Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium., Castro M; Division of Pulmonary, Critical Care and Sleep Medicine, University of Kansas School of Medicine, Kansas City, KS, USA., Chupp GL; Yale Center for Asthma and Airway Disease, Yale School of Medicine, Yale University, New Haven, CT, USA., Wechsler ME; National Jewish Health, Denver, CO, USA., Hunter G; Biometrics, Late-Stage Development, Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Lindsley AW; US Medical Affairs, Amgen, Thousand Oaks, CA, USA., Llanos JP; Global Medical Affairs, Amgen, Thousand Oaks, CA, USA., Burke LK; Respiratory and Immunology, BioPharmaceuticals R&D, AstraZeneca, Cambridge, UK., Chandarana S; Respiratory and Immunology, BioPharmaceuticals Medical, AstraZeneca, 1 MedImmune Way, Gaithersburg, MD, 20878, USA., Ambrose CS; Respiratory and Immunology, BioPharmaceuticals Medical, AstraZeneca, 1 MedImmune Way, Gaithersburg, MD, 20878, USA. chris.ambrose@astrazeneca.com.

المصدر: Advances in therapy [Adv Ther] 2024 Jul; Vol. 41 (7), pp. 2978-2990. Date of Electronic Publication: 2024 May 27.

نوع المنشور: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study

بيانات الدورية: Publisher: Health Communications Inc Country of Publication: United States NLM ID: 8611864 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1865-8652 (Electronic) Linking ISSN: 0741238X NLM ISO Abbreviation: Adv Ther Subsets: MEDLINE

مواضيع طبية MeSH: Asthma*/drug therapy , Antibodies, Monoclonal, Humanized*/therapeutic use , Anti-Asthmatic Agents*/therapeutic use, Humans ; Male ; Middle Aged ; Female ; Double-Blind Method ; Adult ; Aged ; Adolescent ; Young Adult ; Treatment Outcome ; Aged, 80 and over ; Child ; Severity of Illness Index

المؤلفون: Georgescu T; Rowett Institute, University of Aberdeen, Foresterhill, Aberdeen, UK.; Department of Pharmacology, University of Cambridge, Cambridge, UK.; Centre for Neuroendocrinology & Department of Anatomy, University of Otago, Dunedin, New Zealand., Lyons D; Rowett Institute, University of Aberdeen, Foresterhill, Aberdeen, UK., Doslikova B; Department of Pharmacology, University of Cambridge, Cambridge, UK., Garcia AP; Department of Pharmacology, University of Cambridge, Cambridge, UK., Marston O; Department of Pharmacology, University of Cambridge, Cambridge, UK., Burke LK; Department of Pharmacology, University of Cambridge, Cambridge, UK., Chianese R; Rowett Institute, University of Aberdeen, Foresterhill, Aberdeen, UK., Lam BYH; MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK., Yeo GSH; MRC Metabolic Diseases Unit, University of Cambridge Metabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK., Rochford JJ; Department of Pharmacology, University of Cambridge, Cambridge, UK., Garfield AS; Department of Pharmacology, University of Cambridge, Cambridge, UK., Heisler LK; Rowett Institute, University of Aberdeen, Foresterhill, Aberdeen, UK.; Department of Pharmacology, University of Cambridge, Cambridge, UK.

المصدر: Endocrinology [Endocrinology] 2020 Apr 01; Vol. 161 (4).

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375040 Publication Model: Print Cited Medium: Internet ISSN: 1945-7170 (Electronic) Linking ISSN: 00137227 NLM ISO Abbreviation: Endocrinology Subsets: MEDLINE

مواضيع طبية MeSH: Brain Stem/*metabolism , Neurons/*metabolism , Pro-Opiomelanocortin/*metabolism , Receptors, Leptin/*metabolism, Animals ; Brain-Derived Neurotrophic Factor/metabolism ; Cholecystokinin/metabolism ; Choline O-Acetyltransferase/metabolism ; GTP-Binding Protein gamma Subunits/metabolism ; Glucagon-Like Peptide 1/metabolism ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Mice ; Mice, Transgenic ; Nitric Oxide Synthase Type I/metabolism ; Nucleobindins/metabolism ; Promoter Regions, Genetic ; Receptors, Leptin/genetics ; Tyrosine 3-Monooxygenase/metabolism

المؤلفون: McCloskey R; Professor, Department of Nursing & Health Sciences, University of New Brunswick, Saint John, NB., Stewart C; Department of Mathematics and Statistics, University of New Brunswick, Saint John, NB., Burke LK; Associate Dean of Health Research, Department of Nursing & Health Sciences, University of New Brunswick, Saint John, NB.

المصدر: Nursing leadership (Toronto, Ont.) [Nurs Leadersh (Tor Ont)] 2019 Dec; Vol. 32 (4), pp. 30-45.

نوع المنشور: Journal Article; Review

بيانات الدورية: Publisher: Longwoods Pub. Corp. [for the] Academy of Canadian Executive Nurses Country of Publication: Canada NLM ID: 101470760 Publication Model: Print Cited Medium: Internet ISSN: 1910-622X (Print) Linking ISSN: 1910622X NLM ISO Abbreviation: Nurs Leadersh (Tor Ont)

مواضيع طبية MeSH: Predictive Value of Tests*, Clinical Competence/*standards , Educational Measurement/*methods , Licensure, Nursing/*standards, Canada ; Chi-Square Distribution ; Clinical Competence/statistics & numerical data ; Education, Nursing, Baccalaureate/standards ; Education, Nursing, Baccalaureate/statistics & numerical data ; Educational Measurement/statistics & numerical data ; Humans ; Licensure, Nursing/statistics & numerical data ; Logistic Models ; Retrospective Studies ; Surveys and Questionnaires

المؤلفون: D'Agostino G; Rowett Institute, University of Aberdeen, Aberdeen, UK; Department of Pharmacology, University of Cambridge, Cambridge, UK. Electronic address: giuseppe.dagostino@abdn.ac.uk., Lyons D; Rowett Institute, University of Aberdeen, Aberdeen, UK., Cristiano C; Rowett Institute, University of Aberdeen, Aberdeen, UK., Lettieri M; Rowett Institute, University of Aberdeen, Aberdeen, UK., Olarte-Sanchez C; Rowett Institute, University of Aberdeen, Aberdeen, UK., Burke LK; Department of Pharmacology, University of Cambridge, Cambridge, UK., Greenwald-Yarnell M; Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA., Cansell C; Rowett Institute, University of Aberdeen, Aberdeen, UK., Doslikova B; Department of Pharmacology, University of Cambridge, Cambridge, UK., Georgescu T; Rowett Institute, University of Aberdeen, Aberdeen, UK., Martinez de Morentin PB; Rowett Institute, University of Aberdeen, Aberdeen, UK., Myers MG Jr; Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA., Rochford JJ; Rowett Institute, University of Aberdeen, Aberdeen, UK., Heisler LK; Rowett Institute, University of Aberdeen, Aberdeen, UK; Department of Pharmacology, University of Cambridge, Cambridge, UK. Electronic address: lora.heisler@abdn.ac.uk.

المصدر: Cell metabolism [Cell Metab] 2018 Oct 02; Vol. 28 (4), pp. 619-630.e5. Date of Electronic Publication: 2018 Aug 23.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Cell Press Country of Publication: United States NLM ID: 101233170 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-7420 (Electronic) Linking ISSN: 15504131 NLM ISO Abbreviation: Cell Metab Subsets: MEDLINE

مواضيع طبية MeSH: Appetite Depressants/*therapeutic use , Benzazepines/*therapeutic use , Eating/*physiology , Obesity/*drug therapy , Serotonin 5-HT2 Receptor Agonists/*therapeutic use , Solitary Nucleus/*metabolism, Analysis of Variance ; Animals ; Appetite Depressants/metabolism ; Appetite Regulation/drug effects ; Arcuate Nucleus of Hypothalamus/cytology ; Benzazepines/metabolism ; Cell Line, Tumor ; Feeding Behavior/physiology ; Male ; Mice ; Mice, Knockout ; Neurons/metabolism ; Receptor, Serotonin, 5-HT2C/metabolism ; Serotonin 5-HT2 Receptor Agonists/metabolism ; Statistics, Nonparametric ; Transfection

المؤلفون: Burke LK; Department of Pharmacology, University of Cambridge, Cambridge, UK; Department of Medicine and Wellcome Trust/MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Ogunnowo-Bada E; Department of Medicine and Wellcome Trust/MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Georgescu T; The Rowett Institute, University of Aberdeen, Aberdeen, UK., Cristiano C; The Rowett Institute, University of Aberdeen, Aberdeen, UK., de Morentin PBM; The Rowett Institute, University of Aberdeen, Aberdeen, UK., Valencia Torres L; Department of Pharmacology, University of Cambridge, Cambridge, UK; The Rowett Institute, University of Aberdeen, Aberdeen, UK., D'Agostino G; Department of Pharmacology, University of Cambridge, Cambridge, UK; The Rowett Institute, University of Aberdeen, Aberdeen, UK., Riches C; Department of Medicine and Wellcome Trust/MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Heeley N; Department of Medicine and Wellcome Trust/MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Ruan Y; Department of Medicine and Wellcome Trust/MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK., Rubinstein M; Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, Consejo Nacional de Investigaciones Científicas y Técnicas, 1428 Buenos Aires, Argentina., Low MJ; Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA., Myers MG; Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA., Rochford JJ; The Rowett Institute, University of Aberdeen, Aberdeen, UK., Evans ML; Department of Medicine and Wellcome Trust/MRC Institute of Metabolic Science, University of Cambridge, Cambridge, UK. Electronic address: mle24@cam.ac.uk., Heisler LK; Department of Pharmacology, University of Cambridge, Cambridge, UK; The Rowett Institute, University of Aberdeen, Aberdeen, UK. Electronic address: lora.heisler@abdn.ac.uk.

المصدر: Molecular metabolism [Mol Metab] 2017 Oct; Vol. 6 (10), pp. 1092-1102. Date of Electronic Publication: 2017 Jul 21.

نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-8778 (Electronic) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: MEDLINE

مواضيع طبية MeSH: Benzazepines/*pharmacology , Blood Glucose/*drug effects , Receptor, Serotonin, 5-HT2C/*drug effects, Animals ; Benzazepines/metabolism ; Body Weight/drug effects ; Diabetes Mellitus, Type 2/drug therapy ; Disease Models, Animal ; Eating/drug effects ; Energy Metabolism/drug effects ; Glucose/metabolism ; Glucose Tolerance Test ; Homeostasis/physiology ; Humans ; Insulin Resistance/physiology ; Melanocortins/pharmacology ; Mice ; Mice, Transgenic ; Obesity/drug therapy ; Receptors, Melanocortin/drug effects ; Weight Loss/drug effects

المؤلفون: Burke LK; MRC Metabolic Diseases Unit, Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom.; WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom., Darwish T; MRC Metabolic Diseases Unit, Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom.; WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom., Cavanaugh AR; Departments of Medicine and Neuroscience, The Albert Einstein College of Medicine, New York, United States., Virtue S; MRC Metabolic Diseases Unit, Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom.; WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom., Roth E; MRC Metabolic Diseases Unit, Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom.; WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom., Morro J; MRC Metabolic Diseases Unit, Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom.; WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom., Liu SM; Departments of Medicine and Neuroscience, The Albert Einstein College of Medicine, New York, United States., Xia J; Department of Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom., Dalley JW; Department of Psychology, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom.; Department of Psychiatry, Behavioural and Clinical Neuroscience Institute, University of Cambridge, Cambridge, United Kingdom., Burling K; MRC Metabolic Diseases Unit, Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom.; WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom., Chua S; Departments of Medicine and Neuroscience, The Albert Einstein College of Medicine, New York, United States., Vidal-Puig T; MRC Metabolic Diseases Unit, Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom.; WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom., Schwartz GJ; Departments of Medicine and Neuroscience, The Albert Einstein College of Medicine, New York, United States., Blouet C; MRC Metabolic Diseases Unit, Metabolic Research Laboratories, University of Cambridge, Cambridge, United Kingdom.; WT-MRC Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom.

المصدر: ELife [Elife] 2017 May 23; Vol. 6. Date of Electronic Publication: 2017 May 23.

نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't

بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

مواضيع طبية MeSH: Energy Metabolism*, Agouti-Related Protein/*metabolism , Mechanistic Target of Rapamycin Complex 1/*metabolism , Neurons/*physiology, Adipose Tissue/physiology ; Animals ; Mice ; Signal Transduction ; Thermogenesis